611 results on '"Bohr, Vilhelm A."'
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2. Salidroside promotes healthy longevity by interfering with HSP90 activity
3. Nicotinamide riboside modulates the reactive species interactome, bioenergetic status and proteomic landscape in a brain-region-specific manner
4. Human fibroblasts from sporadic Alzheimer's disease (AD) patients show mitochondrial alterations and lysosome dysfunction
5. Boosting NAD ameliorates hematopoietic impairment linked to short telomeres in vivo
6. Mitochondrial PARP1 regulates NAD+-dependent poly ADP-ribosylation of mitochondrial nucleoids
7. Rev1 deficiency induces a metabolic shift in MEFs that can be manipulated by the NAD+ precursor nicotinamide riboside
8. RecQ dysfunction contributes to social and depressive-like behavior and affects aldolase activity in mice
9. NAD⁺ supplementation reduces neuroinflammation and cell senescence in a transgenic mouse model of Alzheimer’s disease via cGAS–STING
10. Molecular markers of DNA repair and brain metabolism correlate with cognition in centenarians
11. Loss of DNA glycosylases improves health and cognitive function in a C. elegans model of human tauopathy.
12. Markers of Mitochondrial Function and DNA Repair Associated with Physical Function in Centenarians.
13. Skin Abnormalities in Disorders with DNA Repair Defects, Premature Aging, and Mitochondrial Dysfunction
14. Urolithin A improves Alzheimer's disease cognition and restores mitophagy and lysosomal functions.
15. Spatial Transcriptomics Reveals Genes Associated with Dysregulated Mitochondrial Functions and Stress Signaling in Alzheimer Disease
16. NAD+ augmentation with nicotinamide riboside improves lymphoid potential of Atm−/− and old mice HSCs
17. Biological sex and DNA repair deficiency drive Alzheimer’s disease via systemic metabolic remodeling and brain mitochondrial dysfunction
18. NAD+ supplementation normalizes key Alzheimer’s features and DNA damage responses in a new AD mouse model with introduced DNA repair deficiency
19. Enhanced mitochondrial DNA repair of the common disease-associated variant, Ser326Cys, of hOGG1 through small molecule intervention
20. Senolytic therapy alleviates Aβ-associated oligodendrocyte progenitor cell senescence and cognitive deficits in an Alzheimer’s disease model
21. Mitophagy inhibits amyloid-β and tau pathology and reverses cognitive deficits in models of Alzheimer’s disease
22. Short-term NAD+ supplementation prevents hearing loss in mouse models of Cockayne syndrome
23. Gene Expression Profiling in Werner Syndrome Closely Resembles That of Normal Aging
24. Cockayne syndrome group A and B proteins converge on transcription-linked resolution of non-B DNA
25. NAD+ in Aging: Molecular Mechanisms and Translational Implications
26. Mitophagy in neurodegeneration and aging
27. Hippocampal tau oligomerization early in tau pathology coincides with a transient alteration of mitochondrial homeostasis and DNA repair in a mouse model of tauopathy
28. NAD+ augmentation restores mitophagy and limits accelerated aging in Werner syndrome
29. A ketogenic diet accelerates neurodegeneration in mice with induced mitochondrial DNA toxicity in the forebrain
30. Altered Spectra of Hypermutation in Antibodies from Mice Deficient for the DNA Mismatch Repair Protein PMS2
31. Reduced RNA Polymerase II Transcription in Intact and Permeabilized Cockayne Syndrome Group B Cells
32. NAD+ Replenishment Improves Lifespan and Healthspan in Ataxia Telangiectasia Models via Mitophagy and DNA Repair
33. Effects of Sex, Strain, and Energy Intake on Hallmarks of Aging in Mice
34. Mitochondrial SIRT3 Mediates Adaptive Responses of Neurons to Exercise and Metabolic and Excitatory Challenges
35. Single-molecule imaging reveals a common mechanism shared by G-quadruplex–resolving helicases
36. Worldwide Studies on Cockayne Syndrome are Needed
37. Long‐term NAD+ supplementation prevents the progression of age‐related hearing loss in mice.
38. Regulation of the Intranuclear Distribution of the Cockayne Syndrome Proteins
39. Partial loss of the DNA repair scaffolding protein, Xrcc1, results in increased brain damage and reduced recovery from ischemic stroke in mice
40. Loss of NEIL1 causes defects in olfactory function in mice
41. A High-Fat Diet and NAD+ Activate Sirt1 to Rescue Premature Aging in Cockayne Syndrome
42. Base excision DNA repair levels in mitochondrial lysates of Alzheimer's disease
43. Modulation of DNA base excision repair during neuronal differentiation
44. Loss of smelling is an early marker of aging and is associated with inflammation and DNA damage in C57BL/6J mice.
45. Endonuclease VIII-like 1 (NEIL1) promotes short-term spatial memory retention and protects from ischemic stroke-induced brain dysfunction and death in mice
46. Human longevity and variation in GH/IGF-1/insulin signaling, DNA damage signaling and repair and pro/antioxidant pathway genes: Cross sectional and longitudinal studies
47. Mitochondrial base excision repair in mouse synaptosomes during normal aging and in a model of Alzheimer's disease
48. Dynamics of the DNA repair proteins WRN and BLM in the nucleoplasm and nucleoli
49. Aprataxin localizes to mitochondria and preserves mitochondrial function
50. Tomatidine enhances lifespan and healthspan in C. elegans through mitophagy induction via the SKN-1/Nrf2 pathway
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