Search

Your search keyword '"Boccalini, M."' showing total 7 results
Start Over Author "Boccalini, M." Search Limiters Peer Reviewed
7 results on '"Boccalini, M."'

4. Thermal cracking of multicomponent white cast iron.

Author

Da Silva, C. R. S. and Boccalini, M.

Subjects
*THERMAL fatigue of metals, *IRON, *CARBIDES, *METAL fractures, *NUCLEATION
Abstract

The effect of the volume fraction of eutectic carbides on the thermal fatigue resistance of multicomponent white cast iron has been investigated. Thermal fatigue tests were carried out for 100 and 500 cycles. Nucleation of thermal fatigue cracks took place mostly at the specimen surface, induced by mechanical and metallurgical stress raisers. The crack nucleated in the matrix as well as at the carbide/matrix interface or at the carbide itself. The surface crack density increased slightly for increasing volume fraction of eutectic carbides from 9 to 14%, approximately. Crack propagation took place mostly at the carbide/matrix interface or through the carbide. The propagation rate was affected by the carbide distribution: the higher was the 'carbide continuity/mean free path between carbides' ratio, the higher was the propagation rate. The propagation rate decreased with increasing test time, regardless of the volume fraction of eutectic carbides. [ABSTRACT FROM AUTHOR]

Published
2005
Full Text
View/download PDF

5. Natural and synthetic geiparvarins are strong and selective MAO-B inhibitors. synthesis and SAR studies

Author

Angelo Carotti, Bernard Testa, Pierre-Alain Carrupt, Antonio Carrieri, Stefano Chimichi, Barbara Cosimelli, Andrea Carotti, Marco Boccalini, Carmela Gnerre, Carotti, A, Carrieri, A, Chimichi, S, Boccalini, M, Cosimelli, Barbara, Gnerre, C, CARRUPT P., A, and Testa, B.

Subjects
Models, Molecular, Monoamine Oxidase/drug effects, Monoamine Oxidase Inhibitors, Stereochemistry, Monoamine oxidase, Clinical Biochemistry, Pharmaceutical Science, Monoamine Oxidase Inhibitors/*chemical synthesis/chemistry/pharmacology, Crystallography, X-Ray, Biochemistry, Geiparvarin, Inhibitory Concentration 50, Structure-Activity Relationship, chemistry.chemical_compound, Coumarins, Drug Discovery, Organic chemistry, Monoamine Oxidase, Molecular Biology, ddc:615, Coumarins/chemical synthesis/chemistry/*pharmacology, Organic Chemistry, Desmethyl, Congener, chemistry, Molecular Medicine, Monoamine oxidase B
Abstract

Natural geiparvarin 1 and a number of its analogues were prepared and tested as inhibitors of both monoamine oxidase isoforms, MAO-B and MAO-A. The desmethyl congener 6 of geiparvarin, proved potent and selective MAO-B inhibitor (pIC(50)=7.55 vs 4.62). X-ray crystallography and molecular modelling studies helped the understanding of the observed structure-activity relationships.

Published
2002
Full Text
View/download PDF

6. New geiparvarin analogues from 7-(2-oxoethoxy)coumarins as efficient in vitro antitumoral agents

Author

Giampietro Viola, Stefano Chimichi, Barbara Cosimelli, Marco Boccalini, Daniela Vedaldi, Francesco Dall'Acqua, Chimichi, S, Boccalini, M, Cosimelli, Barbara, Viola, G, Vedaldi, D, and Dall'Acqua, F.

Subjects
chemistry.chemical_compound, chemistry, Organic Chemistry, Drug Discovery, Organic chemistry, Human cell, Biochemistry, Geiparvarin, In vitro
Abstract

A new class of compounds analogues of geiparvarin is described: aldolic condensation of 3(2H)-furanones and 7-(2-oxoethoxy)coumarins followed by a very efficient dehydration protocol led to the title compounds which show good antitumoral activity against several human cell lines.

Published
2002
Full Text
View/download PDF

7. A convenient synthesis of psoralens

Author

Barbara Cosimelli, Francesco Dall'Acqua, Daniela Vedaldi, Marco Boccalini, Giampietro Viola, Stefano Chimichi, Chimichi, S, Boccalini, M, Cosimelli, Barbara, Viola, G, Vedaldi, D, and Dall'Acqua, F.

Subjects
Stereochemistry, Chemistry, Organic Chemistry, Furocoumarin, Biochemistry, Murine fibroblast, Phototoxicity, Oxyaldehydes, Furocoumarins, Drug Discovery, Coumarin derivative, Psoralen, Cultured Cell Line
Abstract

An efficient synthesis (yields >70%) of linear 7H-furo[3,2-g]chromen-7-one derivatives (psoralens or furocoumarins) has been carried out starting from ring-substituted 2-(coumarin-7-yl)oxyaldehydes; moreover, the phototoxicity of these compounds has been tested on a cultured cell line of murine fibroblast. © 2002 Elsevier Science Ltd. All rights reserved.

Published
2002
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results