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1. Association between night-time surgery and occurrence of intraoperative adverse events and postoperative pulmonary complications

Author

Kroell, W., Metzler, H., Struber, G., Wegscheider, T., Gombotz, H., Hiesmayr, M., Schmid, W., Urbanek, B., Kahn, D., Momeni, M., Pospiech, A., Lois, F., Forget, P., Grosu, I., Poelaert, J., Mossevelde, V., van Malderen, M.C., Dylst, D., Melkebeek, J.V., Beran, M., Hert, S.D., Baerdemaeker, L.D., Heyse, B., Limmen, J.V., Wyffels, P., Jacobs, T., Roels, N., Bruyne, A.D., Velde, S.V.D., Marina, J.Z., Dejana, D.O., Pernar, S., Zunic, J., Miskovic, P., Zilic, A., Kvolik, S., Ivic, D., Darija, A.V., Skiljic, S., Vinkovic, H., Oputric, I., Juricic, K., Frkovic, V., Kopic, J., Mirkovic, I., Saric, J.P., Erceg, G., Dvorscak, M.B., Branka, M.S., Pavicic, A.M., Goranovic, T., Maldini, B., Radocaj, T., Gavranovic, Z., Inga, M.B., Sehovic, M., Stourac, P., Harazim, H., Smekalova, O., Kosinova, M., Kolacek, T., Hudacek, K., Drab, M., Brujevic, J., Vitkova, K., Jirmanova, K., Volfova, I., Dzurnakova, P., Liskova, K., Dudas, R., Filipsky, R., Kafrawy, S.E., Abdelwahab, H.H., Metwally, T., Ahmed, A.R., Ahmed Mostafa, E.S., Hasan, W.F., Ahmed, A.G., Yassin, H., Magdy, M., Abdelhady, M., Mahran, M., Herodes, E., Kivik, P., Oganjan, J., Aun, A., Sormus, A., Sarapuu, K., Mall, M., Karjagin, J., Futier, E., Petit, A., Gerard, A., Marret, E., Solier, M., Jaber, S., Prades, A., Krassler, J., Merzky, S., Abreu, M.G.D., Uhlig, C., Kiss, T., Bundy, A., Bluth, T., Gueldner, A., Spieth, P., Scharffenberg, M., Thiem, D.T., Koch, T., Treschan, T., Schaefer, M., Bastin, B., Geib, J., Weiss, M., Kienbaum, P., Pannen, B., Gottschalk, A., Konrad, M., Westerheide, D., Schwerdtfeger, B., Wrigge, H., Simon, P., Reske, A., Nestler, C., Valsamidis, D., Stroumpoulis, K., Antholopoulos, G., Andreou, A., Karapanos, D., Theodoraki, K., Gkiokas, G., Tasoulis, M.K., Sidiropoulou, T., Zafeiropoulou, F., Florou, P., Pandazi, A., Tsaousi, G., Nouris, C., Pourzitaki, C., Bystritski, D., Pizov, R., Eden, A., Pesce, C.V., Campanile, A., Marrella, A., Grasso, S., Michele, M.D., Bona, F., Giacoletto, G., Sardo, E., Sottosanti, L.G.V., Solca, M., Volta, C.A., Spadaro, S., Verri, M., Ragazzi, R., Zoppellari, R., Cinnella, G., Raimondo, P., Bella, D.L., Mirabella, L., D'antini, D., Pelosi, P., Molin, A., Brunetti, I., Gratarola, A., Pellerano, G., Sileo, R., Pezzatto, S., Montagnani, L., Pasin, L., Landoni, G., Zangrillo, A., Beretta, L., Parma, A.L.D., Tarzia, V., Dossi, R., Sassone, M.E., Sances, D., Tredici, S., Spano, G., Castellani, G., Delunas, L., Peradze, S., Venturino, M., Arpino, I., Sher, S., Tommasino, C., Rapido, F., Morelli, P., Vargas, M., Servillo, G., Cortegiani, A., Raineri, S.M., Montalto, F., Russotto, V., Giarratano, A., Baciarello, M., Generali, M., Cerati, G., Leykin, Y., Bressan, F., Bartolini, V., Zamidei, L., Brazzi, L., Liperi, C., Sales, G., Pistidda, L., Severgnini, P., Brugnoni, E., Musella, G., Bacuzzi, A., Muhardri, D., Agreta, G.G., Sada, F., Bytyqi, A., Karbonskiene, A., Aukstakalniene, R., Teberaite, Z., Salciute, E., Tikuisis, R., Miliauskas, P., Jurate, S., Kontrimaviciute, E., Tomkute, G., Xuereb, J., Bezzina, M., Borg, F. Joseph, Hemmes, S., Schultz, M., Hollmann, M., Wiersma, I., Binnekade, J., Bos, L., Boer, C., Duvekot, A., Veld, B.I ‘t, Werger, A., Dennesen, P., Severijns, C., Jong, J.D., Hering, J., Beek, R.V., Ivars, S., Jammer, I.B., Breidablik, A., Hodt, K.S., Fjellanger, F., Avalos, M.V., Jannicke, M.O., Andersson, E., Amir, S.K., Molina, R., Wutai, S., Morais, E., Tareco, G., Ferreira, D., Amaral, J., Castro, M.D.L.G., Cadilha, S., Appleton, S., Parente, S., Correia, M., Martins, D., Monteirosa, A., Ricardo, A., Rodrigues, S., Horhota, L., Grintescu, I.M., Mirea, L., Grintescu, I.C., Corneci, D., Negoita, S., Dutu, M., Popescu Garotescu, I., Filipescu, D., Prodan, A.B., Droc, G., Fota, R., Popescu, M., Tomescu, D., Petcu, A.M., Tudoroiu, M.I., Moise, A., Guran, C.T., Gherghina, I., Costea, D., Cindea, I., Copotoiu, S.M., Copotoiu, R., Barsan, V., Tolcser, Z., Riciu, M., Moldovan, S.G., Veres, M., Gritsan, A., Kapkan, T., Gritsan, G., Korolkov, O., Kulikov, A., Lubnin, A., Ovezov, A., Prokoshev, P., Lugovoy, A., Anipchenko, N., Babayants, A., Komissarova, I., Zalina, K., Likhvantsev, V., Fedorov, S., Lazukic, A., Pejakovic, J., Mihajlovic, D., Kusnierikova, Z., Zelinkova, M., Bruncakova, K., Polakovicova, L., Sobona, V., Barbka, N.S., Ana, P.G., Jovanov, M., Strazisar, B., Jasmina, M.B., Vesna, N.J., Voje, M., Grynyuk, A., Kostadinov, I., Alenka, S.V., Moral, V., Unzueta, M.C., Puigbo, C., Fava, J., Canet, J., Moret, E., Nunez, M.R., Sendra, M., Brunelli, A., Rodenas, F., Monedero, P., Hidalgo, F., Yepes, M.J., Martinez-Simon, A., Abajo, A., Lisi, A., Perez, G., Martinez, R., Granell, M., Vivo, J.T., Ruiz, C.S., Andrés Ibañez, J.A.D., Pastor, E., Soro, M., Ferrando, C., Defez, M., Cesar Aldecoa, A.S., Perez, R., Rico, J., Jawad, M., Saeed, Y., Gillberg, L., Bengisun, Z.K., Kazbek, B.K., Coskunfirat, N., Boztug, N., Sanli, S., Yilmaz, M., Hadimioglu, N., Senturk, N.M., Camci, E., Kucukgoncu, S., Sungur, Z., Sivrikoz, N., Ozgen, S.U., Toraman, F., Selvi, O., Senturk, O., Yildiz, M., Kuvaki, B., Gunenc, F., Kucukguclu, S., Ozbilgin, S., Maral, J., Canli, S., Arun, O., Saltali, A., Aydogan, E., Akgun, F.N., Sanlikarip, C., Karaman, F.M., Mazur, A., Vorotyntsev, S., Rousseau, G., Barrett, C., Stancombe, L., Shelley, B., Scholes, H., Limb, J., Rafi, A., Wayman, L., Deane, J., Rogerson, D., Williams, J., Yates, S., Rogers, E., Pulletz, M., Moreton, S., Jones, S., Venkatesh, S., Burton, M., Brown, L., Goodall, C., Rucklidge, M., Fuller, D., Nadolski, M., Kusre, S., Lundberg, M., Everett, L., Nutt, H., Zuleika, M., Carvalho, P., Clements, D., Ben, C.B., Watt, P., Raymode, P., Pearse, R., Mohr, O., Raj, A., Creary, T., Chishti, A., Bell, A., Higham, C., Cain, A., Gibb, S., Mowat, S., Franklin, D., West, C., Minto, G., Boyd, N., Mills, G., Calton, E., Walker, R., Mackenzie, F., Ellison, B., Roberts, H., Chikungwa, M., Jackson, C., Donovan, A., Foot, J., Homan, E., Montgomery, J., Portch, D., Mercer, P., Palmer, J., Paddle, J., Fouracres, A., Datson, A., Andrew, A., Welch, L., Rose, A., Varma, S., Simeson, K., Rambhatla, M., Susarla, J., Marri, S., Kodaganallur, K., Das, A., Algarsamy, S., Colley, J., Davies, S., Szewczyk, M., Smith, T., Ana, F.B., Luzier, E., Almagro, A., Melo, M.V., Fernando, L., Sulemanji, D., Sprung, J., Weingarten, T., Kor, D., Scavonetto, F., Tze, Y., Gregoretti, C., Neto, A.S., Hemmes, S.N.T., Ball, L., Hollmann, M.W., Mills, G.H., Melo, M.F.V., Putensen, C., Gama de Abreu, M., and Schultz, M.J.

Published
2019
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10. Association of intraoperative hypotension with postoperative morbidity and mortality: systematic review and meta-analysis.

Author

Wijnberge, M., Schenk, J., Bulle, E., Vlaar, A. P., Maheshwari, K., Hollmann, M. W., Binnekade, J. M., Geerts, B. F., and Veelo, D. P.

Subjects
HYPOTENSION, SURGICAL complications, SYSTEMATIC reviews
Abstract

Background: Intraoperative hypotension, with varying definitions in literature, may be associated with postoperative complications. The aim of this meta-analysis was to assess the association of intraoperative hypotension with postoperative morbidity and mortality. Methods: MEDLINE, Embase and Cochrane databases were searched for studies published between January 1990 and August 2018. The primary endpoints were postoperative overall morbidity and mortality. Secondary endpoints were postoperative cardiac outcomes, acute kidney injury, stroke, delirium, surgical outcomes and combined outcomes. Subgroup analyses, sensitivity analyses and a meta-regression were performed to test the robustness of the results and to explore heterogeneity. Results: The search identified 2931 studies, of which 29 were included in the meta-analysis, consisting of 130 862 patients. Intraoperative hypotension was associated with an increased risk of morbidity (odds ratio (OR) 2.08, 95 per cent confidence interval 1.56 to 2.77) and mortality (OR 1.94, 1.32 to 2.84). In the secondary analyses, intraoperative hypotension was associated with cardiac complications (OR 2.44, 1.52 to 3.93) and acute kidney injury (OR 2.69, 1.31 to 5.55). Overall heterogeneity was high, with an I³ value of SS per cent. When hypotension severity, outcome severity and study population variables were added to the meta-regression, heterogeneity was reduced to 50 per cent. Conclusion: Intraoperative hypotension during non-cardiac surgery is associated with postoperative cardiac and renal morbidity, and mortality. A universally accepted standard definition of hypotension would facilitate further research into this topic. [ABSTRACT FROM AUTHOR]

Published
2021
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11. The practice of diagnosing and reporting transfusion‐associated circulatory overload: a national survey among physicians and haemovigilance officers.

Author

Bosboom, J. J., Klanderman, R. B., Peters, A. L., van de Weerdt, E. K., Goudswaard, E. J., Binnekade, J. M., Zwaginga, J. J., Beckers, E. A. M., Geerts, B. F., Hollmann, M. W., Zeerleder, S. S., van Kraaij, M., and Vlaar, A. P.

Subjects
BLOOD transfusion, BLOOD circulation, CRITICAL care medicine, HEMATOLOGY, BLOOD transfusion reaction, KIDNEY failure, SYMPTOMS
Abstract

SUMMARY: Objectives: This study aims at identifying factors that disciplines consider when diagnosing and reporting transfusion‐associated circulatory overload ('TACO'). Background: TACO is a clinical diagnosis based mainly on subjective factors. Therefore, TACO could be an underreported complication of blood transfusion. Methods: A survey was conducted among critical care physicians, anaesthesiologists, haematologists, transfusion medicine physicians and haemovigilance officers using case vignettes and a questionnaire. Factors that may affect diagnosing TACO were investigated using conjoint analysis. A positive B‐coefficient indicates a positive preference for diagnosing TACO. Participants rated factors influencing reporting TACO on a 0‐ to 100‐point scale. Results: One hundred and seven surveys were returned (62%). Vignettes showed preferences in favour of diagnosing TACO with the onset of symptoms within 2 h [β 0·4(−0·1–1·0)], positive fluid balance [β 0·9(0·4–1·5)] and history of renal failure [β 0·6(0·1–1·2)]. Compared with transfusion of a single unit of red blood cells (RBC), respondents showed a preference for diagnosing TACO following a single unit of solvent/detergent (S/D) plasma or pooled platelet concentrate (PPC) [β 0·3(−0·2–0·7) resp. 0·5(−0·1–1·2)]. Multiple transfusion (6 RBC + 4 S/D plasma) was a strong preference for diagnosing TACO compared to 1 RBC and 1 S/D plasma [β 0·3(−0·8–1·3)]. Respondents did not fully take into account new hypertension and tachycardia when reporting TACO [median 70 (IQR 50–80) resp. 60 (IQR 50–80)]. No differences were observed between disciplines involved. Conclusion: When diagnosing and reporting TACO, physicians and haemovigilance officers do consider known risk factors for TACO. Reporting could be improved by increasing the awareness of haemodynamic variables in future education programmes. [ABSTRACT FROM AUTHOR]

Published
2018
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12. The practice of platelet transfusion prior to central venous catheterization in presence of coagulopathy: a national survey among clinicians.

Author

Weerdt, E. K., Peters, A. L., Goudswaard, E. J., Binnekade, J. M., Lienden, K. P., Biemond, B. J., and Vlaar, A. P. J.

Subjects
BLOOD platelets, BLOOD coagulation disorders, CENTRAL venous catheterization, HEMATOLOGISTS, THROMBOCYTOPENIA
Abstract

Background Correction of coagulopathy prior to central venous catheter ( CVC) placement is advocated by guidelines, while retrospective studies support restrictive use of transfusion products. Study Design and Methods We conducted a mixed vignette and questionnaire web survey to investigate current practice and preferences for CVC placement. Clinical vignettes were used to quantify the tendency to administer platelet concentrate. A positive ß-coefficient is in favour of administering platelet concentrate. Results Ninety-seven physicians answered the survey questions (36 critical care physicians, 14 haematologists, 20 radiologists and 27 anaesthesiologist). Eighty-six physicians subsequently completed the clinical vignettes (response rate 71%). Preferences in favour of correcting thrombocytopenia prior CVC placement were platelet counts of 10 × 109/L and 20 × 109/L (ß = 3·9; ß = 3·2, respectively), the subclavian insertion site (ß = 0·8). An elevated INR ( INR = 3; ß = 0·6) and an elevated aPTT ( aPTT = 60 s; ß = 0·4) showed a positive trend towards platelet transfusion. Platelet transfusion was less likely in an emergency setting (ß = −0·4). Reported transfusion thresholds for CVC placement varied from <10 × 109/L to 80 × 109/L for platelet count, from 1·0 to 10·0 for INR and from 25 s to 150 s for aPTT. Implementation of ultrasound guidance as standard practice was limited. Conclusion Current transfusion practice prior to CVC placement is highly variable. Physicians adjust the decision to correct coagulopathy prior CVC placement based on clinical parameters, insertion site and technique applied. [ABSTRACT FROM AUTHOR]

Published
2017
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13. Implementation of a transfusion bundle reduces inappropriate red blood cell transfusions in intensive care - a before and after study.

Author

Borgert, M., Binnekade, J., Paulus, F., Vroom, M., Vlaar, A., Goossens, A., and Dongelmans, D.

Subjects
*BLOOD transfusion, *ERYTHROCYTES, *CRITICAL care medicine, *HEMOGLOBINS
Abstract

SUMMARY Background Restrictive red blood cell ( RBC) transfusion has been widely described in transfusion guidelines. However, compliance with these guidelines is often poor. Therefore, we developed a care bundle for the transfusion of RBCs in intensive care. We investigated the effect of the application of the transfusion bundle on transfusion practice, hypothesising that the implementation of the transfusion bundle would lead to a reduction of inappropriate RBC transfusions. Study Design and Methods We conducted a before and after study between January and December 2014 in a medical-surgical intensive care unit ( ICU) of a university hospital in Amsterdam, the Netherlands. The primary outcome was the percentage of appropriate transfusions, referring to those transfusions that were in accordance to the patients' individual preset haemoglobin threshold. Results The mean pre-transfusion haemoglobin level was 7·3 g dL−1 [standard deviation ( SD) = 1·15] during baseline and significantly decreased to 7·1 g dL−1 ( SD = 1·04) after transfusion bundle implementation; 95% confidence interval ( CI): 0·009-0·308, P-value = 0·04. The number of inappropriate transfusions significantly decreased from 25% (111/439) during baseline to 15% (42/280) during implementation, a difference of 10%; 95% CI: −0·164 to −0·0416, P-value 0·001. This further decreased to 12% (45/370) in the post-implementation phase. A logistic regression analysis showed that the chance to find an appropriate transfusion is approximately twice as high after transfusion bundle implementation. Conclusions Introduction of a transfusion bundle results in a significant reduction of the number of inappropriate RBC transfusions in the medical-surgical ICU. Our results show that the introduction of a transfusion care bundle helps to improve compliance with transfusion guidelines in daily practice. [ABSTRACT FROM AUTHOR]

Published
2016
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14. Prognostication of neurologic outcome in cardiac arrest patients after mild therapeutic hypothermia: a meta-analysis of the current literature.

Author

Kamps, M., Horn, J., Oddo, M., Fugate, J., Storm, C., Cronberg, T., Wijman, C., Wu, O., Binnekade, J., and Hoedemaekers, C.

Subjects
HYPOTHERMIA, NEUROLOGIC examination, META-analysis, CARDIOPULMONARY resuscitation, COHORT analysis, REFLEXES, EQUIPMENT & supplies
Abstract

Purpose: To assess the sensitivity and false positive rate (FPR) of neurological examination and somatosensory evoked potentials (SSEPs) to predict poor outcome in adult patients treated with therapeutic hypothermia after cardiopulmonary resuscitation (CPR). Methods: MEDLINE and EMBASE were searched for cohort studies describing the association of clinical neurological examination or SSEPs after return of spontaneous circulation with neurological outcome. Poor outcome was defined as severe disability, vegetative state and death. Sensitivity and FPR were determined. Results: A total of 1,153 patients from ten studies were included. The FPR of a bilaterally absent cortical N20 response of the SSEP could be calculated from nine studies including 492 patients. The SSEP had an FPR of 0.007 (confidence interval, CI, 0.001-0.047) to predict poor outcome. The Glasgow coma score (GCS) motor response was assessed in 811 patients from nine studies. A GCS motor score of 1-2 at 72 h had a high FPR of 0.21 (CI 0.08-0.43). Corneal reflex and pupillary reactivity at 72 h after the arrest were available in 429 and 566 patients, respectively. Bilaterally absent corneal reflexes had an FPR of 0.02 (CI 0.002-0.13). Bilaterally absent pupillary reflexes had an FPR of 0.004 (CI 0.001-0.03). Conclusions: At 72 h after the arrest the motor response to painful stimuli and the corneal reflexes are not a reliable tool for the early prediction of poor outcome in patients treated with hypothermia. The reliability of the pupillary response to light and the SSEP is comparable to that in patients not treated with hypothermia. [ABSTRACT FROM AUTHOR]

Published
2013
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16. The Critical Nursing Situation Index for safety assessment in intensive care.

Author

Binnekade, Jan M., de Mol, Bas A., Kesecioglu, Jozef, de Haan, Rob J., Binnekade, J M, de Mol, B A, Kesecioglu, J, and de Haan, R J

Subjects
CRITICAL care medicine, INTENSIVE care nursing, MEDICAL protocols, INTENSIVE care units, CLINICAL medicine
Abstract

Objective: The assessment of critical nursing situations can be a valuable tool in the detection of weak elements in the safety of patients and the quality of care in the ICU. A critical nursing situation can be defined as any observable situation, which deviates from good clinical practice and which may potentially lead to an adverse event. The aim of our study was to establish the feasibility, reliability and validity of the Critical Nursing Situation Index (CNSI) as a tool for assessing the safety and the quality of nursing in the ICU.Design: We described the deviations from standards and protocols in daily ICU nursing care, selected those with an implicit, clear risk for the patients and translated them into explicitly observable items. If an item was applicable during observation of the ICU practice, a critical nursing situation could be recorded as either true or false. The reliability of the CNSI was defined in terms of inter-observer agreement. The validity was assessed by exploring the relationship between the nursing time available (more or less than 30 min per patient per hour) and the incidence of critical nursing situations.Setting: The study was performed in the ICU of a teaching hospital (30 IC beds) in which all disciplines, including cardiothoracic surgery and neurosurgery, were represented.Patients: The CNSI was randomly applied to 83 ICU patients over a period of 3 months (200 times).Measurements and Results: The reliability of the index was substantial (Kappa values in the range > or =0.70 to > 0.80). In terms of validity, less nursing time resulted in more critical situations (pooled relative risk (RR) 1.36; 95% confidence limits 1.11/1.67).Conclusion: The CNSI is simple to use and has encouraging metric properties, whereas the assessments are closely related to direct patient care. Moreover, the CNSI provides a tool for safety assessment by monitoring potentially dangerous situations that are generally regarded as needing to be avoided. [ABSTRACT FROM AUTHOR]

Published
2001
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18. ESICM LIVES 2016: part one: Milan, Italy. 1-5 October 2016

Author

Bos, L., Schouten, L., van Vught, L., Wiewel, M., Ong, D., Cremer, O., Artigas, A., Martin-Loeches, I., Hoogendijk, A., van der Poll, T., Horn, J., Juffermans, N., Schultz, M., de Prost, N., Pham, T., Carteaux, G., Dessap, A. Mekontso, Brun-Buisson, C., Fan, E., Bellani, G., Laffey, J., Mercat, A., Brochard, L., Maitre, B., Howells, P. A., Thickett, D. R., Knox, C., Park, D. P., Gao, F., Tucker, O., Whitehouse, T., McAuley, D. F., Perkins, G. D., Pisani, L., Roozeman, J. P., Simonis, F. D., Giangregorio, A., Schouten, L. R., Van der Hoeven, S. M., Neto, A. Serpa, Festic, E., Dondorp, A. M., Grasso, S., Bos, L. D., Schultz, M. J., Koster-Brouwer, M., Verboom, D., Scicluna, B., van de Groep, K., Frencken, J., Bonten, M., Ko, J. I., Kim, K. S., Suh, G. J., Kwon, W. Y., Kim, K., Shin, J. H., Ranzani, O. T., Prina, E., Menendez, R., Ceccato, A., Mendez, R., Cilloniz, C., Gabarrus, A., Ferrer, M., Torres, A., Urbano, A., Zhang, L. A., Swigon, D., Pike, F., Parker, R. S., Clermont, G., Scheer, C., Kuhn, S. O., Modler, A., Vollmer, M., Fuchs, C., Hahnenkamp, K., Rehberg, S., Gründling, M., Taggu, A., Darang, N., Öveges, N., László, I., Tánczos, K., Németh, M., Lebák, G., Tudor, B., Érces, D., Kaszaki, J., Huber, W., Trásy, D., Molnár, Z., Ferrara, G., Edul, V. S. Kanoore, Canales, H. S., Martins, E., Canullán, C., Murias, G., Pozo, M. O., Eguillor, J. F. Caminos, Buscetti, M. G., Ince, C., Dubin, A., Aya, H. D., Rhodes, A., Fletcher, N., Grounds, R. M., Cecconi, M., Jacquet-Lagrèze, M., Riche, M., Schweizer, R., Portran, P., Fornier, W., Lilot, M., Neidecker, J., Fellahi, J. L., Escoresca-Ortega, A., Gutiérrez-Pizarraya, A., Charris-Castro, L., Corcia-Palomo, Y., Fernandez-Delgado, E., Garnacho-Montero, J., Roger, C., Muller, L., Elotmani, L., Lipman, J., Lefrant, J. Y., Roberts, J. A., Muñoz-Bermúdez, R., Samper, M., Climent, C., Vasco, F., Sara, V., Luque, S., Campillo, N., Cerrato, S. Grau, Masclans, J. R., Alvarez-Lerma, F., Brugger, S. Carvalho, Jimenez, G. Jimenez, Torner, M. Miralbés, Cabello, J. Trujillano, Garrido, B. Balsera, Casals, X. Nuvials, Gaite, F. Barcenilla, Vidal, M. Vallverdú, Martínez, M. Palomar, Gusarov, V., Shilkin, D., Dementienko, M., Nesterova, E., Lashenkova, N., Kuzovlev, A., Zamyatin, M., Demoule, A., Carreira, S., Lavault, S., Palancca, O., Morawiec, E., Mayaux, J., Arnulf, I., Similowski, T., Rasmussen, B. S., Maltesen, R. G., Hanifa, M., Pedersen, S., Kristensen, S. R., Wimmer, R., Panigada, M., Bassi, G. Li, Kolobow, T., Zanella, A., Cressoni, M., Berra, L., Parrini, V., Kandil, H., Salati, G., Livigni, S., Amatu, A., Andreotti, A., Tagliaferri, F., Moise, G., Mercurio, G., Costa, A., Vezzani, A., Lindau, S., Babel, J., Cavana, M., Consonni, D., Pesenti, A., Gattinoni, L., Mansouri, P., Zand, F., Zahed, L., Dehghanrad, F., Bahrani, M., Ghorbani, M., Cambiaghi, B., Moerer, O., Mauri, T., Kunze-Szikszay, N., Ritter, C., Quintel, M., Vilander, L. M., Kaunisto, M. A., Vaara, S. T., Pettilä, V., Mulier, J. L. G. Haitsma, Rozemeijer, S., Spoelstra-de Man, A. M. E., Elbers, P. E., Tuinman, P. R., de Waard, M. C., Oudemans-van Straaten, H. M., Liberatore, A. M. A., Souza, R. B., Martins, A. M. C. R. P. F., Vieira, J. C. F., Koh, I. H. J., Martínez, M. Galindo, Sánchez, R. Jiménez, Gascón, L. Martínez, Mulero, M. D. Rodríguez, Freire, A. Ortín, Muñoz, A. Ojados, Acebes, S. Rebollo, Martínez, Á. Fernández, Aliaga, S. Moreno, Para, L. Herrera, Payá, J. Murcia, Mulero, F. Rodríguez, Guerci, P., Ince, Y., Heeman, P., Ergin, B., Uz, Z., Massey, M., Papatella, R., Bulent, E., Toraman, F., Longbottom, E. R., Torrance, H. D., Owen, H. C., Hinds, C. J., Pearse, R. M., O’Dywer, M. J., Trogrlic, Z., van der Jagt, M., Lingsma, H., Ponssen, H. H., Schoonderbeek, J. F., Schreiner, F., Verbrugge, S. J., Duran, S., van Achterberg, T., Bakker, J., Gommers, D. A. M. P. 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P., Kashiwagi, Y., Hayashi, K., Inagaki, Y., Fujita, S., Blet, A., Sadoune, M., Lemarié, J., Bihry, N., Bern, R., Polidano, E., Merval, R., Launay, J. M., Lévy, B., Samuel, J. L., Hartmann, J., Harm, S., and Weber, V.

Published
2016
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19. Differences in oral health behaviour between children from high and children from low SES schools in the Netherlands.

Author

Jerkovic, K., Binnekade, J. M., van der Kruk, J. J., van der Most, J. A., Talsma, A. C., and van der Schans, C. P.

Abstract

Objective To identify the determinants of dental caries in relation to socio-economic status (SES) within oral health, children's eating habits and parental attitudes towards oral health. Basic research design Dental screening data were collected from 6- and 10- year old schoolchildren from low and high SES schools in the Netherlands in this cross-sectional study. Methods The clinical examination was performed by trained dental hygiene students who collected the data on dental caries, dental plaque and duration of brushing. The paper questionnaire completed by the parents included 18 questions about oral health behaviour, eating habits and parental attitudes towards oral health. Results Two of the six parameters of oral health behaviour were statistically associated with the high caries prevalence in the low SES group (brushing frequency (p = 0.028) and age at the first visit to the dentist (p = 0.044)). High intake of fruit juices and/or soft drinks (p = 0.043) and low calcium intake (p = 0.028) were identified as risk determinants for caries with low SES. All parameters of parental attitudes towards oral health were associated with caries, but not with SES. Conclusions This study confirmed that the high caries prevalence in children from low SES schools was associated with oral health behaviour and eating habits. The role of parents was indirectly associated with the occurrence of dental caries. Therefore, it is important to include parents in all intervention programmes in order to reduce the prevalence of caries. [ABSTRACT FROM AUTHOR]

Published
2009
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20. Can serum and urine levels of cystatin C predict renal recovery in patients treated with renal replacement therapy in the ICU?

Author

Royakkers, A. A. N. M., Stassen, P., Binnekade, J. M., Kamphuis, J. S., Hofstra, L., Kuiper, M. A., Schultz, M. J., and Spronk, P. E.

Subjects
CYSTATINS, BLOOD filtration, ACUTE kidney failure, CRITICALLY ill, CRITICAL care medicine
Abstract

This article reports on a study conducted to determine whether cystatin C (CyC) can predict renal recovery in critically ill patients treated with continuous veno-venous haemofiltration (CVVH) for acute kidney injury (AKI). Findings revealed that serum and urine levels of CyC are probably not reliable in predicting renal recovery in critically ill patients with AKI. The article also discusses the prevalence of AKI and risks and costs of the therapy.

Published
2014

21. Platelet Transfusion before CVC Placement in Patients with Thrombocytopenia.

Author

van Baarle, F. L. F., van de Weerdt, E. K., van der Velden, W. J. F. M., Ruiterkamp, R. A., Tuinman, P. R., Ypma, P. F., van den Bergh, W. M., Demandt, A. M. P., Kerver, E. D., Jansen, A. J. G., Westerweel, P. E., Arbous, S. M., Determann, R. M., van Mook, W. N. K. A., Koeman, M., Mäkelburg, A. B. U., van Lienden, K. P., Binnekade, J. M., Biemond, B. J., and Vlaar, A. P. J.

Subjects
*BLOOD platelet transfusion, *CENTRAL venous catheterization, *THROMBOCYTOPENIA, *INTENSIVE care units, *CATHETERIZATION, *PLATELET count
Abstract

BACKGROUND Transfusion guidelines regarding platelet-count thresholds before the placement of a central venous catheter (CVC) offer conflicting recommendations because of a lack of good-quality evidence. The routine use of ultrasound guidance has decreased CVC-related bleeding complications. METHODS In a multicenter, randomized, controlled, noninferiority trial, we randomly assigned patients with severe thrombocytopenia (platelet count, 10,000 to 50,000 per cubic millimeter) who were being treated on the hematology ward or in the intensive care unit to receive either one unit of prophylactic platelet transfusion or no platelet transfusion before ultrasound-guided CVC placement. The primary outcome was catheter-related bleeding of grade 2 to 4; a key secondary outcome was grade 3 or 4 bleeding. The noninferiority margin was an upper boundary of the 90% confidence interval of 3.5 for the relative risk. RESULTS We included 373 episodes of CVC placement involving 338 patients in the perprotocol primary analysis. Catheter-related bleeding of grade 2 to 4 occurred in 9 of 188 patients (4.8%) in the transfusion group and in 22 of 185 patients (11.9%) in the no-transfusion group (relative risk, 2.45; 90% confidence interval [CI], 1.27 to 4.70). Catheter-related bleeding of grade 3 or 4 occurred in 4 of 188 patients (2.1%) in the transfusion group and in 9 of 185 patients (4.9%) in the no-transfusion group (relative risk, 2.43; 95% CI, 0.75 to 7.93). A total of 15 adverse events were observed; of these events, 13 (all grade 3 catheter-related bleeding [4 in the transfusion group and 9 in the no-transfusion group]) were categorized as serious. The net savings of withholding prophylactic platelet transfusion before CVC placement was $410 per catheter placement. CONCLUSIONS The withholding of prophylactic platelet transfusion before CVC placement in patients with a platelet count of 10,000 to 50,000 per cubic millimeter did not meet the predefined margin for noninferiority and resulted in more CVC-related bleeding events than prophylactic platelet transfusion. [ABSTRACT FROM AUTHOR]

Published
2023
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