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9. Desilicification Reclying Ferrophosphorus Slag under Vacuum

Author

Qian BAI, Bi JING, and Qiuxia LI

Subjects
metallurgical engineering, ferrophosphorus, desilicification, metal phosphide, vacuum, Mining engineering. Metallurgy, TN1-997
Abstract

This is an article in the field of metallurgical engineering. For recycling theferrophosphorus slag which a by-products of phosphorus chemical industry,the thermodynamic calculations and experimentally investigations of the removal of SiO2 by added CaO were carried out. The results of thermodynamic calculations of the reaction between SiO2 and CaO show that: the Gibbs free energy values of generating CaO·SiO2, 2CaO·SiO2, 3CaO·SiO2 and 3CaO·2SiO2 are less than zero, when the temperature in 900～1700 K range and molar ratio of(SiO2∶CaO)= 1∶1～3. It is feasible to generate calcium silicate by adding CaO, which can be used as a method of desilicification for ferrophosphorus slag. The experimental results show that:there are two layers of the products,i.e. Ca2SiO4, Ca3SiO5in the upper layer and Fe2P in the lower layer when the pressure between 10～40 Pa and the temperature 1573 K and molar ratio of SiO2∶CaO = 1∶1. The final products were testified to be ω（Si）

Published
2024
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11. Methylation regulation for FUNDC1 stability in childhood leukemia was up-regulated and facilitates metastasis and reduces ferroptosis of leukemia through mitochondrial damage by FBXL2

Author

Tan Sihai, Ge Yirong, and Bi Jing

Subjects
fundc1, fbxl2, ubiquitination, ferroptosis, methylation, Medicine
Abstract

Leukemia, the most common malignant tumor in childhood, can be categorized into acute leukemia and chronic leukemia. However, the role of FUNDC1 in childhood leukemia (CL) remains unknown. This study aims to investigate the effects of FUNDC1 on patients with CL and its underlying mechanism both in vivo and in vitro. The mRNA expression levels of FUNDC1 were found to be up-regulated in serum samples from CL patients as well as in leukemia cell lines. Furthermore, it was observed that the mRNA expression of FUNDC1 was lower in stage I–II CL patients compared to stage III–IV patients. The up-regulation of FUNDC1 was found to promote leukemia metastasis. Additionally, it was discovered that FUNDC1 up-regulation reduces ferroptosis by inhibiting mitochondrial damage. In a leukemia model, FUNDC1 up-regulation induces the expression of FBXL2. Moreover, FUNDC1 up-regulation reduces FBXL2 ubiquitination, thus maintaining FBXL2 protein expression in leukemia. By inducing FBXL2, FUNDC1 reduces ferroptosis in leukemia through the inhibition of mitochondrial damage. The stability of FUNDC1 is controlled by METTL3 methylation. Overall, this study sheds light on the role of FUNDC1 in CL and provides insights into its underlying mechanisms.

Published
2024
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33. Molecular characteristics and antibiotic resistance of Escherichia coli from foods based on whole genome sequencing

Author

CHEN Wenjie, YU Ying, FANG Zhixin, GU Qifang, ZHU Yanqi, BI Jing, and ZHANG Hongzhi

Subjects
diarrheagenic e. coli, enteroaggregative e. coli, enteropathogenic e. coli, antibiotic resistance, resistant genes, Food processing and manufacture, TP368-456, Nutrition. Foods and food supply, TX341-641
Abstract

ObjectiveThis study aimed to analyze the molecular characteristics and antibiotic resistance of diarrheagenic Escherichia coli （DEC） from meat and aquatic products in Shanghai City.MethodsThe DEC isolates were characterized by applying antibiotic tests and whole genome sequencing （WGS）. The BioNumerics software was used to analyze and assemble WGS data. Then， multilocus sequence typing sequencing， virulence profiles， and antibiotic-resistant genes were analyzed adopting assembled genome sequences. The antimicrobial susceptibility was investigated.ResultsIn this study， most DEC isolates were EAEC （73.2%）， and most of the EAEC isolates carried only the astA gene （90.2%）. All 56 DEC isolates have been typed as 37 STs. The resistance rate to NAL was higher （64.3%），followed by aminoglycoside， beta-lactam， and tetracycline. The multi-drug resistant DEC isolates were 48.2% resistant； furthermore， the resistance genes were detected in these DEC isolates.ConclusionEAEC isolates are dominant DEC isolates from foods in Shanghai City. Furthermore， these DEC isolates exhibited a higher resistance rate， compared with the corresponding resistance genes. These results suggest that molecular surveillance should be enhanced. Moreover， fundamental data can be obtained by employing the WGS for tracing DEC isolates and analyzing pathogenicity.

Published
2023
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