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Getting access to longitudinal samples from the BIO-MUSE trial followed by applying combinatorial tools of spatially resolved and single cell omics technologies, concerning endpoint II-IV, will enable unique deep molecular investigations to empower early identification of MF patients who will progress and thus allow future personalised treatment strategies, see Figure 1. Most patients with MF patients are diagnosed at an early stage with chronic characteristics and exhibit a good prognosis with a 5-year survival of 89%-98%. I Single cell RNA-sequencing. i Gene expression profiles of tumor cells and bulk T cells from peripheral blood will be analyzed by single cell RNA sequencing. [Extracted from the article]

Mercury in blood samples was speciated from mothers and their infants up to 2 mo after delivery. There were significant correlations between umbilical cord blood and maternal blood for methylmercury (MeHg) and inorganic mercury (I-Hg) levels. The MeHg levels in cord blood were significantly higher than in maternal blood, while I-Hg levels were about the same. The maternal MeHg and I-Hg levels remained stable during the sampling period, whereas the MeHg concentration in infant blood decreased more than 45% between the 72-h and 2 mo sampling times. The I-Hg levels in infant blood were low at birth, and remained low during the sampling period. The results of the present study do not support I-Hg absorption through milk as a significant source of exposure. However, the number of observations is small, and a larger study is warranted in order to verify the data. [ABSTRACT FROM AUTHOR]