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2. Diagnostic test accuracy in longitudinal study settings: theoretical approaches with use cases from clinical practice

Author

Bode, Louisa, Mast, Marcel, Wulff, Antje, Marschollek, Michael, Schamer, Sven, Rathert, Henning, Jack, Thomas, Beerbaum, Philipp, Rübsamen, Nicole, Böhnke, Julia, Karch, André, Das, Pronaya Prosun, Wiese, Lena, Groszweski-Anders, Christian, Haller, Andreas, Frank, Torsten, Zapf, Antonia, Kramer, Katharina, and Weber, Philipp

Published
2024
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6. Le Cœur en Sabot: shape associations with adverse events in repaired tetralogy of Fallot

Author

Mîra, Anna, Lamata, Pablo, Pushparajah, Kuberan, Abraham, Georgina, Mauger, Charlène A., McCulloch, Andrew D., Omens, Jeffrey H., Bissell, Malenka M., Blair, Zach, Huffaker, Tyler, Tandon, Animesh, Engelhardt, Sandy, Koehler, Sven, Pickardt, Thomas, Beerbaum, Philipp, Sarikouch, Samir, Latus, Heiner, Greil, Gerald, Young, Alistair A., and Hussain, Tarique

Published
2022
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11. Paediatric aortic valve replacement using decellularized allografts: a multicentre update following 143 implantations and five-year mean follow-up.

Author

Horke, Alexander, Bobylev, Dmitry, Avsar, Murat, Cvitkovic, Tomislav, Meyns, Bart, Rega, Filip, Hazekamp, Mark, Cesnjevar, Robert, Schmiady, Martin, Staebler, Brigitte, Dewald, Oliver, Ciubotaru, Anatol, Michel-Behnke, Ina, Zimpfer, Daniel, Jashari, Ramadan, Boethig, Dietmar, Cebotari, Serghei, Beerbaum, Philipp, Tudorache, Igor, and Sarikouch, Samir

Subjects
AORTIC valve transplantation, PEDIATRICS, CHILD patients, CARDIOPULMONARY bypass, AORTIC valve diseases, HOMOGRAFTS
Abstract

Open in new tab Download slide OBJECTIVES Decellularized aortic homografts (DAH) were introduced in 2008 as a further option for paediatric aortic valve replacement (AVR). METHODS Prospective, multicentre follow-up of all paediatric patients receiving DAH for AVR in 8 European centres. RESULTS A total of 143 DAH were implanted between February 2008 and February 2023 in 137 children (106 male, 74%) with a median age of 10.8 years (interquartile range 6.6–14.6). Eighty-four (59%) had undergone previous cardiac operations and 24 (17%) had undergone previous AVR. The median implanted DAH diameter was 21 mm (interquartile range 19–23). The median operation duration was 348 min (227–439) with a median cardiopulmonary bypass time of 212 min (171–257) and a median cross-clamp time of 135 min (113–164). After a median follow-up of 5.3 years (3.3–7.2, max. 15.2 years), the primary efficacy end-points peak gradient (median 14 mmHg, 9–28) and regurgitation (median 0.5, interquartile range 0–1, grade 0–3) showed good results but an increase over time. Freedom from death/explantation/endocarditis/bleeding/thromboembolism at 5 years were 97.8 ± 1.2/88.7 ± 3.3/99.1 ± 0.9/100 and 99.2 ± 0.8%, respectively. Freedom from death/explantation/endocarditis/bleeding/thromboembolism at 10 years were 96.3 ± 1.9/67.1 ± 8.0/93.6 ± 3.9/98.6 ± 1.4 and 86.9 ± 11.6%, respectively. In total, 21 DAH were explanted. Seven were replaced by a mechanical AVR, 1 Ross operation was performed and a re-do DAH was implanted in 13 patients with no redo mortality. The calculated expected adverse events were lower for DAH compared to cryopreserved homograft patients (mean age 8.4 years), and in the same range as for Ross patients (9.2 years) and mechanical AVR (13.0 years). CONCLUSIONS This large-scale prospective analysis demonstrates excellent mid-term survival using DAH with adverse event rates comparable to paediatric Ross procedures. [ABSTRACT FROM AUTHOR]

Published
2024
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14. Somatic Development in Children with Congenital Heart Defects

Author

Kerst, Gunter, Vazquez-Jimenez, Jaime F., Gkalpakiotis, Dimitrios, Schedifka, Andrea, Buheitel, Gernot, Streble, Joachim, II, Kececioglu, Deniz, Sandica, Eugen, Trusen, Burkhard, Berger, Felix, Miera, Oliver, Ovroutski, Stanislav, Peters, Björn, Schmitt, Katharina, Schubert, Stephan, Photiadis, Joachim, Opgen-Rhein, Bernd, Weiss, Katja, Berns, Christoph, Blumenthal-Barby, Carl-Christian, Boeckel, Thomas, Krusche, Susanne, Busse, Jürgen, Kästner, Andreas, Koch, Heike, Köpcke, Christian, Streichan, Frank, Timme, Jens, Franzbach, Birgit, Senft, Gabriela, Beyer, Frank, Winter, Klaus, Breuer, Johannes, Welz, Armin, Bahlmann, Jens, Griese, Eberhard, Lê, Trong Phi, Hebe, Joachim, Nürnberg, Jan-Hendrik, Magsaam, Annette, Müller, Ronald, Potthoff, Ludger, Voigt, Renate, Krüger, Tim, Gerleve, Hubert, Kleideiter, Ulrich, Schneider-Kulla, Dirk, Feil, Elmo, Menke, Thomas, Lehn, Martin, Grohmann, Martina, Tomczak, Helge, Krogmann, Otto N., Tarusinov, Gleb, Scheld, Michael, Mayatepek, Ertan, Pillekamp, Frank, Lichtenberg, Artur, Terpeluk, Christiane, von Jan, Veronika, Dittrich, Sven, Gundlach, Ulrike, Cesnjevar, Robert, Neudorf, Ulrich, Morf, Geert, Esmaeili, Anoosh, Backhoff, Stephan, Stiller, Brigitte, Beyersdorf, Friedhelm, Kroll, Johannes, Wildberg, Anke, Siaplaouras, Jannos, Masri-Zada, Antje, Jux, Christian, Böning, Andreas, Akintürk, Hakan, Paul, Thomas, Tirilomis, Theodor, Schürer, Gabriele, Hartmann, Johannes, Grabitz, Ralph, Liebaug, Uta, Rotzsch, Claudius, Kozlik-Feldmann, Rainer, Sachweh, Jörg, Riso, Arlindo, Petersen, Volker, Friedrich, Bernd, Schlobohm, Otmar, Beerbaum, Philipp, Böthig, Dietmar, Horke, Alexander, Bauersachs, Johann, Westhoff-Bleck, Mechthild, Gorenflo, Matthias, Karck, Matthias, Loukanov, Tsvetomir, Sebening, Christian, Schrüfer, Hermann, Wilken, Martin, Abdul-Khaliq, Hashim, Rädle-Hurst, Tanja, Rentzsch, Axel, Schäfers, Hans-Joachim, Reichert, Hagen, Kriebel, Thomas, Boysen, Arnulf, Kramer, Hans-Heiner, Cremer, Joachim Thomas, Scheewe, Jens, Buchholz-Berdau, Regina, Möller, Peter, Ram, Wolfgang, Brockmeier, Konrad, Bennink, Gerardus B.W.E., Gillor, Alex, Niehues, Tim, Terhoeven, Peter, Leidig, Steffen, Dähnert, Ingo, Kinzel, Peter, Kostelka, Martin, Kändler, Liane, Bethge, Martin, Köster, Stefan, Schröder, Christoph, Karstedt, Jens, Seitz, Uwe, Kampmann, Christoph, Vahl, Christian-Friedrich, Stahl, Frank, Barth, Helmut, Müller-Scholden, Joachim, Ewert, Peter, Hager, Alfred, Kaemmerer, Harald, Nagdyman, Nicole, Schoetzau, Jörg, Tutarel, Oktay, Lange, Rüdiger, Haas, Nikolaus A., Hakami, Lale, Hauser, Michael, Roithmaier, Alexander, Kehl, Hans Gerd, Malec, Edward, Baumgartner, Helmut, Diller, Gerhard, Bahle, Roswitha, Hofner, Gerald, Zink, Stefan, Reif, Roland, Parlasca, Christoph, Freund, Matthias W., Schumacher, Michael, Darrelmann, Christine, Motz, Reinald, Willmann, Olaf, Schmiedl, Norbert, Quick, Peter, Hillebrand, Dirk, Hirsemann, Petra, Eiselt, Stephan Michele, Nekarda, Torsten, Eberhard, Michael, Schneider, Martin, Asfour, Boulos, Baier, Georg, Uhlemann, Frank, Scheid, Michael, Beyer, Alexander, Binz, Gudrun, Teufel, Thomas, Handke, Ronald-Peter, Hofbeck, Michael, Kaulitz, Renate, Sieverding, Ludger, Schlensak, Christian, Apitz, Christian, Kupferschmid, Christoph, Holtvogt, Jürgen, Wippermann, Carl-Friedrich, Heusch, Andreas, Wirbelauer, Johannes, Brosi, Wolfgang, Poryo, Martin, Paes, Laura Antonia, Pickardt, Thomas, Bauer, Ulrike M.M., Meyer, Sascha, and Wagenpfeil, Stefan

Published
2018
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20. Editor’s Note

Author

Di Carli, Marcelo F., Davidoff, Ravin, Beerbaum, Philipp, Dorbala, Sharmila, Gillam, Linda D., Hoffmann, Udo, Raman, Subha V., and Ruberg, Frederick L.

Published
2017
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25. Intra-Abdominal Hypertension and Compartment Syndrome after Pediatric Liver Transplantation: Incidence, Risk Factors and Outcome.

Author

Junge, Norman, Artmann, Annika, Richter, Nicolas, Vondran, Florian W. R., Böthig, Dietmar, Sasse, Michael, Köditz, Harald, Baumann, Ulrich, Beerbaum, Philipp, and Kaussen, Torsten

Subjects
CHILDREN'S hospitals, COMPARTMENT syndrome, HEALTH outcome assessment, DISEASE incidence, RISK assessment, INTRA-abdominal hypertension, LIVER transplantation, PEDIATRIC surgery, LONGITUDINAL method, DISEASE risk factors
Abstract

In pediatric liver transplantation (pLT), the risk for the manifestation and relevance of intra-abdominal hypertension (IAH) and abdominal compartment syndrome (ACS) is high. This observational study aimed to evaluate the incidence, relevance and risk factors for IAH and ACS by monitoring the intra-abdominal pressure (IAP), macro- and microcirculation (near-infrared spectroscopy (NIRS)), clinical and laboratory status and outcomes of 27 patients (16 female) after pLT (median age at pLT 35 months). Of the patients, 85% developed an elevated IAP, most of them mild. However, 17% achieved IAH° 3, 13% achieved IAH° 4 and 63% developed ACS. A multiple linear regression analysis identified aortal hepatic artery anastomosis and cold ischemia time (CIT) as risk factors for increased IAP and longer CIT and staged abdominal wall closure for ACS. ACS patients had significantly longer mechanical ventilation (p = 0.004) and LOS-PICU (p = 0.003). No significant correlation between NIRS or biliary complications and IAH or ACS could be shown. IAH and ACS after pLT were frequent. NIRS or grade of IAH alone should not be used for monitoring. A longer CIT is an important risk factor for higher IAP and ACS. Therefore, approaches such as the ex vivo machine perfusion of donor organs, reducing CIT effects on them, have great potential. Our study provides important basics for studying such approaches. [ABSTRACT FROM AUTHOR]

Published
2022
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29. Integrated analysis of atrioventricular interactions in tetralogy of Fallot

Author

Riesenkampff, Eugenie, Mengelkamp, Lena, Mueller, Matthias, Kropf, Siegfried, Abdul-Khaliq, Hashim, Sarikouch, Samir, Beerbaum, Philipp, Hetzer, Roland, Steendijk, Paul, Berger, Felix, and Kuehne, Titus

Subjects
Heart atrium -- Physiological aspects, Tetralogy of Fallot -- Risk factors, Tetralogy of Fallot -- Development and progression, Biological sciences
Abstract

The atria play an important role in cardiac performance. We evaluated their function and the atrioventricular interaction in operated patients with tetralogy of Fallot (TOF). Twenty patients who had undergone surgical repair of TOF and seven controls were investigated. Patients had residual pulmonary but no major tricuspid valve insufficiency. Atrial and ventricular strain rates were obtained by echocardiographic speckle tracking. Cine MRI-derived volumetric analysis provided atrial and ventricular time volume and time volume change curves yielding emptying and filling parameters. In addition, at the atrial level, reservoir, conduit and pump function, and cyclic volume change were calculated. At the atrioventricular valve level, tricuspid and mitral annular plane systolic excursion (TAPSE and MAPSE, respectively) were measured by two-dimensional echocardiography. In the patients compared with controls, right ventricular end-diastolic volumes were increased and biventricular ejection fraction was decreased (all P < 0.05). Biventricular measures of early diastolic ventricular filling were at control levels, but in late diastole, right ventricular filling parameters and strain rates were decreased (P < 0.001). The maximal right atrial size was slightly but not significantly diminished, but cyclic volume change was significantly reduced (P < 0.0001). Pump and reservoir function were decreased (P < 0.05), and conduit function was elevated (P < 0.001). The left atrium showed reduced reservoir function and cyclic volume change (P < 0.05). TAPSE and MAPSE were also decreased (P < 0.05). There were statistically significant interdependencies between RV ejection fraction, TAPSE, and right atrial filling and emptying parameters (all P < 0.05). In TOF patients, moderate systolic and diastolic right ventricular dysfunction is associated with clearly impaired right atrial function. The left atrium is affected to a lesser extent. congenital heart disease; atrial function; magnetic resonance imaging doi: 10.1152/ajpheart.00264.2010.

Published
2010

36. Towards an Evolutionary Open Pediatric Intensive Care Dataset in the ELISE Project.

Author

WULFF, Antje, MAST, Marcel, BODE, Louisa, RATHERT, Henning, JACK, Thomas, Marschollek, Michael, Schamer, Sven, Beerbaum, Philipp, Rübsamen, Nicole, Böhnke, Julia, Karch, André, Das, Pronaya Prosun, Wiese, Lena, Groszewski-Anders, Christian, Haller, Andreas, and Frank, Torsten

Abstract

Background: To embrace the need for freely accessible training data sets originating from the real world, in the ELISE project, we integrate source data from a pediatric intensive care unit and provide it to researchers. Objective: We present our vision, initial results and steps on a trail towards an evolutionary open pediatric intensive care data set. Methods: Our evolution plan for the data set comprises three steps. The final data set will include raw clinical data and labels on critical outcomes such as organ dysfunction and sepsis, generated automatically by computerized and well-evaluated methods. Results: First step resulted in an initial version data set available in a central repository. Conclusions: Our approach has great potential to provide a comprehensive open intensive care data set labeled for critical pediatric outcomes and, thus, contributing to overcome the current lack of real-world pediatric intensive care data usable for training data-driven algorithms. [ABSTRACT FROM AUTHOR]

Published
2022
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37. 4D-flow cardiac magnetic resonance imaging after aortic root replacement with long-valved decellularized aortic homografts: comparison to valve-sparing aortic root replacement and healthy controls.

Author

Cvitkovic, Tomislav, Bobylev, Dmitry, Horke, Alexander, Avsar, Murat, Beerbaum, Philipp, Martens, Andreas, Böthig, Dietmar, Petenà, Elena, Gutberlet, Marcel, Beyer, Frerk Hinnerk, Wacker, Frank, Cebotari, Serghei, Haverich, Axel, Vogel-Claussen, Jens, Sarikouch, Samir, and Czerner, Christoph

Subjects
HOMOGRAFTS, CARDIAC magnetic resonance imaging, AORTA, THORACIC aorta, AORTIC valve diseases, BLOOD flow
Abstract

Open in new tab Download slide Open in new tab Download slide OBJECTIVES Long-valved decellularized aortic homografts (DAH) may be used in young patients to treat aortic valve disease associated with aortic root dilatation, thereby eliminating the need for prosthetic material and anticoagulation. METHODS Thirty-three male subjects in 3 equally sized cohorts were compared: patients following DAH implantation with a median age of 29 years [interquartile range (IQR) 27.5–37.5], patients post-valve-sparing aortic root replacement (VSARR), median 44 years (IQR 31.5–49) and healthy controls, median 33 years (IQR 28–40, P  = 0.228). Time-resolved three-dimensional phase-contrast cardiac magnetic resonance imaging was performed to assess maximum blood flow velocity, pulse wave velocity, mechanical energy loss (EL), wall shear stress and flow patterns (vorticity, eccentricity, helicity) in 5 different planes of the aorta. RESULTS The mean time between surgery and cardiovascular magnetic resonance was 2.56 ± 2.0 years in DAH vs 2.67 ± 2.1 in VSARR, P  = 0.500. No significant differences in maximum velocity and pulse wave velocity were found between healthy controls and DAH across all planes. Velocity in the proximal aorta was significantly higher in VSARR (182.91 ± 53.91 cm/s, P  = 0.032) compared with healthy controls. EL was significantly higher in VSARR in the proximal aorta with 1.85 mW (IQR 1.39–2.95) compared with healthy controls, 1.06 mW (0.91–1.22, P  = 0.016), as well as in the entire thoracic aorta. In contrast, there was no significant EL in DAH in the proximal, 1.27 m/W (0.92–1.53, P  = 0.296), as well as in the thoracic aorta, 7.7 m/W (5.25–9.90, P  = 0.114), compared with healthy controls. There were no significant differences in wall shear stress parameters for all 5 regions of the thoracic aorta between the 3 groups. DAH patients, however, showed more vorticity, helicity and eccentricity in the ascending aorta compared with healthy controls (P  < 0.019). CONCLUSIONS Decellularized long aortic homografts exhibit near to normal haemodynamic parameters 2.5 years postoperatively compared with healthy controls and VSARR. [ABSTRACT FROM AUTHOR]

Published
2022
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45. Predicting hemodynamics in native and residual coarctation: preliminary results of a Rigid-Wall Computational-Fluid-Dynamics model (RW-CFD) validated against clinically invasive pressure measures at rest and during pharmacological stress

Author

Lawford Patricia, Greil Gerald, Tzifa Aphrodite, Hussain Tarique, Brown Alistair G, Rhode Kawal, Shi Yubing, Marzo Alberto, Grotenhuis Heynric, Staicu Cristina, Valverde Israel, Razavi Reza, Hose Rod, and Beerbaum Philipp

Subjects
Diseases of the circulatory (Cardiovascular) system, RC666-701
Published
2011
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