Search

Your search keyword '"Bazzocchi, Alberto"' showing total 274 results
Start Over Author "Bazzocchi, Alberto" Search Limiters Peer Reviewed
274 results on '"Bazzocchi, Alberto"'

5. Interdisciplinary consensus statements on imaging of DRUJ instability and TFCC injuries

Author

Cerezal, Luis, del Piñal, Francisco, Atzei, Andrea, Schmitt, Rainer, Becce, Fabio, Klich, Maciej, Bień, Maciej, de Jonge, Milko C., Teh, James, Boutin, Robert Downey, Toms, Andoni Paul, Omoumi, Patrick, Fritz, Jan, Bazzocchi, Alberto, Shahabpour, Maryam, Zanetti, Marco, Llopis, Eva, Blum, Alain, Lalam, Radhesh Krishna, Reto, Sutter, Afonso, P. Diana, Mascarenhas, Vasco V., Cotten, Anne, Drapé, Jean-Luc, Bierry, Guillaume, Pracoń, Grzegorz, Dalili, Danoob, Mespreuve, Marc, Garcia-Elias, Marc, Bain, Gregory Ian, Mathoulin, Christophe L., Van Overstraeten, Luc, Szabo, Robert M., Camus, Emmanuel J., Luchetti, Riccardo, Chojnowski, Adrian Julian, Gruenert, Joerg G., Czarnecki, Piotr, Corella, Fernando, Nagy, Ladislav, Yamamoto, Michiro, Golubev, Igor O., van Schoonhoven, Jörg, Goehtz, Florian, Sudoł-Szopińska, Iwona, and Dietrich, Tobias Johannes

Published
2023
Full Text
View/download PDF

6. 3-T magnetic resonance–guided high-intensity focused ultrasound (3 T-MR-HIFU) for the treatment of pain from bone metastases of solid tumors

Author

Bongiovanni, Alberto, Foca, Flavia, Oboldi, Devil, Diano, Danila, Bazzocchi, Alberto, Fabbri, Laura, Mercatali, Laura, Vanni, Silvia, Maltoni, Marco, Bianchini, David, Casadei, Carla, Matteucci, Federica, Nanni, Oriana, Rossi, Benedetta, Sintuzzi, Emanuele, Martoni, Maria Elena, Zavoiu, Venetia, Barone, Domenico, Altini, Mattia, and Ibrahim, Toni

Published
2022
Full Text
View/download PDF

8. Radiological diagnosis of prevalent osteoporotic vertebral fracture on radiographs: an interim consensus from a group of experts of the ESSR osteoporosis and metabolism subcommittee.

Author

Wáng, Yì Xiáng J., Diacinti, Daniele, Aparisi Gómez, Maria Pilar, Santiago, Fernando Ruiz, Becce, Fabio, Tagliafico, Alberto Stefano, Prakash, Mahesh, Isaac, Amanda, Dalili, Danoob, Griffith, James F., Guglielmi, Giuseppe, and Bazzocchi, Alberto

Subjects
VERTEBRAL fractures, BONE fractures, OLDER women, OLDER men, RADIOSCOPIC diagnosis, VERTEBRAE injuries
Abstract

When a low-energy trauma induces an acute vertebral fracture (VF) with clinical symptoms, a definitive diagnosis of osteoporotic vertebral fracture (OVF) can be made. Beyond that, a "gold" radiographic standard to distinguish osteoporotic from non-osteoporotic VFs does not exist. Fracture-shaped vertebral deformity (FSVD) is defined as a deformity radiographically indistinguishable from vertebral fracture according to the best of the reading radiologist's knowledge. FSVD is not uncommon among young populations with normal bone strength. FSVD among an older population is called osteoporotic-like vertebral fracture (OLVF) when the FSVD is likely to be associated with compromised bone strength. In more severe grade deformities or when a vertebra is collapsed, OVF diagnosis can be made with a relatively high degree of certainty by experienced readers. In "milder" cases, OVF is often diagnosed based on a high probability rather than an absolute diagnosis. After excluding known mimickers, singular vertebral wedging in older women is statistically most likely an OLVF. For older women, three non-adjacent minimal grade OLVF (< 20% height loss), one minimal grade OLVF and one mild OLVF (20–25% height loss), or one OLVF with ≥ 25% height loss, meet the diagnosis of osteoporosis. For older men, a single OLVF with < 40% height loss may be insufficient to suggest the subject is osteoporotic. Common OLVF differential diagnoses include X-ray projection artifacts and scoliosis, acquired and developmental short vertebrae, osteoarthritic wedging, oncological deformities, deformity due to high-energy trauma VF, lateral hyperosteogeny of a vertebral body, Cupid's bow, and expansive endplate, among others. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

9. Bone Marrow and Metabolic Bone Disease.

Author

Aparisi Gómez, Maria Pilar and Bazzocchi, Alberto

Subjects
*BONE health, *METABOLIC bone disorders, *BONE marrow diseases, *BONE marrow, *ORGANS (Anatomy)
Abstract

The bone marrow represents one of the largest organs in the body, with a relevant metabolic role that continues to be investigated. Numerous studies have focused on marrow adipose tissue (MAT). Evidence indicates that the bone marrow adipocytes do not only work as storage tissue but also consist of endocrine and paracrine cells, with the potential to contribute to local and systemic metabolism. MAT plays a role in bone health through its interaction with the other components of bone. Many metabolic disorders (osteoporosis, obesity, diabetes) have a complex and still not well-established or understood relationship with bone health. This article surveys the literature on the relationship of bone marrow and metabolic disorders, and how it is being studied using imaging techniques, with a special focus on bone health. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

10. Rationale and Protocol of the ETERNITY-ITA Study: Use of Etelcalcetide for Preserving Vitamin K-Dependent Protein Activity—An Italian Study.

Author

Fusaro, Maria, Aghi, Andrea, Marino, Carmela, Mallamaci, Francesca, Plebani, Mario, Zaninotto, Martina, Grano, Maria, Colucci, Silvia, Gallieni, Maurizio, Nickolas, Thomas L., Giannini, Sandro, Sella, Stefania, Simioni, Paolo, Bazzocchi, Alberto, Guglielmi, Giuseppe, Taddei, Fulvia, Schileo, Enrico, Versace, Maria Carmela, and Tripepi, Giovanni

Subjects
RENAL osteodystrophy, MATRIX Gla protein, VITAMIN K, BONE health, ARTERIAL calcification
Abstract

Background/Objectives: Chronic kidney disease and mineral bone disorders (CKD-MBD) are frequently associated with an increased risk of both vascular calcifications (VCs) and bone fractures (BFs). The complex pathogenesis of VCs and BFs involves various factors such as calcium overload, phosphate imbalance, and secondary hyperparathyroidism. Key players, such as the vitamin K-dependent proteins (VKDPs) matrix Gla protein (MGP) and bone Gla protein (BGP), have pivotal roles both for VCs and BFs. The VIKI study highlighted that hemodialysis patients treated with calcimimetics had higher levels of total BGP and MGP compared to those untreated, suggesting a potential protective effect of these drugs on BFs and VCs beyond the beneficial effect of reducing PTH levels. Methods: ETERNITY-ITA is a multi-center, comparative effectiveness, observational, longitudinal study that will enroll 160 hemodialysis patients (80 patients treated with Etelcalcetide and 80 age- and sex-matched patients treated with calcitriol or vitamin D analogs). Nephrologists will tailor the target dose of Etelcalcetide on an individual level to achieve the KDIGO PTH target. In the Etelcalcetide-treated group, the addition of calcitriol will be allowed when required by clinical practice (for correction of hypocalcemia). Conclusions: This study will evaluate the real-world effect of Etelcalcetide on VKDP levels, such as BGP and MGP, at 3, 9, and 18 months from baseline. The resulting preservation of vascular and bone health will be assessed for the first time by examining aortic and iliac artery calcifications and vertebral fractures, respectively. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

11. Artificial Intelligence Applications for Imaging Metabolic Bone Diseases.

Author

Isaac, Amanda, Akdogan, Asli Irmak, Dalili, Danoob, Saber, Nuran, Drobny, David, Guglielmi, Giuseppe, Modat, Marc, and Bazzocchi, Alberto

Subjects
NATURAL language processing, METABOLIC bone disorders, MACHINE learning, ARTIFICIAL intelligence, COMPUTER vision, OSTEOMALACIA
Abstract

Artificial intelligence (AI) has significantly impacted the field of medical imaging, particularly in diagnosing and managing metabolic bone diseases (MBDs) such as osteoporosis and osteopenia, Paget's disease, osteomalacia, and rickets, as well as rare conditions such as osteitis fibrosa cystica and osteogenesis imperfecta. This article provides an in-depth analysis of AI techniques used in imaging these conditions, recent advancements, and their clinical applications. It also explores ethical considerations and future perspectives. Through comprehensive examination and case studies, we highlight the transformative potential of AI in enhancing diagnostic accuracy, improving patient outcomes, and contributing to personalized medicine. By integrating AI with existing imaging techniques, we can significantly enhance the capabilities of medical imaging in diagnosing, monitoring, and treating MBDs. We also provide a comprehensive overview of the current state, challenges, and future prospects of AI applications in this crucial area of health care. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

12. Imaging of Body Composition.

Author

Gazzotti, Silvia, Sassi, Rebecca, Aparisi Gómez, Maria Pilar, Guglielmi, Riccardo, Vasilevska Nikodinovska, Violeta, Messina, Carmelo, Guglielmi, Giuseppe, and Bazzocchi, Alberto

Subjects
DUAL-energy X-ray absorptiometry, BODY composition, MAGNETIC resonance imaging, ARTIFICIAL intelligence, BODY image
Abstract

Body composition is now recognized to have a major impact on health and disease. Imaging enables its analysis in an objective and quantitative way through diverse techniques such as dual-energy X-ray absorptiometry, computed tomography, magnetic resonance imaging, and ultrasonography. This review article first surveys the methodological aspects underpinning the use of these modalities to assess body composition, highlighting their strengths and limitations as well as the set of parameters that they measure and their clinical relevance. It then provides an update on the main applications of body composition imaging in current practice, with a focus on sarcopenia, obesity, lipodystrophies, cancer, and critical care. We conclude by considering the emerging role of artificial intelligence in the analysis of body composition, enabling the extraction of numerous metrics with the potential to refine prognostication and management across a number of pathologies, paving the way toward personalized medicine. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

13. Radiofrequency Echographic Multi-Spectrometry in the Diagnosis of Metabolic Bone Disease.

Author

Gifuni, Rossella, Montatore, Manuela, Guglielmi, Riccardo, Bazzocchi, Alberto, Messina, Carmelo, and Guglielmi, Giuseppe

Subjects
BONE health, YOUNG adults, CANCER hormone therapy, DUAL-energy X-ray absorptiometry, BONE density
Abstract

Dual-energy X-ray absorptiometry (DXA) and bone mineral density (BMD) pose several limitations in some patient categories, such as pregnant women and young people. This review article explores whether the innovative radiofrequency echographic multi-spectrometry (REMS) technology is beneficial for assessing the bone condition of various patient groups. Common consequences in patients with acromegalia, prostate cancer undergoing hormone therapy, osteogenesis imperfecta, anorexia nervosa, and in a peritoneal dialysis setting include decreased BMD and an increased risk of fragility fracture. DXA is currently regarded as the gold standard for BMD assessment. However, using the DXA technique has several drawbacks in a young patient who requires repeated BMD tests because it uses ionizing radiation. Because of its precision and consistency, the REMS technique may be a valuable tool to assess changes in bone condition in patients of all ages, particularly in female patients who are fertile or who are pregnant or nursing. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

14. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part V, knee

Author

Sconfienza, Luca Maria, Adriaensen, Miraude, Albano, Domenico, Alcala-Galiano, Andrea, Allen, Georgina, Aparisi Gómez, Maria Pilar, Aringhieri, Giacomo, Bazzocchi, Alberto, Beggs, Ian, Chianca, Vito, Corazza, Angelo, Dalili, Danoob, De Dea, Miriam, del Cura, Jose Luis, Di Pietto, Francesco, Drakonaki, Elena, Facal de Castro, Fernando, Filippiadis, Dimitrios, Gitto, Salvatore, Grainger, Andrew J., Greenwood, Simon, Gupta, Harun, Isaac, Amanda, Ivanoski, Slavcho, Khanna, Monica, Klauser, Andrea, Mansour, Ramy, Martin, Silvia, Mascarenhas, Vasco, Mauri, Giovanni, McCarthy, Catherine, McKean, David, McNally, Eugene, Melaki, Kalliopi, Mirón Mombiela, Rebeca, Moutinho, Ricardo, Obradov, Marina, Olchowy, Cyprian, Orlandi, Davide, Prada González, Raquel, Prakash, Mahesh, Posadzy, Magdalena, Rutkauskas, Saulius, Snoj, Žiga, Stefano Tagliafico, Alberto, Talaska, Alexander, Tomas, Xavier, Vasilevska-Nikodinovska, Violeta, Vucetic, Jelena, Wilson, David, Zaottini, Federico, Zappia, Marcello, and Messina, Carmelo

Published
2022
Full Text
View/download PDF

15. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part VII, nerves of the lower limb

Author

Sconfienza, Luca Maria, Adriaensen, Miraude, Albano, Domenico, Alcala-Galiano, Andrea, Allen, Georgina, Aparisi Gómez, Maria Pilar, Aringhieri, Giacomo, Bazzocchi, Alberto, Beggs, Ian, Chianca, Vito, Corazza, Angelo, Dalili, Danoob, De Dea, Miriam, del Cura, Jose Luis, Di Pietto, Francesco, Drakonaki, Elena, Facal de Castro, Fernando, Filippiadis, Dimitrios, Gitto, Salvatore, Grainger, Andrew J., Greenwood, Simon, Gupta, Harun, Ivanoski, Slavcho, Khanna, Monica, Klauser, Andrea, Mansour, Ramy, Martin, Silvia, Mascarenhas, Vasco, Mauri, Giovanni, McCarthy, Catherine, McKean, David, McNally, Eugene, Melaki, Kalliopi, Messina, Carmelo, Miron Mombiela, Rebeca, Moutinho, Ricardo, Olchowy, Cyprian, Orlandi, Davide, Prada González, Raquel, Prakash, Mahesh, Posadzy, Magdalena, Rutkauskas, Saulius, Snoj, Žiga, Tagliafico, Alberto Stefano, Talaska, Alexander, Tomas, Xavier, Vasilevska Nikodinovska, Violeta, Vucetic, Jelena, Wilson, David, Zaottini, Federico, Zappia, Marcello, and Isaac, Amanda

Published
2022
Full Text
View/download PDF

16. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part VI, foot and ankle

Author

Sconfienza, Luca Maria, Adriaensen, Miraude, Albano, Domenico, Alcala-Galiano, Andrea, Allen, Georgina, Aparisi Gómez, Maria Pilar, Aringhieri, Giacomo, Bazzocchi, Alberto, Beggs, Ian, Chianca, Vito, Corazza, Angelo, Dalili, Danoob, De Dea, Miriam, del Cura, Jose Luis, Di Pietto, Francesco, Drakonaki, Elena, Facal de Castro, Fernando, Filippiadis, Dimitrios, Gitto, Salvatore, Grainger, Andrew J, Greenwood, Simon, Gupta, Harun, Isaac, Amanda, Ivanoski, Slavcho, Khanna, Monica, Klauser, Andrea, Mansour, Ramy, Martin, Silvia, Mascarenhas, Vasco, Mauri, Giovanni, McCarthy, Catherine, McKean, David, McNally, Eugene, Melaki, Kalliopi, Messina, Carmelo, Mirón Mombiela, Rebeca, Moutinho, Ricardo, Olchowy, Cyprian, Orlandi, Davide, Prada González, Raquel, Prakash, Mahesh, Posadzy, Magdalena, Rutkauskas, Saulius, Snoj, Žiga, Tagliafico, Alberto Stefano, Talaska, Alexander, Tomas, Xavier, Vasilevska Nikodinovska, Violeta, Vucetic, Jelena, Wilson, David, Zaottini, Federico, Zappia, Marcello, and Obradov, Marina

Published
2022
Full Text
View/download PDF

17. Clinical indications for image-guided interventional procedures in the musculoskeletal system: a Delphi-based consensus paper from the European Society of Musculoskeletal Radiology (ESSR)—part IV, hip

Author

Sconfienza, Luca Maria, Adriaensen, Miraude, Alcala-Galiano, Andrea, Allen, Georgina, Aparisi Gómez, Maria Pilar, Aringhieri, Giacomo, Bazzocchi, Alberto, Beggs, Ian, Chianca, Vito, Corazza, Angelo, Dalili, Danoob, De Dea, Miriam, del Cura, Jose Luis, Di Pietto, Francesco, Drakonaki, Elena, de Castro, Fernando Facal, Filippiadis, Dimitrios, Gitto, Salvatore, Grainger, Andrew J, Greenwood, Simon, Gupta, Harun, Isaac, Amanda, Ivanoski, Slavcho, Khanna, Monica, Klauser, Andrea, Mansour, Ramy, Martin, Silvia, Mascarenhas, Vasco, Mauri, Giovanni, McCarthy, Catherine, McKean, David, McNally, Eugene, Melaki, Kalliopi, Messina, Carmelo, Mombiela, Rebeca Mirón, Moutinho, Ricardo, Obradov, Marina, Olchowy, Cyprian, Orlandi, Davide, González, Raquel Prada, Prakash, Mahesh, Posadzy, Magdalena, Rutkauskas, Saulius, Snoj, Žiga, Tagliafico, Alberto Stefano, Talaska, Alexander, Tomas, Xavier, Vasilevska Nikodinovska, Violeta, Vucetic, Jelena, Wilson, David, Zaottini, Federico, Zappia, Marcello, and Albano, Domenico

Published
2022
Full Text
View/download PDF

18. Focused Ultrasound and RadioTHERapy for non-invasive palliative pain treatment in patients with bone metastasis: a study protocol for the three armed randomized controlled FURTHER trial

Author

Slotman, Derk J., Bartels, Marcia M. T. J., Ferrer, Cyril J., Bos, Clemens, Bartels, Lambertus W., Boomsma, Martijn F., Phernambucq, Erik C. J., Nijholt, Ingrid M., Morganti, Alessio G., Siepe, Giambattista, Buwenge, Milly, Grüll, Holger, Bratke, Grischa, Yeo, Sin Yuin, Blanco Sequeiros, Roberto, Minn, Heikki, Huhtala, Mira, Napoli, Alessandro, De Felice, Francesca, Catalano, Carlo, Bazzocchi, Alberto, Gasperini, Chiara, Campanacci, Laura, Simões Corrêa Galendi, Julia, Müller, Dirk, Braat, Manon N. G. J. A., Moonen, Chrit, and Verkooijen, Helena M.

Published
2022
Full Text
View/download PDF

19. Short course palliative radiotherapy in advanced solid tumors: a pooled analysis (the SHARON project)

Author

Donati, Costanza Maria, Macchia, Gabriella, Siepe, Giambattista, Zamagni, Alice, Benini, Anna, Cellini, Francesco, Buwenge, Milly, Cilla, Savino, Cammelli, Silvia, Rizzo, Stefania, Caravatta, Luciana, Wondemagegnhu, Tigeneh, Uddin, A. F. M. Kamal, Deressa, Biniyam Tefera, Sumon, Mostafa A., Lodi Rizzini, Elisa, Bazzocchi, Alberto, Morganti, Alessio G., Deodato, Francesco, and Farina, Eleonora

Published
2022
Full Text
View/download PDF

20. Interdisciplinary consensus statements on imaging of scapholunate joint instability

Author

Dietrich, Tobias Johannes, Toms, Andoni Paul, Cerezal, Luis, Omoumi, Patrick, Boutin, Robert Downey, Fritz, Jan, Schmitt, Rainer, Shahabpour, Maryam, Becce, Fabio, Cotten, Anne, Blum, Alain, Zanetti, Marco, Llopis, Eva, Bień, Maciej, Lalam, Radhesh Krishna, Afonso, P. Diana, Mascarenhas, Vasco V., Sutter, Reto, Teh, James, Pracoń, Grzegorz, de Jonge, Milko C., Drapé, Jean-Luc, Mespreuve, Marc, Bazzocchi, Alberto, Bierry, Guillaume, Dalili, Danoob, Garcia-Elias, Marc, Atzei, Andrea, Bain, Gregory Ian, Mathoulin, Christophe L., del Piñal, Francisco, Van Overstraeten, Luc, Szabo, Robert M., Camus, Emmanuel J., Luchetti, Riccardo, Chojnowski, Adrian Julian, Grünert, Jörg G., Czarnecki, Piotr, Corella, Fernando, Nagy, Ladislav, Yamamoto, Michiro, Golubev, Igor O., van Schoonhoven, Jörg, Goehtz, Florian, Klich, Maciej, and Sudoł-Szopińska, Iwona

Published
2021
Full Text
View/download PDF

21. DXA beyond bone mineral density and the REMS technique: new insights for current radiologists practice.

Author

Messina, Carmelo, Fusco, Stefano, Gazzotti, Silvia, Albano, Domenico, Bonaccorsi, Gloria, Guglielmi, Giuseppe, and Bazzocchi, Alberto

Abstract

Osteoporosis is the most prevalent skeletal disorder, a condition that is associated with significant social and healthcare burden. In the elderly, osteoporosis is commonly associated with sarcopenia, further increasing the risk of fracture. Several imaging techniques are available for a non-invasive evaluation of osteoporosis and sarcopenia. This review focuses on dual-energy X-ray absorptiometry (DXA), as this technique offers the possibility to evaluate bone mineral density and body composition parameters with good precision and accuracy. DXA is also able to evaluate the amount of aortic calcification for cardiovascular risk estimation. Additionally, new DXA-based parameters have been developed in recent years to further refine fracture risk estimation, such as the Trabecular Bone Score and the Bone Strain Index. Finally, we describe the recent advances of a newly developed ultrasound-based technology known as Radiofrequency Echographic Multi-Spectrometry, which represent the latest non-ionizing approach for osteoporosis evaluation at central sites. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

25. Gender-specific association of body composition with inflammatory and adipose-related markers in healthy elderly Europeans from the NU-AGE study

Author

Santoro, Aurelia, Guidarelli, Giulia, Ostan, Rita, Giampieri, Enrico, Fabbri, Cristina, Bertarelli, Claudia, Nicoletti, Claudio, Kadi, Fawzi, de Groot, Lisette C. P. G. M., Feskens, Edith, Berendsen, Agnes, Brzozowska, Anna, Januszko, Olga, Kozlowska, Katarzyna, Fairweather-Tait, Susan, Jennings, Amy, Meunier, Nathalie, Caumon, Elodie, Napoli, Alessandro, Mercatelli, Daniele, Battista, Giuseppe, Capri, Miriam, Franceschi, Claudio, and Bazzocchi, Alberto

Published
2019
Full Text
View/download PDF

27. Percutaneous management of bone metastases: state of the art, interventional strategies and joint position statement of the Italian College of MSK Radiology (ICoMSKR) and the Italian College of Interventional Radiology (ICIR)

Author

Cazzato, Roberto Luigi, Arrigoni, Francesco, Boatta, Emanuele, Bruno, Federico, Chiang, Jean Betsy, Garnon, Julien, Zugaro, Luigi, Giordano, Aldo Victor, Carducci, Sergio, Varrassi, Marco, Beomonte Zobel, Bruno, Bazzocchi, Alberto, Aliprandi, Alberto, Basile, Antonio, Marcia, Stefano, Masala, Salvatore, Grasso, Rosario Francesco, Squarza, Silvia, Floridi, Chiara, Ierardi, Anna Maria, Burdi, Nicola, Cioni, Roberto, Napoli, Alessandro, Niola, Raffaella, Rossi, Giuseppe, Rossi, Umberto Geremia, Venturini, Massimo, De Cobelli, Francesco, Carotti, Marina, Gravina, Giovanni Luca, Di Staso, Mario, Zoccali, Carmine, Biagini, Roberto, Tonini, Giuseppe, Santini, Daniele, Carrafiello, Gianpaolo, Cariati, Maurizio, Silvestri, Enzo, Sconfienza, Luca Maria, Giovagnoni, Andrea, Masciocchi, Carlo, Gangi, Afshin, and Barile, Antonio

Published
2019
Full Text
View/download PDF

28. Sarcopenic Obesity in Cervical Carcinoma: A Strong and Independent Prognostic Factor beyond the Conventional Predictors (ESTHER Study—AFRAID Project).

Author

Medici, Federica, Ferioli, Martina, Cammelli, Silvia, Forlani, Ludovica, Laghi, Viola, Ma, Johnny, Cilla, Savino, Buwenge, Milly, Macchia, Gabriella, Deodato, Francesco, Vadalà, Maria, Malizia, Claudio, Tagliaferri, Luca, Perrone, Anna Myriam, De Iaco, Pierandrea, Strigari, Lidia, Bazzocchi, Alberto, Rizzo, Stefania, Arcelli, Alessandra, and Morganti, Alessio Giuseppe

Subjects
CANCER prognosis, CERVIX uteri tumors, BODY mass index, BODY composition, HEMOGLOBINS, MULTIVARIATE analysis, DESCRIPTIVE statistics, KAPLAN-Meier estimator, LOG-rank test, ANTHROPOMETRY, PROGRESSION-free survival, DATA analysis software, SARCOPENIA, OBESITY, OVERALL survival, PROPORTIONAL hazards models, REGRESSION analysis
Abstract

Simple Summary: This study investigates how the assessment of body mass index (BMI), together with body fat and muscle mass, might influence the success of treatments for advanced cervical cancer. Unlike most research which focuses on general health and cancer stages, this research pays particular attention to the patient's weight-to-height ratio, muscle mass, and especially the condition known as sarcopenic obesity—a combination of high body fat and low muscle mass. The findings reveal that sarcopenic obesity significantly affects patient outcomes, suggesting that it could be a key factor in deciding the best course of treatment. Recognizing these body composition indicators could lead to more personalized and effective treatment plans, marking a step forward in the way we approach care for cervical cancer patients. Locally advanced cervical cancer represents a significant treatment challenge. Body composition parameters such as body mass index, sarcopenia, and sarcopenic obesity, defined by sarcopenia and BMI ≥ 30 kg/m2, have been identified as potential prognostic factors, yet their overall impact remains underexplored. This study assessed the relationship between these anthropometric parameters alongside clinical prognostic factors on the prognosis of 173 cervical cancer patients. Survival outcomes in terms of local control (LC), distant metastasis-free survival (DMFS), disease-free survival (DFS), and overall survival (OS) were analyzed using Kaplan regression methods—Meier and Cox. Older age, lower hemoglobin levels, higher FIGO (International Federation of Gynecology and Obstetrics) stages, and lower total radiation doses were significantly associated with worse outcomes. Univariate analysis showed a significant correlation between BMI and the outcomes examined, revealing that normal-weight patients show higher survival rates, which was not confirmed by the multivariate analysis. Sarcopenia was not correlated with any of the outcomes considered, while sarcopenic obesity was identified as an independent negative predictor of DFS (HR: 5.289, 95% CI: 1.298–21.546, p = 0.020) and OS (HR: 2.645, 95% CI: 1.275–5.488, p = 0.009). This study highlights the potential of sarcopenic obesity as an independent predictor of clinical outcomes. These results support their inclusion in prognostic assessments and treatment planning for patients with advanced cervical cancer. [ABSTRACT FROM AUTHOR]

Published
2024
Full Text
View/download PDF

29. Clinical indications for musculoskeletal ultrasound updated in 2017 by European Society of Musculoskeletal Radiology (ESSR) consensus

Author

Sconfienza, Luca Maria, Albano, Domenico, Allen, Georgina, Bazzocchi, Alberto, Bignotti, Bianca, Chianca, Vito, Facal de Castro, Fernando, Drakonaki, Elena E., Gallardo, Elena, Gielen, Jan, Klauser, Andrea Sabine, Martinoli, Carlo, Mauri, Giovanni, McNally, Eugene, Messina, Carmelo, Mirón Mombiela, Rebeca, Orlandi, Davide, Plagou, Athena, Posadzy, Magdalena, de la Puente, Rosa, Reijnierse, Monique, Rossi, Federica, Rutkauskas, Saulius, Snoj, Ziga, Vucetic, Jelena, Wilson, David, and Tagliafico, Alberto Stefano

Published
2018
Full Text
View/download PDF

31. NTRK rearranged sarcoma of the bone. Role for larotrectinib in the neoadjuvant setting of an ultra-rare tumor: a case report.

Author

Palmerini, Emanuela, Frega, Giorgio, Gambarotti, Marco, Frisoni, Tommaso, Cesari, Marilena, Bazzocchi, Alberto, Miceli, Marco, Donati, Davide Maria, Fanti, Stefano, Nanni, Cristina, Benini, Stefania, Longhi, Alessandra, Paioli, Anna, Marrari, Andrea, Hakim, Rossella, Righi, Alberto, and Ibrahim, Toni

Subjects
OSTEOSARCOMA, DRUG approval, SYMPTOMS, BONE cells, TUMORS
Abstract

Background: Neurotrophic tyrosine receptor kinase (NTRK) gene-fusion targeted molecules revolutionized the paradigm of treatment of a limited subgroup of cancers of various histologies. Entrectinib and larotrectinib obtained unprecedented response rates in patients with cancer harboring NTRK rearrangements. This evidence recently led to the agnostic approval of these drugs, and evidence (confirmation) of their activity in a broader disease setting is emerging. Here, we report the case of a patient affected by EML4-NTRK3 rearranged undifferentiated spindle cell bone sarcoma treated with larotrectinib, and we argue (discuss about) the incidence and clinical presentation of NTRK gene-fusion positive bone sarcomas, the potential use of upfront treatment with NTRK inhibitors in neoadjuvant setting, and the role of a multidisciplinary tumor board. Despite the rarity of these rearrangements in patients with primitive bone sarcomas, the therapy with NTRK inhibitors represents a highly effective strategy to be pursued in selected cases even in neoadjuvant settings. The management of these very rare cancers should always be discussed in a multidisciplinary board of reference centers. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

32. Current Role of Conventional Radiography of Sacroiliac Joints in Adults and Juveniles with Suspected Axial Spondyloarthritis: Opinion from the ESSR Arthritis and Pediatric Subcommittees.

Author

Sudoł-Szopińska, Iwona, Herregods, Nele, Zejden, Anna, Jans, Lennart, Giraudo, Chiara, Boesen, Mikael, Becce, Fabio, Bazzocchi, Alberto, Simoni, Paolo, Aparisi, Pilar, Jaremko, Jacob, Maas, Mario, Teh, James, Hermann, Kay-Geert, Menegotto, Flavia, Isaac, Amanda, Reijnierse, Monique, Shah, Amit, Rennie, Winston, and Jurik, Anne Grethe

Subjects
SACROILIAC joint, SPONDYLOARTHROPATHIES, RADIOGRAPHY, PUBIC symphysis, ADULTS
Abstract

This opinion article by the European Society of Musculoskeletal Radiology Arthritis and Pediatric Subcommittees discusses the current use of conventional radiography (CR) of the sacroiliac joints in adults and juveniles with suspected axial spondyloarthritis (axSpA). The strengths and limitations of CR compared with magnetic resonance imaging (MRI) and computed tomography (CT) are presented. Based on the current literature and expert opinions, the subcommittees recognize the superior sensitivity of MRI to detect early sacroiliitis. In adults, supplementary pelvic radiography, low-dose CT, or synthetic CT may be needed to evaluate differential diagnoses. CR remains the method of choice to detect structural changes in patients with suspected late-stage axSpA or established disease and in patients with suspected concomitant hip or pubic symphysis involvement. In children, MRI is the imaging modality of choice because it can detect active as well as structural changes and is radiation free. [ABSTRACT FROM AUTHOR]

Published
2023
Full Text
View/download PDF

38. Imaging of Metabolic Bone Diseases.

Author

Bazzocchi, Alberto and Guglielmi, Giuseppe

Subjects
*MAGNETIC resonance imaging, *BODY composition, *DUAL-energy X-ray absorptiometry, *LIFE expectancy, *COMPUTED tomography
Abstract

The article "Imaging of Metabolic Bone Diseases" published in Seminars in Musculoskeletal Radiology discusses the importance of understanding metabolism in relation to aging and frailty. It emphasizes the role of imaging techniques, such as MRI and nuclear medicine, in diagnosing and managing metabolic bone diseases that affect the musculoskeletal system. The article highlights the significance of early detection and monitoring of these conditions to prevent fractures and improve quality of life. Additionally, it provides updates on various radiologic techniques used in the diagnosis and management of metabolic bone diseases. [Extracted from the article]

Published
2024
Full Text
View/download PDF

45. Role of Magnetic Resonance Thermometry in Magnetic Resonance Image-guided Focused UltrasonographyTreatment: Advantages and Pitfalls.

Author

de Carvalho, Dr. Adriano Novais, Gasperini, Dr. Chiara, D'Agostino, Dr. Valerio, Gazzotti, Dr. Silvia, Gomez, Maria Pilar Aparisi, and Bazzocchi, Alberto

Subjects
MAGNETIC resonance, PROTON magnetic resonance
Abstract

Although high-intensity focused ultrasonography (HIFU) can be performed as an US-guided technique, magnetic resonance imaging (MRI) guidance is preferred for bone treatments. I Purpose or Learning Objective: i To review the importance of magnetic resonance thermometry, its technical advances but also possible pitfalls regarding technical obstacles pertaining to temperature measurement accuracy in noninvasive thermal ablation treatments such as magnetic resonance image-guided focused ultrasonography (MRgFUS). [Extracted from the article]

Published
2023
Full Text
View/download PDF

Catalog

Books, media, physical & digital resources
See catalog results