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4. Identification of Prognostic Phenotypes of Esophageal Adenocarcinoma in 2 Independent Cohorts

Author

Noorani, Ayesha, Edwards, Paul A.W., Grehan, Nicola, Nutzinger, Barbara, Hughes, Caitriona, Fidziukiewicz, Elwira, Bornschein, Jan, MacRae, Shona, Crawte, Jason, Contino, Gianmarco, Li, Xiaodun, Rue, Rachel de la, O’Donovan, Maria, Miremad, Ahmad, Malhotra, Shalini, Tripathi, Monika, Tavaré, Simon, Lynch, Andy G., Eldridge, Matthew, Secrier, Maria, Bower, Lawrence, Devonshire, Ginny, Perner, Juliane, Jammula, Sriganesh, Davies, Jim, Crichton, Charles, Carroll, Nick, Safranek, Peter, Hindmarsh, Andrew, Sujendran, Vijayendran, Hayes, Stephen J., Ang, Yeng, Preston, Shaun R., Oakes, Sarah, Bagwan, Izhar, Save, Vicki, Skipworth, Richard J.E., Hupp, Ted R., O’Neill, J. Robert, Tucker, Olga, Beggs, Andrew, Taniere, Philippe, Puig, Sonia, Underwood, Timothy J., Noble, Fergus, Owsley, Jack, Barr, Hugh, Shepherd, Neil, Old, Oliver, Lagergren, Jesper, Gossage, James, Davies, Andrew, Chang, Fuju, Zylstra, Janine, Mahadeva, Ula, Goh, Vicky, Ciccarelli, Francesca D., Sanders, Grant, Berrisford, Richard, Harden, Catherine, Bunting, David, Lewis, Mike, Cheong, Ed, Kumar, Bhaskar, Parsons, Simon L., Soomro, Irshad, Kaye, Philip, Saunders, John, Lovat, Laurence, Haidry, Rehan, Eneh, Victor, Igali, Laszlo, Scott, Michael, Sothi, Sharmila, Suortamo, Sari, Lishman, Suzy, Hanna, George B., Peters, Christopher J., Grabowska, Anna, Turkington, Richard, Sawas, Tarek, Killcoyne, Sarah, Iyer, Prasad G., Wang, Kenneth K., Smyrk, Thomas C., Kisiel, John B., Qin, Yi, Ahlquist, David A., Rustgi, Anil K., Costa, Rui J., Gerstung, Moritz, Fitzgerald, Rebecca C., and Katzka, David A.

Published
2018
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10. Genome-wide association studies in oesophageal adenocarcinoma and Barrett's oesophagus: a large-scale meta-analysis

Author

Gharahkhani, Puya, Fitzgerald, Rebecca C, Vaughan, Thomas L, Palles, Claire, Gockel, Ines, Tomlinson, Ian, Buas, Matthew F, May, Andrea, Gerges, Christian, Anders, Mario, Becker, Jessica, Kreuser, Nicole, Noder, Tania, Venerito, Marino, Veits, Lothar, Schmidt, Thomas, Manner, Hendrik, Schmidt, Claudia, Hess, Timo, Böhmer, Anne C, Izbicki, Jakob R, Hölscher, Arnulf H, Lang, Hauke, Lorenz, Dietmar, Schumacher, Brigitte, Hackelsberger, Andreas, Mayershofer, Rupert, Pech, Oliver, Vashist, Yogesh, Ott, Katja, Vieth, Michael, Weismüller, Josef, Nöthen, Markus M, Attwood, Stephen, Barr, Hugh, Chegwidden, Laura, de Caestecker, John, Harrison, Rebecca, Love, Sharon B, MacDonald, David, Moayyedi, Paul, Prenen, Hans, Watson, R G Peter, Iyer, Prasad G, Anderson, Lesley A, Bernstein, Leslie, Chow, Wong-Ho, Hardie, Laura J, Lagergren, Jesper, Liu, Geoffrey, Risch, Harvey A, Wu, Anna H, Ye, Weimin, Bird, Nigel C, Shaheen, Nicholas J, Gammon, Marilie D, Corley, Douglas A, Caldas, Carlos, Moebus, Susanne, Knapp, Michael, Peters, Wilbert H M, Neuhaus, Horst, Rösch, Thomas, Ell, Christian, MacGregor, Stuart, Pharoah, Paul, Whiteman, David C, Jankowski, Janusz, and Schumacher, Johannes

Published
2016
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17. An Anatomy of Continuing Interprofessional Education

Author

Barr, Hugh

Abstract

Continuing interprofessional education is the means by which experienced health, social care, and other practitioners learn with, from, and about each other, formally and informally, to improve their collective practice and to cultivate closer collaboration. It applies principles of interprofessional education through media commonly employed in continuing professional education grounded in team-based practice. Among many approaches, it may be enriched by guided or self-directed reading, by open, distance, or e-learning, and during workshops, seminars, conferences, or courses. No one medium is preferable; nor are they mutually exclusive. Each complements the others. Subsequent articles in this issue put flesh on these bones. (Contains 1 table.)

Published
2009
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18. Faculty Response to that Implementation of an Open Source Learning Management System in Three Tertiary Institutions in New Zealand

Author

Barr, Hugh, Gower, Beverly, and Clayton, John

Abstract

In spite of their apparent benefits, learning management systems can be regarded as a hindrance to effective online learning. Their design, functionality, complexity, price, and value are beginning to be questioned by some users. As a new generation of Web-based tools and approaches evolves, Web-based learning management systems are becoming better suited to meet the need for dynamic online learning, interaction, collaboration, and networking. The new tools and collaborative approaches these systems provide allow learners to take proactive control of their own learning. In June 2004 a consortium of New Zealand Tertiary Institutions led by the Waikato Institute of Technology secured a one-year Ministry of Education grant to support the "Open Source Courseware Initiative New Zealand" (OSCINZ). The OSCINZ project focused on the development and implementation of "Moodle" (Modular Object-Oriented Dynamic Learning Environment) to create a uniquely New Zealand learning management system, based on quality open source code developed and tested by leading educational providers. This paper describes the response of faculty in three of the project's partner tertiary institutions to the implementation of Moodle in their institutions.

Published
2008
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19. Germline variation in inflammation-related pathways and risk of Barrettʼs oesophagus and oesophageal adenocarcinoma

Author

Buas, Matthew F, He, Qianchuan, Johnson, Lisa G, Onstad, Lynn, Levine, David M, Thrift, Aaron P, Gharahkhani, Puya, Palles, Claire, Lagergren, Jesper, Fitzgerald, Rebecca C, Ye, Weimin, Caldas, Carlos, Bird, Nigel C, Shaheen, Nicholas J, Bernstein, Leslie, Gammon, Marilie D, Wu, Anna H, Hardie, Laura J, Pharoah, Paul D, Liu, Geoffrey, Iyer, Prassad, Corley, Douglas A, Risch, Harvey A, Chow, Wong-Ho, Prenen, Hans, Chegwidden, Laura, Love, Sharon, Attwood, Stephen, Moayyedi, Paul, MacDonald, David, Harrison, Rebecca, Watson, Peter, Barr, Hugh, deCaestecker, John, Tomlinson, Ian, Jankowski, Janusz, Whiteman, David C, MacGregor, Stuart, Vaughan, Thomas L, and Madeleine, Margaret M

Published
2017
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20. The evidence base for interprofessional education within health professions education: A protocol for an update review.

Author

Kitto, Simon, Wondwossen Fantaye, Arone, Davies, Nigel, McFadyen, Angus Kennedy, Rivera, Josette, Birch, Ivan, Barr, Hugh, Fletcher, Simon, Fournier, Karine, and Xyrichis, Andreas

Subjects
SYSTEMATIC reviews, ABILITY, TRAINING, INTERPROFESSIONAL relations, INTERDISCIPLINARY education, MEDICAL education, BEHAVIOR modification
Abstract

Interprofessional education (IPE) interventions aiming to promote collaborative competence and improve the delivery of health and social care processes and outcomes continue to evolve. This paper reports on a protocol for an update review that we will conduct to identify and describe how the IPE evidence base has evolved in the last 7 years. We will identify literature through a systematic search of the following electronic databases: Medline, Embase, CINAHL, Education Source, ERIC, and BEI. We will consider all IPE interventions delivered to health professions students and accredited professionals. Peer-reviewed empirical research studies published in any language from June 2014 onwards will be eligible for inclusion. The outcomes of interest are changes in the reaction, attitudes/perceptions, knowledge/skills acquisition, behaviors, organizational practice, and/or benefits to patients. We will perform each task of screening, critical appraisal, data abstraction, and synthesis using at least two members of the review team. The review will enable an update and comprehensive understanding of the IPE evidence base to inform future IPE developments, delivery and evaluation across education and clinical settings. [ABSTRACT FROM AUTHOR]

Published
2023
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22. Consensus Statements for Management of Barrett's Dysplasia and Early-Stage Esophageal Adenocarcinoma, Based on a Delphi Process

Author

Bennett, Cathy, Vakil, Nimish, Bergman, Jacques, Harrison, Rebecca, Odze, Robert, Vieth, Michael, Sanders, Scott, Gay, Laura, Pech, Oliver, Longcroft–Wheaton, Gaius, Romero, Yvonne, Inadomi, John, Tack, Jan, Corley, Douglas A., Manner, Hendrik, Green, Susi, Al Dulaimi, David, Ali, Haythem, Allum, Bill, Anderson, Mark, Curtis, Howard, Falk, Gary, Fennerty, M. Brian, Fullarton, Grant, Krishnadath, Kausilia, Meltzer, Stephen J., Armstrong, David, Ganz, Robert, Cengia, Gianpaolo, Going, James J., Goldblum, John, Gordon, Charles, Grabsch, Heike, Haigh, Chris, Hongo, Michio, Johnston, David, Forbes–Young, Ricky, Kay, Elaine, Kaye, Philip, Lerut, Toni, Lovat, Laurence B., Lundell, Lars, Mairs, Philip, Shimoda, Tadakuza, Spechler, Stuart, Sontag, Stephen, Malfertheiner, Peter, Murray, Iain, Nanji, Manoj, Poller, David, Ragunath, Krish, Regula, Jaroslaw, Cestari, Renzo, Shepherd, Neil, Singh, Rajvinder, Stein, Hubert J., Talley, Nicholas J., Galmiche, Jean–Paul, Tham, Tony C.K., Watson, Peter, Yerian, Lisa, Rugge, Massimo, Rice, Thomas W., Hart, John, Gittens, Stuart, Hewin, David, Hochberger, Juergen, Kahrilas, Peter, Preston, Sean, Sampliner, Richard, Sharma, Prateek, Stuart, Robert, Wang, Kenneth, Waxman, Irving, Abley, Chris, Loft, Duncan, Penman, Ian, Shaheen, Nicholas J., Chak, Amitabh, Davies, Gareth, Dunn, Lorna, Falck–Ytter, Yngve, Decaestecker, John, Bhandari, Pradeep, Ell, Christian, Griffin, S. Michael, Attwood, Stephen, Barr, Hugh, Allen, John, Ferguson, Mark K., Moayyedi, Paul, and Jankowski, Janusz A.Z.

Published
2012
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30. Social Studies by Electronic Mail.

Author

Barr, Hugh

Abstract

Asserts that electronic mail provides opportunities to engage students actively in cross-cultural contact with students in other nations. Discusses advantages and problems with using electronic mail in the social studies classroom. Describes electronic mail projects that link students in New Zealand, England, and the United States. (CFR)

Published
1994

31. Survival in the South Pacific: The New Social Studies in New Zealand.

Author

Barr, Hugh

Abstract

Reviews the history, characteristics, and impact of the New Social Studies movement in the United States during the 1960s and 1970s. Describes the educational goals, teaching methods, and instructional materials commonly used in the New Zealand social studies curriculum. (CFR)

Published
1993

33. The stem cell organisation, and the proliferative and gene expression profile of Barrettʼs epithelium, replicates pyloric-type gastric glands

Author

Lavery, Danielle L, Nicholson, Anna M, Poulsom, Richard, Jeffery, Rosemary, Hussain, Alia, Gay, Laura J, Jankowski, Janusz A, Zeki, Sebastian S, Barr, Hugh, Harrison, Rebecca, Going, James, Kadirkamanathan, Sritharan, Davis, Peter, Underwood, Timothy, Novelli, Marco R, Rodriguez-Justo, Manuel, Shepherd, Neil, Jansen, Marnix, Wright, Nicholas A, and McDonald, Stuart A C

Published
2014
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36. Liquid Biopsy for Pancreatic Cancer Detection Using Infrared Spectroscopy.

Author

Sala, Alexandra, Cameron, James M., Jenkins, Cerys A., Barr, Hugh, Christie, Loren, Conn, Justin J. A., Evans, Thomas R. Jeffry, Harris, Dean A., Palmer, David S., Rinaldi, Christopher, Theakstone, Ashton G., and Baker, Matthew J.

Subjects
PANCREATIC tumors, MINIMALLY invasive procedures, EARLY detection of cancer, MACHINE learning, DESCRIPTIVE statistics, BODY fluid examination, INFRARED spectroscopy, SENSITIVITY & specificity (Statistics), RECEIVER operating characteristic curves, ALGORITHMS
Abstract

Simple Summary: Pancreatic tumors are extremely difficult to detect in their early stages due to the lack of early symptomatic evidence and fast, simple, non-invasive, and accurate diagnostic tests. Computed tomography (CT) scans are the usual first step in investigating suspected pancreatic cancer, but may not detect early tumors—especially in asymptomatic patients. Equally, the carbohydrate antigen (CA) 19-9 blood test is not specific to pancreatic cancer, as CA 19-9 levels can be raised in symptomatic patients with other non-malignant diseases, or with other tumors located in the surrounding area. In this proof-of-concept study, infrared spectroscopy was used to discriminate cancers versus healthy controls, as well as cancers versus symptomatic controls. Classification algorithms successfully discriminated the classes with high performances, accounting for detection rates of up to 92%. Simple, minimally invasive, and accurate approaches can represent a powerful aid in the achievement of pancreatic cancer's earlier detection to improve patients' prognosis and quality of life. Pancreatic cancer claims over 460,000 victims per year. The carbohydrate antigen (CA) 19-9 test is the blood test used for pancreatic cancer's detection; however, its levels can be raised in symptomatic patients with other non-malignant diseases, or with other tumors in the surrounding area. Attenuated total reflection Fourier-transform infrared (ATR-FTIR) spectroscopy has demonstrated exceptional potential in cancer diagnostics, and its clinical implementation could represent a significant step towards early detection. This proof-of-concept study, investigating the use of ATR-FTIR spectroscopy on dried blood serum, focused on the discrimination of both cancer versus healthy control samples, and cancer versus symptomatic non-malignant control samples, as a novel liquid biopsy approach for pancreatic cancer diagnosis. Machine learning algorithms were applied, achieving results of up to 92% sensitivity and 88% specificity when discriminating between cancers (n = 100) and healthy controls (n = 100). An area under the curve (AUC) of 0.95 was obtained through receiver operating characteristic (ROC) analysis. Balanced sensitivity and specificity over 75%, with an AUC of 0.83, were achieved with cancers (n = 35) versus symptomatic controls (n = 35). Herein, we present these results as demonstration that our liquid biopsy approach could become a simple, minimally invasive, and reliable diagnostic test for pancreatic cancer detection. [ABSTRACT FROM AUTHOR]

Published
2022
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41. Barrettʼs esophagus: histology and immunohistology

Author

Barr, Hugh, Upton, Melissa P., Orlando, Roy C., Armstrong, David, Vieth, Michael, Neumann, Helmut, Langner, Cord, Wiley, Elizabeth L., Das, Kiron M., Pickett-Blakely, Octavia E., Bajpai, Manisha, Amenta, Peter S., Bennett, Ana, Going, James J., Younes, Mamoun, Wang, Helen H., Taddei, Antonio, Freschi, Giancarlo, Ringressi, Maria Novella, DegliʼInnocenti, Duccio Rossi, Castiglione, Francesca, and Bechi, Paolo

Published
2011
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42. Barrettʼs esophagus: genetic and cell changes

Author

Souza, Rhonda F., Freschi, Giancarlo, Taddei, Antonio, Ringressi, Maria Novella, Bechi, Paolo, Castiglione, Francesca, DeglʼInnocenti, Duccio Rossi, Triadafilopoulos, George, Wang, Jean S., Chang, Andrew C., Barr, Hugh, Bajpai, Manisha, Das, Kiron M., Schneider, Paul M., Krishnadath, Kausilia K., Malhotra, Usha, and Lynch, John P.

Published
2011
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46. Round up

Author

SHAH, PARIN R, PATEL, MOTI R, HARAY, PUTHUCODE N, BARR, HUGH, DONOVAN, SHEILA, ROSS, FIONA, SMITH, ELIZABETH, GLASBY, JON, AEBERHARD, PENNY, WILSON, ANNA, and SACKIN, PAUL

Published
2005

48. Round up

Author

ERNST, EDZARD, SCHMIDT, KATJA, ROSS, FIONA, VALENTINE, MALCOLM, LYONS, NICK, BARR, HUGH, and SANDARS, JOHN

Published
2003

49. Round up

Author

VALENTINE, MALCOLM, BARR, HUGH, SCHRIEBER, VIC, and BEDI, AJAY

Published
2003

50. Round up

Author

TAYLOR, GEORGE, SLOAN, RICHARD, BARR, HUGH, HOLMES, STEVE, VALENTINE, MALCOLM, SMITH, ELIZABETH, and ROSS, FIONA

Published
2003

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