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Introduction: rehabilitation of Anterior Cruciate Ligament (ACL) reconstruction is fundamental component after surgery, but this period is long and sometimes boring. To investigate the feasibility of the Nintendo Wii Fit instead of conventional rehabilitation after Anterior Cruciate Ligament Reconstruction. Material and methods: 43 healthy sedentary men (age: 29.5±7.9yrs, height: 176.3±5.3cm, body weight: 79.6±9.3kg, BMI: 25.6±3.0 kg/cm2) were included into this study. They were randomly separated into two groups: 21 subjects were included in Wii therapy group (group1), while 22 of them were taken in the conventional rehabilitation group (group2). The subjects went through the rehabilitation protocol during 12 weeks. Flexion and extension strengths of knee were assessed by Isomed 2000 isokinetic dynamometer at 60°/s and 180°/s angular velocities, and ACL outcome questionnaire was employed to assess the patients' life quality during the rehabilitation. Student t-test was used for all statistical analysis. This study has 80% power with 5% type 1 error level as statistically significant Results: hypothesis 0: there are efficency of wii therapy as well as standard rehabilitation protocol on muscle strength and quality of life after ACL reconstruction with single-bundle hamstring tendon graft. There were significant differences between both groups in life quality outcome questionnaire at 4th (p=0.03) and 8th weeks (p=0.04) of the rehabilitation. However, there was no significant difference between the groups in terms of peak torque in flexion and extension at 60°/s (p=0.363, p=0.852) and at 180°/s (p=0.914, p=0.694) angular velocities in the 12th week of the rehabilitation. Similarly, there was no significant difference between the groups regarding total work in flexion and extension at 60°/s (p=0.706, p=0.891) and at 180°/s (p=0.807, p=0.539) angular velocities in the12th week. Conclusions: what this study illustrated was that Wii therapy might be used instead of /with combination of conventional rehabilitation as it gives the feeling of competition and makes the rehabilitation more fun after ACL reconstruction. [ABSTRACT FROM AUTHOR]