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Abstract: Process-based modelling approaches developed for field crops were adapted to address the behaviour of indoor-grown soil-less lettuce under alternative growth conditions. The equations for crop growth and development were simplified to common and consistent terms, re-designed against the peculiarities of a controlled environment and implemented into an easy-to-use, management-oriented, software tool. An array of experiments, where lettuce was grown in growth chambers under water- and nutrient-unlimited conditions, at various temperature and radiation levels, was performed to build a data set to evaluate the model. Critical parameters and suitable relationships were identified and evaluated for possible use in management-oriented applications. Summary statistics of the evaluation indicated a satisfactory description of crop growth (EF>0.50) and development (±1 day discrepancy). As a result, there is a potential for the present approach to be applied to soil-less lettuce systems under alternative management options. [Copyright &y& Elsevier]