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Bullous pemphigoid (BP), the most common autoimmune blistering disease, is characterized by the presence of autoantibodies targeting BP180 and BP230 in the basement membrane zone. This leads to the activation of complement-dependent and independent pathways, resulting in proteolytic cleavage at the dermoepidermal junction and an eosinophilic inflammatory response. While numerous drugs have been associated with BP in the literature, causality and pathogenic mechanisms remain elusive in most cases. Dipeptidyl peptidase 4 inhibitors (DPP4i), in particular, are the most frequently reported drugs related to BP and, therefore, have been extensively investigated. They can potentially trigger BP through the impaired proteolytic degradation of BP180, combined with immune dysregulation. DPP4i-associated BP can be categorized into true drug-induced BP and drug-triggered BP, with the latter resembling classic BP. Antineoplastic immunotherapy is increasingly associated with BP, with both B and T cells involved. Other drugs, including biologics, diuretics and cardiovascular and neuropsychiatric agents, present weaker evidence and poorly understood pathogenic mechanisms. Further research is needed due to the growing incidence of BP and the increasing identification of new potential triggers. [ABSTRACT FROM AUTHOR]

Cutaneous cancers are, by far, the most common malignant neoplasms of the human being. Due to the great array of clinical conditions, their worldwide increasing incidence and the steady ageing of the population, non-invasive treatments modalities that show a good clinical response, a proper benefit–risk ratio and cosmetic results are becoming increasingly important in the clinical setting. Imiquimod is a topically applied immunomodulator which is often used in the management of several premalignant and malignant cutaneous disorders. This article is a review of the current literature on its mechanism of action, pharmacokinetics, and therapeutical effects. [ABSTRACT FROM AUTHOR]

Sexual intercourses, probably through skin-to-skin contact, may be playing a key role in the transmission of the disease.[3] Conversely, our patient had no genital lesions, and skin rash showed some clinical particularities: (1) Truncal syphilitic-roseola-like maculopapular rash admixed with some pustules; (2) Lineal distribution of plaques on the flank reminiscent of Koebner phenomenon. A 48-year-old man attended to the Emergency Department with a one-week history of high fever, odynophagia, arthralgias and generalized skin lesions with mild pruritus. Monkeypox virus infection with a syphilitic-roseola-like rash and its histopathologic characterization during 2022 outbreak. [Extracted from the article]

The article discusses a hypothesis regarding the clinical pattern of frontal fibrosing alopecia (FFA), a type of hair loss. The authors suggest that residues from leave-on facial products, such as sunscreen and moisturizers, may be linked to the development of FFA. They conducted an experiment where a cream with fluorescein was applied to the faces of volunteers, and the residue predominantly settled in the frontotemporal hairline and eyebrows. The authors believe that their observation provides a plausible explanation for the clinical pattern of FFA, although the role of facial products in its development is still controversial. [Extracted from the article]

Physical examination demonstrated oral erosions (Figure 1A) and tense serous blisters on her left submammary fold (Figure 1B), abdomen, and right forearm. Piperacillin-tazobactam-induced linear IgA bullous dermatosis presenting clinically as Stevens-Johnson syndrome/toxic epidermal necrolysis overlap. Data sharing not applicable to this article as no datasets were generated or analysed during the current study. [Extracted from the article]

Dear Editor, The severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has been a global health issue for more than a year now, and most of its cutaneous manifestations have already been described.1 This letter reports a dermatologic finding appearing one month after mild COVID-19 diagnosis. Dermatological examination showed millimetric keratotic spiny papules distributed in both palms, predominantly along the palm and digit lateral margins (Fig. Close-up view of the fifth finger (b) and hypothenar eminence (c) gl A 4-mm punch biopsy was taken from one of the spiny papules of the right palm to confirm the diagnosis. [Extracted from the article]