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Describes a general and convenient synthesis of (1S,5S)-4-alkyl-6,6-dimethylbicyclo[3.1.1]- hept-3-en-2-ones including (-)-verbenone. Simplest compound from (1R,5S)-(+)-nopinone via (+)-apoverbenone; Cyclobutane-opening reactions; Addition reactions; Use as building blocks for asymmetric synthesis.

The Mannich reaction of methylsilyl enol ether with aryl�aldimine proceeded in the presence of a catalytic amount of lithium chloride in dimethylformamide at room temperature. The reaction was mild enough to apply to aldimines having the AcO, TBDMSO, or MeS group. Microwave irradiation accelerated the reaction substantially to reduce reaction time. [ABSTRACT FROM AUTHOR]

Purpose: To develop and validate a new, simple, sensitive, rapid, cost-effective and accurate reverse phase-high performance liquid chromatography (RP-HPLC) method for the determination of aprepitant (APT) in capsule dosage form. Methods: The method developed for the determination of APT in capsule formulation involved using RP-HPLC which incorporated a C18 column 250 x 2.5 mm i.d, 5 μm particle size, in isocratic mode, with mobile phase comprising of methanol: water in the ratio of 90:10 (v/v). The flow rate was 1 mL/min and the detection was monitored at 220 nm. The total run time was 10 min and the column was maintained at ambient temperature. Results: APT was eluted in the given mobile phase with a retention time (tr) of 4.473 min. The linearity for the quantification of APT was 0.1 - 10 μg/mL (R2 =0.989, Y= 33032x + 71501) with coefficients of variation (based on mean peak area for six replicate injections) in the range 0.04 to 0.132. The limits of detection and of quantification were 0.028 and 0.094 μg/mL, respectively. Recovery of the method was 99.56 - 100.5 % while the relative standard deviation (RSD) of intra-day and inter-day precision was 0.85 and 1.05, respectively. System precision and method precision were 0.013 and 1.400 %, respectively. The specificity data of the proposed method indicated that excipients in the capsules did not interfere with the drug peak. Furthermore, the well-shaped peaks buttressed the specificity of the method. Conclusion: The proposed RP-HPLC method is simple, sensitive, rapid, cost-effective and accurate for the determination of APT in both bulk materials and pharmaceutical dosage forms. [ABSTRACT FROM AUTHOR]

In vitro study was carried out to determine the antibacterial activity of root extracts of Berberis lycium by using various solvents for extraction. The methanolic root extract showed higher inhibitory effect as compared to the other solvent extracts, against the mixed culture of human pathogenic bacteria viz., Pseudomonas sp., Escherchia coli, Streptococcus sp. and Staphylococcus sp. However, methanolic extract when used separately were less effective compared to Gentamycin and Amoxicillin showing inhibition zone of 10, 11 and 12 against Staphylococcus, Pseudomonas sp. and E. coli respectively. [ABSTRACT FROM AUTHOR]

In the title molecular salt, C14H18N22+·C6H8O42−, both the dication and the dianion lie on inversion centers. There is an approximate 61:39 disorder in the central linkage of the cation. In the crystal structure, the components associate via N—H...O and C—H...O interactions, resulting in R22(9) rings. [ABSTRACT FROM AUTHOR]