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299 results on '"Autran, Brigitte"'

1. Clonal succession after prolonged antiretroviral therapy rejuvenates CD8+ T cell responses against HIV-1

Author

White, Eoghann, Papagno, Laura, Samri, Assia, Sugata, Kenji, Hejblum, Boris, Henry, Amy R., Rogan, Daniel C., Darko, Samuel, Recordon-Pinson, Patricia, Dudoit, Yasmine, Llewellyn-Lacey, Sian, Chakrabarti, Lisa A., Buseyne, Florence, Migueles, Stephen A., Price, David A., Andreola, Marie-Aline, Satou, Yorifumi, Thiebaut, Rodolphe, Katlama, Christine, Autran, Brigitte, Douek, Daniel C., and Appay, Victor

Published
2024
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2. Preclinical in vivo assessment of the activity of AZD7442 anti-SARS-CoV-2 monoclonal antibodies against Omicron sublineages

Author

Driouich, Jean-Sélim, Cochin, Maxime, Lingas, Guillaume, Luciani, Léa, Baronti, Cécile, Bernadin, Ornéllie, Gilles, Magali, Villarroel, Paola Mariela Saba, Moureau, Grégory, Petit, Paul-Rémi, Dupont, Axelle, Izopet, Jacques, Kamar, Nassim, Autran, Brigitte, Paintaud, Gilles, Caillard, Sophie, le Bourgeois, Amandine, Richez, Christophe, Couzi, Lionel, Xhaard, Aliénor, Marjanovic, Zora, Avouac, Jerome, Jacquet, Caroline, Anglicheau, Dany, Cheminant, Morgane, Nguyen, Stéphanie, Terrier, Benjamin, Gottenberg, Jacques Eric, Besson, Caroline, Letrou, Sophie, Tine, Josephine, Basilua, Joe Miantezila, Angoulvant, Denis, Tardivon, Coralie, Blancho, Gilles, Martin-Blondel, Guillaume, Yazdanpanah, Yazdan, Mentré, France, Lévy, Vincent, Touret, Franck, Guedj, Jérémie, de Lamballerie, Xavier, and Nougairède, Antoine

Published
2024
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4. Charting a course for global progress in PIDs by 2030 — proceedings from the IPOPI global multi-stakeholders’ summit (September 2023).

Author

Van Coillie, Samya, Prévot, Johan, Sánchez-Ramón, Silvia, Lowe, David M., Borg, Michael, Autran, Brigitte, Segundo, Gesmar, Pecoraro, Antonio, Garcelon, Nicolas, Boersma, Cornelis, Silva, Susana L., Drabwell, Jose, Quinti, Isabella, Meyts, Isabelle, Ali, Adli, Burns, Siobhan O., van Hagen, Martin, Pergent, Martine, and Mahlaoui, Nizar

Subjects
PANDEMIC preparedness, PRIMARY immunodeficiency diseases, ARTIFICIAL intelligence, DRUG resistance in microorganisms, CRISIS management
Abstract

The International Patient Organisation for Primary Immunodeficiencies (IPOPI) held its second Global Multi-Stakeholders’ Summit, an annual stimulating and forward-thinking meeting uniting experts to anticipate pivotal upcoming challenges and opportunities in the field of primary immunodeficiency (PID). The 2023 summit focused on three key identified discussion points: (i) How can immunoglobulin (Ig) therapy meet future personalized patient needs? (ii) Pandemic preparedness: what’s next for public health and potential challenges for the PID community? (iii) Diagnosing PIDs in 2030: what needs to happen to diagnose better and to diagnose more? Clinician-Scientists, patient representatives and other stakeholders explored avenues to improve Ig therapy through mechanistic insights and tailored Ig preparations/products according to patient-specific needs and local exposure to infectious agents, amongst others. Urgency for pandemic preparedness was discussed, as was the threat of shortage of antibiotics and increasing antimicrobial resistance, emphasizing the need for representation of PID patients and other vulnerable populations throughout crisis and care management. Discussion also covered the complexities of PID diagnosis, addressing issues such as global diagnostic disparities, the integration of patient-reported outcome measures, and the potential of artificial intelligence to increase PID diagnosis rates and to enhance diagnostic precision. These proceedings outline the outcomes and recommendations arising from the 2023 IPOPI Global Multi-Stakeholders’ Summit, offering valuable insights to inform future strategies in PID management and care. Integral to this initiative is its role in fostering collaborative efforts among stakeholders to prepare for the multiple challenges facing the global PID community. [ABSTRACT FROM AUTHOR]

Published
2024
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6. How to improve vaccine acceptability (evaluation, pharmacovigilance, communication, public health, mandatory vaccination, fears and beliefs)

Author

Autran, Brigitte, Béhier, Jehan-Michel, Borel, Thomas, Bresse, Xavier, Chêne, Geneviève, Courcier, Soizic, Dufour, Véronique, Faurisson, François, Gagneur, Arnaud, Gelpi, Odile, Gérald, Franck, Kheloufi, Farid, Koeck, Jean-Louis, Lamarque-Garnier, Véronique, Lery, Telma, Ménin, Géraldine, Molimard, Mathieu, Opinel, Annick, Roger, Claire, Rouby, Franck, Schuck, Stéphane, Simon, Laurent, Soubeyrand, Benoît, Truchet, Marie-Christine, Dutilleul, Alain, Morel, Jacques, Schilte, Clémentine, and Launay, Odile

Published
2019
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7. Comment améliorer l’acceptabilité vaccinale (évaluation, pharmacovigilance, communication, santé publique, obligation vaccinale, peurs et croyances)

Author

Autran, Brigitte, Béhier, Jehan-Michel, Borel, Thomas, Bresse, Xavier, Chêne, Geneviève, Courcier, Soizic, Dufour, Véronique, Faurisson, François, Gagneur, Arnaud, Gelpi, Odile, Gérald, Franck, Kheloufi, Farid, Koeck, Jean-Louis, Lamarque-Garnier, Véronique, Lery, Telma, Ménin, Géraldine, Molimard, Mathieu, Opinel, Annick, Roger, Claire, Rouby, Franck, Schuck, Stéphane, Simon, Laurent, Soubeyrand, Benoît, Truchet, Marie-Christine, Dutilleul, Alain, Morel, Jacques, Schilte, Clémentine, and Launay, Odile

Published
2019
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8. Comprehensive analysis of early T cell responses to acute Zika Virus infection during the first epidemic in Bahia, Brazil.

Author

Samri, Assia, Bandeira, Antonio Carlos, Gois, Luana Leandro, Silva, Carlos Gustavo Regis, Rousseau, Alice, Corneau, Aurelien, Tarantino, Nadine, Maucourant, Christopher, Queiroz, Gabriel Andrade Nonato, Vieillard, Vincent, Yssel, Hans, Campos, Gubio Soares, Sardi, Silvia, Autran, Brigitte, and Rios Grassi, Maria Fernanda

Subjects
T cells, ZIKA virus infections, MONONUCLEAR leukocytes, IMMUNOLOGIC memory, T cell receptors, ZIKA virus, FATIGUE (Physiology)
Abstract

Background: In most cases, Zika virus (ZIKV) causes a self-limited acute illness in adults, characterized by mild clinical symptoms that resolve within a few days. Immune responses, both innate and adaptive, play a central role in controlling and eliminating virus-infected cells during the early stages of infection. Aim: To test the hypothesis that circulating T cells exhibit phenotypic and functional activation characteristics during the viremic phase of ZIKV infection. Methods: A comprehensive analysis using mass cytometry was performed on peripheral blood mononuclear cells obtained from patients with acute ZIKV infection (as confirmed by RT-PCR) and compared with that from healthy donors (HD). The frequency of IFN-γ-producing T cells in response to peptide pools covering immunogenic regions of structural and nonstructural ZIKV proteins was quantified using an ELISpot assay. Results: Circulating CD4+ and CD8+ T lymphocytes from ZIKV-infected patients expressed higher levels of IFN-γ and pSTAT-5, as well as cell surface markers associated with proliferation (Ki-67), activation ((HLA-DR, CD38) or exhaustion (PD1 and CTLA-4), compared to those from HD. Activation of CD4+ and CD8+ memory T cell subsets, including Transitional Memory T Cells (TTM), Effector Memory T cells (TEM), and Effector Memory T cells Re-expressing CD45RA (TEMRA), was prominent among CD4+ T cell subset of ZIKV-infected patients and was associated with increased levels of IFN-γ, pSTAT-5, Ki-67, CTLA-4, and PD1, as compared to HD. Additionally, approximately 30% of ZIKV-infected patients exhibited a T cell response primarily directed against the ZIKV NS5 protein. Conclusion: Circulating T lymphocytes spontaneously produce IFN-γ and express elevated levels of pSTAT-5 during the early phase of ZIKV infection whereas recognition of ZIKV antigen results in the generation of virus-specific IFN-γ-producing T cells. [ABSTRACT FROM AUTHOR]

Published
2024
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9. Dynamics in HIV-DNA levels over time in HIV controllers

Author

Avettand-Fenoel, Veronique, Bayan, Tatiana, Gardiennet, Elise, Boufassa, Faroudy, Lopez, Pauline, Lecuroux, Camille, Noel, Nicolas, Tremeaux, Pauline, Monceaux, Valerie, Autran, Brigitte, Meyer, Laurence, Saez-Cirion, Asier, Lambotte, Olivier, and Rouzioux, Christine

Subjects
HIV infections -- Development and progression -- Genetic aspects, HIV carriers -- Health aspects, Health
Abstract

Introduction: HIV controllers (HIC) maintain viraemia at low levels without antiretroviral treatment and have small HIV reservoirs. Nevertheless, they are heterogeneous regarding their risk of infection progression. The study of reservoirs can help elucidate this control. This study aimed to explore the factors implicated in the pathogenesis of HIV infection that are potentially associated with HIV reservoirs and their dynamics in HIC. Methods: Individuals living with HIV included in the ANRS-CODEX cohort with at least two HIV-DNA measurements between 2009 and 2016 were selected. The total HIV-DNA levels had been quantified prospectively from blood samples. Mixed-effect linear models estimated the HIV-DNA dynamics over time. Results: The median (interquartile range (IQR)) HIV-DNA level was 1.5 (1.3 to 1.9) log copies/million peripheral blood mononuclear cells at inclusion (n = 202 individuals). These low levels showed heterogeneity among HIC. Lower levels were then associated with the protective HLA-B*27/B*57 alleles and/or lower HIV-RNA level at inclusion, negative hepatitis C virus serology, lower HIV-suppressive capacity of specific CD8 T cells and lower levels of immune activation and inflammation. Interestingly, mathematical modelling of the dynamics of HIV-DNA over time (840 measurements) showed that the number of infected cells decreased in 46% of HIC (follow-up: 47.6 months) and increased in 54% of HIC. A multivariate analysis indicated that HLA-B*27/B*57 alleles, a low level of HIV-RNA and a low level of HIV-DNA at inclusion were markers independently associated with this decrease. Conclusions: These results offer new insights into the mechanisms of long-term control in HIC. In half of HIC, the decrease in HIV-DNA level could be linked to tighter viral control and progressive loss of infected cells. These findings allow the identification of HIC with a low risk of progression who may not need treatment. Keywords: HIV reservoir; HIV controllers; total HIV-DNA; dynamics; long-term follow-up, 1 | INTRODUCTION Human immunodeficiency virus type 1 (HIV-1) controllers (HIC) are a rare group of individuals living with HIV who maintain HIV viraemia at extremely low or even undetectable [...]

Published
2019
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19. HIV therapeutic vaccine enhances non-exhausted CD4+ T cells in a randomised phase 2 trial

Author

Vieillard, Vincent, Combadière, Béhazine, Tubiana, Roland, Launay, Odile, Pialoux, Gilles, Cotte, Laurent, Girard, Pierre-Marie, Simon, Anne, Dudoit, Yasmine, Reynes, Jacques, Rockstroh, Jürgen, Garcia, Felipe, Gatell, Jose, Devidas, Alain, Yazdanpanah, Yazdan, Weiss, Laurence, Fätkenheuer, Gerd, Autran, Brigitte, Joyeux, Delphine, Gharakhanian, Shahin, Debré, Patrice, and Katlama, Christine

Published
2019
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25. Low to undetectable Omicron BQ.1.1 neutralization by patient's sera a month after initiation of AZD7442 600 mg.

Author

Touret, Franck, Martin-Blondel, Guillaume, de Lamballerie, Xavier, Dupont, Axelle, Izopet, Jacques, Mentré, France, Kamar, Nassim, Autran, Brigitte, Paintaud, Gilles, Caillard, Sophie, Richez, Christophe, Couzi, Lionel, Xhaard, Aliénor, Marjanovic, Zora, Avouac, Jerome, Jacquet, Caroline, Anglicheau, Dany, Cheminant, Morgane, Yazdanpanah, Yazdan, and N'Guyen, Stéphanie

Published
2023
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27. A Therapeutic Dendritic Cell-Based Vaccine for HIV-1 Infection

Author

García, Felipe, Climent, Núria, Assoumou, Lambert, Gil, Cristina, González, Nuria, Alcamí, José, León, Agathe, Romeu, Joan, Dalmau, Judith, Martínez-Picado, Javier, Lifson, Jeff, Autran, Brigitte, Costagliola, Dominique, Clotet, Bonaventura, Gatell, Josep M, Plana, Montserrat, and Gallart, Teresa

Published
2011
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28. A Step Ahead on the HIV Collaboratory

Author

Murphy, Robert L., Katlama, Christine, Debre, Patrice, Clotet, Bonaventura, Costagliola, Dominique, Dorrell, Lucy, Gatell, Jose, Klein, Michel, McMichael, Andrew J., Schacker, Timothy W., Walker, Bruce D., Autran, Brigitte, Brucker, Gilles, Calvez, Vincent, Clumeck, Nathan, Deeks, Steven G., Haase, Ashley, Lazzarin, Adriano, Papagno, Laura, Wain-Hobson, Simon, and Youle, Michael

Published
2009

30. HIV disease progression despite suppression of viral replication is associated with exhaustion of lymphopoiesis

Author

Sauce, Delphine, Larsen, Martin, Fastenackels, Solène, Pauchard, Michèle, Ait-Mohand, Hocine, Schneider, Luminita, Guihot, Amélie, Boufassa, Faroudy, Zaunders, John, Iguertsira, Malika, Bailey, Michelle, Gorochov, Guy, Duvivier, Claudine, Carcelain, Guislaine, Kelleher, Anthony D., Simon, Anne, Meyer, Laurence, Costagliola, Dominique, Deeks, Steven G., Lambotte, Olivier, Autran, Brigitte, Hunt, Peter W., Katlama, Christine, and Appay, Victor

Published
2011
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34. Characterization of pandemic influenza immune memory signature after vaccination or infection

Author

Bonduelle, Olivia, Carrat, Fabrice, Luyt, Charles-Edouard, Leport, Catherine, Mosnier, Anne, Benhabiles, Nora, Krivine, Anne, Rozenberg, Flore, Yahia, Nora, Samri, Assia, Rousset, Dominique, van der Werf, Sylvie, Autran, Brigitte, and Combadiere, Behazine

Subjects
Vaccination -- Physiological aspects, Physiological research, Immune response -- Research, Influenza -- Identification and classification, Health care industry
Abstract

The magnitude, quality, and maintenance of immunological memory after infection or vaccination must be considered for future design of effective influenza vaccines. In 2009, the influenza pandemic produced disease that ranged from mild to severe, even fatal, illness in infected healthy adults and led to vaccination of a portion of the population with the adjuvanted, inactivated influenza A(H1N1)pdm09 vaccine. Here, we have proposed a multiparameter quantitative and qualitative approach to comparing adaptive immune memory to influenza 1 year after mild or severe infection or vaccination. One year after antigen encounter, severely ill subjects maintained high levels of humoral and polyfunctional effector/memory [CD4.sup.+] T cells responses, while mildly ill and vaccinated subjects retained strong cellular immunity, as indicated by high levels of mucosal homing and degranulation markers on IFN-[γ.sup.+] antigen-specific T cells. A principal component analysis distinguished 3 distinct clusters of individuals. The first group comprised vaccinated and mildly ill subjects, while clusters 2 and 3 included mainly infected individuals. Each cluster had immune memory profiles that differed in magnitude and quality. These data provide evidence that there are substantial similarities between the antiinfluenza response that mildly ill and vaccinated individuals develop and that this immune memory signature is different from that seen in severely ill individuals., Introduction Influenza A infection is still a major infectious disease that has appreciable morbidity and mortality during the annual seasonal epidemic as during the 2009 pandemic (1). Genetic mutations are [...]

Published
2014
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35. Impact of Therapeutic Immunization on HIV-1 Viremia after Discontinuation of Antiretroviral Therapy Initiated during Acute Infection

Author

QUEST Study Group, Kinloch-de Loes Loes, Sabine, Hoen, Bruno, Smith, Don E., Autran, Brigitte, Lampe, Fiona C., Phillips, Andrew N., Goh, Li-Ean, Andersson, Jan, Tsoukas, Christos, Sonnerborg, Anders, Tambussi, Giuseppe, Girard, Pierre-Marie, Bloch, Mark, Battegay, Manuel, Carter, Nick, El Habib, Raphaelle, Theofan, Georgia, Cooper, David A., and Perrin, Luc

Published
2005

37. Immunity, inflammation and reservoir in patients at an early stage of HIV infection on intermittent ART (ANRS 141 TIPI Trial)

Author

Piroth, Lionel, Moinot, Laetitia, Yeni, Patrick, Avettand-Fénoel, Véronique, Reynes, Jacques, Girard, Pierre-Marie, Marchou, Bruno, Georget, Aurore, Rouzioux, Christine, Autran, Brigitte, Duvillard, Laurence, Chêne, Geneviève, Fagard, Catherine, Anglaret, Xavier, Boué, François, Commoy, Marie-Josèphe, Couffin-Cadiergues, Sandrine, Diallo, Alpha, Piketty, Christophe, Préau, Marie, Taburet, Anne-Marie, Buseyne, Florence, Costagliola, Dominique, Delaugerre, Constance, Hoen, Bruno, Lortholary, Olivier, Pilorgé, Fabrice, Arvieux, Cédric, Jacomet, Christine, Sgro, Catherine, Loïodice, Laurence, Ait-Ouferoukh, Sofiane, Assuied, Alex, Colin, Céline, Couturier, Françoise, Rouch, Elodie, Soutthiphong, Anne-Aygline, and Taïeb, Audrey

Published
2016
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38. Low serum neutralization of Omicron variants a month after AZD7442 prophylaxis initiation.

Author

de Lamballerie, Xavier, Martin-Blondel, Guillaume, Dupont, Axelle, Izopet, Jacques, Mentré, France, Kamar, Nassim, Autran, Brigitte, Paintaud, Gilles, Caillard, Sophie, le Bourgeois, Amandine, Richez, Christophe, Couzi, Lionel, Xhaard, Aliénor, Marjanovic, Zora, Avouac, Jerome, Jacquet, Caroline, Anglicheau, Denis, Cheminant, Morgane, Yazdanpanah, Yazdan, and Guyen, Stéphanie N

Published
2023
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39. Towards an HBV cure: state-of-the-art and unresolved questions—report of the ANRS workshop on HBV cure

Author

Zeisel, Mirjam B, Lucifora, Julie, Mason, William S, Sureau, Camille, Beck, Jürgen, Levrero, Massimo, Kann, Michael, Knolle, Percy A, Benkirane, Monsef, Durantel, David, Michel, Marie-Louise, Autran, Brigitte, Cosset, François-Loïc, Strick-Marchand, Hélène, Trépo, Christian, Kao, Jia-Horng, Carrat, Fabrice, Lacombe, Karine, Schinazi, Raymond F, Barré-Sinoussi, Françoise, Delfraissy, Jean-François, and Zoulim, Fabien

Published
2015
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40. Combined ART started during acute HIV infection protects central memory CD4+ T cells and can induce remission

Author

Chéret, Antoine, Bacchus-Souffan, Charline, Avettand-Fenoël, Veronique, Mélard, Adeline, Nembot, Georges, Blanc, Catherine, Samri, Assia, Sáez-Cirión, Asier, Hocqueloux, Laurent, Lascoux-Combe, Caroline, Allavena, Clotilde, Goujard, Cécile, Valantin, Marc Antoine, Leplatois, Anne, Meyer, Laurence, Rouzioux, Christine, Autran, Brigitte, Hoen, B., Bourdeaux, C., Delfraissy, J. F., Goujard, C., Amri, I., Fourn, E., Quertainmont, Y., Môle, M., Rami, A., Durel, A., Diemer, M., Parrinello, M., Allègre, T., Lafeuillade, A., Hittinger, G., Lambry, V., Carrerre, M., Philip, G., Duvivier, C., Consigny, P. H., Charlier, C., Shoai, M., Touam, F., Pialoux, G., Slama, L., LʼYavanc, T., Mathurin, P., Adda, A., Berrebi, V., Salmon, D., Chakvetadze, E., Tassadit, T., Ousseima, E., Pietri, M. P., Levy, Y., Lascaux, A. S., Lelievre, J. D., Giovanna, M., Dominguez, S., Dumont, C., Katlama, C., Valentin, M. A., Seang, S., Schneider, L., Kiorza, N., Chermak, A., Ben Abdallah, S., Simon, A., Pichon, F., Pauchard, M., Molina, J. M., Lascoux, C., Ponscarme, D., Colin De Verdiere, N., Scemla, A., De Castro, N., Rachline, A., Garrait, V., Rozenbaum, W., Ferret, S., Balkan, S., Clavel, F., Tourdjman, M., Lafaurie, M., Aslan, A., Goguel, J., Thierry, S. M., De Lastours, V., Gallien, S., Pavie, J., Delgado, J., Mededji, C., Veron, R., Abel, S., Pierre-François, S., Baringhton, C., Chennebault, J. M., Vandamme, Y. M., Fialaire, P., Rehaiem, S., Rabier, V., Abgueguen, P., Morlat, P., Vandenhende, M. A., Bernard, N., Lacoste, D., Michaux, C., Paccalin, F., Receveur, M. C., Caldato, S., Delaune, J., Ragnaud, J. M., Neau, D., Lacaze-Buzy, L., Livrozet, J. M., Jeanblanc, F., Makhloufi, D., Brunel Dalmas, F., Jourdain, J. J., Chiarello, P., Yeni, P., Phung, B., Rioux, C., Godard, C., Louni, F., El Alami Talbi, N., Catalano, G., Guiroy, F., Reynes, J., Jacquet, J. M., Fauchere, V., Merle, C., Lemoine, V., Loriette, M., Morquin, D., Makinson, A., Atoui, N., Tramoni, C., Raffi, F., Allavena, C., Bonnet, B., Bouchez, S., Feuillebois, N., Brunet-François, C., Reliquet, V., Mounoury, O., Morineau-Le-Houssine, P., Billaud, E., Brosseau, D., Hüe, H., Dellamonica, P., Vassallo, M., Leplatois, A., Durant, J., Naqvi, A., Joulié, A., Souala, F., Michelet, C., Arvieux, C., Tattevin, P., Leroy, H., Revest, M., Fily, F., Chapplain, J. M., Ratajczak, C. M., Gras, G., Bernard, L., Dailloux, J. F., Laplantine, V., Cuzin, L., Marchou, B., Larrigue, S., Chauveau, M., Balsarin, F., Obadia, M., Chéret, A., Bonne, S., Huleux, T., Ajana, F., Alcaraz, I., Baclet, V., Melliez, H., Viget, N., De La Tribonniere, X., Aissi, E., Poissy, J., Ravaux, I., Vallon, A., Varan, M., May, T., Letranchant, L., Burty, C., Briaud, A., Wassoumbou, S., Stenzel, M., Bouillon, M. P., Debab, Y., Caron, F., Gueit, I., Chapuzet, C., Borsa Lebas, F., Etienne, M., Miailhes, P., Perpoint, T., Senechal, A., Schlienger, I., Cotte, L., Augustin Normand, C., Boibieux, A., Ferry, T., Corsini, N., Braun, E., Lippran, J., Biron, F., Chidiac, C., Pailhes, S., Lipman, J., Braun, E., Koffi, J., Thoirain, V., Brochier, C., Greder Belan, A., Therby, A., Monnier, S., Ruquet, M., Garrait, V., Richier, L., Prevoteau Du Clary, F., Philibert, P., Chapus, C., Cabié, A., and Abel, S.

Published
2015
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45. Control of vaccinia virus skin lesions by long-term-maintained [IFN-γ.sup.+][TNF-α.sup.+] effector/memory [CD4.sup.+] lymphocytes in humans

Author

Puissant-Lubrano, Benedicte, Bossi, Philippe, Gay, Frederick, Crance, Jean-Marc, Bonduelle, Olivia, Garin, Daniel, Bricaire, Francois, Autran, Brigitte, and Combadiere, Behazine

Subjects
Vaccination -- Complications and side effects, Cutaneous manifestations of general diseases -- Development and progression -- Care and treatment -- Complications and side effects, Lymphocytes -- Properties, Vaccinia -- Development and progression -- Care and treatment -- Complications and side effects, Health care industry
Abstract

Vaccinia virus (VV) vaccination is used to immunize against smallpox and historically was considered to have been successful if a skin lesion formed at the vaccination site. While antibody responses have been widely proposed as a correlate of efficacy and protection in humans, the role of cellular and humoral immunity in VV-associated skin lesion formation was unknown. We therefore investigated whether long-term residual humoral and cellular immune memory to VV, persisting 30 years after vaccination, could control VV-induced skin lesion in revaccinated individuals. Here, we have shown that residual VV-specific [IFN-γ.sup.+][TNF-α.sup.+] or [IFN-γ.sup.+][IL-2.sup.+] [CD4.sup.+] lymphocytes but not [CD8.sup.+] effector/memory lymphocytes expressing a skin-homing marker are inversely associated with the size of the skin lesion formed in response to revaccination. Indeed, high numbers of residual effector T cells were associated with lower VV skin lesion size after revaccination. In contrast, long-term residual VV-specific neutralizing antibody (NAbs) titers did not affect skin lesion formation. However, the size of the skin lesion strongly correlated with high levels of NAbs boosted after revaccination. These findings demonstrate a potential role for VV-specific [CD4.sup.+] responses at the site of VV-associated skin lesion, thereby providing new insight into immune responses at these sites and potentially contributing to the development of new approaches to measure the efficacy of VV vaccination., Introduction The persistence of a long-lasting immune memory against vaccinia and smallpox viruses has been a subject of considerable debate, and its efficacy in protection remains unclear in the absence [...]

Published
2010
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46. Low Titers of Serum Antibodies Inhibiting Hemagglutination Predict Fatal Fulminant Influenza A(H1N1) 2009 Infection

Author

Guihot, Amélie, Luyt, Charles-Edouard, Parrot, Antoine, Rousset, Dominique, Cavaillon, Jean-Marc, Boutolleau, David, Fitting, Catherine, Pajanirassa, Priya, Mallet, Alain, Fartoukh, Muriel, Agut, Henri, Musset, Lucile, Zoorob, Rima, Kirilovksy, Amos, Combadière, Béhazine, van der Werf, Sylvie, Autran, Brigitte, and Carcelain, Guislaine

Published
2014
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