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7. Outcomes in children of women with type 2 diabetes exposed to metformin versus placebo during pregnancy (MiTy Kids): a 24-month follow-up of the MiTy randomised controlled trial

Author

Feig, DS, Galper, A, Cleave, B, Strom, M, Poolman, K, Fong, D, Viguiliouk, E, Legault, L, Boutin, L, Ho, J, Virtanen, H, Zahedi, A, Szwiega, K, Coolen, J, Dias, R, Sellers, E, Fletcher, B, Bourrier, L, Haqq, A, Rylance, H, Hadjiyannakis, S, Courtney, J, McManus, R, Halperin, I, Miller, D, Coles, K, Simmons, D, Nema, J, Weisnagel, SJ, Dubé, MC, Chanoine, JP, Kwan, J, McIntyre, HD, Laurie, J, Maguire, F, Soper, J, Bridger, T, Houlden, R, Breen, A, McLean, M, Duke, A, Hendon, S, Sigmund, A, Feig, Denice S, Sanchez, J Johanna, Murphy, Kellie E, Asztalos, Elizabeth, Zinman, Bernard, Simmons, David, Haqq, Andrea M, Fantus, I George, Lipscombe, Lorraine, Armson, Anthony, Barrett, Jon, Donovan, Lois, Karanicolas, Paul, Tobin, Siobhan, Mangoff, Kathryn, Klein, Gail, Jiang, Yidi, Tomlinson, George, and Hamilton, Jill

Published
2023
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12. Metformin in women with type 2 diabetes in pregnancy (MiTy): a multicentre, international, randomised, placebo-controlled trial

Author

Feig, Denice, Donat, Diane, Gandhi, Shital, Cleave, Barbara, Zhou, Vivian, Viguiliouk, Effie, Fong, Debbie, Strom, Michele, Deans, Melissa, Kamath, Aarthi, Godbout, Ariane, Weber, Florence, Mahone, Michele, Wo, Bi Lan, Bedard, Marie-Josee, Robinson, Melanie, Daigle, Sylvie, Leblanc, Sophie, Ludwig, Sora, Pockett, Sherri, Slater, Laurie, Donovan, Lois, Oldford, Carolyn, Young, Catherine, Virtanen, Heidi, Lodha, Abhay, Cooper, Stephanie, Yamamoto, Jennifer, Gougeon, Claire, Verhesen, Cheryl, Zahedi, Afshan, Taha, Nashwah, Turner, Marci, Neculau, Madalena, Robb, Cathy, Szwiega, Krystyna, Lee, Grace, Rey, Evelyne, Perreault, Sophie, Coolen, Jillian, Armson, Anthony B, Ransom, Thomas, Dias, Raquel, Slaunwhite, Janet, Baxendale, Darlene, Fanning, Cora, Halperin, Ilana, Gale, Veronica, Kader, Tina, Hirsimaki, Heidi, Long, Hélène, Lambert, Julie, Castonguay, Annie, Chalifoux, Steve, McManus, Ruth, Watson, Margaret, Powell, Anne-Marie, Sultana, Munira, ArthurHayward, Vinolia, Marin, Mauricio, Cauchi, Lorraine, MacBean, Leila, Keely, Erin, Malcolm, Janine, Clark, Heather, Karovitch, Allan, Belanger, Heather, Champagne, Josee, Schutt, Kayla, Sloan, Jennifer, Mitchell, Joyce, Favreau, Colette, O'Shea, Elaine, McGuire, Debbie, Peng, Melin, St Omer, Dynika, Lee, Julie, Klinke, Jennifer, Young, Sharon, Barts, Agnieszka, Carr, Francina, Subrt, Peter, Miller, David, Coles, Karen, Capes, Sarah, Smushkin, Galina, Phillips, Richard, Fergusson, Carol, Lacerte, Stacey, Houlden, Robyn, Breen, Adriana, Stone-Hope, Bonnie, Ryan, Edmond A, Kwong, Sarah, Rylance, Heather, Khurana, Rshmi, McNab, Tammy, Beauchamp, Shirley, Weisnagel, S John, D'Amours, Martin, Allen, Christyne, Dubé, Marie-Christine, Julien, Valérie-Ève, Lambert, Camille, Bourbonniere, Marie-Claude, Rheaume, Louise, Bouchard, Myriam, Carson, George, Williams, Suzanne, Wolfs, Maria, Berger, Howard, Cheng, Alice, Ray, Joel, Hanna, Amir, De Souza, Leanne, Berndl, Leslie, Meltzer, Sara, Garfield, Natasha, El-Messidi, Amira, Bastien, Louise, Segal, Shari, Thompson, David, Lim, Ken, Kong, Jason, Thompson, Sharon, Orr, Christine, Galway, Brenda, Parsons, Minnie, Rideout, Krista, Rowe, Bernadette, Crane, Joan, Andrews, Wayne, Joyce, Carol, Newstead-Angel, Jill, Brandt, Judy, Meier, Simona, Laurie, Josephine, McIntyre, David, Liley, Helen, Fox, Jane, Barrett, Helen, Maguire, Frances, Nerdal-Bussell, Marnie, Nie, Wenjun, Bergan, Carolyn, Cavallaro, Bekki, Tremellen, Anne, Cook, Anne, Simmons, David, Rajagopal, Rohit, Vizza, Lisa, Mattick, Maureen, Bishop, Claudia, Nema, Jodie, Kludas, Renee, McLean, Mark, Hendon, Susan, Sigmund, Allison, Wong, Vincent, Lata, Prem, Russell, Hamish, Singh, Razita, Zinman, Bernard, Asztalos, Elizabeth, Fantus, George I, Lipscombe, Lorraine L, Barrett, Jon, Tomlinson, George, Murphy, Kellie, McMurray, Keitha, Karanicolas, Paul, Murphy, Helen, Sanchez, Johanna, Klein, Gail, Tian, Simon, Tobin, Siobhan, Mangoff, Kathryn, Feig, Denice S, Donovan, Lois E, Sanchez, J Johanna, Fantus, I George, Hutton, Eileen, Barrett, Jon F R, Karanicolas, Paul J, McIntyre, H David, Tian, Simon Yu, and Murphy, Kellie E

Published
2020
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19. Prediction of Late Death or Disability at Age 5 Years Using a Count of 3 Neonatal Morbidities in Very Low Birth Weight Infants

Author

Schmidt, Barbara, D'Ilario, Judy, Cairnie, Janice, Dix, Joanne, Adams, Beth Anne, Warriner, Erin, Marie Kim, Mee-Hai, Anderson, Peter, Davis, Peter, Doyle, Lex, Argus, Brenda, Callanan, Catherine, Davis, Noni, Duff, Julianne, McDonald, Marion, Asztalos, Elizabeth, Hohn, Denise, Lacy, Maralyn, Haslam, Ross, Barnett, Christopher, Goodchild, Louise, Lontis, Rosslyn Marie, Fraser, Simon, Keng, Julie, Saunders, Kerryn, Opie, Gillian, Kelly, Elaine, Woods, Heather, Marchant, Emma, Turner, Anne-Marie, Magrath, Emma, Williamson, Amanda, Bairam, Aida, Bélanger, Sylvie, Fraser, Annie, Blayney, Marc, Lemyre, Brigitte, Frank, Jane, Solimano, Alfonso, Synnes, Anne, Grunau, Ruth E., Hubber-Richard, Philippa, Rogers, Marilyn, Mackay, Margot, Petrie-Thomas, Julianne, Butt, Arsalan, van Wassenaer, Aleid, Nuytemans, Debbie, Houtzager, Bregje, van Sonderen, Loekie, Regev, Rivka, Itzchack, Netter, Arnon, Shmuel, Chalaf, Adiba, Ohlsson, Arne, O'Brien, Karel, Hamilton, Anne-Marie, Chan, May Lee, Sankaran, Koravangattu, Proctor, Pat, Golan, Agneta, Goldsch-Lerman, Esther, Reynolds, Graham, Dromgool, Barbara, Meskell, Sandra, Parr, Vanessa, Maher, Catherine, Broom, Margaret, Kecskes, Zsuzsoka, Ringland, Cathy, McMillan, Douglas, Spellen, Elizabeth, Sauve, Reginald S., Christianson, Heather, Anseeuw-Deeks, Deborah, Creighton, Dianne, Heath, Jennifer, Alvaro, Ruben, Chiu, Aaron, Porter, Ceceile, Turner, Gloria, Moddemann, Diane, Granke, Naomi, Penner, Karen, Bow, Jane, Mulder, Antonius, Wassenberg, Renske, van der Hoeven, Markus, Clarke, Maxine, Parfitt, Judy, Parker, Kevin, Nwaesei, Chukwuma, Ryan, Heather, Saunders, Cory, Schulze, Andreas, Wermuth, Inga, Hilgendorff, Anne, Flemmer, Andreas W., Herlenius, Eric, Legnevall, Lena, Lagercrantz, Hugo, Matthew, Derek, Amos, Wendy, Tulsiani, Suresh, Tan-Dy, Cherrie, Turner, Marilyn, Phelan, Constance, Shinwell, Eric S., Levine, Michael, Juster-Reicher, Ada, Khairy, May, Grier, Patricia, Vachon, Julie, Perepolkin, Larissa, Barrington, Keith J., Sinha, Sunil Kumar, Tin, Win, Fritz, Susan, Walti, Herve, Royer, Diane, Halliday, Henry, Millar, David, Mayes, Clifford, McCusker, Christopher, McLaughlin, Olivia, Fahnenstich, Hubert, Tillmann, Bettina, Weber, Peter, Wariyar, Unni, Embleton, Nicholas, Swamy, Ravi, Bucher, Hans U., Fauchere, Jean-Claude, Dietz, Vera, Harikumar, Chidambara, Anderson, Peter J., Asztalos, Elizabeth V., Davis, Peter G., Dewey, Deborah, Doyle, Lex W., Roberts, Robin S., Gent, Michael, Fraser, William, Hey, Edmund, Perlman, Max, Thorpe, Kevin, Gray, Shari, Chambers, Carole, Costantini, Lorrie, Yacura, Wendy, McGean, Erin, and Scapinello, Lori

Published
2015
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20. Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

Author

Schmidt, Barbara, D'Ilario, Judy, Cairnie, Janice, Dix, Joanne, Anne Adams, Beth, Warriner, Erin, Kim, Mee-Hai Marie, Anderson, Peter, Davis, Peter, Doyle, Lex, Argus, Brenda, Callanan, Catherine, Davis, Noni, Duff, Julianne, McDonald, Marion, Asztalos, Elizabeth, Hohn, Denise, Lacy, Maralyn, Haslam, Ross, Barnett, Christopher, Goodchild, Louise, Lontis, Rosslyn Marie, Fraser, Simon, Keng, Julie, Saunders, Kerryn, Opie, Gillian, Kelly, Elaine, Woods, Heather, Marchant, Emma, Turner, Anne-Marie, Magrath, Emma, Williamson, Amanda, Bairam, Aida, Bélanger, Sylvie, Fraser, Annie, Blayney, Marc, Lemyre, Brigitte, Frank, Jane, Solimano, Alfonso, Synnes, Anne, Grunau, Ruth E., Hubber-Richard, Philippa, Rogers, Marilyn, Mackay, Margot, Petrie-Thomas, Julianne, Butt, Arsalan, van Wassenaer, Aleid, Nuytemans, Debbie, Houtzager, Bregje, van Sonderen, Loekie, Regev, Rivka, Itzchack, Netter, Arnon, Shmuel, Chalaf, Adiba, Ohlsson, Arne, O'Brien, Karel, Hamilton, Anne-Marie, Chan, May Lee, Sankaran, Koravangattu, Proctor, Pat, Golan, Agneta, Goldsch-Lerman, Esther, Reynolds, Graham, Dromgool, Barbara, Meskell, Sandra, Parr, Vanessa, Maher, Catherine, Broom, Margaret, Kecskes, Zsuzsoka, Ringland, Cathy, McMillan, Douglas, Spellen, Elizabeth, Sauve, Reginald S., Christianson, Heather, Anseeuw-Deeks, Deborah, Creighton, Dianne, Heath, Jennifer, Alvaro, Ruben, Chiu, Aaron, Porter, Ceceile, Turner, Gloria, Moddemann, Diane, Granke, Naomi, Penner, Karen, Bow, Jane, Mulder, Antonius, Wassenberg, Renske, van der Hoeven, Markus, Clarke, Maxine, Parfitt, Judy, Parker, Kevin, Nwaesei, Chukwuma, Ryan, Heather, Saunders, Cory, Schulze, Andreas, Wermuth, Inga, Hilgendorff, Anne, Flemmer, Andreas W., Herlenius, Eric, Legnevall, Lena, Lagercrantz, Hugo, Matthew, Derek, Amos, Wendy, Tulsiani, Suresh, Tan-Dy, Cherrie, Turner, Marilyn, Phelan, Constance, Shinwell, Eric S., Levine, Michael, Juster-Reicher, Ada, Khairy, May, Grier, Patricia, Vachon, Julie, Perepolkin, Larissa, Barrington, Keith J., Sinha, Sunil Kumar, Tin, Win, Fritz, Susan, Walti, Herve, Royer, Diane, Halliday, Henry, Millar, David, Mayes, Clifford, McCusker, Christopher, McLaughlin, Olivia, Fahnenstich, Hubert, Tillmann, Bettina, Weber, Peter, Wariyar, Unni, Embleton, Nicholas, Swamy, Ravi, Bucher, Hans U., Fauchere, Jean-Claude., Dietz, Vera, Harikumar, Chidambara, Anderson, Peter J., Asztalos, Elizabeth V., Davis, Peter G., Dewey, Deborah, Doyle, Lex W., Roberts, Robin S., Gent, Michael, Fraser, William, Hey, Edmund, Perlman, Max, Thorpe, Kevin, Gray, Shari, Chambers, Carole, Costantini, Lorrie, Yacura, Wendy, McGean, Erin, Scapinello, Lori, Manley, Brett J., Böhm, Birgitta, and van Wassenaer-Leemhuis, Aleid G.

Published
2015
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21. Early-Onset Invasive Candidiasis in Extremely Low Birth Weight Infants: Perinatal Acquisition Predicts Poor Outcome

Author

Paediatric Investigators Collaborative Network on Infections in Canada (PICNIC), Barton, Michelle, Shen, Alex, O'Brien, Karel, Robinson, Joan L., Davies, H. Dele, Simpson, Kim, Asztalos, Elizabeth, Langley, Joanne, Le Saux, Nicole, Sauve, Reginald, Synnes, Anne, Tan, Ben, de Repentigny, Louis, Rubin, Earl, Hui, Chuck, Kovacs, Lajos, Yau, Yvonne C. W., and Richardson, Susan E.

Published
2017

22. Continuous glucose monitoring in pregnant women with type 1 diabetes (CONCEPTT): a multicentre international randomised controlled trial

Author

Grisoni, Jeannie, Byrne, Carolyn, Davenport, Katy, Neoh, Sandra, Gougeon, Claire, Oldford, Carolyn, Young, Catherine, Green, Louisa, Rossi, Benedetta, Rogers, Helen, Cleave, Barbara, Strom, Michelle, Adelantado, Juan María, Isabel Chico, Ana, Tundidor, Diana, Malcolm, Janine, Henry, Kathy, Morris, Damian, Rayman, Gerry, Fowler, Duncan, Mitchell, Susan, Rosier, Josephine, Temple, Rosemary, Turner, Jeremy, Canciani, Gioia, Hewapathirana, Niranjala, Piper, Leanne, Kudirka, Anne, Watson, Margaret, Bonomo, Matteo, Pintaudi, Basilio, Bertuzzi, Federico, Daniela, Giuseppina, Mion, Elena, Lowe, Julia, Halperin, Ilana, Rogowsky, Anna, Adib, Sapida, Lindsay, Robert, Carty, David, Crawford, Isobel, Mackenzie, Fiona, McSorley, Therese, Booth, John, McInnes, Natalia, Smith, Ada, Stanton, Irene, Tazzeo, Tracy, Weisnagel, John, Mansell, Peter, Jones, Nia, Babington, Gayna, Spick, Dawn, MacDougall, Malcolm, Chilton, Sharon, Cutts, Terri, Perkins, Michelle, Scott, Eleanor, Endersby, Del, Dover, Anna, Dougherty, Frances, Johnston, Susan, Heller, Simon, Novodorsky, Peter, Hudson, Sue, Nisbet, Chloe, Ransom, Thomas, Coolen, Jill, Baxendale, Darlene, Holt, Richard, Forbes, Jane, Martin, Nicki, Walbridge, Fiona, Dunne, Fidelma, Conway, Sharon, Egan, Aoife, Kirwin, Collette, Maresh, Michael, Kearney, Gretta, Morris, Juliet, Quinn, Susan, Bilous, Rudy, Mukhtar, Rasha, Godbout, Ariane, Daigle, Sylvie, Lubina, Alexandra, Jackson, Margaret, Paul, Emma, Taylor, Julie, Houlden, Robyn, Breen, Adriana, Banerjee, Anita, Brackenridge, Anna, Briley, Annette, Reid, Anna, Singh, Claire, Newstead-Angel, Jill, Baxter, Janet, Philip, Sam, Chlost, Martyna, Murray, Lynne, Castorino, Kristin, Frase, Donna, Lou, Olivia, Pragnell, Marlon, Feig, Denice S, Donovan, Lois E, Corcoy, Rosa, Murphy, Kellie E, Amiel, Stephanie A, Hunt, Katharine F, Asztalos, Elizabeth, Barrett, Jon F R, Sanchez, J Johanna, de Leiva, Alberto, Hod, Moshe, Jovanovic, Lois, Keely, Erin, McManus, Ruth, Hutton, Eileen K, Meek, Claire L, Stewart, Zoe A, Wysocki, Tim, O'Brien, Robert, Ruedy, Katrina, Kollman, Craig, Tomlinson, George, and Murphy, Helen R

Published
2017
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23. Growth and Neurodevelopmental Outcomes of Preterm Infants Born < 26 Weeks Gestation before and after Implementation of a Nutrition-Care Bundle.

Author

Res, Giulia, Bishara, Rosine F., Church, Paige Terrien, Rosenthal, Rena, Bishara, Rita Maria, Dupuis, Annie, Asztalos, Elizabeth, and Banihani, Rudaina

Subjects
NEURAL development, PREMATURE infant diseases, NEONATAL intensive care units, NEONATAL intensive care, HUMAN growth, RETROSPECTIVE studies, DESCRIPTIVE statistics, DEVELOPMENTAL disabilities, ENTERAL feeding, DATA analysis software
Abstract

Background: This study aimed to assess the impact of a nutrition-care bundle on growth and neurodevelopmental outcomes of micro-preterm infants born in a level III neonatal intensive care unit (NICU) by two years corrected age. Methods: A nutrition-care bundle emphasizing the prompt initiation of parenteral nutrition at birth, initiation of enteral feeds within 6 h after birth, and early addition of human milk fortifiers was implemented in 2015 for infants born < 26 weeks gestation. This before-and-after study evaluated growth and neurodevelopmental outcomes in infants born between 2012–2013 (before-nutrition-bundle, BNB) and 2016–2017 (after-nutrition-bundle, ANB). Results: A total of 145 infants were included in the study. Infants in the ANB group (n = 73) were smaller (birthweight and gestational age), and there were more male infants and multiples included compared to the BNB group (n = 72). Enteral feeds and fortifiers started earlier in the ANB group. Growth velocity and weight z-score changes were similar in both groups during NICU stay and post-discharge. Systemic steroid use, but not cohort, was linked to lower Bayley scores across all domains. Conclusions: Implementing a nutrition-care bundle was not consistently associated with improved weight gain and neurodevelopmental outcomes in the micro-preterm infant population, possibly due to ongoing high-quality nutritional care by the clinical team. [ABSTRACT FROM AUTHOR]

Published
2024
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24. Long-Term Outcomes of Multiple versus a Single Course of Antenatal Steroids: A Systematic Review.

Author

Ninan, Kiran, Liyanage, Sugee K., Murphy, Kellie E., Asztalos, Elizabeth V., and McDonald, Sarah D.

Subjects
PSYCHOLOGY information storage & retrieval systems, CINAHL database, ADRENOCORTICAL hormones, PREMATURE infants, MEDICAL information storage & retrieval systems, CONFIDENCE intervals, SYSTEMATIC reviews, ANTHROPOMETRY, PSYCHOSES, STEROIDS, FETAL development, PREGNANCY outcomes, NEURAL development, MEDLINE, RESPIRATORY distress syndrome, ODDS ratio
Abstract

Multiple courses versus a single course of antenatal corticosteroids (ACS) have been associated with mild respiratory benefits but also adverse outcomes like smaller head circumference and birth weight. Long-term effects warrant study. We systematically reviewed long-term outcomes (≥1 year) in both preterm and term birth after exposure to preterm multiple courses (including a rescue dose or course) versus a single course. We searched seven databases from January 2000 to October 2021. We included follow-up studies of randomized controlled trials (RCTs) and cohort studies with births occurring in/after the year 2000, given advances in perinatal care. Two reviewers assessed titles/abstracts, articles, quality, and outcomes including psychological disorders, neurodevelopment, and anthropometry. Six follow-up studies of three RCTs and two cohort studies (over 2,860 children total) met inclusion criteria. Among children born preterm, randomization to multiple courses versus a single course of ACS was not associated with adjusted beneficial or adverse neurodevelopmental/psychological or other outcomes, but data are scant after a rescue dose (120 and 139 children, respectively, low certainty) and nonexistent after a rescue course. For children born at term (i.e., 27% of the multiple courses of ACS 5-year follow-up study of 1,728 preterm/term born children), preterm randomization to multiple courses (at least one additional course) versus a single course was significantly associated with elevated odds of neurosensory impairment (adjusted odds ratio = 3.70, 95% confidence interval: 1.57–8.75; 212 and 247 children, respectively, moderate certainty). In this systematic review of long-term outcomes after multiple courses versus a single course of ACS, there were no significant benefits or risks regarding neurodevelopment in children born preterm but little data after one rescue dose and none after a rescue course. However, multiple courses (i.e., at least one additional course) should be considered cautiously: after term birth, there are no long-term benefits but neurosensory harms. Key Points We systematically reviewed the long-term impact of multiple versus a single course of ACS. Long-term follow-up data were scant after a rescue dose and absent after one rescue course of ACS. In children born preterm, multiple courses of ACS were not associated with long-term benefits/harms. In children born at term, multiple courses of ACS were associated with neurosensory impairment. Preterm administration of multiple courses of ACS should be considered cautiously. [ABSTRACT FROM AUTHOR]

Published
2024
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25. Women's views and postpartum follow-up in the CHIPS Trial (Control of Hypertension in Pregnancy Study)

Author

Vidler, Marianne, Magee, Laura A., von Dadelszen, Peter, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E., Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K., Lee, Terry, Logan, Alexander G., Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G., and Moutquin, Jean-Marie

Published
2016
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30. Cohort profile update: The Canadian Maternal-Infant Research on Environmental Chemicals Child Development study (MIREC-CD PLUS).

Author

Fisher, Mandy, Muckle, Gina, Lanphear, Bruce, Arbuckle, Tye E., Braun, Joseph M., Zidek, Angelika, Vélez, Maria P., Lupien, Nicole, Bastien, Stephanie, Ashley-Martin, Jillian, Oulhote, Youssef, Borghese, Michael M., Walker, Mark, Asztalos, Elizabeth, Bouchard, Maryse F., Booij, Linda, Palmert, Mark R., Morrison, Katherine M., Cummings, Elizabeth A., and Khatchadourian, Karine

Subjects
ENVIRONMENTAL research, CHILD development, GROWTH of children, ENVIRONMENTAL exposure, NEUROPSYCHOLOGICAL tests, PRENATAL exposure, PREGNANCY outcomes
Abstract

Background: The pan-Canadian Maternal-Infant Research on Environmental Chemicals (MIREC) study was established to determine whether maternal environmental chemical exposures were associated with adverse pregnancy outcomes in 2001 pregnant women. Objectives: The MIREC-Child Development (CD PLUS) study followed this cohort with the goal of assessing the potential effects of prenatal exposures on anthropometry and neurodevelopment in early childhood. Population: MIREC families with children between the ages of 15 months and 5 years who had agreed to be contacted for future research (n = 1459) were invited to participate in MIREC-CD PLUS which combines data collected from an online Maternal Self-Administered Questionnaire with biomonitoring and neurodevelopment data collected from two in-person visits. Preliminary Results: Between April 2013 and March 2015, 803 children participated in the Biomonitoring visit where we collected anthropometric measures, blood, and urine from the children. The Behavioural Assessment System for Children-2, Behaviour Rating Inventory of Executive Function, MacArthur-Bates Communicative Development Inventories and the Communication subscale of the Adaptive Behaviour Scale from the Bayley Scales of Infant and Toddler Development-III are available on close to 900 children. There were 610 singleton children who completed in-person visits for neurodevelopment assessments including the Social Responsiveness Scale, Wechsler Preschool Primary Scale of Intelligence-III and NEuroPSYchological assessments (NEPSY). Currently, we are following the cohort into early adolescence to measure the impact of early life exposures on endocrine and metabolic function (MIREC-ENDO). Conclusions: Data collection for the MIREC-CD PLUS study is complete and analysis of the data continues. We are now extending the follow-up of the cohort into adolescence to measure the impact of early life exposures on endocrine and metabolic function (MIREC-ENDO). MIREC-CD PLUS is limited by loss to follow-up and the fact that mothers are predominately of higher socioeconomic status and 'White' ethnicity, which limits our generalizability. However, the depth of biomonitoring and clinical measures in MIREC provides a platform to examine associations of prenatal, infancy and childhood exposures with child growth and development. [ABSTRACT FROM AUTHOR]

Published
2023
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39. Predicting severe motor impairment in preterm children at age 5 years

Author

Synnes, Anne, Anderson, Peter J, Grunau, Ruth E, Dewey, Deborah, Moddemann, Diane, Tin, Win, Davis, Peter G, Doyle, Lex W, Foster, Gary, Khairy, May, Nwaesei, Chukwuma, Schmidt, Barbara, DʼIlario, Judy, Cairnie, Janice, Dix, Joanne, Adams, Beth Anne, Warriner, Erin, Kim, Mee-Hai Marie, Argus, Brenda, Callanan, Catherine, Davis, Noni, Duff, Julianne, McDonald, Marion, Asztalos, Elizabeth, Hohn, Denise, Lacy, Maralyn, Haslam, Ross, Barnett, Christopher, Goodchild, Louise, Lontis, Rosslyn Marie, Fraser, Simon, Keng, Julie, Saunders, Kerryn, Opie, Gillian, Kelly, Elaine, Woods, Heather, Marchant, Emma, Turner, Anne-Marie, Magrath, Emma, Williamson, Amanda, Bairam, Aida, Bélanger, Sylvie, Fraser, Annie, Blayney, Marc, Lemyre, Brigitte, Frank, Jane, Solimano, Alfonso, Hubber-Richard, Philippa, Rogers, Marilyn, Mackay, Margot, Petrie-Thomas, Julianne, Butt, Arsalan, van Wassenaer, Aleid, Nuytemans, Debbie, Houtzager, Bregje, van Sonderen, Loekie, Regev, Rivka, Itzchack, Netter, Arnon, Shmuel, Chalaf, Adiba, Ohlsson, Arne, OʼBrien, Karel, Hamilton, Anne-Marie, Chan, May Lee, Sankaran, Koravangattu, Proctor, Pat, Golan, Agneta, Goldsch-Lerman, Esther, Reynolds, Graham, Dromgool, Barbara, Meskell, Andra, Parr, Vanessa, Maher, Catherine, Broom, Margaret, Kecskes, Zsuzsoka, Ringland, Cathy, McMillan, Douglas, Spellen, Elizabeth, Sauve, Reginald S, Christianson, Heather, Anseeuw-Deeks, Deborah, Creighton, Dianne, Heath, Jennifer, Alvaro, Ruben, Chiu, Aaron, Porter, Ceceile, Turner, Gloria, Granke, Naomi, Penner, Karen, Bow, Jane, Mulder, Antonius, Wassenberg, Renske, van der Hoeven, Markus, Clarke, Maxine, Parfitt, Judy, Parker, Kevin, Ryan, Heather, Saunders, Cory, Schulze, Andreas, Wermuth, Inga, Hilgendorff, Anne, Flemmer, Andreas W, Herlenius, Eric, Legnevall, Lena, Lagercrantz, Hugo, Matthew, Derek, Amos, Wendy, Tulsiani, Suresh, Tan-Dy, Cherrie, Turner, Marilyn, Phelan, Constance, Shinwell, Eric S, Levine, Michael, Juster-Reicher, Ada, Grier, Patricia, Vachon, Julie, Perepolkin, Larissa, Barrington, Keith J, Sinha, Sunil Kumar, Fritz, Susan, Walti, Herve, Royer, Diane, Halliday, Henry, Millar, David, Mayes, Clifford, McCusker, Christopher, McLaughlin, Olivia, Fahnenstich, Hubert, Tillmann, Bettina, Weber, Peter, Wariyar, Unni, Embleton, Nicholas, Swamy, Ravi, Bucher, Hans U, Fauchere, Jean-Claude, Dietz, Vera, Harikumar, Chidambara, Anderson, Peter J, Asztalos, Elizabeth V, Barrington, Keith J, Davis, Peter G, Doyle, Lex W, Ohlsson, Arne, Solimano, Alfonso, Gent, Michael, Fraser, William, Hey, Edmund, Thorpe, Kevin, Gray, Shari, Roberts, Robin S, Chambers, Carole, Costantini, Lorrie, Yacura, Wendy, McGean, Erin, and Scapinello, Lori

Published
2015
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40. PROspective Meta‐analysis Of Trials of Initial Oxygen in preterm Newborns (PROMOTION): Protocol for a systematic review and prospective meta‐analysis with individual participant data on initial oxygen concentration for resuscitation of preterm infants

Author

Sotiropoulos, James X., Schmölzer, Georg M., Oei, Ju Lee, Libesman, Sol, Hunter, Kylie E., Williams, Jonathan G., Webster, Angela C., Tarnow‐Mordi, William O., Vento, Maximo, Asztalos, Elizabeth, Shah, Prakesh S., Katheria, Anup, and Seidler, Anna Lene

Subjects
PREMATURE infants, RESEARCH protocols, NEWBORN infants, RESUSCITATION, HOSPITAL admission & discharge
Abstract

Background: Clinicians favour low oxygen concentrations when resuscitating preterm infants immediately after birth despite inconclusive evidence to support this practice. Prospective meta‐analysis (PMA) is a novel approach where studies are identified as eligible for inclusion in the meta‐analysis before their results are known. Aims: To explore whether high (60%) or low (30%) oxygen is associated with greater efficacy and safety for the initial resuscitation (immediately after birth) of preterm infants born at <29 weeks' gestation. Methods: We will conduct a prospective meta‐analysis (PMA) with individual participant data (IPD). We will perform a systematic search to identify ongoing RCTs including infants <29 weeks' gestation randomised to high (60%) or low (30%) oxygen for initial resuscitation after birth. IPD will be sought for all infants randomised for the purpose of meta‐analysis. We will employ a one‐stage random‐effects approach to IPD meta‐analysis. Potential heterogeneity and the differential effect of high or low oxygen will be explored through subgroup and interaction analyses. The primary outcome of this study is all‐cause mortality prior to hospital discharge. There will be a follow‐up analysis of neurodevelopmental outcomes once available. Results/Conclusion: The results of neonatal outcomes at hospital discharge are expected by 2025, and neurodevelopmental outcomes by 2027. [ABSTRACT FROM AUTHOR]

Published
2023
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44. Social Variables Predict Gains in Cognitive Scores across the Preschool Years in Children with Birth Weights 500 to 1250 Grams

Author

Manley, Brett J., Roberts, Robin S., Doyle, Lex W., Schmidt, Barbara, Anderson, Peter J., Barrington, Keith J., Böhm, Birgitta, Golan, Agneta, van Wassenaer-Leemhuis, Aleid G., Davis, Peter G., Schmidt, Barbara, DʼIlario, Judy, Cairnie, Janice, Dix, Joanne, Adams, Beth Anne, Warriner, Erin, Kim, Mee-Hai Marie, Anderson, Peter, Davis, Peter, Doyle, Lex, Argus, Brenda, Callanan, Catherine, Davis, Noni, Duff, Julianne, McDonald, Marion, Asztalos, Elizabeth, Hohn, Denise, Lacy, Maralyn, Haslam, Ross, Barnett, Christopher, Goodchild, Louise, Lontis, Rosslyn Marie, Fraser, Simon, Keng, Julie, Saunders, Kerryn, Opie, Gillian, Kelly, Elaine, Woods, Heather, Marchant, Emma, Turner, Anne-Marie, Magrath, Emma, Williamson, Amanda, Bairam, Aida, Bélanger, Sylvie, Fraser, Annie, Blayney, Marc, Lemyre, Brigitte, Frank, Jane, Solimano, Alfonso, Synnes, Anne, Grunau, Ruth E., Hubber-Richard, Philippa, Rogers, Marilyn, Mackay, Margot, Petrie-Thomas, Julianne, Butt, Arsalan, van Wassenaer, Aleid, Nuytemans, Debbie, Houtzager, Bregje, van Sonderen, Loekie, Regev, Rivka, Itzchack, Netter, Arnon, Shmuel, Chalaf, Adiba, Ohlsson, Arne, OʼBrien, Karel, Hamilton, Anne-Marie, Chan, May Lee, Sankaran, Koravangattu, Proctor, Pat, Goldsch-Lerman, Esther, Reynolds, Graham, Dromgool, Barbara, Meskell, Sandra, Parr, Vanessa, Maher, Catherine, Broom, Margaret, Kecskes, Zsuzsoka, Ringland, Cathy, McMillan, Douglas, Spellen, Elizabeth, Sauve, Reginald S., Christianson, Heather, Anseeuw-Deeks, Deborah, Creighton, Dianne, Heath, Jennifer, Alvaro, Ruben, Chiu, Aaron, Porter, Ceceile, Turner, Gloria, Moddemann, Diane, Granke, Naomi, Penner, Karen, Bow, Jane, Mulder, Antonius, Wassenberg, Renske, van der Hoeven, Markus, Clarke, Maxine, Parfitt, Judy, Parker, Kevin, Nwaesei, Chukwuma, Ryan, Heather, Saunders, Cory, Schulze, Andreas, Wermuth, Inga, Hilgendorff, Anne, Flemmer, Andreas W., Herlenius, Eric, Legnevall, Lena, Lagercrantz, Hugo, Matthew, Derek, Amos, Wendy, Tulsiani, Suresh, Tan-Dy, Cherrie, Turner, Marilyn, Phelan, Constance, Shinwell, Eric S., Levine, Michael, Juster-Reicher, Ada, Khairy, May, Grier, Patricia, Vachon, Julie, Perepolkin, Larissa, Barrington, Keith J., Sinha, Sunil Kumar, Tin, Win, Fritz, Susan, Walti, Herve, Royer, Diane, Halliday, Henry, Millar, David, Mayes, Clifford, McCusker, Christopher, McLaughlin, Olivia, Fahnenstich, Hubert, Tillmann, Bettina, Weber, Peter, Wariyar, Unni, Embleton, Nicholas, Swamy, Ravi, Bucher, Hans U., Fauchere, Jean-Claude., Dietz, Vera, Harikumar, Chidambara, Asztalos, Elizabeth V., Dewey, Deborah, Moddemann, Diane, Gent, Michael, Fraser, William, Hey, Edmund, Perlman, Max, Thorpe, Kevin, Gray, Shari, Chambers, Carole, Costantini, Lorrie, Yacura, Wendy, McGean, Erin, and Scapinello, Lori

Published
2015
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47. Less-tight versus tight control of hypertension in pregnancy

Author

Magee, Laura A, Dadelszen, Peter von, Rey, Evelyne, Ross, Susan, Asztalos, Elizabeth, Murphy, Kellie E, Menzies, Jennifer, Sanchez, Johanna, Singer, Joel, Gafni, Amiram, Gruslin, Andrée, Helewa, Michael, Hutton, Eileen, Lee, Shoo K, Lee, Terry, Logan, Alexander G, Ganzevoort, Wessel, Welch, Ross, Thornton, Jim G, and Moutquin, Jean-Marie

Published
2015

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