22 results on '"Asiimwe, Caroline"'
Search Results
2. Bar Attendance and Alcohol Use Before and After COVID-19 Related Restrictions Among HIV-infected Adults in South-Western Uganda
- Author
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Asiimwe, Caroline, Fatch, Robin, Cheng, Debbie M., Emenyonu, Nneka I., Ngabirano, Christine, Muyindike, Winnie R., and Hahn, Judith A.
- Published
- 2023
- Full Text
- View/download PDF
3. Dead-infant carrying by chimpanzee mothers in the Budongo Forest
- Author
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Soldati, Adrian, Fedurek, Pawel, Crockford, Catherine, Adue, Sam, Akankwasa, John Walter, Asiimwe, Caroline, Asua, Jackson, Atayo, Gideon, Chandia, Boscou, Freymann, Elodie, Fryns, Caroline, Muhumuza, Geresomu, Taylor, Derry, Zuberbühler, Klaus, and Hobaiter, Catherine
- Published
- 2022
- Full Text
- View/download PDF
4. The ecology and epidemiology of malaria parasitism in wild chimpanzee reservoirs
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Scully, Erik J., Liu, Weimin, Li, Yingying, Ndjango, Jean-Bosco N., Peeters, Martine, Kamenya, Shadrack, Pusey, Anne E., Lonsdorf, Elizabeth V., Sanz, Crickette M., Morgan, David B., Piel, Alex K., Stewart, Fiona A., Gonder, Mary K., Simmons, Nicole, Asiimwe, Caroline, Zuberbühler, Klaus, Koops, Kathelijne, Chapman, Colin A., Chancellor, Rebecca, Rundus, Aaron, Huffman, Michael A., Wolfe, Nathan D., Duraisingh, Manoj T., Hahn, Beatrice H., and Wrangham, Richard W.
- Published
- 2022
- Full Text
- View/download PDF
5. Predicting the impacts of land management for sustainable development on depression risk in a Ugandan case study
- Author
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Pienkowski, Thomas, Keane, Aidan, Kinyanda, Eugene, Asiimwe, Caroline, and Milner-Gulland, E. J.
- Published
- 2022
- Full Text
- View/download PDF
6. Maternal cannibalism in two populations of wild chimpanzees
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Fedurek, Pawel, Tkaczynski, Patrick, Asiimwe, Caroline, Hobaiter, Catherine, Samuni, Liran, Lowe, Adriana E., Dijrian, Appolinaire Gnahe, Zuberbühler, Klaus, Wittig, Roman M., and Crockford, Catherine
- Published
- 2020
- Full Text
- View/download PDF
7. Intra-community infanticide in wild, eastern chimpanzees: a 24-year review
- Author
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Lowe, Adriana E., Hobaiter, Catherine, Asiimwe, Caroline, Zuberbühler, Klaus, and Newton-Fisher, Nicholas E.
- Published
- 2020
- Full Text
- View/download PDF
8. Impact of Snare Injuries on Parasite Prevalence in Wild Chimpanzees (Pan troglodytes)
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Yersin, Harmony, Asiimwe, Caroline, Voordouw, Maarten J., and Zuberbühler, Klaus
- Published
- 2017
- Full Text
- View/download PDF
9. Foodborne Pathogens at the Livestock–Wildlife–Human Interface in Rural Western Uganda.
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Dias-Alves, Andrea, Espunyes, Johan, Ayats, Teresa, Sente, Celsus, Sebulime, Peregrine, Muro, Jesus, Tushabe, Josephine, Asiimwe, Caroline, Fernandez Aguilar, Xavier, Aruho, Robert, Marco, Ignasi, Planellas, Marta, Cardells, Jesús, Cabezón, Oscar, and Cerdà-Cuéllar, Marta
- Subjects
FOOD pathogens ,CAMPYLOBACTER jejuni ,SALMONELLA ,CAMPYLOBACTER ,DIAGNOSTIC use of polymerase chain reaction ,INFECTIOUS disease transmission ,LIVESTOCK - Abstract
Foodborne pathogens are an important cause of morbidity and mortality worldwide. To assess the presence of Salmonella, Campylobacter and Arcobacter spp. in livestock, wildlife, and humans from different regions across western Uganda, 479 faecal samples were tested by PCR. Salmonella and Campylobacter spp. were more frequently detected in livestock (5.1% and 23.5%, respectively) compared to wildlife (1.9% and 16.8%, respectively). Wildlife from remote areas showed lower Salmonella and Campylobacter spp. occurrence than in areas where interactions with livestock are common, suggesting that spill-over may exist from livestock or humans. Further studies are needed to better understand the transmission dynamics of these pathogens at the wildlife–livestock–human interface in western Uganda. [ABSTRACT FROM AUTHOR]
- Published
- 2023
- Full Text
- View/download PDF
10. Cars kill chimpanzees: case report of a wild chimpanzee killed on a road at Bulindi, Uganda
- Author
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McLennan, Matthew R. and Asiimwe, Caroline
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- 2016
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- View/download PDF
11. Highly Sensitive Detection of Malaria Parasitemia in a Malaria-Endemic Setting: Performance of a New Loop-Mediated Isothermal Amplification Kit in a Remote Clinic in Uganda
- Author
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Hopkins, Heidi, González, Iveth J., Polley, Spencer D., Angutoko, Patrick, Ategeka, John, Asiimwe, Caroline, Agaba, Bosco, Kyabayinze, Daniel J., Sutherland, Colin J., Perkins, Mark D., and Bell, David
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- 2013
- Full Text
- View/download PDF
12. First observation of a chimpanzee with albinism in the wild: Social interactions and subsequent infanticide.
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Leroux, Maël, Monday, Gideon, Chandia, Bosco, Akankwasa, John W., Zuberbühler, Klaus, Hobaiter, Catherine, Crockford, Catherine, Townsend, Simon W., Asiimwe, Caroline, and Fedurek, Pawel
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CHIMPANZEES ,ALBINISM ,SOCIAL interaction ,INFANTICIDE ,RARE animals ,ULTRAVIOLET radiation - Abstract
Albinism—the congenital absence of pigmentation—is a very rare phenomenon in animals due to the significant costs to fitness of this condition. Both humans and non‐human individuals with albinism face a number of challenges, such as reduced vision, increased exposure to ultraviolet radiation, or compromised crypticity resulting in an elevated vulnerability to predation. However, while observations of social interactions involving individuals with albinism have been observed in wild non‐primate animals, such interactions have not been described in detail in non‐human primates (hereafter, primates). Here, we report, to our knowledge, the first sighting of an infant with albinism in wild chimpanzees (Pan troglodytes schweinfurthii), including social interactions between the infant, its mother, and group members. We also describe the subsequent killing of the infant by conspecifics as well as their behavior towards the corpse following the infanticide. Finally, we discuss our observations in relation to our understanding of chimpanzee behavior or attitudes towards individuals with very conspicuous appearances. Research Highlights: Observations of wild non‐human primates with albinism are extremely rareWe report the first observation of a chimpanzee with albinism in the wildWe describe interactions between the infant with albinism and other group membersWe describe the subsequent infanticide of the individual with albinismWe discuss these observations in light of our understanding of chimpanzee behavior [ABSTRACT FROM AUTHOR]
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- 2022
- Full Text
- View/download PDF
13. The effect of warning signs on the presence of snare traps in a Ugandan rainforest.
- Author
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Fedurek, Pawel, Akankwasa, John W., Danel, Dariusz P., Fensome, Samuel, Zuberbühler, Klaus, Muhanguzi, Geoffrey, Crockford, Catherine, and Asiimwe, Caroline
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CHIMPANZEES ,RAIN forests ,TROPICAL forests ,PSYCHOLOGICAL factors ,WARNINGS - Abstract
Since chimpanzee (Pan troglodytes) conservation often involves local human populations, conservation strategies must consider psychological factors that impact their behavior. In Budongo Forest, Uganda, for example, local communities commonly engage in snare trap (hereafter: snare) setting for wild meat. This illegal activity posits a substantial threat to wild chimpanzees, causing permanent wounds or death for those who are snared. Despite various schemes previously implemented to address snare setting—an activity that is fueled by poverty, the problem and its detrimental impact on chimpanzees persists. Here, we experimentally tested a novel intervention, a systematic display of specially designed warning signs aimed at local poachers. We monitored the presence of snares before and after introducing these signs over a total period of two years and compared it with that of a similar sized control area with no intervention. Results show that snares were less likely to be present during the "sign" period than during the "non‐sign" period in the experimental but not in the control area. We discuss the potential of this cost‐effective intervention for limiting illegal activities that pose a severe threat to chimpanzees and other species inhabiting tropical forests. [ABSTRACT FROM AUTHOR]
- Published
- 2022
- Full Text
- View/download PDF
14. Programme level implementation of malaria rapid diagnostic tests (RDTs) use: outcomes and cost of training health workers at lower level health care facilities in Uganda
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Kyabayinze Daniel J, Asiimwe Caroline, Nakanjako Damalie, Nabakooza Jane, Bajabaite Moses, Strachan Clare, Tibenderana James K, and Van Geetruyden Jean
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Public aspects of medicine ,RA1-1270 - Abstract
Abstract Background The training of health workers in the use of malaria rapid diagnostic tests (RDTs) is an important component of a wider strategy to improve parasite-based malaria diagnosis at lower level health care facilities (LLHFs) where microscopy is not readily available for all patients with suspected malaria. This study describes the process and cost of training to attain competence of lower level health workers to perform malaria RDTs in a public health system setting in eastern Uganda. Methods Health workers from 21 health facilities in Uganda were given a one-day central training on the use of RDTs in malaria case management, including practical skills on how to perform read and interpret the test results. Successful trainees subsequently integrated the use of RDTs into their routine care for febrile patients at their LLHFs and transferred their acquired skills to colleagues (cascade training model). A cross-sectional evaluation of the health workers’ competence in performing RDTs was conducted six weeks following the training, incorporating observation, in-depth interviews with health workers and the review of health facility records relating to tests offered and antimalarial drug (AMD) prescriptions pre and post training. The direct costs relating to the training processes were also documented. Results Overall, 135 health workers were trained including 63 (47%) nursing assistants, a group of care providers without formal medical training. All trainees passed the post-training concordance test with ≥ 80% except 12 that required re-training. Six weeks after the one-day training, 51/64 (80%) of the health workers accurately performed the critical steps in performing the RDT. The performance was similar among the 10 (16%) participants who were peer-trained by their trained colleagues. Only 9 (14%) did not draw the appropriate amount of blood using pipette. The average cost of the one-day training was US$ 101 (range $92-$112), with the main cost drivers being trainee travel and per-diems. Health workers offered RDTs to 76% of febrile patients and AMD prescriptions reduced by 37% six weeks post-training. Conclusion One-day training on the use of RDTs successfully provided adequate skill and competency among health workers to perform RDTs in fever case management at LLHF in a Uganda setting. The cost averaged at US$101 per health worker trained, with the main cost drivers being trainee travel and per diems. Given the good peer training noted in this study, there is need to explore the cost-effectiveness of a cascade training model for large scale implementation of RDTs.
- Published
- 2012
- Full Text
- View/download PDF
15. Early experiences on the feasibility, acceptability, and use of malaria rapid diagnostic tests at peripheral health centres in Uganda-insights into some barriers and facilitators
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Asiimwe Caroline, Kyabayinze Daniel J, Kyalisiima Zephaniah, Nabakooza Jane, Bajabaite Moses, Counihan Helen, and Tibenderana James K
- Subjects
Medicine (General) ,R5-920 - Abstract
Abstract Background While feasibility of new health technologies in well-resourced healthcare settings is extensively documented, it is largely unknown in low-resourced settings. Uganda's decision to deploy and scale up malaria rapid diagnostic tests (mRDTs) in public health facilities and at the community level provides a useful entry point for documenting field experience, acceptance, and predictive variables for technology acceptance and use. These findings are important in informing implementation of new health technologies, plans, and budgets in low-resourced national disease control programmes. Methods A cross-sectional qualitative descriptive study at 21 health centres in Uganda was undertaken in 2007 to elucidate the barriers and facilitators in the introduction of mRDTs as a new diagnostic technology at lower-level health facilities. Pre-tested interview questionnaires were administered through pre-structured patient exit interviews and semi-structured health worker interviews to gain an understanding of the response to this implementation. A conceptual framework on technology acceptance and use was adapted for this study and used to prepare the questionnaires. Thematic analysis was used to generate themes from the data. Results A total of 52 of 57 health workers (92%) reported a belief that a positive mRDT result was true, although only 41 of 57 (64%) believed that treatment with anti-malarials was justified for every positive mRDT case. Of the same health workers, only 49% believed that a negative mRDT result was truly negative. Factors linked to these findings were related to mRDT acceptance and use, including the design and characteristics of the device, availability and quality of mRDT ancillary supplies, health worker capacity to investigate febrile cases testing negative with the device and provide appropriate treatment, availability of effective malaria treatments, reliability of the health commodity supply chain, existing national policy recommendations, individual health worker dynamism, and vitality of supervision. Conclusions mRDTs were found to be acceptable to and used by the target users, provided clear policy guidelines exist, ancillary tools are easy to use and health supplies beyond the diagnostic tools are met. Based on our results, health workers' needs for comprehensive case management should be met, and specific guidance for managing febrile patients with negative test outcomes should be provided alongside the new health technology. The extent, to which the implementation process of mRDT-led, parasite-based diagnosis accommodates end user beliefs, attitudes, perceptions, and satisfaction, as well as technology learnability and suitability, influences the level of acceptance and use of mRDTs. The effectiveness of the health system in providing the enabling environment and the integration of the diagnostic tool into routine service delivery is critical.
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- 2012
- Full Text
- View/download PDF
16. Blood transfer devices for malaria rapid diagnostic tests: evaluation of accuracy, safety and ease of use
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Albertini Audrey, Asiimwe Caroline, Mationg Mary, Luchavez Jennifer, Oyibo Wellington, Hopkins Heidi, González Iveth J, Gatton Michelle L, and Bell David
- Subjects
Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Malaria rapid diagnostic tests (RDTs) are increasingly used by remote health personnel with minimal training in laboratory techniques. RDTs must, therefore, be as simple, safe and reliable as possible. Transfer of blood from the patient to the RDT is critical to safety and accuracy, and poses a significant challenge to many users. Blood transfer devices were evaluated for accuracy and precision of volume transferred, safety and ease of use, to identify the most appropriate devices for use with RDTs in routine clinical care. Methods Five devices, a loop, straw-pipette, calibrated pipette, glass capillary tube, and a new inverted cup device, were evaluated in Nigeria, the Philippines and Uganda. The 227 participating health workers used each device to transfer blood from a simulated finger-prick site to filter paper. For each transfer, the number of attempts required to collect and deposit blood and any spilling of blood during transfer were recorded. Perceptions of ease of use and safety of each device were recorded for each participant. Blood volume transferred was calculated from the area of blood spots deposited on filter paper. Results The overall mean volumes transferred by devices differed significantly from the target volume of 5 microliters (p < 0.001). The inverted cup (4.6 microliters) most closely approximated the target volume. The glass capillary was excluded from volume analysis as the estimation method used is not compatible with this device. The calibrated pipette accounted for the largest proportion of blood exposures (23/225, 10%); exposures ranged from 2% to 6% for the other four devices. The inverted cup was considered easiest to use in blood collection (206/226, 91%); the straw-pipette and calibrated pipette were rated lowest (143/225 [64%] and 135/225 [60%] respectively). Overall, the inverted cup was the most preferred device (72%, 163/227), followed by the loop (61%, 138/227). Conclusions The performance of blood transfer devices varied in this evaluation of accuracy, blood safety, ease of use, and user preference. The inverted cup design achieved the highest overall performance, while the loop also performed well. These findings have relevance for any point-of-care diagnostics that require blood sampling.
- Published
- 2011
- Full Text
- View/download PDF
17. Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda
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Nabakooza Jane, Counihan Helen, Nakanjako Damalie, Asiimwe Caroline, Kyabayinze Daniel J, and Tibenderana James K
- Subjects
Arctic medicine. Tropical medicine ,RC955-962 ,Infectious and parasitic diseases ,RC109-216 - Abstract
Abstract Background Early and accurate diagnosis of malaria followed by prompt treatment reduces the risk of severe disease in malaria endemic regions. Presumptive treatment of malaria is widely practised where microscopy or rapid diagnostic tests (RDTs) are not readily available. With the introduction of artemisinin-based combination therapy (ACT) for treatment of malaria in many low-resource settings, there is need to target treatment to patients with parasitologically confirmed malaria in order to improve quality of care, reduce over consumption of anti-malarials, reduce drug pressure and in turn delay development and spread of drug resistance. This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda. Methods All health workers (HWs) in 21 selected intervention (where RDTs were deployed) LLHF were invited for training on the use RDTs. All HWs were trained to use RDTs for parasitological diagnosis of all suspected malaria cases irrespective of age. Five LLHCFs with clinical diagnosis (CD only) were included for comparison. Subsequently AMD prescriptions were compared using both a 'pre - post' and 'intervention - control' analysis designs. In-depth interviews of the HWs were conducted to explore any factors that influence AMD prescription practices. Results A total of 166,131 out-patient attendances (OPD) were evaluated at 21 intervention LLHCFs. Overall use of RDTs resulted in a 38% point reduction in AMD prescriptions. There was a two-fold reduction (RR 0.62, 95% CI 0.55-0.70) in AMD prescription with the greatest reduction in the hypo-endemic setting (RR 0.46 95% CI 0.51-0.53) but no significant change in the urban setting (RR1.01, p-value = 0.820). Over 90% of all eligible OPD patients were offered a test. An average of 30% (range 25%-35%) of the RDT-negative fever patients received AMD prescriptions. When the test result was negative, children under five years of age were two to three times more likely (OR 2.6 p-value Conclusion Use of RDTs resulted in a 2-fold reduction in anti-malarial drug prescription at LLHCFs. The study demonstrated that RDT use is feasible at LLHCFs, and can lead to better targetting of malaria treatment. Nationwide deployment of RDTs in a systematic manner should be prioritised in order to improve fever case management. The process should include plans to educate HWs about the utility of RDTs in order to maximize acceptance and uptake of the diagnostic tools and thereby leading to the benefits of parasitological diagnosis of malaria.
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- 2010
- Full Text
- View/download PDF
18. Chimpanzees in mantraps: lethal crop protection and conservation in Uganda.
- Author
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McLennan, Matthew R., Hyeroba, David, Asiimwe, Caroline, Reynolds, Vernon, and Wallis, Janette
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CHIMPANZEE behavior ,HUMAN trapping ,PLANT protection ,CROP management ,WILDLIFE conservation ,POTAMOCHOERUS - Abstract
A main concern of farmers worldwide is how to reduce crop losses to wildlife. Some potentially lethal crop protection methods are non-selective. It is important to understand the impact of such methods on species of conservation concern. Uganda has important populations of Endangered eastern chimpanzees Pan troglodytes schweinfurthii. Farmers sometimes use large metal mantraps to guard their fields against crop-raiding wildlife, particularly baboons Papio anubis and wild pigs Potamochoerus sp.. Chimpanzees that range onto farmland also step in these illegal devices and without rapid veterinary invention face severe injury or eventual death. Unlike inadvertent snaring of great apes in African forests, the problem of mantraps in forest–farm ecotones has received little attention. We report 10 cases of entrapped chimpanzees in the cultivated landscape surrounding Uganda's Budongo Forest during 2007–2011, undoubtedly only a portion of the actual number of cases. Mantraps currently present a substantial threat to ape populations in this important conservation landscape. Our data underscore the need for conservation programmes to consider the techniques used by rural farmers to protect their livelihoods from wild animals. [ABSTRACT FROM PUBLISHER]
- Published
- 2012
- Full Text
- View/download PDF
19. Blood transfer devices for malaria rapid diagnostic tests: evaluation of accuracy, safety and ease of use.
- Author
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Hopkins, Heidi, Oyibo, Wellington, Luchavez, Jennifer, Mationg, Mary Lorraine, Asiimwe, Caroline, Albertini, Audrey, González, Iveth J., Gatton, Michelle L., and Bell, David
- Subjects
MALARIA ,BLOOD collection ,HEMODYNAMICS ,RAPID methods (Microbiology) - Abstract
Background: Malaria rapid diagnostic tests (RDTs) are increasingly used by remote health personnel with minimal training in laboratory techniques. RDTs must, therefore, be as simple, safe and reliable as possible. Transfer of blood from the patient to the RDT is critical to safety and accuracy, and poses a significant challenge to many users. Blood transfer devices were evaluated for accuracy and precision of volume transferred, safety and ease of use, to identify the most appropriate devices for use with RDTs in routine clinical care. Methods: Five devices, a loop, straw-pipette, calibrated pipette, glass capillary tube, and a new inverted cup device, were evaluated in Nigeria, the Philippines and Uganda. The 227 participating health workers used each device to transfer blood from a simulated finger-prick site to filter paper. For each transfer, the number of attempts required to collect and deposit blood and any spilling of blood during transfer were recorded. Perceptions of ease of use and safety of each device were recorded for each participant. Blood volume transferred was calculated from the area of blood spots deposited on filter paper. Results: The overall mean volumes transferred by devices differed significantly from the target volume of 5 microliters (p < 0.001). The inverted cup (4.6 microliters) most closely approximated the target volume. The glass capillary was excluded from volume analysis as the estimation method used is not compatible with this device. The calibrated pipette accounted for the largest proportion of blood exposures (23/225, 10%); exposures ranged from 2% to 6% for the other four devices. The inverted cup was considered easiest to use in blood collection (206/ 226, 91%); the straw-pipette and calibrated pipette were rated lowest (143/225 [64%] and 135/225 [60%] respectively). Overall, the inverted cup was the most preferred device (72%, 163/227), followed by the loop (61%, 138/227). Conclusions: The performance of blood transfer devices varied in this evaluation of accuracy, blood safety, ease of use, and user preference. The inverted cup design achieved the highest overall performance, while the loop also performed well. These findings have relevance for any point-of-care diagnostics that require blood sampling. [ABSTRACT FROM AUTHOR]
- Published
- 2011
- Full Text
- View/download PDF
20. Use of RDTs to improve malaria diagnosis and fever case management at primary health care facilities in Uganda.
- Author
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Kyabayinze, Daniel J., Asiimwe, Caroline, Nakanjako, Damalie, Nabakooza, Jane, Counihan, Helen, and Tibenderana, James K.
- Subjects
- *
MALARIA diagnosis , *PRIMARY health care , *COMMUNITY health services , *DRUG resistance - Abstract
Background: Early and accurate diagnosis of malaria followed by prompt treatment reduces the risk of severe disease in malaria endemic regions. Presumptive treatment of malaria is widely practised where microscopy or rapid diagnostic tests (RDTs) are not readily available. With the introduction of artemisinin-based combination therapy (ACT) for treatment of malaria in many low-resource settings, there is need to target treatment to patients with parasitologically confirmed malaria in order to improve quality of care, reduce over consumption of anti-malarials, reduce drug pressure and in turn delay development and spread of drug resistance. This study evaluated the effect of malaria RDTs on health workers' anti-malarial drug (AMD) prescriptions among outpatients at low level health care facilities (LLHCF) within different malaria epidemiological settings in Uganda. Methods: All health workers (HWs) in 21 selected intervention (where RDTs were deployed) LLHF were invited for training on the use RDTs. All HWs were trained to use RDTs for parasitological diagnosis of all suspected malaria cases irrespective of age. Five LLHCFs with clinical diagnosis (CD only) were included for comparison. Subsequently AMD prescriptions were compared using both a 'pre - post' and 'intervention - control' analysis designs. In-depth interviews of the HWs were conducted to explore any factors that influence AMD prescription practices. Results: A total of 166,131 out-patient attendances (OPD) were evaluated at 21 intervention LLHCFs. Overall use of RDTs resulted in a 38% point reduction in AMD prescriptions. There was a two-fold reduction (RR 0.62, 95% CI 0.55-0.70) in AMD prescription with the greatest reduction in the hypo-endemic setting (RR 0.46 95% CI 0.51-0.53) but no significant change in the urban setting (RR1.01, p-value = 0.820). Over 90% of all eligible OPD patients were offered a test. An average of 30% (range 25%-35%) of the RDT-negative fever patients received AMD prescriptions. When the test result was negative, children under five years of age were two to three times more likely (OR 2.6 p-value <0.001) to receive anti-malarial prescriptions relative to older age group. Of the 63 HWs interviewed 92% believed that a positive RDT result confirmed malaria, while only 49% believed that a negative RDT result excluded malaria infection. Conclusion: Use of RDTs resulted in a 2-fold reduction in anti-malarial drug prescription at LLHCFs. The study demonstrated that RDT use is feasible at LLHCFs, and can lead to better targetting of malaria treatment. Nationwide deployment of RDTs in a systematic manner should be prioritised in order to improve fever case management. The process should include plans to educate HWs about the utility of RDTs in order to maximize acceptance and uptake of the diagnostic tools and thereby leading to the benefits of parasitological diagnosis of malaria. [ABSTRACT FROM AUTHOR]
- Published
- 2010
- Full Text
- View/download PDF
21. Sparse Evidence for Giardia intestinalis , Cryptosporidium spp. and Microsporidia Infections in Humans, Domesticated Animals and Wild Nonhuman Primates Sharing a Farm–Forest Mosaic Landscape in Western Uganda.
- Author
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Cibot, Marie, McLennan, Matthew R., Kváč, Martin, Sak, Bohumil, Asiimwe, Caroline, and Petrželková, Klára
- Subjects
CRYPTOSPORIDIUM ,MICROSPORIDIOSIS ,GIARDIA lamblia ,HUMAN-animal relationships ,PRIMATES ,DOMESTIC animals ,TRIOSE-phosphate isomerase - Abstract
Zoonotic pathogen transmission is considered a leading threat to the survival of non-human primates and public health in shared landscapes. Giardia spp., Cryptosporidium spp. and Microsporidia are unicellular parasites spread by the fecal-oral route by environmentally resistant stages and can infect humans, livestock, and wildlife including non-human primates. Using immunoassay diagnostic kits and amplification/sequencing of the region of the triosephosphate isomerase, small ribosomal subunit rRNA and the internal transcribed spacer genes, we investigated Giardia, Cryptosporidium, and microsporidia infections, respectively, among humans, domesticated animals (livestock, poultry, and dogs), and wild nonhuman primates (eastern chimpanzees and black and white colobus monkeys) in Bulindi, Uganda, an area of remarkably high human–animal contact and spatial overlap. We analyzed 137 fecal samples and revealed the presence of G. intestinalis assemblage B in two human isolates, G. intestinalis assemblage E in one cow isolate, and Encephalitozoon cuniculi genotype II in two humans and one goat isolate. None of the chimpanzee and colobus monkey samples were positive for any of the screened parasites. Regular distribution of antiparasitic treatment in both humans and domestic animals in Bulindi could have reduced the occurrence of the screened parasites and decreased potential circulation of these pathogens among host species. [ABSTRACT FROM AUTHOR]
- Published
- 2021
- Full Text
- View/download PDF
22. Access to antimalarial therapy: accurate diagnosis is essential to achieving long term goals.
- Author
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Hopkins, Heidi, Asiimwe, Caroline, and Bell, David
- Subjects
- *
MALARIA , *THERAPEUTICS , *DIAGNOSIS , *PUBLIC health , *DIAGNOSTIC microbiology , *PROTOZOAN diseases - Abstract
The article argues that without diagnostic testing, efforts to improve access to effective malaria treatment will not be successful. The authors noted that making effective malarial treatment available is very vital. However, they added that implementing malarial diagnostics is also significant to improve care and allocation of resources, and achieve long-term goals. Reasons for the need to consider improved treatment targeting as a public health priority are explained. Information on a policy on parasite based diagnosis is also presented, along with the potential benefits of such diagnostic technique.
- Published
- 2009
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