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Objective: This study aimed to see the clinical presentation and histological pattern of various head and neck lesions. Materials and Methods: This descriptive study was conducted in the Department of Pathology, Bannu Medical College in association with the Department of Surgery and ENT, Khalifa Gul Nawaz Teaching Hospital, Bannu. A total of 184 cases of head and neck lesions biopsy were subjected to histopathological diagnosis. Patients' age, gender, anatomical location, and other relevant necessary clinical findings were recorded on an already designed proforma. All biopsies were received in 10% buffered formalin, fixed overnight, and processed for histopathological examination and diagnosis. Inclusion criteria were patients with head and neck lesions including skin, salivary gland, lymph node, and oral cavity of any age and gender. Exclusion criteria were thyroid, nasal cavity lesions, autolysed, and insufficient biopsy specimen. Results: In this study, the mean age was 28.58 ± 17.34 years, and the age range was from 10 to 80 years. The male-to-female ratio was 1.3:1. The most common age group was 36-45 years followed by 46-55 years and 26-35 years etc. The most common inflammatory lesion was granulomatous lymphadenitis 14.67% followed by reactive lymphoid hyperplasia 9.23%. Common benign lesions were pleomorphic adenoma 5.97% followed by lipoma and hemangioma 3.80% and 3.26% respectively. Amongst malignant lesions basal cell carcinoma 23.91% of the face was the commonest lesion followed by squamous cell carcinoma 22.28% of the oral cavity. Conclusion: This study show spectrum of lesions from inflammatory to benign and malignant, occurring in the head and neck region. Malignant lesions are more common as compared to benign and inflammatory lesions, basal cell carcinoma of the skin is the commonest malignant lesion followed by squamous cell carcinoma of the skin and oral cavity.

Human immunodeficiency virus (HIV) causes the potentially life‐threatening and chronic disease called acquired immune deficiency syndrome (AIDS). The main target of this viral disease is to suppress the immune system and make the body unresponsive to external stimuli. According to global health observatory data since epidemic, more than 78 million people were affected by HIV and 39 million people died globally. Until 2017, 36.5 million people were living with HIV. An estimated 0.8% (0.6%–0.9%) of adults aged 15–49 years worldwide is living with HIV. The World Health Organization (WHO) reported that the African region remains most severely affected, with nearly one in every 25 adults (4.1%) living with HIV and accounting for nearly two‐thirds of the people living with HIV worldwide. WHO reported that globally only 21.7 million (19.1 million–22.6 million) people have had access to antiretroviral therapy up to 2017. Currently, antiretroviral therapy (ART) is available for the control of HIV but has serious associated side effects such as lipodystrophy. Because of the limitations, associated with ART, researchers throughout the world are trying to explore and develop more reliable and safe drugs from natural resources to manage HIV infection. A wide range of medicinal plants have been studied and have reported significant potential against HIV. Plants like Rheum palmatum L., Rheum officinale, Trigonostem axyphophylloides, Vatica astrotricha, Vernonia amygdalina, Hypoxias pelargonium, Sidoides hemerocallidea and Sutherlandia frutescens etc. have high efficacy to cure HIV. The exact mechanism of action is still not known but various phytoconstituents isolated from medicinal plants such as alkaloids, flavonoids, polyphenols, terpenoids, tannins, proteins and coumarins have the potential to interrupt the life cycle of HIV as well as act as immunomodulators to enhance the immune system of infected patients with no well reported side effects. It could be concluded that medicinal plants have potential for the management of HIV/AIDS but more studies are needed to reveal rigorous efficacy and safety concerns by conducting clinical trials at vast level to explore therapeutic impact of medicinal plants. [ABSTRACT FROM AUTHOR]