174 results on '"Anne E Holland"'
Search Results
2. HIP fracture Supplemental Therapy to Enhance Recovery (HIPSTER): a protocol for a randomised controlled trial
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Belinda J Gabbe, Ian A Harris, Graham Hepworth, Richard Page, Ilana N Ackerman, Anthony Harris, Anne E Holland, Justine M Naylor, Christina L Ekegren, Angela T Burge, Maame Esi Woode, Eleanor Raper, and Lara A Kimmel
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Medicine - Abstract
Introduction Hip fractures result in substantial health impacts for patients and costs to health systems. Many patients require prolonged hospital stays and up to 60% do not regain their prefracture level of mobility within 1 year. Physical rehabilitation plays a key role in regaining physical function and independence; however, there are no recommendations regarding the optimal intensity. This study aims to compare the clinical efficacy and cost-effectiveness of early intensive in-hospital physiotherapy compared with usual care in patients who have had surgery following a hip fracture.Methods and analysis This two-arm randomised, controlled, assessor-blinded trial will recruit 620 participants who have had surgery following a hip fracture from eight hospitals. Participants will be randomised 1:1 to receive usual care (physiotherapy according to usual practice at the site) or intensive physiotherapy in the hospital over the first 7 days following surgery (two additional sessions per day, one delivered by a physiotherapist and the other by an allied health assistant). The primary outcome is the total hospital length of stay, measured from the date of hospital admission to the date of hospital discharge, including both acute and subacute hospital days. Secondary outcomes are functional mobility, health-related quality of life, concerns about falling, discharge destination, proportion of patients remaining in hospital at 30 days, return to preadmission mobility and residence at 120 days and adverse events. Twelve months of follow-up will capture data on healthcare utilisation. A cost-effectiveness evaluation will be undertaken, and a process evaluation will document barriers and facilitators to implementation.Ethics and dissemination The Alfred Hospital Ethics Committee has approved this protocol. The trial findings will be published in peer-reviewed journals, submitted for presentation at conferences and disseminated to patients and carers.Trial registration number ACTRN12622001442796.
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- 2024
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3. Implementation of offering choice of pulmonary rehabilitation location to people with COPD: a protocol for the process evaluation of a cluster randomised controlled trial
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Narelle S Cox, Anne E Holland, Arwel W Jones, Christine F McDonald, Paul O’Halloran, Ajay Mahal, Graham Hepworth, and Natasha A Lannin
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Process evaluation ,Pulmonary rehabilitation ,Implementation ,Telerehabilitation ,Chronic obstructive pulmonary disease ,Medicine (General) ,R5-920 - Abstract
Abstract Background Pulmonary rehabilitation (PR) is a core component of management people with chronic obstructive pulmonary disease (COPD); yet, people with COPD face significant barriers to attending centre-based PR programs. The emergence of new models of PR, remotely delivered directly into people’s homes, has the potential to improve rehabilitation access and completion by providing patients with a choice of rehabilitation location (centre or home). However, offering patients a choice of rehabilitation model is not usual practice. We are undertaking a 14-site cluster randomised controlled trial to determine whether offering choice of PR location improves rehabilitation completion rates resulting in reduced all-cause unplanned hospitalisation over 12 months. The aim of this paper is to describe the protocol for the process evaluation of the HomeBase2 trial. Methods A mixed methods process evaluation, to be undertaken in real time, has been developed in accordance with UK Medical Research Council (MRC) recommendations on process evaluation of complex interventions. This protocol describes the intended use of two theoretical frameworks (RE-AIM framework (Reach; Effectiveness; Adoption; Implementation; Maintenance) and Theoretical Domains Framework (TDF)) to synthesise findings and interpret data from a combination of qualitative (semi-structured interviews) and quantitative (questionnaires, clinical outcome data, intervention fidelity) methodologies. Data will be collected at an intervention, patient and clinician level. Qualitative and quantitative data will be used to derive context-specific potential and actual barriers and facilitators to offering patients choice of rehabilitation location. Acceptability and sustainability of the intervention will be evaluated for future scale-up. Discussion The process evaluation described here will appraise the clinical implementation of offering a choice of rehabilitation program location for people with COPD. It will identify and evaluate key factors for future scale-up and sustainability and scale-up of offering choice of pulmonary rehabilitation program model for people. Trial registration ClinicalTrials.gov NCT04217330 Registration date: January 3 2020.
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- 2023
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4. Implementing a choice of pulmonary rehabilitation models in chronic obstructive pulmonary disease (HomeBase2 trial): protocol for a cluster randomised controlled trial
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Christine F McDonald, Graham Hepworth, Paul O'Halloran, Anne E Holland, Natasha A Lannin, Arwel W Jones, Ajay Mahal, and Narelle Cox
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Medicine - Abstract
Introduction There is compelling evidence that either centre-based or home-based pulmonary rehabilitation improves clinical outcomes in chronic obstructive pulmonary disease (COPD). There are known health service and personal barriers which prevent potentially eligible patients from accessing the benefits of pulmonary rehabilitation. The aim of this hybrid effectiveness-implementation trial is to examine the effects of offering patients a choice of pulmonary rehabilitation locations (home or centre) compared with offering only the traditional centre-based model.Method and analysis This is a two-arm cluster randomised, controlled, assessor-blinded trial of 14 centre-based pulmonary rehabilitation services allocated to intervention (offering choice of home-based or centre-based pulmonary rehabilitation) or control (continuing to offer centre-based pulmonary rehabilitation only), stratified by centre-based programme setting (hospital vs non-hospital). 490 participants with COPD will be recruited. Centre-based pulmonary rehabilitation will be delivered according to best practice guidelines including supervised exercise training for 8 weeks. At intervention sites, the home-based pulmonary rehabilitation will be delivered according to an established 8-week model, comprising of one home visit, unsupervised exercise training and telephone calls that build motivation for exercise participation and facilitate self-management. The primary outcome is all-cause, unplanned hospitalisations in the 12 months following rehabilitation. Secondary outcomes include programme completion rates and measurements of 6-minute walk distance, chronic respiratory questionnaire, EQ-5D-5L, dyspnoea-12, physical activity and sedentary time at the end of rehabilitation and 12 months following rehabilitation.Direct healthcare costs, indirect costs and changes in EQ-5D-5L will be used to evaluate cost-effectiveness. A process evaluation will be undertaken to understand how the choice model is implemented and explore sustainability beyond the clinical trial.Ethics and dissemination Alfred Hospital Ethics Committee has approved this protocol. The trial findings will be published in peer-reviewed journals, submitted for presentation at conferences and disseminated to patients across Australia with support from national lung charities and societies.Trial registration number NCT04217330.
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- 2022
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5. Effectiveness of knowledge brokering and recommendation dissemination for influencing healthcare resource allocation decisions: A cluster randomised controlled implementation trial.
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Mitchell N Sarkies, Lauren M Robins, Megan Jepson, Cylie M Williams, Nicholas F Taylor, Lisa O'Brien, Jenny Martin, Anne Bardoel, Meg E Morris, Leeanne M Carey, Anne E Holland, Katrina M Long, and Terry P Haines
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Medicine - Abstract
BackgroundImplementing evidence into clinical practice is a key focus of healthcare improvements to reduce unwarranted variation. Dissemination of evidence-based recommendations and knowledge brokering have emerged as potential strategies to achieve evidence implementation by influencing resource allocation decisions. The aim of this study was to determine the effectiveness of these two research implementation strategies to facilitate evidence-informed healthcare management decisions for the provision of inpatient weekend allied health services.Methods and findingsThis multicentre, single-blinded (data collection and analysis), three-group parallel cluster randomised controlled trial with concealed allocation was conducted in Australian and New Zealand hospitals between February 2018 and January 2020. Clustering and randomisation took place at the organisation level where weekend allied health staffing decisions were made (e.g., network of hospitals or single hospital). Hospital wards were nested within these decision-making structures. Three conditions were compared over a 12-month period: (1) usual practice waitlist control; (2) dissemination of written evidence-based practice recommendations; and (3) access to a webinar-based knowledge broker in addition to the recommendations. The primary outcome was the alignment of weekend allied health provision with practice recommendations at the cluster and ward levels, addressing the adoption, penetration, and fidelity to the recommendations. The secondary outcome was mean hospital length of stay at the ward level. Outcomes were collected at baseline and 12 months later. A total of 45 clusters (n = 833 wards) were randomised to either control (n = 15), recommendation (n = 16), or knowledge broker (n = 14) conditions. Four (9%) did not provide follow-up data, and no adverse events were recorded. No significant effect was found with either implementation strategy for the primary outcome at the cluster level (recommendation versus control β 18.11 [95% CI -8,721.81 to 8,758.02] p = 0.997; knowledge broker versus control β 1.24 [95% CI -6,992.60 to 6,995.07] p = 1.000; recommendation versus knowledge broker β -9.12 [95% CI -3,878.39 to 3,860.16] p = 0.996) or ward level (recommendation versus control β 0.01 [95% CI 0.74 to 0.75] p = 0.983; knowledge broker versus control β -0.12 [95% CI -0.54 to 0.30] p = 0.581; recommendation versus knowledge broker β -0.19 [-1.04 to 0.65] p = 0.651). There was no significant effect between strategies for the secondary outcome at ward level (recommendation versus control β 2.19 [95% CI -1.36 to 5.74] p = 0.219; knowledge broker versus control β -0.55 [95% CI -1.16 to 0.06] p = 0.075; recommendation versus knowledge broker β -3.75 [95% CI -8.33 to 0.82] p = 0.102). None of the control or knowledge broker clusters transitioned to partial or full alignment with the recommendations. Three (20%) of the clusters who only received the written recommendations transitioned from nonalignment to partial alignment. Limitations include underpowering at the cluster level sample due to the grouping of multiple geographically distinct hospitals to avoid contamination.ConclusionsOwing to a lack of power at the cluster level, this trial was unable to identify a difference between the knowledge broker strategy and dissemination of recommendations compared with usual practice for the promotion of evidence-informed resource allocation to inpatient weekend allied health services. Future research is needed to determine the interactions between different implementation strategies and healthcare contexts when translating evidence into healthcare practice.Trial registrationAustralian New Zealand Clinical Trials Registry ACTRN12618000029291.
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- 2021
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6. Ambulatory oxygen for treatment of exertional hypoxaemia in pulmonary fibrosis (PFOX trial): a randomised controlled trial
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Andrew J Palmer, Christine F McDonald, Lauren K Troy, Tamera Corte, Graham Hepworth, Magnus Sköld, Daniel C Chambers, Anne E Holland, Ian Glaspole, Magnus Per Ekström, Nicole S L Goh, Yet H Khor, Mariana Hoffman, Ross Vlahos, Leona Dowman, Jyotika D Prasad, and James Walsh
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Medicine - Abstract
Introduction Interstitial lung diseases are characterised by scarring of lung tissue that leads to reduced transfer of oxygen into the blood, decreased exercise capacity and premature death. Ambulatory oxygen therapy may be used to treat exertional oxyhaemoglobin desaturation, but there is little evidence to support its efficacy and there is wide variation in clinical practice. This study aims to compare the clinical efficacy and cost-effectiveness of ambulatory oxygen versus ambulatory air in people with fibrotic interstitial lung disease and exertional desaturation.Methods and analysis A randomised, controlled trial with blinding of participants, clinicians and researchers will be conducted at trial sites in Australia and Sweden. Eligible participants will be randomised 1:1 into two groups. Intervention participants will receive ambulatory oxygen therapy using a portable oxygen concentrator (POC) during daily activities and control participants will use an identical POC modified to deliver air. Outcomes will be assessed at baseline, 3 months and 6 months. The primary outcome is change in physical activity measured by number of steps per day using a physical activity monitor (StepWatch). Secondary outcomes are functional capacity (6-minute walk distance), health-related quality of life (St George Respiratory Questionnaire, EQ-5D-5L and King’s Brief Interstitial Lung Disease Questionnaire), breathlessness (Dyspnoea-12), fatigue (Fatigue Severity Scale), anxiety and depression (Hospital Anxiety and Depression Scale), physical activity level (GENEActive), oxygen saturation in daily life, POC usage, and plasma markers of skeletal muscle metabolism, systematic inflammation and oxidative stress. A cost-effectiveness evaluation will also be undertaken.Ethics and dissemination Ethical approval has been granted in Australia by Alfred Hospital Human Research Ethics Committee (HREC/18/Alfred/42) with governance approval at all Australian sites, and in Sweden (Lund Dnr: 2019-02963). The results will be published in peer-reviewed scientific journals, presented at conferences and disseminated to consumers in publications for lay audiences.Trial registration number ClinicalTrials.gov Registry (NCT03737409).
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- 2020
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7. How do healthcare professionals perceive physical activity prescription for community-dwelling people with COPD in Australia? A qualitative study
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Christine F McDonald, Anne E Holland, Aroub Lahham, and Angela T Burge
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Medicine - Abstract
Objectives Clinical practice guidelines recommend that people with chronic obstructive pulmonary disease (COPD) should be encouraged to increase their physical activity levels. However, it is not clear how these guidelines are applied in clinical practice. This study aimed to understand the perspectives of respiratory healthcare professionals on the provision of physical activity advice to people with COPD. These perspectives may shed light on the translation of physical activity recommendations into clinical practice.Design A qualitative study using thematic analysis.Setting Healthcare professionals who provided care for people with COPD at two major tertiary referral hospitals in Victoria, Australia.Participants 30 respiratory healthcare professionals including 12 physicians, 10 physical therapists, 4 nurses and 4 exercise physiologists.Interventions Semistructured voice-recorded interviews were conducted, transcribed verbatim and analysed by two independent researchers using an inductive thematic analysis approach.Results Healthcare professionals acknowledged the importance of physical activity for people with COPD. They were conscious of low physical activity levels among such patients; however, few specifically addressed this in consultations. Physicians described limitations including time constraints, treatment prioritisation and perceived lack of expertise; they often preferred that physical therapists provide more comprehensive assessment and advice regarding physical activity. Healthcare professionals perceived that there were few evidence-based strategies to enhance physical activity. Physical activity was poorly differentiated from the prescription of structured exercise training. Although healthcare professionals were aware of physical activity guidelines, few were able to recall specific recommendations for people with COPD.Conclusion Practical strategies to enhance physical activity prescription may be required to encourage physical activity promotion in COPD care.
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- 2020
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8. Beyond forest plots: clinical gestalt and its influence on COPD telemonitoring studies and outcomes review
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Christine F McDonald, Sheree M Smith, and Anne E Holland
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Medicine - Abstract
Background Chronic obstructive pulmonary disease (COPD) is a progressive chronic condition. Improvements in therapies have resulted in better patient outcomes. The use of technology such as telemonitoring as an additional intervention is aimed at enhancing care and reducing unnecessary acute hospital service use. The influence of verbal communication between health staff and patients to inform decision making regarding use of acute hospital services within telemonitoring studies has not been assessed.Method A systematic overview of published systematic reviews of COPD and telemonitoring was conducted using an a priori protocol to ascertain the impact of verbal communication in telemonitoring studies on health service outcomes such as emergency department attendances, hospitalisation and hospital length of stay. The search of the following electronic databases: Cochrane Library, Medline, Pubmed, CINAHL, Embase, TROVE, Australian Digital Thesis and Proquest International Dissertations and Theses was conducted in 2017 and updated in September 2019.Results Six systematic reviews were identified. All reviews involved home monitoring of COPD symptoms and biometric data. Included reviews reported 5–28 studies with sample sizes ranging from 310 to 2891 participants. Many studies reported in the systematic reviews were excluded as they were telephone support, cost effectiveness studies, and/or did not report the outcomes of interest for this overview. Irrespective of group assignment, verbal communication with the health or research team did not alter the emergency attendance or hospitalisation outcome. The length of stay was longer for those who were assigned home telemonitoring in the majority of studies.Conclusion This overview of telemonitoring for COPD had small sample sizes and a wide variety of included studies. Communication was not consistent in all included studies. Understanding the context of communication with study participants and the decision-making process for referring patients to various health services needs to be reported in future studies of telemonitoring and COPD.
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- 2019
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9. A rehabilitation programme for people with multimorbidity versus usual care
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Kathryn Barker, Anne E Holland, Annemarie L Lee, Kathryn Ritchie, Claire Boote, Stephanie Lowe, Fiona Pazsa, Lee Thomas, Monica Turczyniak, and Elizabeth H Skinner
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Medicine - Abstract
Background: Multimorbidity, the coexistence of two or more chronic conditions, is common in clinical practice. Rehabilitation for people with multimorbidity may provide access to a rehabilitation programme that can address common symptoms and risk factors for multiple chronic diseases. Objective: The aims of this study were to (1) evaluate the feasibility of a rehabilitation programme compared to usual medical care (UMC) in people with multimorbidity and (2) gather preliminary data regarding clinical effects and impact on functional exercise capacity, activities of daily living, health-related quality of life and resource utilization. Design: A pilot feasibility parallel randomized controlled trial was undertaken. Adults with multimorbidity were randomized to the rehabilitation programme (intervention) or UMC (control). The duration of the rehabilitation programme was 8 weeks and comprised exercise (1 h, twice weekly) and education (1 h, once weekly). The UMC group did not participate in a structured exercise programme. Results: One hundred people were screened to recruit 16 participants, with a 71% completion rate for the intervention group. The rehabilitation group achieved a mean (standard deviation) improvement in 6-minute walk distance of 44 (41) m and the UMC group of 23 (29) m. Conclusions: This study suggests that it would be feasible to conduct a larger randomized control trial investigating a rehabilitation programme for people with multimorbidity. Low uptake of the study suggests that refinement of the inclusion criteria, recruitment sources and programme model will be needed to achieve the number of participants required.
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- 2018
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10. Thoracic Society of Australia and New Zealand ( <scp>TSANZ</scp> ) position statement on <scp>chronic suppurative lung disease and bronchiectasis in children</scp> , <scp>adolescents and adults in Australia and New Zealand</scp>
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Anne B. Chang, Scott C. Bell, Catherine A. Byrnes, Paul Dawkins, Anne E. Holland, Emma Kennedy, Paul T. King, Pamela Laird, Sarah Mooney, Lucy Morgan, Marianne Parsons, Betty Poot, Maree Toombs, Paul J. Torzillo, and Keith Grimwood
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Pulmonary and Respiratory Medicine - Published
- 2023
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11. A Brief Intervention of Physical Activity Education and Counseling in Community Rehabilitation: A Feasibility Randomized Controlled Trial
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Anne E Holland, Narelle S Cox, and Emily T Green
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Counseling ,medicine.medical_specialty ,medicine.medical_treatment ,Physical activity ,Physical Therapy, Sports Therapy and Rehabilitation ,law.invention ,Randomized controlled trial ,law ,Intervention (counseling) ,Health care ,Or education ,Humans ,Medicine ,Exercise ,Aged ,Protocol (science) ,Rehabilitation ,business.industry ,Exercise Therapy ,Crisis Intervention ,Physical therapy ,Feasibility Studies ,Geriatrics and Gerontology ,Brief intervention ,business ,Gerontology - Abstract
This study aimed to assess the feasibility of delivering a brief physical activity (PA) intervention to community rehabilitation clients. Participants were randomized to receive one session of stage-of-change-based PA education and counseling in addition to written educational material, or education material alone. Outcomes were measured at baseline and 3 months; the primary outcome was feasibility, measured by the percentage of those who were eligible, consented, randomized, and followed-up. A total of 123 individuals were both eligible and interested in participating, 32% of those screened on admission to the program. Forty participants consented, and 35 were randomized, with mean age 72 years (SD = 12.2). At baseline, 66% had recently commenced or intended to begin regular PA in the next 6 months. A total of 30 participants were followed-up. It is feasible to deliver education and counseling designed to support the long-term adoption of regular PA to community rehabilitation clients. Further refinement of the protocol is warranted (ACTRN12617000519358).
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- 2022
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12. Essential Features of an Interstitial Lung Disease Multidisciplinary Meeting An International Delphi Survey
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Alan K. Y. Teoh, Anne E. Holland, Julie Morisset, Kevin R. Flaherty, Athol U. Wells, Simon L. F. Walsh, Ian Glaspole, Wim A. Wuyts, Tamera J. Corte, Huzaifa Adamali, J. Shirine Allam, Sofia Antillon, Katherina M. Antoniou, Rodrigo Athanazio, Sergey Avdeev, Alexander Averyanov, Arata Azuma, Bruno Baldi, Elisabetta Balestro, Rebecca Bascom, Shalini Bastiampillai, Lutz Beckert, Jü¨ergen Behr, Paul Beirne, David Bennett, Raphael Borie, Demosthenes Bouros, Ben Brockway, Kevin Brown, Francisco Javier Callejas González, Diego Castillo, Ronald Chacon Chaves, Daniel Chambers, Sally Chapman, Nazia Chaudhuri, Harold Collard, Vincent Cottin, Bruno Crestani, Jesper Rømhild Davidsen, Devesh J. Dhasmana, Sahajal Dhooria, Juan Ignacio Enghelmayer, Alexandre Todorovic Fabro, Puneet Garcha, Nicole Goh, Alejandro Gomez, Christopher Grainge, Tomohiro Handa, Tristan Huie, Gary Hunninghake, Yoshikazu Inoue, Helen Jo, Kerri Johannson, Rene Jonkers, Eoin Judge, Yasemin Kabasakal, Leticia Kawano Dourado, Gregory Keir, Nasreen Khalil, Yet Hong Khor, Melissa King Biggs, Maria Kokosi, Yasuhiro Kondoh, Vasillis Kouranos, Michael Kreuter, David Lederer, Su Ying Low, Joachim Mü¨ller Quernheim, Toby Maher, Eliane Mancuzo, George Margaritopoulos, Carol Mason, Mariano Mazeini, Nesrin Mogulkoc, Maria Molina, Yuben Moodley, António Morais, Anoop Nambiar, Imre Noth, Hilario Nunes, Takashi Ogura, Oguzhan Okutan, Nina Patel, Carlos Pereira, Wojciech Piotrowski, Venerino Poletti, Silvia Quadrelli, Elzbieta Radzikowska, Pilar Rivera Ortega, Christopher J. Ryerson, Mauricio Salinas, Rafaela Sanchez, Recep Savas, Moises Selman, Adrian Shifren, Maria Raquel Soares, Eman Sobh, Jin Woo Song, Paolo Spagnolo, Martina Sterclova, Irina Strambu, Mary E. Strek, Takafumi Suda, Gabriela Tabaj, Jasna Tekavec Trkanjec, Fatma Tokgoz Akyil, Claudia Toma, Rade Tomic, Hiromi Tomioka, Daniel Traila, Lauren Troy, Sergio Trukillo, Argyrios Tzouvelekis, Carlo Vancheri, Brenda Elena Varela, Francesco Varone, Martina Vasakova, Elizabeth Veitch, Vanesa Vicens Zygmunt, Thomas Wessendorf, Glen Westall, Marlies Wijsenbeek, Margaret L. Wilsher, Jeremy Wrobel, Cesar Yoshito Fukuda, Chris Zappala, Pulmonary Medicine, University of St Andrews. School of Medicine, University of St Andrews. Infection and Global Health Division, AII - Amsterdam institute for Infection and Immunity, Pulmonology, and AII - Inflammatory diseases
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Pulmonary and Respiratory Medicine ,PNEUMONIA ,medicine.medical_specialty ,Respiratory System ,Delphi method ,NDAS ,Interstitial lung disease ,THORACIC SOCIETY ,R Medicine (General) ,DIAGNOSIS ,behavioral disciplines and activities ,Delphi ,03 medical and health sciences ,0302 clinical medicine ,Lung diseases, interstitial/diagnosis ,Multidisciplinary approach ,Delphi technique ,Medicine ,Humans ,CRITERIA ,Medical physics ,030212 general & internal medicine ,Pulmonologists ,Essential features ,Science & Technology ,business.industry ,STATEMENT ,respiratory system ,medicine.disease ,R1 ,respiratory tract diseases ,body regions ,surgical procedures, operative ,030228 respiratory system ,AGREEMENT ,Multidisciplinary meeting ,business ,Surveys and questionnaires ,CONSENSUS ,Life Sciences & Biomedicine - Abstract
Supported by the National Health and Medical Research Council Centre of Research Excellence in Pulmonary Fibrosis (GNT1116371), and by foundation partner, Boehringer Ingelheim, and program partners, Roche and Galapagos. Rationale : The interstitial lung disease (ILD) multidisciplinary meetings (MDM), composed of pulmonologists, radiologists, and pathologists, is integral to the rendering of an accurate ILD diagnosis. However, there is significant heterogeneity in the conduct of ILD MDMs, and questions regarding their best practices remain unanswered. Objectives : To achieve consensus among ILD experts on essential components of an ILD MDM. Methods : Using a Delphi methodology, semi-structured interviews with ILD experts were used to identify key themes and features of ILD MDMs. These items informed two subsequent rounds of online questionnaires that were used to achieve consensus among a broader, international panel of ILD experts. Experts were asked to rate their level of agreement on a five-point Likert scale. An a priori threshold for consensus was set at a median score 4 or 5 with an interquartile range of 0. Results : We interviewed 15 ILD experts, and 102 ILD experts participated in the online questionnaires. Five items and two exploratory statements achieved consensus on being essential for an ILD MDM following two questionnaire rounds. There was consensus that the presence of at least one radiologist, a quiet setting with a visual projection system, a high-quality chest high-resolution computed tomography, and a standardized template summarizing collated patient data are essential components of an ILD MDM. Experts also agreed that it would be useful for ILD MDMs to undergo an annual benchmarking process and a validation process by fulfilling a minimum number of cases annually. Twenty-seven additional features were considered to be either highly desirable or desirable features based on the degree of consensus. Although our findings on desirable features are similar to the current literature, several of these remain controversial and warrant further research. The study also showed an agreement among participants on several future concepts to improve the ILD MDM, such as performing regular self-assessments and conducting research into shared practices to develop an international expert guideline statement on ILD MDMs. Conclusions : This Delphi study showed consensus among international ILD experts on essential and desirable features of an ILD MDM. Our data represent an important step toward potential collaborative research into future standardization of ILD MDMs. Postprint
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- 2022
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13. Oral corticosteroids stewardship for asthma in adults and adolescents: A position paper from the Thoracic Society of Australia and New Zealand
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John Gornall, Laurence Ruane, Li Ping Chung, Anne E Holland, Helen K. Reddel, Philip G. Bardin, Sinthia Bosnic-Anticevich, Trudy Hopkins, Christopher Barton, Mark Hew, Vanessa M. McDonald, Peter G. Gibson, Lata Jayaram, John Blakey, John W. Upham, and John Harrington
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Adult ,Pulmonary and Respiratory Medicine ,Harm reduction ,medicine.medical_specialty ,Adolescent ,business.industry ,medicine.medical_treatment ,Administration, Oral ,medicine.disease ,Asthma ,Harm ,Adrenal Cortex Hormones ,Chronic Disease ,medicine ,Humans ,Position paper ,Smoking cessation ,Anti-Asthmatic Agents ,Stewardship ,Medical prescription ,Intensive care medicine ,business ,Adverse effect ,New Zealand - Abstract
Oral corticosteroids (OCS) are frequently used for asthma treatment. This medication is highly effective for both acute and chronic diseases, but evidence indicates that indiscriminate OCS use is common, posing a risk of serious side effects and irreversible harm. There is now an urgent need to introduce OCS stewardship approaches, akin to successful initiatives that optimized appropriate antibiotic usage. The aim of this TSANZ (Thoracic Society of Australia and New Zealand) position paper is to review current knowledge pertaining to OCS use in asthma and then delineate principles of OCS stewardship. Recent evidence indicates overuse and over-reliance on OCS for asthma and that doses >1000 mg prednisolone-equivalent cumulatively are likely to have serious side effects and adverse outcomes. Patient perspectives emphasize the detrimental impacts of OCS-related side effects such as weight gain, insomnia, mood disturbances and skin changes. Improvements in asthma control and prevention of exacerbations can be achieved by improved inhaler technique, adherence to therapy, asthma education, smoking cessation, multidisciplinary review, optimized medications and other strategies. Recently, add-on therapies including novel biological agents and macrolide antibiotics have demonstrated reductions in OCS requirements. Harm reduction may also be achieved through identification and mitigation of predictable adverse effects. OCS stewardship should entail greater awareness of appropriate indications for OCS prescription, risk–benefits of OCS medications, side effects, effective add-on therapies and multidisciplinary review. If implemented, OCS stewardship can ensure that clinicians and patients with asthma are aware that OCS should not be used lightly, while providing reassurance that asthma can be controlled in most people without frequent use of OCS.
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- 2021
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14. Community Participation by People with Chronic Obstructive Pulmonary Disease
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Amanda Nichols, Pawel Czupryn, Kathryn Barker, Jennifer A. Alison, Christine F McDonald, Christie Mellerick, Janet Bondarenko, Catherine J. Hill, Angela T Burge, Aroub Lahham, Bruna Wageck, Heather MacDonald, Paolo Zanaboni, Ajay Mahal, Helen Boursinos, Anne E Holland, Hayley Crute, Paul O'Halloran, Carla Malaguti, and Narelle S Cox
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Pulmonary and Respiratory Medicine ,Gerontology ,COPD ,Rehabilitation ,business.industry ,medicine.medical_treatment ,medicine.disease ,Hospital Anxiety and Depression Scale ,Quality of life ,Workforce ,medicine ,Anxiety ,Pulmonary rehabilitation ,medicine.symptom ,business ,Depression (differential diagnoses) - Abstract
Little is known regarding community participation in individuals with chronic obstructive pulmonary disease (COPD). The aim of this study was to explore community participation in individuals with COPD and to determine whether there is an association between community participation and activity-related outcome variables commonly collected during pulmonary rehabilitation assessment. We also sought to investigate which of these variables might influence community participation in people with COPD. Ninety-nine individuals with COPD were enrolled (67 ± 9 years, FEV1: 55 ± 22% predicted). We assessed community participation (Community Participation Indicator (CPI) and European Social Survey (ESS) for formal and informal community participation), daily physical activity levels (activity monitor), exercise capacity (6-minute walk test), breathlessness (Modified Medical Research Council, MMRC scale), self-efficacy (Pulmonary Rehabilitation Adapted Index of Self-Efficacy) and anxiety and depression (Hospital Anxiety and Depression Scale). Higher levels of community participation on the CPI were associated with older age and greater levels of physical activity (total, light and moderate-to-vigorous) (all rs = 0.30, p
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- 2021
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15. 'Willingness to Pay': The Value Attributed to Program Location by Pulmonary Rehabilitation Participants
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Angela T Burge, Christine F McDonald, Rosemary Moore, Catherine J. Hill, Rebecca Gillies, Aroub Lahhama, Anne E Holland, Paul O'Halloran, Annemarie L. Lee, Narelle S Cox, Ajay Mahald, and Caroline Nicolson
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Pulmonary and Respiratory Medicine ,Contingent valuation ,Actuarial science ,Rehabilitation ,business.industry ,medicine.medical_treatment ,Bidding ,Home Care Services ,Rehabilitation Centers ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Willingness to pay ,Monetary value ,Value (economics) ,medicine ,Humans ,Female ,Pulmonary rehabilitation ,030212 general & internal medicine ,business ,Aged - Abstract
The "contingent valuation" method is used to quantify the value of services not available in traditional markets, by assessing the monetary value an individual ascribes to the benefit provided by an intervention. The aim of this study was to determine preferences for home or center-based pulmonary rehabilitation for participants with chronic obstructive pulmonary disease (COPD) using the "willingness to pay" (WTP) approach, the most widely used technique to elicit strengths of individual preferences. This is a secondary analysis of a randomized controlled equivalence trial comparing center-based and home-based pulmonary rehabilitation. At their final session, participants were asked to nominate the maximum that they would be willing to pay to undertake home-based pulmonary rehabilitation in preference to a center-based program. Regression analyses were used to investigate relationships between participant features and WTP values. Data were available for 141/163 eligible study participants (mean age 69 [SD 10] years
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- 2021
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16. A quality improvement project targeting physical, cognitive and social activity levels in inpatient rehabilitation
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Valentina Maric, Dina Watterson, Anne E Holland, and Rosemarie Marsiglio
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030506 rehabilitation ,medicine.medical_specialty ,Quality management ,business.industry ,Social activity ,Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,Cognition ,03 medical and health sciences ,0302 clinical medicine ,Patient satisfaction ,Physical therapy ,medicine ,Service improvement ,0305 other medical science ,business ,030217 neurology & neurosurgery ,Inpatient rehabilitation - Abstract
Background/aims People undergoing inpatient rehabilitation largely spend their day by the bedside, inactive and alone. Increasing patients' physical, cognitive and social activity levels may improve rehabilitation outcomes for both the individual and the service. The aim of this study was to trial an activity programME that aimed to increase inpatient physical, cognitive and social activity levels, provided within existing resources whilE maintaining or increasing patient satisfaction. Methods A mixed-methods approach was used to develop and evaluate a multi-component activity programme for patients undergoing inpatient rehabilitation. Results Patient activity across the unit did not change but the amount of time spent alone during a weekday was significantly reduced. Patient satisfaction levels remained high. Each new therapy group was well received by patients and the volunteers who supported implementation. Novel programmes included table tennis coaching and independent gym access for selected inpatients, which were well used and not resource intensive. Therapist prescription of independent practice programmes remained low. Broader initiatives such as patient education folders require revision and further investment to succeed. Conclusions It is possible to change and evaluate multiple therapy services concurrently. The absence of change in overall activity levels demonstrates a need to establish the most successful components, harness support from the organisation to address some of the physical/environmental barriers and expand smaller programmes, and invest more time to consolidate the whole-of-service changes required to push the rehabilitation service in the direction of greater patient activity and ownership. Clinicians should pursue, implement, evaluate and revise novel programmes to engage their patient population.
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- 2021
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17. A Brief Intervention to Support Implementation of Telerehabilitation by Community Rehabilitation Services During COVID-19: A Feasibility Study
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Anne E Holland, Laura McCredie, Katharine Scrivener, Laura Jolliffe, Natasha A. Lannin, Alison Wighton, Narelle S Cox, and Sean Nelson
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Occupational therapy ,Service (systems architecture) ,medicine.medical_specialty ,Attitude of Health Personnel ,medicine.medical_treatment ,Physical Therapy, Sports Therapy and Rehabilitation ,Telehealth ,03 medical and health sciences ,0302 clinical medicine ,Surveys and Questionnaires ,Special Communication ,Intervention (counseling) ,Telerehabilitation ,medicine ,Humans ,030212 general & internal medicine ,Pandemics ,COVID-19, coronavirus disease 2019 ,Social influence ,Department ,Medical education ,Rehabilitation ,SARS-CoV-2 ,TDF, theoretical domains framework ,COVID-19 ,Physical therapists ,3. Good health ,030228 respiratory system ,Feasibility Studies ,Implementation science ,COM-B, behavior change—capability, opportunity and motivation ,Brief intervention ,Psychology - Abstract
The coronavirus disease 2019 (COVID-19) pandemic has necessitated adoption of telerehabilitation in services where face-to-face consultations were previously standard. We aimed to understand barriers to implementing a telerehabilitation clinical service and design a behavior support strategy for clinicians to implement telerehabilitation. A hybrid implementation study design included pre- and post-intervention questionnaires, identification of key barriers to implementation using the theoretical domains framework, and development of a targeted intervention. Thirty-one clinicians completed baseline questionnaires identifying key barriers to the implementation of telerehabilitation. Barriers were associated with behavior domains of knowledge, environment, social influences, and beliefs. A 6-week brief intervention focused on remote clinician support, and education was well received but achieved little change in perceived barriers to implementation. The brief intervention to support implementation of telerehabilitation during COVID-19 achieved clinical practice change, but barriers remain. Longer follow-up may determine the sustainability of a brief implementation strategy, but needs to consider pandemic-related stressors.
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- 2021
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18. Public perspectives on acquired brain injury rehabilitation and components of care: A Citizens’ Jury
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Coralie English, Anne E Holland, Nerida Hyett, Sophie Hill, Julie Ratcliffe, Libby Callaway, Peter Bragge, Megan Coulter, Kate Laver, Carolyn A. Unsworth, and Natasha A. Lannin
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Adult ,Medicine (General) ,Service delivery framework ,media_common.quotation_subject ,medicine.medical_treatment ,Participatory action research ,Citizens' jury ,Context (language use) ,decision making ,consumer participation ,03 medical and health sciences ,0302 clinical medicine ,R5-920 ,Jury ,Nursing ,medicine ,Humans ,030212 general & internal medicine ,Acquired brain injury ,Qualitative Research ,Health policy ,Uncategorized ,media_common ,Rehabilitation ,030503 health policy & services ,traumatic brain injury ,Australia ,Public Health, Environmental and Occupational Health ,health policy ,medicine.disease ,Original Research Paper ,Research Design ,Brain Injuries ,deliberative methods ,Public aspects of medicine ,RA1-1270 ,0305 other medical science ,Psychology ,Original Research Papers - Abstract
© 2020 The Authors. Health Expectations published by John Wiley & Sons Ltd Background: Brain injury rehabilitation is an expensive and long-term endeavour. Very little published information or debate has underpinned policy for service delivery in Australia. Within the context of finite health budgets and the challenges associated with providing optimal care to persons with brain injuries, members of the public were asked ‘What considerations are important to include in a model of care of brain injury rehabilitation?’. Methods: Qualitative study using the Citizen Jury method of participatory research. Twelve adult jurors from the community and seven witnesses participated including a health services funding model expert, peak body representative with lived experience of brain injury, carer of a person with a brain injury, and brain injury rehabilitation specialists. Witnesses were cross-examined by jurors over two days. Results: Key themes related to the need for a model of rehabilitation to: be consumer-focused and supporting the retention of hope; be long-term; provide equitable access to services irrespective of funding source; be inclusive of family; provide advocacy; raise public awareness; and be delivered by experts in a suitable environment. A set of eight recommendations were made. Conclusion: Instigating the recommendations made requires careful consideration of the need for new models of care with flexible services; family involvement; recruitment and retention of highly skilled staff; and providing consumer-focused services that prepare individuals and their carers for the long term. Patient and public contribution: As jury members, the public deliberated information provided by expert witnesses (including a person with a head injury) and wrote the key recommendations.
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- 2021
19. The Impact of Pulmonary Rehabilitation on 24-Hour Movement Behavior in People With Chronic Obstructive Pulmonary Disease: New Insights From a Compositional Perspective
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Angela T Burge, Ajay Mahal, Anne E Holland, Michael J. Abramson, Caroline Nicolson, Catherine J. Hill, Javier Palarea-Albaladejo, Aroub Lahham, Christine F McDonald, Rosemary Moore, Rebecca Gillies, Sebastien F. M. Chastin, Paul O'Halloran, Annemarie L. Lee, and Narelle S Cox
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Male ,medicine.medical_specialty ,Movement ,medicine.medical_treatment ,Psychological intervention ,Body Mass Index ,law.invention ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Randomized controlled trial ,law ,Humans ,Medicine ,Orthopedics and Sports Medicine ,Pulmonary rehabilitation ,030212 general & internal medicine ,Exercise physiology ,Exercise ,Lung ,Rehabilitation ,business.industry ,Perspective (graphical) ,Regression analysis ,030228 respiratory system ,Female ,Sedentary Behavior ,Sleep ,business ,Body mass index - Abstract
Background: Physical activity levels are low in people with chronic obstructive pulmonary disease, and there is limited knowledge about how pulmonary rehabilitation transforms movement behaviors. This study analyzed data from a pulmonary rehabilitation trial and identified determinants of movement behaviors.Methods: Objectively assessed time in daily movement behaviors (sleep, sedentary, light-intensity physical activity, and moderate- to vigorous-intensity physical activity) from a randomized controlled trial (n = 73 participants) comparing home- and center-based pulmonary rehabilitation was analyzed using conventional and compositional analytical approaches. Regression analysis was used to assess relationships between movement behaviors, participant features, and response to the interventions.Results: Compositional analysis revealed no significant differences in movement profiles between the home- and center-based groups. At end rehabilitation, conventional analyses identified positive relationships between exercise capacity (6-min walk distance), light-intensity physical activity, and moderate- to vigorous-intensity physical activity time. Compositional analyses identified positive relationships between a 6-minute walk distance and moderate- to vigorous-intensity physical activity time, accompanied by negative relationships with sleep and sedentary time (relative to other time components) and novel relationships between body mass index and light-intensity physical activity/sedentary time.Conclusion: Compositional analyses following pulmonary rehabilitation identified unique associations between movement behaviors that were not evident in conventional analyses.
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- 2021
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20. Substituting inpatient rehabilitation beds for home‐based multidisciplinary rehabilitation: A qualitative study of patient perceptions
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Catherine Wolters, Belinda Brookes, Dina Watterson, Angela T Burge, Peter Hunter, Anne E Holland, Victoria Lee, Melanie Reed, Ronald Leong, and Lara A Kimmel
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Referral ,medicine.medical_treatment ,media_common.quotation_subject ,03 medical and health sciences ,Nursing ,030502 gerontology ,medicine ,Humans ,Prospective Studies ,Qualitative Research ,media_common ,Community and Home Care ,Service (business) ,Inpatients ,Rehabilitation ,Communication ,General Medicine ,Home based ,Patient perceptions ,Feeling ,Female ,Perception ,Geriatrics and Gerontology ,0305 other medical science ,Psychology ,Inpatient rehabilitation ,Qualitative research - Abstract
Objective To understand the patients' perspectives of the pilot Better at Home program in order to inform the development of bed substitution rehabilitation services. Methods Prospective qualitative study using semi-structured interviews undertaken 3-6 months following program participation was performed. Interviews were transcribed and themes developed by two independent researchers. Results Nineteen participants (14 females) were interviewed. Major themes found included high satisfaction with the service and a high regard for the importance of communication both within the team and with the patients. Patients had inconsistent views on the provision of services with some feeling that the program was not specific to their needs, whilst others felt it was focused and flexible. Involvement in decision-making for referral to the service was also not always fully understood. Conclusions This study provides important information that can be utilised in the development of any bed substitution home-based model of care.
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- 2020
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21. The impact of frailty in critically ill patients after trauma: A prospective observational study
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Anne E Holland, Claire J Tipping, Carol L. Hodgson, Emily Bilish, Meg Harrold, and Terry Chan
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Male ,medicine.medical_specialty ,Critical Illness ,medicine.medical_treatment ,Population ,Glasgow Outcome Scale ,Emergency Nursing ,Critical Care Nursing ,law.invention ,03 medical and health sciences ,Injury Severity Score ,0302 clinical medicine ,law ,Internal medicine ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,education ,APACHE ,Aged ,Mechanical ventilation ,education.field_of_study ,Frailty ,business.industry ,Major trauma ,Australia ,030208 emergency & critical care medicine ,Odds ratio ,Middle Aged ,medicine.disease ,Intensive care unit ,Confidence interval ,Intensive Care Units ,Wounds and Injuries ,Female ,Observational study ,business - Abstract
Background As our population ages, older adults are increasingly exposed to trauma. Frailty could be a useful measure to identify patients at risk of a poor outcome. This study aimed to determine the impact of frailty in an Australian trauma intensive care unit (ICU) population. Methods A prospective observational study of critically ill trauma patients ≥50 years of age. Frailty was determined on admission to the ICU using the frailty phenotype. Demographic and hospital data were collected, and patients were followed up at 6 and 12 months. The primary outcome was 12-month mortality, and multiple regression was used to determine associated factors. Results One hundred thirty-eight patients were included, whose mean age was 68 years; 78.2% (108/138) were classified as major trauma (Injury Severity Score >12). Twenty-two percent (30/138) of patients were identified as frail. Patients with frailty were significantly older: however, they were less severely injured and required lower rates of surgical interventions and mechanical ventilation. Frailty was independently associated with mortality at 6 and 12 months (odds ratio: 5.9, 95% confidence interval: 1.9–18.1 and odds ratio: 7.3, 95% confidence interval: 2.5–21.9, respectively). Patients with frailty had lower measures of global functioning (Glasgow Outcome Scale-Extended frail 3 [1–5] vs nonfrail 6 [(5–7], p = 0.002) and health status (Euro Qol 5Q-5D-5L utility score 0.6 [0.5–0.7] vs 0.7 [0.6–0.9], p = 0.02) at 12 months than patients without frailty. Conclusion Frailty is a useful predictor of poor outcomes in critically ill trauma patients. Registration of protocol number ACTRN12615000039583.
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- 2020
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22. The Utility of the Sit-to-Stand Test for Inpatients in the Acute Hospital Setting After Lung Transplantation
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Bruce Thompson, Megan Poulsen, Monique Corbett, Rebecca Robinson, Caitlin Le Maitre, Brenda M. Button, Anne E Holland, Benjamin J. Tarrant, and Greg Snell
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Male ,medicine.medical_specialty ,Psychometrics ,Intraclass correlation ,Physical Therapy, Sports Therapy and Rehabilitation ,03 medical and health sciences ,Grip strength ,0302 clinical medicine ,Floor effect ,Interquartile range ,Criterion validity ,medicine ,Humans ,Generalizability theory ,Muscle Strength ,030212 general & internal medicine ,Physical Therapy Modalities ,Inpatients ,business.industry ,Reproducibility of Results ,Middle Aged ,Transplantation ,Inter-rater reliability ,030228 respiratory system ,Exercise Test ,Physical therapy ,Female ,business ,Lung Transplantation - Abstract
Objective Measurement of physical function is important to guide physical therapy for patients post-lung transplantation (LTx). The Sit-to-Stand (STS) test has proven utility in chronic disease, but psychometric properties post-LTx are unknown. The study aimed to assess reliability, validity, responsiveness, and feasibility of the 60-second STS post-LTx. Methods This was a measurement study in 62 inpatients post-LTx (31 acute postoperative; 31 medical readmissions). Interrater reliability was assessed with 2 STS tests undertaken by different assessors at baseline. Known group validity was assessed by comparing STS repetitions in postoperative and medical groups. Content validity was assessed using comparisons to knee extensor and grip strength, measured with hand-held dynamometry. Criterion validity was assessed by comparison of STS repetitions and 6-minute walk distance postoperatively. Responsiveness was assessed using effect sizes over inpatient admission. Results Median (interquartile range) age was 62 (56–67) years; time post-LTx was 5 (5–7) days postoperative and 696 (244–1849) days for medical readmissions. Interrater reliability was excellent (intraclass correlation coefficient type 2,1 = 0.96), with a mean learning effect of 2 repetitions. Repetitions were greater for medical at baseline (mean 18 vs 8). More STS repetitions were associated with greater knee extensor strength (postoperative r = 0.57; medical r = 0.47) and 6-minute walk distance (postoperative r = 0.68). Effect sizes were 0.94 and 0.09, with a floor effect of 23% and 3% at baseline (postoperative/medical) improving to 10% at discharge. Patients incapable of attempting a STS test were excluded, reducing generalizability to critical care. Physical rehabilitation was not standardized, possibly reducing responsiveness. Conclusions The 60-second STS demonstrated excellent interrater reliability and moderate validity and was responsive to change postoperatively. Impact The 60-second STS represents a safe, feasible functional performance tool for inpatients post-LTx. Two tests should be completed at each time point.
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- 2020
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23. The impact of home‐based pulmonary rehabilitation on people with mild chronic obstructive pulmonary disease: A randomised controlled trial
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Sarah Rawlings, Christine F McDonald, Rosemary Moore, Amanda Nichols, Narelle S Cox, Anne E Holland, Aroub Lahham, and Athina Liacos
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Male ,Pulmonary and Respiratory Medicine ,Respiratory Therapy ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Vital Capacity ,Walk Test ,Exercise intolerance ,law.invention ,Pulmonary Disease, Chronic Obstructive ,Randomized controlled trial ,Quality of life ,law ,medicine ,Humans ,Immunology and Allergy ,Pulmonary rehabilitation ,Genetics (clinical) ,Aged ,COPD ,Exercise Tolerance ,business.industry ,Middle Aged ,medicine.disease ,Home Care Services ,Confidence interval ,Clinical trial ,Dyspnea ,Treatment Outcome ,Mild chronic obstructive pulmonary disease ,Quality of Life ,Physical therapy ,Female ,medicine.symptom ,business - Abstract
INTRODUCTION People with mild chronic obstructive pulmonary disease (COPD) experience exercise intolerance, dyspnoea and poor quality of life. However, the role of pulmonary rehabilitation (PR) in this group is unclear. OBJECTIVES This randomised controlled trial aimed to explore the effects of home-based PR in people with mild COPD. METHODS People with mild COPD (FEV1 /FVC 80%predicted) with a smoking history of ≥10 packet years were randomised to either 8 weeks of home-based PR (one home visit and seven once-weekly telephone calls) or standard care (weekly social telephone calls). Six minute walk distance (6MWD), and Modified Medical Research Council Dyspnoea Scale (mMRC) and Chronic Respiratory Disease Questionnaire (CRQ) scores were compared. RESULTS A total of 58 participants (34 males, mean age 68 (SD 9) years, FEV1 %predicted 90 (7), 6MWD 496 (105) m) were included with 31 participants randomised to home-based PR. Participants attended an average of 6.8 of the 8 scheduled sessions, ranging from 3 to 8 sessions. Both groups showed improvements in exercise capacity, symptoms and health-related quality of life (HRQoL) over time, however there was no difference in 6MWD at end-intervention (mean difference -3 m, 95% confidence interval (CI) -64 to 58) or 6 months (7 m, 95% CI -59 to 72). At 6 months home-based PR participants were more likely to have clinically important improvements in CRQ emotional function (50% of home PR vs 0% control, P
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- 2020
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24. Peer Connect Service for people with pulmonary fibrosis in Australia: Participants' experiences and process evaluation
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Jamie Maloney, Michael Bartlett, Tamera J. Corte, Ian Glaspole, Jennifer Walsh, Susanne Webster, Tonia Crawford, Anne E Holland, Gabriella Tikellis, Yet H. Khor, Joanna Y T Lee, Debra G. Sandford, Nicole S L Goh, Alison J. Hey-Cunningham, Alan Teoh, John T. Price, Lissa Spencer, Kelcie Herrmann, and Greg Keir
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Male ,Pulmonary and Respiratory Medicine ,Matching (statistics) ,Service delivery framework ,Pulmonary Fibrosis ,education ,Peer support ,Peer Group ,03 medical and health sciences ,0302 clinical medicine ,Medical advice ,Surveys and Questionnaires ,Humans ,Medicine ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Service (business) ,Medical education ,business.industry ,Australia ,Social Support ,Middle Aged ,Telephone ,030228 respiratory system ,Female ,Thematic analysis ,Process evaluation ,business ,Qualitative research - Abstract
BACKGROUND AND OBJECTIVE: People living with pulmonary fibrosis (PF) report unmet needs for information and support. Lung Foundation Australia (LFA) have developed the Peer Connect Service to facilitate telephone support for people with PF across Australia. This project documented the experiences of participants and the resources required to support the service. METHODS: Consenting participants took part in semi-structured interviews by telephone. Primary peers (peers who agreed to initiate contact) and secondary peers (eligible patients who sought a peer match) were interviewed. Thematic analysis was undertaken by two independent researchers. Data were collected on the number of matches and contacts required to establish each match. RESULTS: Interviews were conducted with 32 participants (16 primary peers, 15 secondary peers and 1 who was both), aged from 53 to 89 years with 56% being male. Major themes included the value of shared experiences, providing mutual support and the importance of shared personal characteristics (e.g. gender and hobbies) in allowing information and emotional support needs to be met. Participants saw face-to-face contact with peers as highly desirable whilst acknowledging the practical difficulties. Primary peers were cognizant that their role was not to provide medical advice but to listen and share experiences. In the 12-month period, 60 peer matches were made, each match requiring a minimum of seven staff contacts. CONCLUSION: The Peer Connect Service provides a unique opportunity for people with PF to share experiences and offer mutual support. This telephone matching model may be useful in providing peer support for individuals with rare diseases who are geographically dispersed.
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- 2020
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25. Efficacy of Repeating Pulmonary Rehabilitation in People with COPD: A Systematic Review
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Angela T Burge, Carla Malaguti, Mariana Hoffman, Alan Shiell, Christine F McDonald, David J Berlowitz, and Anne E Holland
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Hospitalization ,Pulmonary Disease, Chronic Obstructive ,Dyspnea ,Quality of Life ,Humans ,General Medicine - Abstract
Pulmonary rehabilitation is an effective intervention for people with chronic obstructive pulmonary disease (COPD). People with COPD undertake repeat programs, but synthesis of evidence regarding such practice has not been undertaken. The aim of this systematic review was to establish the effects of repeating pulmonary rehabilitation subsequent to an initial program in people with COPD.Studies where participants with COPD undertook1 pulmonary rehabilitation program were included, incorporating RCT (randomized controlled trial) and non-randomized studies. Electronic database searches were undertaken. Two authors independently undertook study identification, data extraction and risk of bias assessment. The primary outcome was health-related quality of life (HRQoL); secondary outcomes were exercise capacity, hospitalizations and exacerbations, adherence, mortality and adverse events. Narrative synthesis was undertaken for clinically heterogeneous trials. Data from RCTs and non-randomized studies were not combined for analysis.Ten included studies (2 RCTs) involved 907 participants with COPD (n=653 had undertaken1 program). The majority of studies were at high risk of bias. One RCT (n=33) reported no difference in HRQol after a repeat program vs usual care following exacerbation (Chronic Respiratory Disease Questionnaire dyspnea domain score MD 0.4, 95% CI -0.5 to 3). In stable patients, clinically important and statistically significant improvements in HRQoL and exercise capacity were reported after repeat programs, but of a smaller magnitude than initial programs. There was evidence for reductions in exacerbations and hospitalizations, and shorter hospital length of stay for patients who repeated a program twice in 12 months compared to those who repeated once. No data for mortality or adverse events were available.This systematic review provides limited evidence for benefits of repeating pulmonary rehabilitation in people with COPD, including improved HRQoL and exercise capacity, and reduced hospitalizations. However, most studies have high risk of bias, which reduces the certainty of these conclusions.PROSPERO (CRD42020215093).
- Published
- 2022
26. Clinimetrics: The Breathing Pattern Assessment Tool
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Janet Bondarenko and Anne E Holland
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Physical Therapy, Sports Therapy and Rehabilitation - Published
- 2023
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27. Clinical Outcomes Following Exercise Rehabilitation in People with Multimorbidity: A Systematic Review
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Kathryn Barker, Anne E. Holland, Elizabeth H. Skinner, and Annemarie L. Lee
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Rehabilitation ,Physical Therapy, Sports Therapy and Rehabilitation ,General Medicine - Abstract
Objective: To determine the effectiveness of exercise rehabilitation in people with multimorbidity. Exercise capacity was the primary outcome. Secondary outcomes were: health-related quality of life, activities of daily living, cardiometabolic outcomes, mental health outcomes, symptom scores, resource utilization, health behaviours, economic outcomes, and adverse events.Data sources: A search was conducted in MEDLINE, CINHAL, EMBASE, and Cochrane Central Register of Controlled Trials databases. Study selection and extraction: Randomized and non-randomized controlled trials and cohort studies of exercise rehabilitation vs any comparison in people with multimorbidity.Data synthesis: Forty-four reports (38 studies) were included. Rehabilitation ranged from 8 weeks to 4 years, with 1–7 sessions of rehabilitation weekly. Exercise included aerobic and resistance, limb training, aquatic exercises and tai chi. Compared with usual care, exercise rehabilitation improved 6-min walk distance (weighted mean difference (WMD) 64 m, 95% CI 45–82) and peak oxygen consumption (WMD 2.74 mL/kg/min, 95% CI –3.32 to 8.79). Effects on cardiometabolic outcomes and health-related quality of life also favoured rehabilitation; however; few data were available for other secondary outcomes.Conclusion: In people with multimorbidity, exercise rehabilitation improved exercise capacity, health-related quality of life, and cardiometabolic outcomes. LAY ABSTRACTChronic disease is a common health problem worldwide. It is increasingly common for people to have more than 1 chronic disease, which is called multimorbidity, and the interaction of their multiple health problems may worsen their health outcomes. Exercise rehabilitation is an effective and established treatment to improve health for people with different chronic diseases, such as heart and lung disease; however, the benefit of structured rehabilitation in people with multimorbidity has not been systematically reviewed. A literature search was performed to investigate the clinical outcomes following exercise rehabilitation in people with multimorbidity. Compared with usual medical care, the results showed that exercise rehabilitation improved exercise capacity, measured by walking distance in a formal test, health-related quality of life and the body’s ability to use oxygen, in people with multimorbidity. There were few data regarding the benefit of rehabilitation on other outcomes, and more well-designed robust trials are needed.
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- 2023
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28. Challenges of evaluating the effect of exercise training on salivary IgA in people with COPD
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Anne E Holland, Narelle S Cox, Janet Bondarenko, Christine F McDonald, Lisa Wood, Catherine J. Hill, Maree Gleeson, and Sharron T. Hall
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,COPD ,business.industry ,medicine.medical_treatment ,MEDLINE ,medicine.disease ,Immunoglobulin A ,Salivary iga ,Pulmonary Disease, Chronic Obstructive ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,Pulmonary rehabilitation ,Saliva ,business ,Exercise ,Genetics (clinical) - Published
- 2021
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29. Clinical Characteristics Of Patients With Asthma COPD Overlap (ACO) In Australian Primary Care
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Anne E Holland, Jenifer Liang, Johnson George, Paula Eustace, Nicholas Zwar, Gabriel Izbicki, Michael J. Abramson, Ajay Mahal, Valerie Teo, Sally Wilson, Grant Russell, Kirsten Phillips, Eldho Paul, and Billie Bonevski
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Spirometry ,medicine.medical_specialty ,COPD ,Vital capacity ,medicine.diagnostic_test ,business.industry ,General Medicine ,medicine.disease ,Comorbidity ,respiratory tract diseases ,3. Good health ,Clinical trial ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Quality of life ,Predictive value of tests ,Emergency medicine ,Medicine ,030212 general & internal medicine ,business ,Asthma - Abstract
Purpose Many older adults with a history of smoking and asthma develop clinical features of both asthma and COPD, an entity sometimes called asthma-COPD overlap (ACO). Patients with ACO may be at higher risk of poor health outcomes than those with asthma or COPD alone. However, understanding of ACO is limited in the primary care setting and more information is needed to better inform patient management. We aimed to compare the characteristics of patients with ACO or COPD in Australian general practices. Patients and methods Data were from the RADICALS (Review of Airway Dysfunction and Interdisciplinary Community-based care of Adult Long-term Smokers) trial, an intervention study of an interdisciplinary community-based model of care. Baseline demographic and clinical characteristics, pre- and post-bronchodilator spirometry, dyspnoea and St. George's Respiratory Questionnaire scores were compared between 60 ACO patients and 212 with COPD alone. Results Pre-bronchodilator Forced Expiratory Volume in 1 second (mean±SD 58.4±14.3 vs 67.5±20.1% predicted) and Forced Vital Capacity (mean 82.1±16.9 v 91.9±17.2% predicted) were significantly lower in the ACO group (p
- Published
- 2019
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30. Two Days of Measurement Provides Reliable Estimates of Physical Activity Poststroke: An Observational Study
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Natalie A Fini, Angela T Burge, Anne E Holland, and Julie Bernhardt
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Time Factors ,Wilcoxon signed-rank test ,Intraclass correlation ,Physical activity ,Physical Therapy, Sports Therapy and Rehabilitation ,Walking ,Metabolic equivalent ,Wearable Electronic Devices ,03 medical and health sciences ,0302 clinical medicine ,Accelerometry ,Humans ,Medicine ,Longitudinal Studies ,Prospective Studies ,Prospective cohort study ,Exercise ,Stroke ,Aged ,Aged, 80 and over ,business.industry ,Rehabilitation ,Sedentary behavior ,Middle Aged ,medicine.disease ,Physical therapy ,Female ,Observational study ,Sedentary Behavior ,Energy Metabolism ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
Objective The aim of this study was to determine the duration of physical activity (PA) monitoring required for reliable measurements following stroke. Design Single-center, prospective, observational study. Setting PA was measured in a community setting. Participants Adults (N=70) poststroke. Main Outcome Measures The SenseWear armband was used to monitor PA for 5 days (≥10 hours wear per day). Data Analysis Variance among 2, 3, 4, and 5 days of consecutive measurements for PA variables was examined using intraclass correlation coefficients (ICCs). The minimum number of days to achieve acceptable reliability (ICC ≥0.8) was calculated. Differences between weekdays and weekend days were investigated using paired t tests and Wilcoxon signed rank tests. Results Two days of measurement was sufficient to achieve an ICC ≥0.8 for daily averages of total energy expenditure, step count, and time spent sedentary (≤1.5 metabolic equivalent tasks [METs]) and in light (1.5-3 METs) and moderate- to vigorous-intensity (>3 METs) PA. At least 3 days were required to achieve an ICC ≥0.8 when investigating the number of and time spent in bouts (≥10 minutes) of moderate to vigorous PA and sedentary behavior. Participants took significantly more steps (P=.03) and spent more time in light PA (P=.03) on weekdays than weekends. Conclusion Following stroke, 2 days of measurement appears sufficient to represent habitual PA for many simple variables. Three or more days may be necessary for reliable estimates of bouts of PA and sedentary behavior. Consistent inclusion or exclusion of a weekend day is recommended for measuring step count and light PA. Short periods of monitoring provide reliable PA information and may make PA measurement more feasible in the clinical setting.
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- 2019
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31. Exercise-Based Rehabilitation to Improve Exercise Capacity and Quality of Life in Pulmonary Arterial Hypertension
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Abraham Samuel Babu, Anne E Holland, and Norman R. Morris
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medicine.medical_specialty ,medicine.medical_treatment ,Clinical Decision-Making ,education ,Physical Therapy, Sports Therapy and Rehabilitation ,Scientific literature ,030204 cardiovascular system & hematology ,Cochrane Library ,Scientific evidence ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Health care ,medicine ,Humans ,Intensive care medicine ,Physical Therapy Modalities ,Randomized Controlled Trials as Topic ,Pulmonary Arterial Hypertension ,Exercise Tolerance ,Rehabilitation ,business.industry ,Exercise capacity ,Systematic review ,030228 respiratory system ,Quality of Life ,business ,Systematic Reviews as Topic - Abstract
highlights the findings and application of Cochrane reviews and other evidence pertinent to the practice of physical therapy. The Cochrane Library is a respected source of reliable evidence related to health care. Cochrane systematic reviews explore the evidence for and against the effectiveness and appropriateness of interventions—medications, surgery, education, nutrition, exercise—and the evidence for and against the use of diagnostic tests for specific conditions. Cochrane reviews are designed to facilitate the decisions of clinicians, patients, and others in health care by providing a careful review and interpretation of research studies published in the scientific literature. Each article in this PTJ series summarizes a Cochrane review or other scientific evidence on a single topic and presents clinical scenarios based on real patients or programs to illustrate how the results of the review can be used to directly inform clinical decisions. This article focuses on people diagnosed with pulmonary arterial hypertension. Can exercise-based rehabilitation programs improve exercise capacity and quality of life in people with pulmonary arterial hypertension?
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- 2019
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32. Frailty in Patients With Trauma Who Are Critically Ill: A Prospective Observational Study to Determine Feasibility, Concordance, and Construct and Predictive Validity of 2 Frailty Measures
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Claire J Tipping, Anne E Holland, Meg Harrold, Carol L. Hodgson, and Terry Chan
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Male ,Predictive validity ,medicine.medical_specialty ,Critical Illness ,Concordance ,Population ,Poison control ,Physical Therapy, Sports Therapy and Rehabilitation ,03 medical and health sciences ,0302 clinical medicine ,Humans ,Medicine ,Prospective Studies ,education ,Geriatric Assessment ,Aged ,Geriatrics ,education.field_of_study ,Frailty ,business.industry ,Construct validity ,030208 emergency & critical care medicine ,Hospitalization ,Intensive Care Units ,030228 respiratory system ,Emergency medicine ,Feasibility Studies ,Wounds and Injuries ,Injury Severity Score ,Female ,Observational study ,business - Abstract
Background As the older population increases, more older people are exposed to trauma. Frailty can be used to highlight patients at risk of a poorer outcome. Objective The objectives of this study were to compare 2 frailty measures with regard to concordance, floor and ceiling effects, and construct and predictive validity and to determine which is more valid and clinically applicable in a critically ill trauma population. Design This was a prospective observational study. Methods Patients were included if admitted to an intensive care unit (ICU) under a trauma medical unit and ≥ 50 years old. Frailty was determined using 2 frailty measures, the Frailty Phenotype (FP) and Clinical Frailty Scale (CFS). Results One hundred people were enrolled; their mean age was 69.2 years (SD = 10.4) and 81% had major trauma (as determined with the Injury Severity Score). Frailty was identified with the FP in 22 participants and with the CFS in 13 participants. The 2 frailty measures had an excellent correlation (Spearman rank correlation coefficient = 0.77; 95% confidence interval = 0.66–0.85). Both the FP and the CFS had large floor effects but no ceiling effects. The FP and CFS showed construct validity, with frailty being significantly associated with increasing age, requiring an aid to mobilize, and more falls and hospital admissions. Frailty on the FP was predictive of ICU and hospital mortality, whereas frailty on the CFS was predictive of hospital mortality. Limitations The limitations of this study include the use of a single site, small sample size, and collection of frailty measures retrospectively. Conclusions Measuring frailty in a trauma ICU population was feasible, with excellent correlation between the 2 frailty measures. Both showed aspects of construct and predictive validity; however, the FP identified frailty in more participants and was associated with more comorbidities and higher mortality at ICU discharge. Therefore, the FP might be more clinically relevant in this population.
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- 2019
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33. Exercise as a therapeutic intervention for people with cystic fibrosis
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Kathy Stiller, Nathan Ward, and Anne E Holland
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Reduced exercise tolerance ,Cystic Fibrosis ,business.industry ,Public Health, Environmental and Occupational Health ,Exercise therapy ,medicine.disease ,Cystic fibrosis ,Exercise Therapy ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,Intervention (counseling) ,Internal medicine ,medicine ,Humans ,Immunology and Allergy ,030212 general & internal medicine ,business ,Physical Therapy Modalities - Abstract
The complex multisystem nature of cystic fibrosis (CF) commonly results in reduced exercise tolerance, which is independently associated with poor clinical outcomes. Exercise is routinely recommended as part of the therapeutic regimen in CF to improve both respiratory and non-respiratory impairments. Areas covered: This article summarises the most recent evidence regarding the use of exercise as a therapeutic intervention in CF and discusses some of the practical considerations for exercise prescription in this setting. Clinical trials in progress and future research priorities are outlined. Expert opinion: On the balance of available evidence, exercise is likely to assist in improving physical fitness and health-related quality of life (HRQOL) and may be associated with a slower rate of decline in respiratory function in CF. Limitations to current studies include small sample sizes, study durations insufficient to achieve a training effect and difficulty distinguishing the effects of exercise training from that of other interventions implemented as part of a package of care. Larger, multi-centred trials are required to clarify the role of exercise in CF in improving physical fitness, respiratory function, HRQOL, as a substitute for traditional airway clearance techniques and in the management of common CF-related comorbidities.
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- 2019
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34. Prevalence, impact and specialised treatment of urinary incontinence in women with chronic lung disease
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John W Wilson, Angela T Burge, J Chase, Margaret Sherburn, Anne E Holland, and Brenda M. Button
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Adult ,congenital, hereditary, and neonatal diseases and abnormalities ,030506 rehabilitation ,medicine.medical_specialty ,Stress incontinence ,Cystic Fibrosis ,Population ,Physical Therapy, Sports Therapy and Rehabilitation ,Urinary incontinence ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Quality of life ,Lower urinary tract symptoms ,Internal medicine ,Prevalence ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Prospective cohort study ,education ,Physical Therapy Modalities ,Aged ,COPD ,education.field_of_study ,Pelvic floor ,business.industry ,Age Factors ,Pelvic Floor ,Middle Aged ,medicine.disease ,respiratory tract diseases ,Logistic Models ,Urinary Incontinence ,medicine.anatomical_structure ,Quality of Life ,Female ,medicine.symptom ,0305 other medical science ,business - Abstract
Objectives To determine in women with clinically stable chronic lung disease (CLD) and healthy women; (1) prevalence of urinary incontinence; (2) risk factors for urinary incontinence; (3) effects of a standard course of specialised physiotherapy treatment (PT) in women with CLD. Design Prospective prevalence study; PT study in CLD subgroup. Setting Tertiary metropolitan public hospital. Participants Women with cystic fibrosis (CF, n = 38), chronic obstructive pulmonary disease (COPD, n = 27) and 69 healthy women without CLD. PT study — 10 women with CLD. Interventions Five continence PT sessions over 3 months. Main outcome measures Prevalence and impact of incontinence (questionnaire), number of leakage episodes (7-day accident diary), pelvic floor muscle function (ultrasound imaging) and quality of life (King’s Health Questionnaire). Results The majority of women in all three groups reported episodes of incontinence (CF 71%; COPD 70%; healthy women 55%). Compared to age-matched healthy controls, women with CF reported more episodes of incontinence (P = 0.006) and more commonly reported stress incontinence (P = 0.001). A logistic regression model revealed that women with CLD were twice as likely to develop incontinence than healthy women (P = 0.05). Women with COPD reported significantly more ‘bother’ with incontinence than age-matched women with incontinence. There was a significant reduction in incontinence episodes following treatment, which was maintained after three months. Conclusions The presence of CLD is an independent predictor of incontinence in women. In older women this is associated with more distress than in age-matched peers without CLD. Larger treatment studies are indicated for women with CLD and incontinence.
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- 2019
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35. Recovery Following Acute Exacerbations of Chronic Obstructive Pulmonary Disease – A Review
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Bruna Wageck, Narelle S Cox, and Anne E Holland
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Chronic bronchitis ,Time Factors ,Exacerbation ,Health Status ,Psychological intervention ,Pulmonary disease ,Systemic inflammation ,Pulmonary Disease, Chronic Obstructive ,Quality of life ,medicine ,Humans ,Intensive care medicine ,Exercise ,Lung ,Inflammation ,COPD ,Exercise Tolerance ,business.industry ,Common cold ,Recovery of Function ,medicine.disease ,Acute Disease ,Disease Progression ,Quality of Life ,medicine.symptom ,business ,Biomarkers - Abstract
Acute exacerbations are associated with disease progression, hospital admission and death in people with chronic obstructive pulmonary disease (COPD). The detrimental outcomes associated with acute exacerbations highlights a need to understand the time course of recovery following acute exacerbation of COPD (AECOPD) so that effective and timely interventions can be provided. The aim of this narrative review was to describe the natural recovery in physiology, symptoms and function following AECOPD. Substantial recovery of lung function and airway inflammation occurs in the first week after onset of an AECOPD, whilst systemic inflammatory markers may take up to two weeks to recover. Symptoms generally improve over the first 14 days, however marked variation is evident between studies and individuals. There are limited data regarding the time course of recovery for functional capacity, quality of life and strength. In a small number of patients (
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- 2019
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36. Pulmonary Rehabilitation does not Improve Objective Measures of Sleep Quality in People with Chronic Obstructive Pulmonary Disease
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Janet Bondarenko, Véronique Pepin, Caroline Nicolson, Angela T Burge, Anne E Holland, Christine F McDonald, Rosemary Moore, Annemarie L. Lee, Aroub Lahham, Catherine J. Hill, Narelle S Cox, and Zohra Parwanta
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Pulmonary disease ,Equivalence Trials as Topic ,Pulmonary Disease, Chronic Obstructive ,03 medical and health sciences ,0302 clinical medicine ,Forced Expiratory Volume ,medicine ,Humans ,Pulmonary rehabilitation ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,COPD ,Sleep quality ,business.industry ,Actigraphy ,Middle Aged ,Sleep Latency ,medicine.disease ,Sleep in non-human animals ,Poor sleep ,030228 respiratory system ,Physical therapy ,Female ,Energy Metabolism ,Sleep ,business ,Sleep duration - Abstract
Abnormal sleep duration is associated with poor health. Upwards of 50% of people with chronic obstructive pulmonary disease (COPD) report poor sleep quality. The effect of pulmonary rehabilitation on self-reported sleep quality is variable. The aim of this study was to assess the effect of pulmonary rehabilitation on objectively measured sleep quality (via actigraphy) in people with COPD. Sleep quality was assessed objectively using the SenseWear Armband (SWA, BodyMedia, Pittsburgh, PA), worn for ≥4 days before and immediately after completing an 8-week pulmonary rehabilitation program. Sleep characteristics were derived from accelerometer positional data and registration of sleep state by the SWA, determined from energy expenditure. Forty-eight participants (
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- 2019
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37. Feasibility of Ballistic Strength Training in Subacute Stroke: A Randomized, Controlled, Assessor-Blinded Pilot Study
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Melissa J. Raymond, Genevieve Hendrey, Anne E Holland, Benjamin F. Mentiplay, Gavin Williams, Cristie Windfeld-Lund, Ross A. Clark, and Carly Davis
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Male ,030506 rehabilitation ,medicine.medical_specialty ,Randomization ,Strength training ,medicine.medical_treatment ,Psychological intervention ,Pilot Projects ,Physical Therapy, Sports Therapy and Rehabilitation ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,Randomized controlled trial ,Quality of life ,law ,Muscle Stretching Exercises ,medicine ,Humans ,Single-Blind Method ,Exercise ,Gait ,Stroke ,Muscle Weakness ,Rehabilitation ,business.industry ,Stroke Rehabilitation ,Middle Aged ,medicine.disease ,Treatment Outcome ,Lower Extremity ,Quality of Life ,Physical therapy ,Feasibility Studies ,Female ,Ballistic training ,0305 other medical science ,business ,030217 neurology & neurosurgery - Abstract
To establish the feasibility and effectiveness of a 6-week ballistic strength training protocol in people with stroke.Randomized, controlled, assessor-blinded study.Subacute inpatient rehabilitation.Consecutively admitted inpatients with a primary diagnosis of first-ever stroke with lower limb weakness, functional ambulation category score of ≥3, and ability to walk ≥14 m were screened for eligibility to recruit 30 participants for randomization.Participants were randomized to standard therapy or ballistic strength training 3 times per week for 6 weeks.The primary aim was to evaluate feasibility and outcomes included recruitment rate, participant retention and attrition, feasibility of the exercise protocol, therapist burden, and participant safety. Secondary outcomes included measures of mobility, lower limb muscle strength, muscle power, and quality of life.A total of 30 participants (11% of those screened) with mean age of 50 years (SD 18) were randomized. The median number of sessions attended was 15 of 18 and 17 of 18 for the ballistic and control groups, respectively. Earlier than expected discharge to home (n=4) and illness (n=7) were the most common reasons for nonattendance. Participants performed the exercises safely, with no study-related adverse events. There were significant (P.05) between-group changes favoring the ballistic group for comfortable gait velocity (mean difference [MD] 0.31m/s, 95% confidence interval [CI]: 0.08-0.52), muscle power, as measured by peak jump height (MD 8cm, 95% CI: 3-13), and peak propulsive velocity (MD 64cm/s, 95% CI: 17-112).Ballistic training was safe and feasible in select ambulant people with stroke. Similar rates of retention and attrition suggest that ballistic training was acceptable to patients. Secondary outcomes provide promising results that warrant further investigation in a larger trial.
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- 2018
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38. The minimal important difference of the ICU mobility scale
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Anne E Holland, Tom Crawford, Claire J Tipping, Nick Halliburton, Carol L. Hodgson, and Meg Harrold
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Adult ,Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Critical Care ,Movement ,medicine.medical_treatment ,Critical Care and Intensive Care Medicine ,law.invention ,03 medical and health sciences ,0302 clinical medicine ,law ,medicine ,Humans ,Prospective Studies ,030212 general & internal medicine ,Aged ,Rehabilitation ,Adult patients ,business.industry ,Reproducibility of Results ,030208 emergency & critical care medicine ,Mean age ,Middle Aged ,Intensive care unit ,Hospitalization ,Global Rating ,Intensive Care Units ,Standard error ,ROC Curve ,Scale (social sciences) ,Physical therapy ,Female ,Observational study ,Cardiology and Cardiovascular Medicine ,business - Abstract
Background The intensive care unit mobility scale (IMS) is reliable, valid and responsive. Establishing the minimal important difference (MID) of the IMS is important in order to detect clinically significant changes in mobilization. Objective To calculate the MID of the IMS in intensive care unit patients. Methods Prospective multi center observational study. The IMS was collected from admission and discharge physiotherapy assessments. To calculate the MID we used; anchor based methods (global rating of change) and two distribution-based methods (standard error of the mean and effect size). Results We enrolled 184 adult patients; mean age 62.0 years, surgical, trauma, and medical. Anchor based methods gave a MID of 3 with area under the curve 0.94 (95% CI 0.89-0.97). The two distribution based methods gave a MID between 0.89 and 1.40. Conclusion These data increase our understanding of the clinimetric properties of the IMS, improving its utility for clinical practice and research.
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- 2018
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39. Short- and Long-Term Reliability of the 6-Minute Walk Test in People With Idiopathic Pulmonary Fibrosis
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Nicole S L Goh, Anne E Holland, Leona M. Dowman, Christine F McDonald, Catherine J. Hill, Ian Glaspole, and Annemarie Louise Lee
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Male ,Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Time Factors ,Intraclass correlation ,medicine.medical_treatment ,Walk Test ,Critical Care and Intensive Care Medicine ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,0302 clinical medicine ,Heart Rate ,Diffusing capacity ,Internal medicine ,Heart rate ,Humans ,Learning ,Medicine ,Pulmonary rehabilitation ,Oximetry ,030212 general & internal medicine ,Aged ,Aged, 80 and over ,Exercise Tolerance ,medicine.diagnostic_test ,business.industry ,Pulmonary Diffusing Capacity ,Reproducibility of Results ,General Medicine ,Middle Aged ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,Oxygen ,Pulse oximetry ,030228 respiratory system ,Cardiology ,Female ,business ,Nadir (topography) - Abstract
BACKGROUND: The aim of this work was to investigate the short- and long-term test-retest reliability of the 6-min walk distance (6MWD), peak heart rate, and nadir oxygen desaturation in idiopathic pulmonary fibrosis (IPF). METHODS: A reliability study of 70 adults with IPF was undertaken within out-patient pulmonary rehabilitation programs at 2 tertiary hospitals. Participants completed 2 baseline 6-min walk tests using a standard protocol, with continuous measures of percutaneous SpO2 and heart rate via pulse oximetry. The 6-min walk test was completed immediately following an intervention period and 6 months after. Reproducibility was assessed by intraclass correlation coefficient and Bland-Altman analysis. RESULTS: Participants with a mean ± SD diffusing capacity of the lung for carbon monoxide of 48 ± 14% were included. The reliability of the 6MWD was high (intraclass correlation coefficient = 0.96) with a mean learning effect of 21 m (95% CI 12–30 m). The learning effect persisted at 8 weeks (mean 14 m, 95% CI 5–23 m) but not 6 months (mean 15 m, 95% CI −1 to 30 m). Using the best (greatest) 6MWD significantly reduced the proportion of participants who were classified as having a clinically important response to rehabilitation compared with using the first 6MWD (40% vs 54%, P = .002). Nadir SpO2 was reproducible, with a mean difference of 0.7 ± 2.2%, and limits of agreement of −4 to 5%. Peak heart rate was more variable, with mean difference 5 ± 9 beats/min and limits of agreement of −12 to 20 beats/min. CONCLUSIONS: The 6MWD is a reproducible measure of exercise capacity in people with IPF. Whereas the nadir SpO2 may be accurately determined from one test, evaluating change in 6MWD with interventions may require 2 tests on each occasion. (ClinicalTrials.gov registration NCT0016828.)
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- 2018
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40. The Need for Expanding Pulmonary Rehabilitation Services
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Aroub Lahham and Anne E Holland
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medicine.medical_specialty ,Referral ,Coronavirus disease 2019 (COVID-19) ,Science ,medicine.medical_treatment ,Review ,General Biochemistry, Genetics and Molecular Biology ,Health care ,Pandemic ,Medicine ,Pulmonary rehabilitation ,health care services ,Intensive care medicine ,Ecology, Evolution, Behavior and Systematics ,integrated care ,business.industry ,COVID-19 ,Paleontology ,chronic respiratory disease ,pulmonary rehabilitation ,Integrated care ,Clinical Practice ,Space and Planetary Science ,Lung disease ,health service design ,business - Abstract
Pulmonary rehabilitation is a strongly recommended and effective treatment for people with chronic lung disease. However, access to pulmonary rehabilitation is poor. Globally, pulmonary rehabilitation is accessed by less than 3% of people with chronic lung disease. Barriers to referral, uptake and completion of pulmonary rehabilitation are well documented and linked with organizational, practitioner and patient-related factors. Enhancing the knowledge of health care professionals, family carers, and people with chronic lung disease about the program and its benefits produces modest increases in referral and uptake rates, but evidence of the sustainability of such approaches is limited. Additionally, initiatives focusing on addressing organizational barriers to access, such as expanding services and implementing alternative models to the conventional center-based setting, are not yet widely used in clinical practice. The COVID-19 pandemic has highlighted the urgent need for health care systems to deliver pulmonary rehabilitation programs remotely, safely, and efficiently. This paper will discuss the pressing need to address the issue of the low accessibility of pulmonary rehabilitation. It will also highlight the distinctive challenges to pulmonary rehabilitation delivery in rural and remote regions, as well as low-income countries.
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- 2021
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41. Treatment of idiopathic pulmonary fibrosis in Australia and New Zealand: A position statement from the Thoracic Society of Australia and New Zealand and the Lung Foundation Australia
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Anne E Holland, Sally de Boer, Leonie J Jones, Christopher Grainge, Margaret Wilsher, Peter Hopkins, Ian Glaspole, Sally Chapman, Paul N. Reynolds, Helen Whitford, Tamera J. Corte, Helen E. Jo, Gregory J. Keir, Daniel C. Chambers, David Beatson, Yuben Moodley, Nicole S L Goh, and Lauren K. Troy
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,Indoles ,Pyridones ,medicine.medical_treatment ,Population ,Comorbidity ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,chemistry.chemical_compound ,0302 clinical medicine ,Pulmonary Medicine ,Humans ,Medicine ,Pulmonary rehabilitation ,030212 general & internal medicine ,education ,Intensive care medicine ,Societies, Medical ,Randomized Controlled Trials as Topic ,education.field_of_study ,Evidence-Based Medicine ,Lung ,business.industry ,Anti-Inflammatory Agents, Non-Steroidal ,Australia ,Interstitial lung disease ,Pirfenidone ,respiratory system ,medicine.disease ,Idiopathic Pulmonary Fibrosis ,humanities ,respiratory tract diseases ,Clinical trial ,medicine.anatomical_structure ,030228 respiratory system ,chemistry ,Disease Progression ,Physical therapy ,Nintedanib ,business ,New Zealand ,medicine.drug - Abstract
Idiopathic pulmonary fibrosis (IPF) is a fibrosing interstitial lung disease (ILD) of unknown aetiology with a median survival of only 2–5 years. It is characterized by progressive dyspnoea and worsening lung function, ultimately resulting in death. Until recently, there were no effective therapies for IPF; however, with the publication of two landmark clinical trials in 2014, the anti-fibrotic therapies, nintedanib and pirfenidone, have gained widespread approval. This position paper aims to highlight the current evidence for the treatment of IPF, with particular application to the Australian and New Zealand population. We also consider areas in which evidence is currently lacking, especially with regard to the broader IPF severity spectrum and treatment of co-morbid conditions. The utility of non-pharmacological therapies including pulmonary rehabilitation, oxygen as well as symptom management thought to be important in the holistic care of IPF patients are also discussed.
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- 2017
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42. Does home-based pulmonary rehabilitation improve functional capacity, peripheral muscle strength and quality of life in patients with bronchiectasis compared to standard care?
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Rodrigo Abensur Athanazio, Samia Zahi Rached, Rafael Stelmach, Anne E Holland, Alberto Cukier, Cristiane Santos de Oliveira, Simone Dal Corso, Rejane Agnelo Silva de Castro, Jessyca Pachi Rodrigues Selman, and Anderson José
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Quality of life ,medicine.medical_specialty ,Randomization ,Clinical Trial Protocol ,Exercise test ,medicine.medical_treatment ,Psychological intervention ,Physical Therapy, Sports Therapy and Rehabilitation ,Walking ,law.invention ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Physical medicine and rehabilitation ,Randomized controlled trial ,law ,Exercise tolerance ,medicine ,Aerobic exercise ,Humans ,Orthopedics and Sports Medicine ,Pulmonary rehabilitation ,030212 general & internal medicine ,Muscle Strength ,Exercise ,Bronchiectasis ,Rehabilitation ,business.industry ,Resistance Training ,medicine.disease ,030228 respiratory system ,Physical therapy ,business - Abstract
Highlights • Home-based pulmonary rehabilitation (HBPR) has been used in several chronic pulmonary obstructive diseases. • HBPR has never been investigated in patients with bronchiectasis. • Short- and long-term effects of HBPR will be investigated in this population. • The study will provide evidence to guide recommendations about HBPR for bronchiectasis., Background Home-based pulmonary rehabilitation is a promising intervention that may help patients to overcome the barriers to undergoing pulmonary rehabilitation. However, home-based pulmonary rehabilitation has not yet been investigated in patients with bronchiectasis. Objectives To investigate the effects of home-based pulmonary rehabilitation in patients with bronchiectasis. Methods An open-label, randomized controlled trial with 48 adult patients with bronchiectasis will be conducted. Interventions: The program will consist of three sessions weekly over a period of 8 weeks. Aerobic exercise will consist of stepping on a platform for 20 min (intensity: 60–80% of the maximum stepping rate in incremental step test). Resistance training will be carried out using an elastic band for the following muscles: quadriceps, hamstrings, deltoids, and biceps brachii (load: 70% of maximum voluntary isometric contraction). Control: The patients will receive an educational manual and a recommendation to walk three times a week for 30 min. All patients will receive a weekly phone call to answer questions and to guide the practice of physical activity. The home-based pulmonary rehabilitation group also will receive a home visit every 15 days. Main outcome measures: incremental shuttle walk test, quality of life, peripheral muscle strength, endurance shuttle walk test, incremental step test, dyspnea, and physical activity in daily life. The assessments will be undertaken at baseline, after the intervention, and 8 months after randomization. Discussion The findings of this study will determine the clinical benefits of home-based pulmonary rehabilitation and will contribute to future guidelines for patients with bronchiectasis. Trial registration:www.ClinicalTrials.gov (NCT02731482). https://register.clinicaltrials.gov/prs/app/action/SelectProtocol?sid=S00060X6&selectaction=Edit&uid=U00028HR&ts=2&cx=1jbszg
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- 2017
43. Portable oxygen concentrators versus oxygen cylinder during walking in interstitial lung disease: A randomized crossover trial
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Christine F McDonald, Yet H. Khor, Ian Glaspole, Anita Hazard, Karen Symons, Glen P. Westall, Nicole S L Goh, and Anne E Holland
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,business.industry ,medicine.medical_treatment ,Oxygen concentrator ,chemistry.chemical_element ,Crossover study ,Oxygen ,Surgery ,03 medical and health sciences ,0302 clinical medicine ,030228 respiratory system ,chemistry ,Internal medicine ,Oxygen therapy ,Ambulatory ,medicine ,Room air distribution ,Cardiology ,Breathing ,030212 general & internal medicine ,business ,Oxygen saturation (medicine) - Abstract
Background and objective Ambulatory oxygen therapy is often provided to patients with interstitial lung disease (ILD). Lightweight portable oxygen concentrators (POCs) provide an alternative to traditional portable systems such as compressed oxygen cylinders; however, their efficacy in patients with ILD has not been assessed. This study aimed to evaluate the clinical performance of three ambulatory oxygen systems (two different POCs and a compressed oxygen cylinder) during 6-min walk tests (6MWTs) in patients with ILD and exertional desaturation. Methods A total of 20 participants with ILD of varying aetiologies who demonstrated exertional desaturation to
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- 2017
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44. Mucoactive agents for chronic, non-cystic fibrosis lung disease: A systematic review and meta-analysis
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Benjamin J. Tarrant, Bruce Thompson, Lorena Romero, Brenda M. Button, Caitlin Le Maitre, Anne E Holland, and Ranjana Steward
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Pulmonary and Respiratory Medicine ,Spirometry ,medicine.medical_specialty ,COPD ,Bronchiectasis ,medicine.diagnostic_test ,business.industry ,Dornase alfa ,medicine.disease ,Cystic fibrosis ,respiratory tract diseases ,Hypertonic saline ,03 medical and health sciences ,FEV1/FVC ratio ,0302 clinical medicine ,030228 respiratory system ,Internal medicine ,medicine ,030212 general & internal medicine ,Intensive care medicine ,business ,Asthma ,medicine.drug - Abstract
Inhaled mucoactive agents are used in respiratory disease to improve mucus properties and enhance secretion clearance. The effect of mannitol, recombinant human deoxyribonuclease/dornase alfa (rhDNase) and hypertonic saline (HS) or normal saline (NS) are not well described in chronic lung conditions other than cystic fibrosis (CF). The aim of this review was to determine the benefit and safety of inhaled mucoactive agents outside of CF. We searched Medline, Embase, CINAHL and CENTRAL for randomized controlled trials investigating the effects of mucoactive agents on lung function, adverse events (AEs), health-related quality of life (HRQOL), hospitalization, length of stay, exacerbations, sputum clearance and inflammation. There were detrimental effects of rhDNase in bronchiectasis, with average declines of 1.9–4.3% in forced expiratory volume in 1 s (FEV1 ) and 3.7–5.4% in forced vital capacity (FVC) (n = 410, two studies), and increased exacerbation risk (relative risk = 1.35, 95% CI = 1.01–1.79 n = 349, one study). Some participants exhibited a reduction in FEV1 (≥10–15%) with mucoactive agents on screening (mannitol = 158 of 1051 participants, rhDNase = 2 of 30, HS = 3 of 80). Most AEs were mild and transient, including bronchospasm, cough and breathlessness. NS eased symptomatic burden in COPD, while NS and HS improved spirometry, HRQOL and sputum burden in non-CF bronchiectasis. Mannitol improved mucociliary clearance in asthma and bronchiectasis, while the effects of N-acetylcysteine were unclear. In chronic lung diseases outside CF, there are small benefits of mannitol, NS and HS. Adverse effects of rhDNase suggest this should not be administered in non-CF bronchiectasis.
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- 2017
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45. Australian and New Zealand Pulmonary Rehabilitation Guidelines
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Andrew S. L. Chan, Vanessa M. McDonald, Sarah Candy, Renae J McNamara, Sue Jenkins, Christian R. Osadnik, Anne E Holland, Leona M. Dowman, Peter Jung, Sally L. Wootton, Zoe J. McKeough, Marita Dale, Paul Cafarella, Michelle E Brooke, Catherine L Granger, Nola Cecins, James R. Walsh, Jennifer A. Alison, Regina Leung, Simon Halloran, Catherine J. Hill, Tamara Matulick, Helen Cameron-Tucker, Annemarie L. Lee, Mary Roberts, Lissa Spencer, Peter Frith, and Kylie Johnston
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,education.field_of_study ,COPD ,business.industry ,medicine.medical_treatment ,Population ,Interstitial lung disease ,Guideline ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Quality of life (healthcare) ,Systematic review ,030228 respiratory system ,Family medicine ,Health care ,medicine ,Physical therapy ,Pulmonary rehabilitation ,030212 general & internal medicine ,education ,business - Abstract
Background and objective The aim of the Pulmonary Rehabilitation Guidelines (Guidelines) is to provide evidence-based recommendations for the practice of pulmonary rehabilitation (PR) specific to Australian and New Zealand healthcare contexts. Methods The Guideline methodology adhered to the Appraisal of Guidelines for Research and Evaluation (AGREE) II criteria. Nine key questions were constructed in accordance with the PICO (Population, Intervention, Comparator, Outcome) format and reviewed by a COPD consumer group for appropriateness. Systematic reviews were undertaken for each question and recommendations made with the strength of each recommendation based on the GRADE (Gradings of Recommendations, Assessment, Development and Evaluation) criteria. The Guidelines were externally reviewed by a panel of experts. Results The Guideline panel recommended that patients with mild-to-severe COPD should undergo PR to improve quality of life and exercise capacity and to reduce hospital admissions; that PR could be offered in hospital gyms, community centres or at home and could be provided irrespective of the availability of a structured education programme; that PR should be offered to patients with bronchiectasis, interstitial lung disease and pulmonary hypertension, with the latter in specialized centres. The Guideline panel was unable to make recommendations relating to PR programme length beyond 8 weeks, the optimal model for maintenance after PR, or the use of supplemental oxygen during exercise training. The strength of each recommendation and the quality of the evidence are presented in the summary. Conclusion The Australian and New Zealand Pulmonary Rehabilitation Guidelines present an evaluation of the evidence for nine PICO questions, with recommendations to provide guidance for clinicians and policymakers.
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- 2017
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46. Beyond forest plots: clinical gestalt and its influence on COPD telemonitoring studies and outcomes review
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Sheree M. Smith, Anne E Holland, and Christine F McDonald
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Chronic condition ,medicine.medical_specialty ,020205 medical informatics ,Cost effectiveness ,emergency care ,MEDLINE ,Context (language use) ,02 engineering and technology ,CINAHL ,Cochrane Library ,chronic obstructive pulmonary disease ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,length of stay ,0202 electrical engineering, electronic engineering, information engineering ,medicine ,Humans ,030212 general & internal medicine ,Respiratory Medicine ,health technology ,Original Research ,business.industry ,telemonitoring ,General Medicine ,Emergency department ,Telemedicine ,Systematic review ,Treatment Outcome ,Family medicine ,business - Abstract
BackgroundChronic obstructive pulmonary disease (COPD) is a progressive chronic condition. Improvements in therapies have resulted in better patient outcomes. The use of technology such as telemonitoring as an additional intervention is aimed at enhancing care and reducing unnecessary acute hospital service use. The influence of verbal communication between health staff and patients to inform decision making regarding use of acute hospital services within telemonitoring studies has not been assessed.MethodA systematic overview of published systematic reviews of COPD and telemonitoring was conducted using ana prioriprotocol to ascertain the impact of verbal communication in telemonitoring studies on health service outcomes such as emergency department attendances, hospitalisation and hospital length of stay. The search of the following electronic databases: Cochrane Library, Medline, Pubmed, CINAHL, Embase, TROVE, Australian Digital Thesis and Proquest International Dissertations and Theses was conducted in 2017 and updated in September 2019.ResultsSix systematic reviews were identified. All reviews involved home monitoring of COPD symptoms and biometric data. Included reviews reported 5–28 studies with sample sizes ranging from 310 to 2891 participants. Many studies reported in the systematic reviews were excluded as they were telephone support, cost effectiveness studies, and/or did not report the outcomes of interest for this overview. Irrespective of group assignment, verbal communication with the health or research team did not alter the emergency attendance or hospitalisation outcome. The length of stay was longer for those who were assigned home telemonitoring in the majority of studies.ConclusionThis overview of telemonitoring for COPD had small sample sizes and a wide variety of included studies. Communication was not consistent in all included studies. Understanding the context of communication with study participants and the decision-making process for referring patients to various health services needs to be reported in future studies of telemonitoring and COPD.
- Published
- 2019
47. Seasonal variations in objectively assessed physical activity among people with COPD in two Nordic countries and Australia: a cross-sectional study
- Author
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Bente Morseth, Anne E Holland, Hanne Hoaas, Birthe Dinesen, Narelle S Cox, Paolo Zanaboni, Angela T Burge, and Audhild Hjalmarsen
- Subjects
Male ,Time Factors ,Cross-sectional study ,Denmark ,Health Status ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Medicine ,030212 general & internal medicine ,Lung ,Original Research ,Randomized Controlled Trials as Topic ,COPD ,seasons ,Exercise Tolerance ,Norway ,Minimal clinically important difference ,Chronic obstructive pulmonary disease ,General Medicine ,Middle Aged ,3. Good health ,weather ,language ,Female ,Population comparison ,activity monitoring ,Victoria ,Physical activity ,Norwegian ,Fitness Trackers ,International Journal of Chronic Obstructive Pulmonary Disease ,chronic obstructive pulmonary disease ,Danish ,03 medical and health sciences ,Disease severity ,Humans ,VDP::Medisinske Fag: 700 ,Exercise ,Weather ,Aged ,business.industry ,medicine.disease ,Actigraphy ,language.human_language ,VDP::Medical disciplines: 700 ,Cross-Sectional Studies ,030228 respiratory system ,Sedentary Behavior ,business ,population comparison ,Demography - Abstract
Hanne Hoaas,1,2 Paolo Zanaboni,1 Audhild Hjalmarsen,3,4 Bente Morseth,5 Birthe Dinesen,6 Angela T Burge,7–9 Narelle S Cox,7,9 Anne E Holland7–91Norwegian Centre for E-health Research, University Hospital of North Norway, Tromsø, Norway; 2Faculty of Health Sciences, UiT The Arctic University of Norway, Tromsø, Norway; 3Department of Clinical Medicine, UiT The Arctic University of Norway, Tromsø, Norway; 4Department of Pulmonary Medicine, University Hospital of North Norway, Tromsø, Norway; 5School of Sport Sciences, UiT The Arctic University of Norway, Tromsø, Norway; 6Laboratory of Welfare Technologies – Telehealth & Telerehabilitation, SMI, Department of Health Science and Technology, Aalborg University, Aalborg, Denmark; 7Discipline of Physiotherapy, La Trobe University, Melbourne, Australia; 8Department of Physiotherapy, Alfred Health, Melbourne, Australia; 9Institute for Breathing and Sleep, Melbourne, AustraliaPurpose: Seasons and weather conditions might influence participation in physical activity and contribute to differences between countries. This study aimed at investigating whether there were differences in physical activity levels between Norwegian, Danish and Australian people with chronic obstructive pulmonary disease (COPD), and establishing if any variations in physical activity were attributable to seasons.Patients and methods: A cross-sectional study where study subjects were people with COPD who participated in two separate clinical trials: the iTrain study (Norway, Denmark, and Australia) and the HomeBase study (Australia). Physical activity was objectively assessed with an activity monitor; variables were total energy expenditure, number of daily steps, awake sedentary time, light, and moderate-to-vigorous intensity physical activity. Differences in physical activity between countries and seasons were compared, with adjustment for disease severity.Results: In total, 168 participants were included from Norway (N=38), Denmark (N=36) and Australia (N=94). After controlling for disease severity, time spent in awake sedentary time was greater in Danish participants compared to the other countries (median 784 minutes/day [660–952] vs 775 minutes/day [626–877] for Norwegians vs 703 minutes/day [613–802] for Australians, P=0.013), whilst time spent in moderate to vigorous physical activity was lower (median 21 minutes/day [4–73] vs 30 minutes/day [7–93] for Norwegians vs 48 minutes/day [19–98] for Australians, P=0.024). Participants walked more during summer (median 3502 [1253–5407] steps/day) than in spring (median 2698 [1613–5207] steps/day), winter (median 2373 [1145–4206] steps/day) and autumn (median 1603 [738–4040] steps/day), regardless of geography. The median difference between summer and other seasons exceeded the minimal clinically important difference of 600 steps/day. However, the differences were not statistically significant (P=0.101).Conclusion: After controlling for disease severity, Danish participants spent more time in an awake sedentary state and less time in moderate to vigorous physical activity than their counterparts in Norway and Australia. People with COPD increased their physical activity in summer compared to other seasons. Weather conditions and seasonal variations may influence outcomes in clinical trials and health registries measuring physical activity over time, irrespective of the interventions delivered, and should be taken into account when interpreting results.Keywords: chronic obstructive pulmonary disease, activity monitoring, population comparison, seasons, weather  
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- 2019
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48. Greater endurance capacity and improved dyspnoea with acute oxygen supplementation in idiopathic pulmonary fibrosis patients without resting hypoxaemia
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Ross Vlahos, Steven Bozinovski, Christine F McDonald, Leona M. Dowman, Rebecca Gillies, Nicole S L Goh, Catherine J. Hill, Anne E Holland, and Dodie S. Pouniotis
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Pulmonary and Respiratory Medicine ,medicine.medical_specialty ,biology ,business.industry ,Hypoxia (medical) ,medicine.disease ,medicine.disease_cause ,Surgery ,03 medical and health sciences ,Idiopathic pulmonary fibrosis ,0302 clinical medicine ,Blood pressure ,030228 respiratory system ,Internal medicine ,Heart rate ,medicine ,Breathing ,biology.protein ,Cardiology ,TBARS ,Creatine kinase ,030212 general & internal medicine ,medicine.symptom ,business ,Oxidative stress - Abstract
Background and objective: Supplemental oxygen is commonly prescribed in patients with idiopathic pulmonary fibrosis (IPF), although its benefits have not been proven. The aims of this study were to investigate the effect of oxygen on oxidative stress, cytokine production, skeletal muscle metabolism and physiological response to exercise in IPF. Methods: Eleven participants with IPF received either oxygen, at an FiO2 of 0.50, or compressed air for 1h at rest and during a cycle endurance test at 85% of peak work rate. Blood samples collected at rest and during exercise were analysed for markers of oxidative stress, skeletal muscle metabolism and cytokines. The protocol was repeated a week later with the alternate intervention. Results: Compared with air, oxygen did not adversely affect biomarker concentrations at rest and significantly improved endurance time (mean difference=99±81s, P=0.002), dyspnoea (-1±1U, P=0.02), systolic blood pressure (BP; -11±11mm Hg, P=0.006), nadir oxyhaemoglobin saturation (SpO2 ; 8±6%, P=0.001), SpO2 at 2-min (7±6%, P=0.003) and 5-min isotimes (5±3, P< 0.001) and peak exercise xanthine concentrations (-42±73μmol/L, P=0.03). Air significantly increased IL-10 (5±5pg/mL, P=0.04) at 2-min isotime. Thiobarbituric acid-reactive substances (TBARs), IL-6, TNF-α, creatine kinase, lactate, heart rate and fatigue did not differ between the two interventions at any time point. Conclusion: In patients with IPF, breathing oxygen at FiO2 of 0.50 at rest seems safe. During exercise, oxygen improves exercise tolerance, alleviates exercise-induced hypoxaemia and reduces dyspnoea. A potential relationship between oxygen administration and improved skeletal muscle metabolism should be explored in future studies.
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- 2017
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49. Exercise training alone or with the addition of activity counseling improves physical activity levels in COPD: a systematic review and meta-analysis of randomized controlled trials
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Aroub Lahham, Anne E Holland, and Christine F McDonald
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Counseling ,Male ,medicine.medical_specialty ,Time Factors ,medicine.medical_treatment ,Health Status ,Psychological intervention ,MEDLINE ,physical activity ,CINAHL ,Review ,International Journal of Chronic Obstructive Pulmonary Disease ,Severity of Illness Index ,law.invention ,03 medical and health sciences ,Pulmonary Disease, Chronic Obstructive ,0302 clinical medicine ,Randomized controlled trial ,law ,Forced Expiratory Volume ,medicine ,Humans ,Pulmonary rehabilitation ,030212 general & internal medicine ,interventions ,Exercise ,Lung ,Uncategorized ,pulmonary disease ,Aged ,Randomized Controlled Trials as Topic ,Aged, 80 and over ,COPD ,Chi-Square Distribution ,Exercise Tolerance ,chronic obstructive ,business.industry ,General Medicine ,Recovery of Function ,Middle Aged ,medicine.disease ,Confidence interval ,Exercise Therapy ,Treatment Outcome ,030228 respiratory system ,Meta-analysis ,Physical therapy ,Female ,business - Abstract
Aroub Lahham,1,2 Christine F McDonald,2–4 Anne E Holland1,2,5 1Discipline of Physiotherapy, La Trobe University, 2Institute for Breathing and Sleep, 3Department of Respiratory and Sleep Medicine, Austin Health, 4Department of Medicine, The University of Melbourne, 5Department of Physiotherapy, Alfred Health, Melbourne, VIC, Australia Background: Physical inactivity is associated with poor outcomes in COPD, and as a result, interventions to improve physical activity (PA) are a current research focus. However, many trials have been small and inconclusive.Objective: The aim of this systematic review and meta-analysis was to study the effects of randomized controlled trials (RCTs) targeting PA in COPD.Methods: Databases (Physiotherapy Evidence Database [PEDro], Embase, MEDLINE, CINAHL and the Cochrane Central Register for Controlled Trials) were searched using the following keywords: “COPD”, “intervention” and “physical activity” from inception to May 20, 2016; published RCTs that aimed to increase PA in individuals with COPD were included. The PEDro scale was used to rate study quality. Standardized mean differences (effect sizes, ESs) with 95% confidence intervals (CIs) were determined. Effects of included interventions were also measured according to the minimal important difference (MID) in daily steps for COPD (599 daily steps).Results: A total of 37 RCTs with 4,314 participants (mean forced expiratory volume in one second (FEV1) % predicted 50.5 [SD=10.4]) were identified. Interventions including exercise training (ET; n=3 studies, 103 participants) significantly increased PA levels in COPD compared to standard care (ES [95% CI]; 0.84 [0.44–1.25]). The addition of activity counseling to pulmonary rehabilitation (PR; n=4 studies, 140 participants) showed important effects on PA levels compared to PR alone (0.47 [0.02–0.92]), achieving significant increases that exceeded the MID for daily steps in COPD (mean difference [95% CI], 1,452 daily steps [549–2,356]). Reporting of methodological quality was poor in most included RCTs.Conclusion: Interventions that included ET and PA counseling during PR were effective strategies to improve PA in COPD. Keywords: pulmonary disease, chronic obstructive, physical activity, interventions
- Published
- 2016
50. An observational study on usual physiotherapy care in a stroke rehabilitation unit
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Genevieve Hendrey, Anne E Holland, Ross A. Clark, and Gavin Williams
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030506 rehabilitation ,medicine.medical_specialty ,Rehabilitation ,Stroke patient ,business.industry ,medicine.medical_treatment ,Psychological intervention ,Physical Therapy, Sports Therapy and Rehabilitation ,Rehabilitation unit ,medicine.disease ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Gait training ,Usual care ,Physical therapy ,Medicine ,Observational study ,0305 other medical science ,business ,Stroke ,030217 neurology & neurosurgery - Abstract
Aim: To document the range of physiotherapy interventions undertaken by stroke patients with mobility deficits during ‘usual care’ in inpatient rehabilitation. Methods: Twenty consecutively admitted adults were approached to participate if they met the inclusion criteria: diagnosis of first stroke with leg weakness; functional ambulation category score ≥3; able to mobilise ≥14 metres on level ground; and able to provide consent. All individual physiotherapy sessions for each participant were observed for one day. The duration of each therapy session was recorded, as well as the duration and type of specific physiotherapy interventions. Findings: Twenty participants (12 males, 8 females; mean ± SD age: 69 ± 20 years) were observed. All participants attended at least one individual session of physiotherapy on the day this study was conducted. Physiotherapy sessions lasted 47.8 ± 7.6 minutes, with an average of 17.9 ± 6.9 minutes spent resting. The most frequently provided therapies were: gait training (10.8 ± 4.7 minutes per session); strength training (8.5 ± 7.0 minutes per session); and balance training (6.2 ± 3.6 minutes per session). Conclusions: In this sample of ambulant patients following stroke, inpatient physiotherapy rehabilitation focused on gait training, lower limb strengthening and balance training. Active therapy time was low and long rest periods with no prescribed activity were evident, which suggests therapy time is not optimally utilised in this population.
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- 2016
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