6 results on '"Anabel Chade"'
Search Results
2. Detecting cognitive impairment in patients with Parkinson's disease using a brief cognitive screening tool: Addenbrooke's Cognitive Examination (ACE)
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Anabel Chade, María Roca, Teresa Torralva, Ezequiel Gleichgerrcht, Nicolás Fabbro, Gonzalo Gómez Arévalo, Oscar Gershanik, and Facundo Manes
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Parkinson's disease ,Alzheimer's disease ,frontotemporal dementia ,screening tools ,Addenbrooke's Cognitive Examination (ACE). ,Neurosciences. Biological psychiatry. Neuropsychiatry ,RC321-571 - Abstract
Abstract Detecting cognitive impairment in patients with Parkinson's disease is crucial for good clinical practice given the new therapeutic possibilities available. When full neuropsychological evaluations are not available, screening tools capable of detecting cognitive difficulties become crucial. Objective: The goal of this study was to investigate whether the Spanish version of the Addenbrooke's Cognitive Examination (ACE) is capable of detecting cognitive difficulties in patients with Parkinson's disease and discriminating their cognitive profile from patients with dementia. Methods: 77 early dementia patients (53 with Alzheimer's Disease and 24 with Frontotemporal Dementia), 22 patients with Parkinson's disease, and 53 healthy controls were evaluated with the ACE. Results: Parkinson's disease patients significantly differed from both healthy controls and dementia patients on ACE total score. Conclusions: This study shows that the Spanish version of the ACE is capable of detecting patients with cognitive impairment in Parkinson's disease and is able to differentiate them from patients with dementia based on their general cognitive status. more...
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3. Performance of Patients with Early Parkinson Disease on an Executive and Social Cognition Battery
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Oscar S. Gershanik, Gonzalo Gómez Arévalo, María Roca, Sol Esteves, Facundo Manes, Ezequiel Gleichgerrcht, Anabel Chade, and Teresa Torralva
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Male ,Battery (electricity) ,medicine.medical_specialty ,Cognitive Neuroscience ,Disease ,Neuropsychological Tests ,050105 experimental psychology ,Executive Function ,03 medical and health sciences ,0302 clinical medicine ,Physical medicine and rehabilitation ,Social cognition ,medicine ,Humans ,0501 psychology and cognitive sciences ,Social Behavior ,05 social sciences ,Neuropsychology ,Parkinson Disease ,Cognition ,General Medicine ,Middle Aged ,Psychiatry and Mental health ,Patient population ,Early Diagnosis ,Neuropsychology and Physiological Psychology ,Case-Control Studies ,Female ,Cognitive Assessment System ,Cognition Disorders ,Psychology ,030217 neurology & neurosurgery - Abstract
Objective To demonstrate the usefulness of incorporating the Executive and Social Cognition Battery (ESCB) to detect executive and social cognition deficits, which are otherwise not captured by more "classical" executive tests in early Parkinson disease (PD). Background PD is a neurodegenerative disorder that includes executive and social cognition deficits. While cognitive assessment in PD still relies on classical executive tasks to detect frontal deficits, these traditional tests often fail to uncover subtle, yet relevant, frontal impairment. Methods We evaluated 39 PD patients and 47 controls with a battery of classical executive tests and the ESCB. The ESCB includes a series of tasks that more closely resemble real-life activities and have been previously shown to be useful in detecting executive deficits in other neuropsychiatric disorders with frontal involvement. Results We observed that both batteries used in a complementary way yielded better results, as 15 of the 39 patients presented deficits only on some of the ESCB tests, but not on the classical battery, while 5 patients presented deficits only on some tests of the classical battery, but not on the ESCB. Fourteen patients presented deficits on some tests of either battery, and 5 patients did not present deficits on any of the tests. Conclusions We found that, used along with traditional neuropsychological tasks, the ESCB may be useful in providing a more comprehensive evaluation of frontal dysfunction among patients with PD, thus contributing to the early diagnosis of cognitive disorders in this patient population. more...
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- 2018
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4. Dietary fat intake, pesticide use, and Parkinson's disease
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G. Webster Ross, Honglei Chen, David M. Umbach, Gina Richardson, Meike Kasten, Freya Kamel, Monica Korell, Jane A. Hoppin, Cheryl Meng, Connie Marras, Anabel Chade, Marie Richards Barber, Dale P. Sandler, Caroline M. Tanner, Aaron Blair, J. William Langston, Kathleen Comyns, Grace S. Bhudhikanok, and Samuel M. Goldman more...
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Male ,Aging ,Parkinson's disease ,Physiology ,Rural Health ,Neurodegenerative ,chemistry.chemical_compound ,Paraquat ,Risk Factors ,80 and over ,Food science ,Aged, 80 and over ,Omega-3 ,chemistry.chemical_classification ,Fatty Acids ,Parkinson Disease ,Middle Aged ,Neurology ,Neurological ,Cohort ,Female ,Cognitive Sciences ,Polyunsaturated fatty acid ,Adult ,Clinical Sciences ,Article ,Clinical Research ,Fatty Acids, Omega-3 ,medicine ,Humans ,Pesticides ,Aged ,Nutrition ,Neurology & Neurosurgery ,business.industry ,Prevention ,Neurosciences ,Rotenone ,Odds ratio ,Pesticide ,medicine.disease ,Dietary Fats ,Confidence interval ,Diet ,Brain Disorders ,chemistry ,Case-Control Studies ,Polyunsaturated fatty acids ,Neurology (clinical) ,Geriatrics and Gerontology ,business ,Dietary fat - Abstract
Background: Dietary fat intake may modify Parkinson’s disease (PD) risk directly or by altering the response to environmental neurotoxicants including pesticides. Methods: We conducted a case-control study of PD nested in the Agricultural Health Study (AHS), a cohort of pesticide applicators and spouses. We evaluated diet and pesticide use before diagnosis in 89 PD cases, confirmed by movement disorder specialists, or a corresponding date in 336 frequencymatched controls. Associations were evaluated using multivariate logistic regression to estimate odds ratios (ORs) and 95% confidence intervals (CIs). Results: In the AHS, PD was inversely associated with N-3 polyunsaturated fatty acids (PUFAs) (OR 0.4, 95% CI 0.2e0.8 for highest vs. lowest tertile) and the N-3 precursor a-linolenic acid (0.4, 0.2e0.8). In a meta-analysis of nine studies, including the present one, PD was inversely associated with a-linolenic acid (0.81, 0.68e0.96). In the AHS, associations of PD with the pesticides paraquat and rotenone were modified by fat intake. The OR for paraquat was 4.2 (1.5e12) in individuals with PUFA intake below the median but 1.2 (0.4e3.4) in those with higher intake (p-interaction ¼ 0.10). The OR for rotenone was 5.8 (2.3e15) in those with saturated fat intake above the median but 1.5 (0.5e4.2) in those with lower intake (p-interaction ¼ 0.02). Conclusions: PUFA intake was consistently associated with lower PD risk, and dietary fats modified the association of PD risk with pesticide exposure. If confirmed, these findings suggest that a diet high in PUFAs and low in saturated fats might reduce risk of PD. Published by Elsevier Ltd. more...
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- 2014
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5. Impairments in Social Cognition in Early Medicated and Unmedicated Parkinson Disease
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Gonzalo Gomez Arevalo, María Roca, Ezequiel Gleichgerrcht, Oscar S. Gershanik, Facundo Manes, Anabel Chade, and Teresa Torralva
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Time Factors ,Matched-Pair Analysis ,Cognitive Neuroscience ,Theory of Mind ,Disease ,Neuropsychological Tests ,Statistics, Nonparametric ,Developmental psychology ,Antiparkinson Agents ,Levodopa ,Executive Function ,Cognition ,Degenerative disease ,Quality of life ,Reference Values ,Social cognition ,Theory of mind ,medicine ,Humans ,Aged ,Analysis of Variance ,Social perception ,Parkinson Disease ,General Medicine ,Middle Aged ,Executive functions ,medicine.disease ,Psychiatry and Mental health ,Neuropsychology and Physiological Psychology ,Social Perception ,Case-Control Studies ,Disease Progression ,Psychology ,Clinical psychology - Abstract
Background Theory of mind (ToM) refers to the ability to infer others' mental states, including intentions and feelings, and is considered to be a critical part of social cognition. Earlier studies in individuals with Parkinson disease (PD) have shown ToM deficits in the more advanced stages of the disease. There is currently no evidence of social cognition deficits in patients in the early stages of PD. Methods In this study, we compared patients with early PD (n=36) and a control group of healthy subjects (n=36). Patients were assessed with 2 ToM tasks designed to differentially detect subtle deficits in the affective and cognitive aspects of ToM. Patients were also assessed with a complete neuropsychologic battery which included classic executive tests aimed at investigating the relationship between ToM and executive functions. Performance of medicated (n=16) and unmedicated (n=20) patients was also compared. Results Our results are the first to indicate that ToM is affected in the early stages of PD. As has already been reported in more advanced stages of PD, such deficits seem to be related to the cognitive aspects of this domain. In our study, these deficits were not related with performance on executive functioning, depression, or medication usage. Conclusions These results provide evidence for ToM impairments early in the course of PD. Recognition of ToM impairments in early PD is important, as these deficits may impact patients' social interactions and quality of life. more...
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- 2010
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6. Comparing the Neuropsychiatric Profile of Patients with Alzheimer Disease Who Present Spared versus Impaired Executive Functioning
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Facundo Manes, Anabel Chade, Ezequiel Gleichgerrcht, Teresa Torralva, and María Roca
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medicine.medical_specialty ,Article Subject ,business.industry ,Significant difference ,Neuropsychology ,Functional impact ,lcsh:Geriatrics ,medicine.disease ,Motor symptoms ,lcsh:RC952-954.6 ,medicine ,Clinical Study ,Dementia ,In patient ,Geriatrics and Gerontology ,Alzheimer's disease ,Differential diagnosis ,Psychiatry ,business ,Clinical psychology - Abstract
Background. A “dysexecutive” group of patients with Alzheimer disease (AD) has been previously identified, and these patients have been found to present higher frequency of psychiatric symptoms and more pronounced functional impact. This study aimed at evaluating the frequency of neuropsychiatric symptoms in patients with early AD who present with impaired executive functioning.Methods. Thirty patients with early AD diagnosis were divided into a spared (SEF) and an impaired (IEF) executive functioning group according to their performance scores on neuropsychological tests. Their closest relatives or caregivers completed the Cambridge behavioral inventory (CBI), which assesses behavioral symptoms grouped into 13 categories.Results. A significant difference was exclusively found between SEF and IEF in terms of the frequency of stereotypies and repetitive motor behavior (U=60.5,P=.024).Conclusions. The presence of stereotypies could be associated with a dysexecutive profile in AD patients. These results shed light on the role of frontal circuitry in the expression of motor symptoms in AD and prompt for further research that will contribute to the differential diagnosis both of different subtypes of AD and other types of dementia. more...
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- 2011
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