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Objective: To determine the frequency of NSTEMI (non- st elevation myocardial infarction) in acute coronary syndrome patients presenting with the chest pain in emergency department of tertiary care hospital. Study Design: Cross Sectional study. Setting: Jinnah Post graduate Medical College Hospital Karachi. Period: June 20, 2023. Methods: Enrolling 112 consecutive volunteers was carried out Interview questions focused on the participants’ smoking, blood pressure, diabetes, and type of chest pain. Whether or not the participants had ACS, their diagnosis was documented. NSTEMI frequency was computed. Results: We have 112 patients enrolled with mean age was 52.73±14.24 years. Sixty five (58%) were male while forty seven (41.9 %) were females. out of 112 patients 45 (40.1%) were hypertensive, 32(28.5%) were diabetes and 29 (25.8%) were smoker. Among the participants 21 (18.7%) had NSTEMI and showed positive correlation with age, gender, nature of chest pain, hypertension and smoking. Conclusion: Among the individuals, one of the most frequent causes of chest pain was acute coronary syndrome. High suspicion and additional testing are they key tools for early diagnosis and management. [ABSTRACT FROM AUTHOR]

Immunosuppressants, such as methotrexate (MTX), can suppress the COVID-19 vaccine response in patients with autoimmune diseases. Thus, this study aims to evaluate the effects of MTX hold following COVID-19 vaccination on vaccine efficacy response. A systematic review and meta-analysis of relevant studies retrieved from Web of Science, SCOPUS, PubMed, and CENTRAL from inception until Oct 1, 2023, was conducted. Covidence was used to screen the eligible articles, and all relevant outcomes data were synthesized using risk ratios (RRs) or standardized mean differences (SMDs) with 95% confidence intervals (CIs) in meta-analysis models within RevMan 5.4. PROSPERO ID: CRD42024511628. Four studies with a total of 762 patients with autoimmune inflammatory disorders were included. Holding MTX following the COVID-19 vaccination for approximately 2 weeks was associated with significantly higher antibody titer (SMD: 0.70, 95% CI [0.54, 0.87], P < 0.00001). However, the flare rate was significantly higher in the MTX hold group based on CDAI > 10 or DAS28-CRP > 1.2 either after 1st dose (RR: 2.49 with 95% CI [1.39, 4.47], P = 0.002) or 2nd dose (RR: 2.16 with 95% CI [1.37, 3.41], P = 0.0009) and self-reported disease flare (RR: 1.71 with 95% CI [1.35, 2.17], P < 0.00001). Holding MTX for 2 weeks after the COVID-19 vaccination resulted in significantly higher antibody titer but also had a higher disease flare rate, necessitating cautious clinical monitoring during this period. There is still a need to investigate safer MTX hold duration, considering patients' vulnerability to COVID-19, disease status, and demographics while adopting this strategy. [ABSTRACT FROM AUTHOR]

This study conducted a comprehensive statistical analysis of the symptoms and impact of dengue fever, incorporating additional factors such as prevention awareness, disease control, aftereffects, disease stages, serotypes, recovery, and treatment. Data were gathered through questionnaires from 400 students across various departments at Peshawar University, representing both urban and rural areas. The data were processed using SPSS (Version 20) and analyzed using methods like odds ratio, chisquare, pie charts, and bar charts to examine the different symptoms and impacts of dengue fever in this study the findings revealed that approximately one-third of the respondents aged 18-30 had been affected by dengue fever. The results indicate a significant association between these two variables. Furthermore, the odds ratio of 0.5 suggests that respondents aged 18 to 25 are half as likely to isolate during dengue compared to those aged 26 to 35. The study identified common symptoms such as headache, flu-like symptoms, rash, joint and muscle pain, loss of appetite, abdominal pain, and bleeding from the gums. A majority (68.25%) considered dengue a serious illness, and 63.3% perceived it as more prevalent in urban areas. Additionally, the research indicated that a significant number of respondents were skeptical about the long-term effects of dengue, such as hair loss and alopecia, despite existing evidence suggesting these outcomes this study underscores the importance of understanding the prevalence and implications of dengue fever and emphasizes the need for heightened awareness and effective preventive measures. [ABSTRACT FROM AUTHOR]

Cricket is the sports of the day. Almost all age groups have their association with cricket. Nowadays time is a constraint and people have thrust to earn more money in less time. To attract more people, ICC decided in 2005 to reduce number of overs and time with new exciting rules for cricket matches. To model players' performance with multidimensional factors statistical techniques are found to be so useful and predictable. Present study aims to quantify the worth of bowler, batter and fielder in T-20. Study develops a performance index for performance measurement. The tuned index will help the team selectors to compare performance of players. The technique will help in identifying the best performance and player's induction for coming events. From seven cricket squads a sample of 12 players satisfying the set criteria, is taken from Bangladesh premier league(BPL) 2013-16 and T-20 world cup (WC) 2014-16. Data regarding selected variables are obtained from entertainment and sports programming network (ESPN), the single sport world's leading cricket website. For measurement, each player was observed for a certain skill and the level of skill it has, derived index is ranged from zero to one. High index score reveals a high performance. Shakib Ul Hasan comes up with highest index and is declared as the best player with highest score for both BPL T-20 and WC T-20. [ABSTRACT FROM AUTHOR]

Background: Postpartum Hemorrhage (PPH) is the most common reason of maternal death globally. Misoprostol and oxytocin are two first line and effective management protocols. But controversies exist in literature. For that matter, this study was conducted. Objectives: To compare the frequency of postpartum hemorrhage with per rectal misoprostol in relation to intramuscular oxytocin in females undergoing normal vaginal delivery at term. Methods: This randomized controlled trial was conducted in Department of Obstetrics & Gynaecology, Sheikh Zayed Hospital, Lahore from 01-01-2019 to 01-12-2019. Patients were divided randomly into equal halves through the lottery method. Group A received Misoprostol and group B received Oxytocin. Medications were administered within one minute of clamping and the cutting of cord. During 24 hours, soaked pads were evaluated for blood loss and total blood loss was calculated. If blood loss>500ml, then PPH was labeled. Results: Mean age of women in Group A and in Group-B were 29.11±6.67 and 29.23±6.70 years. The mean gestational age for Group A came as 39.60±1.78 weeks and for Group-B, it was 39.53±1.72. In Group-A 24(15.7%) and in Group-B 59(38.6%) women suffered from PPH. PPH was significantly lower in comparison to the women in Group-B. Pvalue=0.000. Conclusion: Results of this study showed that use of per rectal Misoprostol is more suitable and effective in the prevention of Post-partum hemorrhages compared to oxytocin in females undergoing normal vaginal delivery at term. [ABSTRACT FROM AUTHOR]

A study of the loss of hydrophobicity of high temperature vulcanized (HTV) silicone rubber (SIR) after immersion in saline solutions as a function of time (0 to 3000 h) at different temperatures is reported. The hydrophobicity is determined by measuring the static contact 0 between the tangent to the droplet of distilled water and the horizontal surface of the HTV SIR. The conductivity of the saline solution was varied from 0.005 to 100 mS/cm and the temperature from 0 to 98 °C. The contact angle which gives a measure of the hydrophobicity of the surface decreased sharply during immersion. The contact angle decreased from the original value of 100±4.6° to low value of 15° after 3000 h of immersion at 98 °C in a solution of 0.005 mS/cm. The lower the conductivity, the larger was the decrease in the contact angle. The changes in the weight of the HTV SIR due to the uptake of water and the average surface roughness (ASR) are determined during the immersion. The increase/decrease in the weight and surface roughness of the HTV SIR are correlated with the contact angle and hence with the loss of hydrophobicity. The surface free energies γsd, γsh and γs, the interfacial energy of HTV SIR and water γsl, and the energy of adhesion Wsl of water on HTV SIR are determined as a function of time during the immersion and related to the loss of hydrophobicity. [ABSTRACT FROM AUTHOR]