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Introduction: As the pharmaceutical advertising landscape evolves with digital advancements, this study examines public awareness and perceptions of medication advertisements in Saudi Arabia. It focuses on the effects of regulatory frameworks and evaluates how they influence public understanding and attitudes toward these advertisements. Method: A cross-sectional study was conducted using an electronic survey in Saudi Arabia in December 2023. The survey was distributed on social media platforms and reached a diverse sample of 440 participants. It covered public perception and attitudes toward drug advertisements, knowledge of regulatory laws, and preferences regarding advertising mediums. Results: Out of the 440 participants in the study, who were primarily employees with bachelor's degrees, there was a clear awareness of drug advertisements. The average age of the group was 33 years, and a significant portion (71.1%) held a bachelor's degree, with 51.1% being employed. The findings revealed that 25.5% of participants frequently noticed drug ads, while 22.7% saw them very often. Although many found the ads informative, there were significant concerns about unrealistic expectations and the risk of overmedication; 89.8% believed the ads set unrealistic expectations about the effectiveness of medications. Additionally, 60.7% thought that celebrity endorsements might mislead the audience, and 91.1% felt that ads should provide more detailed information about potential risks and side effects. Regarding preferred advertising platforms, mobile apps and websites were favored (47%), followed closely by social media (46.4%). A striking 93.2% of participants believed that drug ads on social media should be subject to stricter regulations, and 96.4% wanted more proactive monitoring of online advertising. Many also reported using other sources, such as medical review sites, to verify medication information. Conclusions: Pharmaceutical advertising in Saudi Arabia must balance ethical transparency with educational value. The influence of digital platforms underscores the necessity for stricter regulation and accurate information dissemination. A collaborative approach is essential to align advertising practices with public health interests and regulatory standards. [ABSTRACT FROM AUTHOR]

Objective: This study aimed to identify and measure the awareness of anterior cruciate ligament (ACL) pre- vention programs among professional and semi-professional soccer players in the Qassim region. Methods: This cross-sectional study was conducted by interviewing the professional players in the Qassim region and using an online questionnaire for the semi-professional players. The questionnaire and the inter- view were designed to assess awareness and interest in preventive training programs (PTPs). Results: In total, 740 soccer players were surveyed. The predominant age bracket was 21-25 years, comprising 45.8% of the participants. A notable 28.8% participated in tournaments. Awareness of ACL preventive pro- grams was observed among 12.2% of the players. In a multivariate regression analysis, factors such as prior ACL injury history, education concerning ACL injuries, and ongoing engagement in ACL PTPs emerged as signif- icant independent predictors influencing awareness of ACL PTPs. Conclusion: Athletes demonstrated limited awareness of ACL preventive programs. Factors such as prior ACL injury history, education about ACL injuries, and active participation in ACL injury prevention programs were identified as significant drivers for increased awareness of ACL PTPs. Moreover, the involvement of physical therapists and coaches played an important role in enhancing athletes' understanding of ACL PTP concepts. [ABSTRACT FROM AUTHOR]

Oxidative stress has been hypothesized to play a crucial role in the complications of type 2 diabetes (T2D). Hyperglycaemia-mediated increases in free radicals have a deleterious effect on cellular compartments and nucleic acids, leading to imbalances between free radicals and antioxidant enzymes. This case–control study comprised two groups with 100 participants (50 T2D and 50 DN patients) and aimed to examine the association between single-nucleotide polymorphisms (SNPs) in the genes encoding nicotinamide adenine dinucleotide phosphate oxidase (NOX), glutathione S-transferase P (GSTP1), and glutathione peroxidase 1(GPX1) and diabetic nephropathy (DN) risk in patients with T2D. An SNP genotyping assay was performed using TaqMan assay and real-time PCR to identify the SNPs (NOX rs4673, GSTP rs1695, GPX1 rs1050450). The Sanger method was used to validate our findings. Fisher chi-square analyses revealed no significant differences in these genes when comparing T2D patients with and without DN. Our findings suggest no association between the rs4673, rs1695, and rs1050450 SNPs and DN in Saudi patients with T2D. [ABSTRACT FROM AUTHOR]

Introduction: One of the complications of diabetes mellitus (DM) is diabetic nephropathy (DN), which plays a significant role in the progression of end‐stage renal disease. Oxidative stress is implicated in DN pathogenesis, and genetic variations in antioxidant enzymes such as superoxide dismutase 2 (SOD2) and catalase (CAT) may contribute to the susceptibility. This study aimed to investigate the potential association between single nucleotide polymorphisms (SNPs) in antioxidant enzymes, specifically SOD2 rs4880 and CAT rs769217, and the risk of T2D and susceptibility to DN within the Saudi population. Methods: This case–control study included 150 participants, comprising 50 patients with T2D without DN (group 1), 50 patients with T2D with DN (group 2), and 50 healthy participants (group 3). The samples were genotyped using real‐time PCR for SOD2 rs4880 and CAT rs769217 SNPs. Sanger sequencing was used for validation. Statistical analyses were performed to explore associations between these SNPs and T2D with or without DN. Results: No significant difference was observed in CAT rs769217 expression between the groups. However, a significant difference was observed in SOD2 rs4880 expression between the healthy controls and patients with T2D with DN (p =.028). Furthermore, SOD2 rs4880 was associated with approximately threefold increased risk of DN in patients with T2D compared to that in healthy participants (odds ratio [OR] = 2.99 [1.31–6.83]). Validation through Sanger sequencing further confirmed these findings. Conclusions: The findings of this study provide evidence that SOD2 rs4880 SNP may contribute to inadequate defence by the antioxidant enzyme, SOD2, against DM‐induced oxidative stress and thus cause DN in Saudi patients with T2D. Therefore, SOD2 rs4880 may serve as a predictive marker to prevent the development and progression of DN in patients with T2D. [ABSTRACT FROM AUTHOR]

The COVID-19 pandemic has had a global impact, with >771 million confirmed cases and 6 million deaths reported by October 2023. Cancer patients, due to their immunosuppressed status, face an increased infection risk and higher COVID-19 complications. The present study aimed to assess clinical outcomes in COVID-19-infected cancer patients, focusing on mortality rates and other aspects, providing valuable insight for better protection and outcomes. This systematic review was conducted by searching the PubMed, Cochrane and Embase databases from August 2023 following the PRISMA guidelines. Studies from 2020 to 2023 pertaining to the impact of COVID-19 on patients previously diagnosed with malignancies were considered. Inclusion criteria entailed a pre-existing malignancy diagnosis, confirmed COVID-19 infection and an impact of COVID-19 on any aspect of the patient's cancer management. Studies written in English were exclusively reviewed. Post-COVID-19 malignancy diagnoses, case reports, review articles and data-insufficient studies were excluded. Screening and consensus on eligibility were carried out by a team of four authors, with disputes resolved by a non-screening author. Data extraction was performed by a five-author team, detailing study and population characteristics, as well as cancer patient outcomes related to COVID-19. Cross-checking was conducted by the same team, with conflicts resolved by a third author. The review of 27 studies explored COVID-19's impact on oncology, revealing diverse sample sizes (1,807,559 to 177 participants). Studies spanned various cancer types, including gastric adenocarcinoma, breast, lung, gynecologic, colorectal and non-melanoma skin cancer. Mortality rates were higher among cancer patients with COVID-19 compared to those without. Gastric adenocarcinoma exhibited a 5.9% mortality rate. Thoracic cancer patients faced elevated mortality and gastrectomies decreased. A meta-analysis (10 studies, 5,151 patients) showed a 19.1% mortality rate for COVID-19-infected cancer patients, contrasting with 1% for non-COVID-19 cancer patients (5 studies, 54,528 patients). The odds ratio for mortality in non-COVID-19 vs. COVID-19 cancer patients was 0.1036 (3 studies, 3,496 patients). Cancer patients consistently faced elevated mortality during the pandemic, with specific cancers showing unique impacts. Gastric adenocarcinoma exhibited a significant COVID-19 mortality rate. Patients with thoracic cancer faced increased risks, influencing surgical trends. Meta-analysis revealed an overall elevated mortality rate among COVID-19-infected cancer patients compared to non-COVID-19 counterparts. [ABSTRACT FROM AUTHOR]

Background: Ear health and hearing loss (HL) among infants has devastating outcomes. With most HL being deemed preventable, the assessment of one's knowledge and attitude regarding this impairment is important. In Saudi Arabia, the state of the general population's knowledge on infant HL remains unknown. Objectives: To determine and further elucidate the general population's knowledge and attitude with regard to HL in Saudi Arabia. Methods: This is a cross-sectional survey-based study conducted on the general population of Saudi Arabia. A predetermined questionnaire was translated into Arabic. This was distributed among the targeted participants in several provinces of Saudi Arabia (central, northern, eastern, western, and southern) by using an online survey via social media. The data were collected and analyzed via the SPSS program. Results: The knowledge with moderate, poor, and good was determined among 60.9%, 29.6%, and 9.4% of the participants, respectively. The participants with positive and negative attitudes were detected among 92.6% and 7.4% of respondents, respectively. Increasing age was associated with better attitude, while increased knowledge was directly related to higher educational attainment. Those who have a child with HL had nearly twice as poor knowledge as those who do not have a child with HL (P < 0.001). Conclusions: Although most of the respondents possessed a positive attitude toward infant HL, their knowledge about it seems to be lacking. Thus, there is a need to address these knowledge gaps regarding infant HL. [ABSTRACT FROM AUTHOR]

Introduction: In the population, there is a notable prevalence of unruptured intracranial aneurysms. These can only be detected early using high-resolution imaging modalities. A discussion of the different imaging modalities is warranted, and an intracranial aneurysm can often be fatal if left undetected. Methodology: PubMed database was used for article selection, and papers were obtained and reviewed. PubMed database was used for article selection, and the following keys terms: magnetic resonance angiography, computerized tomography angiography, digital subtraction angiography, aneurysms, imaging in cerebrovascular hemorrhage. Review: Patients with subarachnoid hemorrhage should initially be investigated by CT angiography as it is quick and accurate for the diagnosis of early hemorrhage. Further imaging by magnetic resonance angiography and digital subtraction angiography could be useful in late presentations, or to have more detailed images of CT confirmed aneurysms. Conclusion: The physician should utilize their clinical judgment of intracranial aneurysms combined with specific case presentations to decide upon the best imaging choice. The imaging modality chosen should help in identifying the aneurysm, following up unruptured aneurysms, and alerting the radiologist to any recurrence of a previously treated ruptured aneurysm. [ABSTRACT FROM AUTHOR]

Context: Diabetes-related retinopathy (DR), the most common complication of diabetes mellitus (DM), is a severe and preventable cause of visual loss and blindness that has been reported to be the fourth leading cause of blindness among four million cases globally. Aims: This study aimed to evaluate the knowledge, attitudes, and practices of fourth- and fifth-year medical students concerning patients with DR. Methods and Materials: This cross-sectional descriptive study was conducted at a College of Medicine in Saudi Arabia, in November 2018, and comprised 153 fourth- and fifth-year medical students of both sexes. Participants were required to complete a previously validated hard copy questionnaire. Results: In total, > 50% of participants showed good knowledge of DR (poor participant knowledge, n = 65, 42.5%). We found 16 (10.5%) participants had poor attitudes to DR compared to 137 (89.5%) of participants with good attitudes, and 32 (20.9%) participants showed poor practices compared to 121 (79.1%) participants showing good practices. There was a statistically significant difference between the sexes and the level of practice (P = 0.021). Conclusions: More than 50% of participants in our study showed good knowledge concerning DR, with excellent attitudes and practices. Moreover, participants' age was identified as a significant factor affecting practice regarding DR. More targeted education is required to improve their knowledge base in regard to DR. Medical faculties have a significant role in the education of medical students to ensure greater awareness of DR. [ABSTRACT FROM AUTHOR]