21 results on '"Ahmed, Mostafa M"'
Search Results
2. Passive immunization against inhibin increases testicular blood flow in male goats
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Samir, Haney, El Sayed, Mohamed A.I., Nagaoka, Kentaro, Sasaki, Kazuaki, Abo El-Maaty, Amal M., Karen, Aly, Abou-Ahmed, Mostafa M., and Watanabe, Gen
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- 2020
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3. Effect of breeding season and age on follicular dynamics and hemodynamics in embryo donor mares subjected to luteolysis after embryo flushing.
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Alkhadrawy, Jamal M. H., Aboelmaaty, Amal M., Abou-Ahmed, Mostafa M., and Ghallab, Abdelraouf M.
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MARES ,LUTEOLYSIS ,ESTRUS ,HORSE breeding ,OVUM donation ,HEMODYNAMICS ,INDUCED ovulation ,CHORIONIC gonadotropins - Abstract
Background: Mares are the only companion animals simulating women in the large diameter of their follicles. Horses start reproduction at the age of three years, and some of them live for >30 years, so aging influences their reproductive capacity. Mares are sensitive to summer heat stress as they can sweat like humans. Aim: The current work aimed to study the effects of age (young versus senile), season (cold versus hot), and the hormonal treatments during embryo collection on the dominant and subordinate follicular dynamics and hemodynamics and circulating ovarian hormones in embryo donor mares ovulated twice spontaneously before inducing ovulation for flushing embryos. Methods: Spontaneous oestrous cycles were studied for young mares (<10 years; N = 6) or senile (>20 years; N = 5) during months of the cold season (November to April) and hot season (May to August). In young embryo donor mares, oestrous cycles after inducing ovulation and luteolysis were studied using Doppler ultrasound. Estradiol (E2), progesterone (P4), nitric oxide (NO), total cholesterol, and lactate dehydrogenase (LDH) were measured in blood serum. Results: A decrease in the dominant follicle antrum diameter (p > 0.05) and LDH (p = 0.016) was observed after inducing luteolysis in young embryo donor mares. Both human chorionic gonadotropin (hCG) and PGF2a treatments increased dominant follicle area (p = 0.0001), antrum area (p = 0.001), perimeter (p = 0.001), granulosa area (p = 0.0001), cholesterol (p = 0.0001), NO (p = 0.0001), and E2 (p = 0.0001). The dominant follicle area, antrum area, perimeter, color area, granulosa area, LDH, cholesterol, NO, and E2 increased (p = 0.0001) during the oestrous cycles of the hot season, but the circulatory % (p = 0.0001) declined. Senile mares had lower dominant follicle area (p = 0.002), antrum area (p = 0.0001), granulosa area (p > 0.05), LDH (p = 0.001), cholesterol (p = 0.0001), NO (p = 0.0001), and E2 (p = 0.0001) but higher circulatory % (p = 0.0001) and color area % (p = 0.023). The dominant follicle possesses the largest diameter, area, perimeter, granulosa area, and color area but the lowest circulatory % during spontaneous oestrous cycles, after inducing ovulation, or luteolysis with significant effects of the day of the spontaneous oestrous cycles on their dynamics and hemodynamics. Conclusion: During hot months, mares treated with hCG ovulated 24 hours later and prostaglandin-induced luteolysis was followed by new ovulation five days later. Follicles ovulated during the hot months were larger than those ovulated during the cold months and both had nearly the same color area %. Senile mares ovulated follicles with a lower area and antrum area but a higher color area %, so senile mares can be used as embryo or oocyte donors during the hot season. [ABSTRACT FROM AUTHOR]
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- 2024
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4. The Fertility Outcomes of Egyptian Buffalo Cows after Ovsynch and Presynch-Ovsynch Protocols.
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Othman, Mahmoud A., El-Shalofy, Amr S., Abou-Ahmed, Mostafa M., and Ghallab, Abdel Raouf M.
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WATER buffalo artificial insemination ,WATER buffalo breeds ,BLOOD sampling ,TRANSVAGINAL ultrasonography - Abstract
The present study aimed to compare the reproductive outcomes after the blind application of the standard Ovsynch and Presynch Ovsynch protocols on Egyptian Buffaloes (Bubalus bubalis) during the breeding season. Fifty multiparous Egyptian buffalo cows of an unknown stage of the estrous cycle were randomly divided into two groups: 1) the standard Ovsynch protocol (first GnRH (G1) at d0, PGF
2α at d7, and second GnRH; G2 56 h later and 2) the pre-synch Ovsynch (G6G-Ovsynch) protocol (PGF2α and GnRH 2 days apart 6 days before starting G1 of the standard Ovsynch). Cows were subjected to timed artificial insemination (TAI) 16 and 40 h after the G2 injection in both groups. Blood sampling and ovarian transrectal ultrasonography were performed at three time points, PGF2α, G2, and 2 days after G2. Serum progesterone (P4) (ng/mL) concentrations were significantly higher in the G6G-Ovsynch group than in the Ovsynch group at the time of PGF2α and two days after the G2 injection, but they were lower (P < 0.05) at the G2 injection. The Vascularity index of the corpus luteum (CL) and dominant follicle (DF) wall area (%) were higher (P < 0.05) in the G6G-Ovsynch group compared to the Ovsynch group. The ovulatory response indicated by the presence of CL at d7 was significantly higher in G6G-Ovsynch than in Ovsynch (73 vs. 51%, respectively). Moreover, a higher (P < 0.05) pregnancy rate was observed in G6G-Ovsynch than in the Ovsynch group. In conclusion, the blind application of the G6G-Ovsynch improved the ovulatory response in the early stages of the synchronization protocol and raised the pregnancy rates in Egyptian buffaloes. [ABSTRACT FROM AUTHOR]- Published
- 2023
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5. Persistent phosphorylation of NKCC1 and WNK1 in the epicenter of the spinal cord following contusion injury
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Lee, Hyun Kyung, Ahmed, Mostafa M., King, Kevin C., Miranpuri, Gurwattan S., Kahle, Kristopher T., Resnick, Daniel K., and Sun, Dandan
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- 2014
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6. Type IIB Thyroplasty for Phonic Tics in a Pediatric Patient With Autism Spectrum Disorder: A Case Report
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Ahmed, Mostafa M., Heckman, W. Wesley, and Dailey, Seth H.
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- 2013
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7. Cannabinoid subtype-2 receptors modulate the antihyperalgesic effect of WIN 55,212-2 in rats with neuropathic spinal cord injury pain
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Ahmed, Mostafa M., Rajpal, Sharad, Sweeney, Clayton, Gerovac, Tiffany A., Allcock, Bradley, McChesney, Shannon, Patel, Ami U., Tilghman, Jessica I., Miranpuri, Gurwattan S., and Resnick, Daniel K.
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- 2010
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8. Novel Magnet-Retained Prosthetic System for Facial Reconstruction
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Ahmed, Mostafa M., Piper, James M., Hansen, Nancy A., Sutton, Alan J., and Schmalbach, Cecelia E.
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- 2014
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9. Noise-Induced Hearing Loss Treatment: Systematic Review and Meta-analysis.
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Ahmed, Mostafa M, Allard, Rhonda J, and Esquivel, Carlos R
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STEROID drugs , *RESEARCH , *META-analysis , *RESEARCH methodology , *SYSTEMATIC reviews , *SENSORINEURAL hearing loss , *RETROSPECTIVE studies , *EVALUATION research , *TREATMENT effectiveness , *COMPARATIVE studies , *NOISE-induced deafness , *LONGITUDINAL method - Abstract
Objective: To determine the efficacy of steroid and hyperbaric oxygen therapy (HBOT) in the setting of acute noise-induced hearing loss.Methods: Systematic review and meta-analysis of noise-induced hearing loss treatment studies that reported on patients who (1) reported individual frequencies up to 8,000 Hz with mean and SDs; (2) were treated only with steroids ± HBOT; and (3) sustained acute acoustic trauma. The Newcastle-Ottawa Scale was used to assess risk of bias across cohorts. Data sources were Embase, Web of Science, Cochrane Databases (via Ovid EBM Reviews), and PubMed.Results: Four studies were of retrospective cohorts and one of a prospective cohort. Only one study examined blast acoustic trauma, and the remaining four examined gunfire acoustic trauma. This meta-analysis used a random-effects model for pure tone average (PTA) (0.5, 1, and 2 kHz) and "high-frequency" PTA (HPTA) (4, 6, and 8 kHz) for the five studies included. Steroid therapy demonstrated a 6.55-dB (95% CI, 0.08-13.17 dB) PTA (n = 55) improvement and a 9.02-dB (95% CI, 1.45-16.59 dB) HPTA (n = 71) improvement. Steroid with HBOT demonstrated a 7.00-dB (95% CI, 0.84-13.17 dB) PTA (n = 133) improvement and a 12.41-dB (95% CI, 3.97-20.86 dB) HPTA (n = 150) improvement. According to our statistical analysis of the pooled studies' heterogeneity, there was moderate inconsistency in the cross-study results of both treatment groups.Conclusion: Steroids with or without HBOT appear to improve both low and high hearing thresholds following acoustic trauma. Future studies will require inclusion of control groups, precise definition of acoustic trauma intensity and duration, and genetic polymorphisms. [ABSTRACT FROM AUTHOR]- Published
- 2022
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10. Role of NKCC1 and KCC2 in the development of chronic neuropathic pain following spinal cord injury
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Hasbargen, Tera, Ahmed, Mostafa M., Miranpuri, Gurwattan, Li, Lin, Kahle, Kristopher T., Resnick, Daniel, and Sun, Dandan
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- 2010
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11. Melatonin can improve viability and functional integrity of cooled and frozen/thawed rabbit spermatozoa.
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Fadl, Aya M., Ghallab, Abdel Raouf M., Abou‐Ahmed, Mostafa M., and Moawad, Adel R.
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FROZEN semen ,SPERMATOZOA ,MELATONIN ,SEMEN ,RABBITS ,INTEGRITY - Abstract
Melatonin is known to protect sperm against freezing‐inflicted damage in different domestic species. The aim of the study was to evaluate the effect of supplementation of semen extender with melatonin on the quality and DNA integrity of cooled and frozen/thawed rabbit spermatozoa. We also investigated whether the addition of melatonin to the semen extender could improve the fertility of rabbit does artificially inseminated with frozen/thawed semen. Semen samples collected from eight rabbit bucks were pooled and then diluted in INRA‐82 supplemented either with (0.5, 1.0 or 1.5 mM) or without (0.0 mM) melatonin. Diluted semen was cooled at 5°C for 24 hr. For cryopreservation and based on the first experiment's best result, semen samples were diluted in INRA‐82 in the presence or absence of 1.0 mM melatonin and then frozen in 0.25 ml straws. Following cooling or thawing, sperm quality and DNA integrity were evaluated. Furthermore, the fertility of frozen/thawed semen was investigated after artificial insemination. Supplementation of semen extender with 1.0 mM melatonin improved (p <.05) motility, viability, membrane and acrosome integrities in cooled semen compared with other groups. Sperm quality and DNA integrity were higher (p <.05) in frozen/thawed semen diluted in 1.0 mM melatonin‐supplemented extender than in the control group. Conception and birth rates were higher in does inseminated with 1.0 mM melatonin treated semen compared with the controls. In conclusion, supplementation of semen extender with 1.0 mM melatonin improved the quality of cooled and frozen/thawed rabbit spermatozoa. Melatonin can preserve DNA integrity and enhance the fertility of frozen/thawed rabbit spermatozoa. [ABSTRACT FROM AUTHOR]
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- 2021
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12. Effect of high-dose vocal fold injection of cidofovir and bevacizumab in a porcine model.
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Ahmed, Mostafa. M., Connor, Matthew. P., Palazzolo, Mitzi, Thompson, Michelle E., Lospinoso, Josh, O'Connor, Peter, Howard, N. Scott, and Maturo, Stephen. C.
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Objectives: Perform a follow-up study to investigate the histologic impact of high-dose intralaryngeal cidofovir injections in porcine vocal cords, either alone or in combination with bevacizumab, and compared to saline controls.Study Design: This was an in vivo study involving 24 pigs with blinded pathologist review of specimens. Six groups were created, with four subjects in each group. Each subject received 10 or 20 mg of either cidofovir or bevacizumab alone, or in combination, injected into the right vocal cord. The left vocal fold was used as a saline control. Three separate injections were made at 2-week intervals. Larynges were harvested at 8 and 12 weeks, stained with hematoxylin and eosin and trichrome stain, and reviewed for histologic changes by two blinded pathologists.Results: Minimal inflammation, edema, and atypia were noted with all treatments. Increased glandular inflammation was noted with 10 mg bevacizumab (P < 0.05), which decreased when combined with 10 mg cidofovir (P < 0.05). No lamina propria or muscle fibrosis was observed. Drug duration had no statistically significant histologic impact.Conclusion: High-dose cidofovir and bevacizumab do not induce detrimental vocal fold changes. Combination cidofovir and bevacizumab do not cause vocal fold scarring. Further work is needed to assess systemic concentration with this high-dose combination in humans.Level Of Evidence: N/A. Laryngoscope, 127:671-675, 2017. [ABSTRACT FROM AUTHOR]- Published
- 2017
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13. Development of Intelligent Façade Based on Outdoor Environment and Indoor Thermal Comfort.
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Ahmed, Mostafa M. S., Abel-Rahman, Ali K., and Ahmed Hamza H. Ali
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BUILDINGS ,FACADES ,ARCHITECTURAL details ,THERMAL comfort ,SUSTAINABILITY - Abstract
In the last decades, the development of innovative solutions is considered as a prominent issue for achieving sustainability within the built environment. Facades are crucial to energy consumption and comfort within buildings. Incorporating intelligence in their design is an effective way to achieve low energy consumption buildings. The ability of specific facade systems to work reliably and effectively is one of the challenges towards sustainability. This study presents the state of art for intelligent facades at different outdoor environment in different climates. In addition the indoor environmental parameters such as thermal comfort, indoor air quality and visual comfort are outlined. The study concluded that intelligent facades in buildings and indoor thermal comfort require more development targeting low energy buildings and thermal comfort. [ABSTRACT FROM AUTHOR]
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- 2015
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14. A Multidisciplinary Approach to Castleman Disease of the Neck.
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Shams, Alexandra A., Ahmed, Mostafa M., Scalzitti, Nicholas J., Howell, Della L., Hall, Jordan M., Ritter, John L., and Maturo, Stephen C.
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LYMPHOPROLIFERATIVE disorders , *CASTLEMAN'S disease , *NECK muscles , *NECK injuries , *BIOPSY , *NECK surgery , *COMPUTED tomography , *HEALTH care teams , *INTERPROFESSIONAL relations , *NECK , *NEEDLE biopsy , *DIAGNOSIS ,NECK radiography - Abstract
Castleman disease (CD) is a rare lymphoproliferative disorder that occurs in adults and rarely in the pediatric population. The disease is characterized by slowly enlarging masses that can form anywhere within the lymphatic system. It is an uncommon cause of a neck mass in both children and adults that presents insidiously and nonspecifically. A 21-year-old woman was referred to the otolaryngology service because of an asymptomatic neck mass found incidentally on computed tomographic imaging 15 months earlier. On repeat imaging, the lesion was characterized as a homogenously enhancing soft tissue mass and appeared stable in size compared with previous studies. Given the nondiagnostic radiologic features, tissue sampling was pursued, first using fine-needle aspiration and ultimately excisional biopsy. The excision revealed histopathology consistent with unicentric, hyaline-vascular CD. Excision is the gold standard for treatment of this variant of CD. The patient was referred to the hematology/oncology service but was subsequently lost to follow-up. This case illustrates a rare cause of a neck mass in a young adult and exemplifies the extremely broad differential in this setting. In addition, it highlights the importance of a systematic and thorough approach to diagnosing neck masses in children and adults. [ABSTRACT FROM AUTHOR]
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- 2016
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15. Robust navigation based on bistatic radar and BiSensors for unmanned air systems (UASs) using integration of multiple sensors fusion architecture.
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Madany, Yasser M., Elkamchouchi, Hassan M., and Ahmed, Mostafa M.
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- 2014
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16. Pathogenesis of spinal cord injury induced edema and neuropathic pain: expression of multiple isoforms of wnk1.
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Ahmed, Mostafa M., Lee, HyunKyung, Clark, Zach, Miranpuri, Gurwattan S., Nacht, Carrie, Patel, Kush, Lisa Liu, Joslin, Jiliian, Kintner, Douglus, and Resnick, Daniel K.
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NEUROPATHY , *SPINAL cord injuries , *EDEMA , *MOLECULAR pathology , *HYPERESTHESIA , *LAMINECTOMY - Abstract
Background: Neuropathic pain (NP) is a common occurrence following spinal cord injury (SCI). Identification of specific molecular pathways that are involved in pain syndromes has become a major priority in current SCI research. We have investigated the role of a cation-dependent chloride transporter, Cl-regulatory protein Na+- K+-Cl+ 1 (NKCC1), phosphorylation profile of NKCC1 and its specific involvement in neuropathic pain following contusion SCI (cSCI) using a rat model. Administration of the NKCC1 inhibitor bumetanide (BU) increases the mean hindpaw withdrawal latency time (WLT), thermal hyperalgesia (TH) following cSCI. These results demonstrate implication of NKCC1 co-transporter and BUin SCI-induced neuropathic pain. The with-no-lysine (K)-1 (WNK1) kinase has been shown to be an important regulator of NKCC1 phosphorylation in many systems, including nocioception. Mutations in a neuronal-specific exon of WNK1 (HSN2) was identified in patients that have hereditary sensory neuropathy type II (HSANII) also implicates WNK1 in nocioception, such that these patients have loss of perception to pain, touch and heat. In our ongoing research we proposed two studies utilizing our contusion SCI (cSCI) NP model of rat. Purpose: Study 1 aimed at NKCC1 expression and activity is up-regulated following cSCI in the early edema and chronic neuropathic pain phases. Study 2 aimed at identifying the expression profile of alternatively spliced WNK1 isoforms in animals exhibiting thermal hyperalgesia (TH) following cSCI. Methods: Adult male Sprague Dawley rats (275-300 g) following laminectomy received cSCI at T9 with the NYU impactor-device II by dropping 10 g weight from the height of 12.5 mm. Control rats obtained laminectomy but no impaction. Following injury, functional recovery was assessed by BBB locomotor scores on day 1, 7, 14, 21, 35, and 42 and development of thermal hyperalgesia on day 21, 28, 35, and 42 day of injury by monitoring hind paw withdraw latency time (WLT) in seconds compared with the baseline data before injury. Results: Increased NKCC1 may explain observed increase in magnetic resonance imaging (MRI) T2, exhibiting NKCC1 localization in neurons. This data supports NKCC1's role in the pathogenesis of acute and chronic phases of injury, namely spinal cord edema and chronic phase neuropathic pain. NKCC1 dependent chloride influx requires the phosphorylation at specific residues. Probing for the HSN2 exon of WNK1 reveals two key findings: i) the HSN2 exon is found in alternatively spliced neuronal isoforms found at 250 kDa and 230 kDa; ii) the 250 kDa isoform is found only in tissue that is injured. Conclusions: This data implicates the NKCC1/ WNK1/WNK1HSN2 involvement in post-injury response that contributes to the development of neuropathic pain. Targeting this system may have therapeutic benefit. [ABSTRACT FROM AUTHOR]
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- 2014
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17. Utility of Head and Neck Cutaneous Squamous Cell Carcinoma Sentinel Node Biopsy: A Systematic Review.
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Ahmed, Mostafa M., Moore, Brian A., and Schmalbach, Cecelia E.
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- 2014
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18. Novel targets for Spinal Cord Injury related neuropathic pain.
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Ahmed, Mostafa M, King, Kevin C, Pearce, Shane M, Ramsey, Melissa A, Miranpuri, Gurwattan S, and Resnick, Daniel K
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METALLOPROTEINASES , *CANNABINOIDS , *SPINAL cord injuries , *NEUROPATHY , *ANIMAL models in research , *INJURY risk factors - Abstract
Millions of people suffer from spinal cord injury (SCI) with little known effective clinical therapy. Neuropathic pain (NP) is often accompanied with SCI, making clinical treatment challenging. Even though the key mediators in the development of NP have been discovered, the pathogenesis is still unclear. Some of the key mediators in the sustenance of NP include the inflammatory processes, cannabinoid receptors, matrix metalloproteases, and their tissue inhibitors. Animal models have shown promising results with modulation of these mediators, yet the clinical models have been unsuccessful. One such study with matrix metalloproteases (MMPs) has yielded encouraging results. The relationship between MMPs and their tissue inhibitors (TIMPs) plays a significant role in the pathogenesis and recovery of SCI and the CNS. Key factors that lead to the functional consequences of MMP activity are cellular localization, tissue distribution, and temporal pattern of MMP expression. Studies concluding that MMPs can be seen as contributors of tissue damage and as contributors in the repair mechanisms have provided a need to reexamine their roles after acute and chronic neuropathic pain [ABSTRACT FROM AUTHOR]
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- 2011
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19. Synthesis and binding behaviors of monomethyl cucurbit[6]uril
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Ahmed, Mostafa M., Koga, Kazutaka, Fukudome, Makoto, Sasaki, Hideaki, and Yuan, De-Qi
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CARBAZOLE , *CHEMICAL reactions , *ORGANIC synthesis , *AMINES , *COMPLEX compounds , *POLYOXYMETHYLENE - Abstract
Abstract: By reacting 3a-methylglycoluril and glycoluril with paraformaldehyde, monomethyl cucurbit[6]uril was synthesized in 14% yield. The new host molecule forms stable inclusion complexes with diamine and hexylaminocarbazole derivatives. [Copyright &y& Elsevier]
- Published
- 2011
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20. Mechanical processing of banana slices-stem for fiber extraction.
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El-Magd Mahmoud, Wael Abou, Elkaoud, Nabil Shaban M., Eissa, Ahmed Salah, and Mousa, Ahmed Mostafa M.
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BANANAS , *MACHINE theory , *FIBERS , *ELECTRIC motors , *INDUSTRIAL costs , *RAW materials - Abstract
This research aimed to manufacture a simple fiber extraction machine. The machine prototype consisted of available raw materials. The beater cylinder is the most significant component in this machine. The electric motor of 0.75 kW was used to rotate the beater cylinder. The machine theory is based on the repeated rapid beating of the beaters on a slice-stem of banana. This beating simulated what labor does by using hand hammers to eliminate the juice and extract the fibers. The machine was tested under three rotational speeds of the beater cylinder 650, 750, and 850 rpm and using three beater cylinders with a different number of beaters 8, 10, and 12. The fibers produced by the machine were straight, of good quality, and not shredded, this was achieved in abundance when using the cylinder that has 10 beaters with 750 rpm rotational speeds of the beater cylinder. Thus, under these operating conditions, the extraction efficiency, the time required, and machine productivity were 88%, 40 min, and 8.6 kg h-1, respectively. The minimum value of the power required was 0.45 kW at the rotational speed of 650 rpm and using the eight beaters. While the maximum value of the power required was 0.64 kW at the rotational speed of 850 rpm and using the number of beaters 12. At the machine productivity of 8.6 kg h-1, the production cost will be 2.7 L.E. kg-1. While the costs of manual extraction of the fibers were 10 L.E. kg-1. [ABSTRACT FROM AUTHOR]
- Published
- 2023
21. Progressive severe kyphosis as a complication of multilevel cervical percutaneous facet neurotomy: a case report
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Ahmed, Mostafa M., Lake, Wendell B., and Resnick, Daniel K.
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KYPHOSIS , *JOINT diseases , *HEADACHE , *SURGICAL complications , *NECK pain , *NEUROSURGERY , *ELECTROMYOGRAPHY - Abstract
Abstract: Background context: Percutaneous facet neurotomy is a procedure commonly used for the treatment of pain thought to originate from zygoapophyseal joint dysfunction. Some practitioners have also used this technique to treat cervicogenic headache. Previously reported complications for this procedure have been minimal and have included dysthesias and local pain. Study design: Case report. Methods: Bilateral multilevel cervical percutaneous facet neurotomies were used to treat a patient suffering from a chronic headache and neck pain that had failed to respond to extensive medical management. Results: Within days of completing the bilateral facet neurotomies, the patient developed head drop. Subsequent electromyography revealed denervation of the patient''s paraspinous muscles. Initially the patient was managed conservatively in a cervical collar with the hope that he would recover some function. After few years, the patient developed fixed kyphotic deformity. Correction of the patient''s deformity required multilevel anterior cervical discectomy and fusion followed by posterior instrumented fusion. Conclusions: When performing multilevel percutaneous cervical facet neurotomies, there is a risk of paraspinous muscle denervation, and subsequent kyphotic deformity may occur. The likelihood of this rare and previously unreported complication can probably be reduced by proper needle positioning and by minimizing the number of levels at which the procedure is performed. [Copyright &y& Elsevier]
- Published
- 2012
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