243 results on '"Aggarwal, Aneel"'
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2. Cryo-EM structure of the Rev1–Polζ holocomplex reveals the mechanism of their cooperativity in translesion DNA synthesis
3. Burkholderia cenocepacia epigenetic regulator M.BceJIV simultaneously engages two DNA recognition sequences for methylation
4. Nucleic acid mediated activation of a short prokaryotic Argonaute immune system
5. Activation of CBASS Cap5 endonuclease immune effector by cyclic nucleotides
6. H19 influenza A virus exhibits species-specific MHC class II receptor usage
7. Signal-induced enhancer activation requires Ku70 to read topoisomerase1–DNA covalent complexes
8. High-resolution structures of the SARS-CoV-2 N7-methyltransferase inform therapeutic development
9. Discovery of a dual WDR5 and Ikaros PROTAC degrader as an anti-cancer therapeutic
10. Cryo-EM structure of translesion DNA synthesis polymerase ζ with a base pair mismatch
11. FANCI functions as a repair/apoptosis switch in response to DNA crosslinks
12. Shape of promoter antisense RNAs regulates ligand-induced transcription activation
13. A Contaminant Impurity, Not Rigosertib, Is a Tubulin Binding Agent
14. Structure and mechanism of B-family DNA polymerase ζ specialized for translesion DNA synthesis
15. Simultaneous CK2/TNIK/DYRK1 inhibition by 108600 suppresses triple negative breast cancer stem cells and chemotherapy-resistant disease
16. Structural basis of DNA synthesis opposite 8-oxoguanine by human PrimPol primase-polymerase
17. Eukaryotic DNA polymerases
18. Dismissal of RNA Polymerase II Underlies a Large Ligand-Induced Enhancer Decommissioning Program
19. Epigenomic characterization of Clostridioides difficile finds a conserved DNA methyltransferase that mediates sporulation and pathogenesis
20. Cryo-EM structure and dynamics of eukaryotic DNA polymerase δ holoenzyme
21. Phase separation of ligand-activated enhancers licenses cooperative chromosomal enhancer assembly
22. Proximity-Induced Activation of Human Cdc34 through Heterologous Dimerization
23. Rev1 Employs a Novel Mechanism of DNA Synthesis Using a Protein Template
24. Structure of Adeno-Associated Virus Type 2 Rep40-ADP Complex: Insight into Nucleotide Recognition and Catalysis by Superfamily 3 Helicases
25. Allosteric Effects of Pit-1 DNA Sites on Long-Term Repression in Cell Type Specification
26. FokI Dimerization is Required for DNA Cleavage
27. Structure of FokI has Implications for DNA Cleavage
28. A Small Molecule RAS-Mimetic Disrupts RAS Association with Effector Proteins to Block Signaling
29. Discovery of 2-(1H-indol-5-ylamino)-6-(2,4-difluorophenylsulfonyl)-8-methylpyrido[2,3-d]pyrimidin-7(8H)-one (7ao) as a potent selective inhibitor of Polo like kinase 2 (PLK2)
30. Structural insights into mutagenicity of anticancer nucleoside analog cytarabine during replication by DNA polymerase η
31. Discovery of Potent and Selective WDR5 Proteolysis Targeting Chimeras as Potential Therapeutics for Pancreatic Cancer.
32. An Inhibitor of PIDDosome Formation
33. Phosphatidylinositol 4,5-Bisphosphate Clusters the Cell Adhesion Molecule CD44 and Assembles a Specific CD44-Ezrin Heterocomplex, as Revealed by Small Angle Neutron Scattering
34. Ligand-Dependent Enhancer Activation Regulated by Topoisomerase-I Activity
35. Bisphosphonates inactivate human EGFRs to exert antitumor actions
36. Repurposing of bisphosphonates for the prevention and therapy of nonsmall cell lung and breast cancer
37. Structural basis for polymerase η–promoted resistance to the anticancer nucleoside analog cytarabine
38. Brd4 and JMJD6-Associated Anti-Pause Enhancers in Regulation of Transcriptional Pause Release
39. The focal facial dermal dysplasias: phenotypic spectrum and molecular genetic heterogeneity
40. Structures of SARS-CoV-2 N7-methyltransferase with DOT1L and PRMT7 inhibitors provide a platform for new antivirals.
41. Structure and Dynamics of the Second CARD of Human RIG-I Provide Mechanistic Insights into Regulation of RIG-I Activation
42. Human DNA Polymerase η Is Pre-Aligned for dNTP Binding and Catalysis
43. Role of Human DNA Polymerase κ in Extension Opposite from a cis–syn Thymine Dimer
44. DNA Synthesis across an Abasic Lesion by Yeast Rev1 DNA Polymerase
45. Negative Role of RIG-I Serine 8 Phosphorylation in the Regulation of Interferon-β Production
46. Structural Basis for Error-free Replication of Oxidatively Damaged DNA by Yeast DNA Polymerase η
47. Replication across Template T/U by Human DNA Polymerase-ι
48. DNA Synthesis across an Abasic Lesion by Human DNA Polymerase ι
49. Structure of the Human Rev1–DNA–dNTP Ternary Complex
50. Recognition of a DNA Operator by the Repressor of Phage 434: A View at High Resolution
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