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Your search keyword '"Aerden, Leo A. M."' showing total 12 results
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12 results on '"Aerden, Leo A. M."'

1. Safety and efficacy of active blood-pressure reduction to the recommended thresholds for intravenous thrombolysis in patients with acute ischaemic stroke in the Netherlands (TRUTH): a prospective, observational, cluster-based, parallel-group study

Author

Zonneveld, Thomas P, Vermeer, Sarah E, van Zwet, Erik W, Groot, Adrien E D, Algra, Ale, Aerden, Leo A M, Alblas, Kees C L, de Beer, Frank, Brouwers, Paul J A M, de Gans, Koen, van Gemert, H Maarten A, van Ginneken, Bart C A M, Grooters, Gerke S, Halkes, Patricia H A, van der Heijden-Montfroy, Tonny A M H G, Jellema, Korné, de Jong, Sonja W, Lövenich-Ciccarello, Harry, van der Meulen, Willem D M, Peters, Edwin W, van der Ree, Taco C, Remmers, Michel J M, Richard, Edo, Rovers, Jörgen M P, Saxena, Ritu, van Schaik, Sander M, Schonewille, Wouter J, Schreuder, Tobien A H C M L, de Schryver, Els L L M, Schuiling, Wouter J, Spaander, Fianne H, van Tuijl, Julia H, Visser, Marieke C, Zinkstok, Sanne M, Zock, Elles, Dippel, Diederik W J, Kappelle, L Jaap, van Oostenbrugge, Robert J, Roos, Yvo B W E M, Vermeij, Frederique H, Wermer, Marieke J H, van der Worp, H Bart, Nederkoorn, Paul J, and Kruyt, Nyika D

Published
2024
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2. Dual thrombolytic therapy with mutant pro-urokinase and small bolus alteplase for ischemic stroke (DUMAS): study protocol for a multicenter randomized controlled phase II trial

Author

van der Ende, Nadinda A. M., Roozenbeek, Bob, Smagge, Lucas E. M., Luijten, Sven P. R., Aerden, Leo A. M., Kraayeveld, Petra, van den Wijngaard, Ido R., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Flach, H. Zwenneke, Wallace, Alexis C., Gurewich, Victor, del Zoppo, Gregory J., Meurer, William J., Lingsma, Hester F., van der Lugt, Aad, and Dippel, Diederik W. J.

Published
2022
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4. A decrease in blood pressure is associated with unfavorable outcome in patients undergoing thrombectomy under general anesthesia

Author

Treurniet, Kilian M, Berkhemer, Olvert A, Immink, Rogier V, Lingsma, Hester F, Ward-van der Stam, Vivian M C, Hollmann, Markus W, Vuyk, Jaap, van Zwam, Wim H, van der Lugt, Aad, van Oostenbrugge, Robert J, Dippel, Diederik W J, Coutinho, Jonathan M, Roos, Yvo B W E M, Marquering, Henk A, Majoie, Charles B L M, Dippel, Diederik W J, Lugt, Aad van der, Majoie, Charles B L M, Roos, Yvo B W E M, van Oostenbrugge, Robert J, van Zwam, Wim H, Berkhemer, Olvert A, Fransen, Puck S S, Beumer, Debbie, van den Berg, Lucie A, Schonewille, Wouter J, Vos, Jan Albert, Majoie, Charles B L M, Roos, Yvo B W E M, Nederkoorn, Paul J, Wermer, Marieke J H, Walderveen, Marianne A A van, van Oostenbrugge, Robert J, van Zwam, Wim H, Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A, Nijeholt, Geert J Lycklama à, Boiten, Jelis, Dippel, Diederik W J, Brouwer, Patrick A, Emmer, Bart J, de Bruijn, Sebastiaan F, van Dijk, Lukas C, Kappelle, L Jaap, Lo, Rob H, van Dijk, Ewoud J, de Vries, Joost, de Kort, Paul L M, van den Berg, Jan S P, van Rooij, Willem Jan J, van Hasselt, Boudewijn A A M, Aerden, Leo A M, Dallinga, René J, Visser, Marieke C, Bot, Joseph C J, Vroomen, Patrick C, Eshghi, Omid, Schreuder, Tobien H C M L, Heijboer, Roel J J, Keizer, Koos, Tielbeek, Alexander V, Hertog, Heleen M den, Gerrits, Dick G, van den Berg-Vos, Renske M, Karas, Giorgos B, Majoie, Charles B L M, van Zwam, Wim H, van der Lugt, Aad, Nijeholt, Geert J Lycklama à, van Walderveen, Marianne A A, Bot, Joseph C J, Marquering, Henk A, Beenen, Ludo F, Sprengers, Marieke E S, Jenniskens, Sjoerd F M, van den Berg, René, Berkhemer, Olvert A, Yoo, Albert J, Roos, Yvo B W E M, Koudstaal, Peter J, Boiten, Jelis, van Dijk, Ewoud J., van Oostenbrugge, Robert J, Wermer, Marieke J H, Flach, H Zwenneke, Steyerberg, Ewout W, and Lingsma, Hester F

Published
2018
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5. Comparison of Prehospital Assessment by Paramedics and In-Hospital Assessment by Physicians in Suspected Stroke Patients: Results From 2 Prospective Cohort Studies.

Author

Dekker, Luuk, Daems, Jasper D., Duvekot, Martijne H. C., My Nguyen, T. Truc, Venema, Esmee, van Es, Adriaan C. G. M., Rozeman, Anouk D., Moudrous, Walid, Dorresteijn, Kirsten R. I. S., Hensen, Jan-Hein J., Bosch, Jan, van Zwet, Erik W., de Schryver, Els L. L. M., Kloos, Loet M. H., de Laat, Karlijn F., Aerden, Leo A. M., van den Wijngaard, Ido R., Dippel, Diederik W. J., Kerkhoff, Henk, and Wermer, Marieke J. H.

Published
2023
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6. Prehospital Stroke Triage: A Modeling Study on the Impact of Triage Tools in Different Regions.

Author

Duvekot, Martijne H. C., Garcia, Bjarty L., Dekker, Luuk, Nguyen, Truc My, van den Wijngaard, Ido R., de Laat, Karlijn F., de Schryver, Els L. L. M., Kloos, Loet M. H., Aerden, Leo A. M., Zylicz, Stas A., Bosch, Jan, van Belle, Eduard, van Zwet, Erik W., Rozeman, Anouk D., Moudrous, Walid, Vermeij, Frédérique H., Lingsma, Hester F., Bakker, Jeannette, van Doormaal, Pieter Jan, and van Es, Adriaan C. G. M.

Subjects
STROKE, MEDICAL triage, TREATMENT delay (Medicine), COMPARATIVE studies, RESEARCH funding, STROKE patients, SENSITIVITY & specificity (Statistics), EMERGENCY medicine, LONGITUDINAL method
Abstract

Direct transportation to a thrombectomy-capable intervention center is beneficial for patients with ischemic stroke due to large vessel occlusion (LVO), but can delay intravenous thrombolytics (IVT). The aim of this modeling study was to estimate the effect of prehospital triage strategies on treatment delays and overtriage in different regions. We used data from two prospective cohort studies in the Netherlands: the Leiden Prehospital Stroke Study and the PRESTO study. We included stroke code patients within 6 h from symptom onset. We modeled outcomes of Rapid Arterial oCclusion Evaluation (RACE) scale triage and triage with a personalized decision tool, using drip-and-ship as reference. Main outcomes were overtriage (stroke code patients incorrectly triaged to an intervention center), reduced delay to endovascular thrombectomy (EVT), and delay to IVT. We included 1798 stroke code patients from four ambulance regions. Per region, overtriage ranged from 1-13% (RACE triage) and 3-15% (personalized tool). Reduction of delay to EVT varied by region between 24 ± 5 min (n = 6) to 78 ± 3 (n = 2), while IVT delay increased with 5 (n = 5) to 15 min (n = 21) for non-LVO patients. The personalized tool reduced delay to EVT for more patients (25 ± 4 min [n = 8] to 49 ± 13 [n = 5]), while delaying IVT with 3-14 min (8-24 patients). In region C, most EVT patients were treated faster (reduction of delay to EVT 31 ± 6 min (n = 35), with RACE triage and the personalized tool. In this modeling study, we showed that prehospital triage reduced time to EVT without disproportionate IVT delay, compared to a drip-and-ship strategy. The effect of triage strategies and the associated overtriage varied between regions. Implementation of prehospital triage should therefore be considered on a regional level. [ABSTRACT FROM AUTHOR]

Published
2023
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7. Safety and Efficacy of Dual Thrombolytic Therapy With Mutant Prourokinase and Small Bolus Alteplase for Ischemic Stroke: A Randomized Clinical Trial.

Author

van der Ende, Nadinda A. M., Roozenbeek, Bob, Smagge, Lucas E. M., Luijten, Sven P. R., Aerden, Leo A. M., Kraayeveld, Petra, van den Wijngaard, Ido R., Lycklama à Nijeholt, Geert J., den Hertog, Heleen M., Flach, H. Zwenneke, Postma, Alida A., Roosendaal, Stefan D., Krietemeijer, G. Menno, Yo, Lonneke S. F., de Maat, Moniek P. M., Nieboer, Daan, Del Zoppo, Gregory J., Meurer, William J., Lingsma, Hester F., and van der Lugt, Aad

Published
2023
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8. Time to Reperfusion and Treatment Effect for Acute Ischemic Stroke: A Randomized Clinical Trial

Author

Fransen, Puck S. S., Berkhemer, Olvert A., Lingsma, Hester F., Beumer, Debbie, van den Berg, Lucie A., Yoo, Albert J., Schonewille, Wouter J., Vos, Jan Albert, Nederkoorn, Paul J., Wermer, Marieke J. H., van Walderveen, Marianne A. A., Staals, Julie, Hofmeijer, Jeannette, van Oostayen, Jacques A., Lycklama à Nijeholt, Geert J., Boiten, Jelis, Brouwer, Patrick A., Emmer, Bart J., de Bruijn, Sebastiaan F., van Dijk, Lukas C., Kappelle, L. Jaap, Lo, Rob H., van Dijk, Ewoud J., de Vries, Joost, de Kort, Paul L. M., van den Berg, J. S. Peter, van Hasselt, Boudewijn A. A. M., Aerden, Leo A. M., Dallinga, René J., Visser, Marieke C., Bot, Joseph C. J., Vroomen, Patrick C., Eshghi, Omid, Schreuder, Tobien H. C. M. L., Heijboer, Roel J. J., Keizer, Koos, Tielbeek, Alexander V., den Hertog, Heleen M., Gerrits, Dick G., van den Berg-Vos, Renske M., Karas, Giorgos B., Steyerberg, Ewout W., Flach, H. Zwenneke, Marquering, Henk A., Sprengers, Marieke E. S., Jenniskens, Sjoerd F. M., Beenen, Ludo F. M., van den Berg, René, Koudstaal, Peter J., van Zwam, Wim H., Roos, Yvo B.W. E. M., van Oostenbrugge, Robert J., Majoie, Charles B. L. M., van der Lugt, Aad, and Dippel, Diederik W. J.

Published
2016
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9. The Cortical Response Evoked by Robotic Wrist Perturbations Reflects Level of Proprioceptive Impairment After Stroke.

Author

van Kordelaar, Joost, van de Ruit, Mark, Solis-Escalante, Teodoro, Aerden, Leo A. M., Meskers, Carel G. M., van Wegen, Erwin E. H., Schouten, Alfred C., Kwakkel, Gert, and van der Helm, Frans C. T.

Subjects
WRIST, PROPRIOCEPTION, FORELIMB, SIGNAL-to-noise ratio, ROBOTICS
Abstract

Background: Proprioception is important for regaining motor function in the paretic upper extremity after stroke. However, clinical assessments of proprioception are subjective and require verbal responses from the patient to applied proprioceptive stimuli. Cortical responses evoked by robotic wrist perturbations and measured by electroencephalography (EEG) may be an objective method to support current clinical assessments of proprioception. Objective: To establish whether evoked cortical responses reflect proprioceptive deficits as assessed by clinical scales and whether they predict upper extremity motor function at 26 weeks after stroke. Methods: Thirty-one patients with stroke were included. In week 1, 3, 5, 12, and 26 after stroke, the upper extremity sections of the Erasmus modified Nottingham Sensory Assessment (EmNSA-UE) and the Fugl-Meyer Motor Assessment (FM-UE) and the EEG responses (64 channels) to robotic wrist perturbations were measured. The extent to which proprioceptive input was conveyed to the affected hemisphere was estimated by the signal-to-noise ratio (SNR) of the evoked response. The relationships between SNR and EmNSA-UE as well as SNR and time after stroke were investigated using linear regression. Receiver-operating-characteristic curves were used to compare the predictive values of SNR and EmNSA-UE for predicting whether patients regained some selective motor control (FM-UE > 22) or whether they could only move their paretic upper extremity within basic limb synergies (FM-UE ≤ 22) at 26 weeks after stroke. Results: Patients (N = 7) with impaired proprioception (EmNSA-UE proprioception score < 8) had significantly smaller SNR than patients with unimpaired proprioception (N = 24) [EmNSA-UE proprioception score = 8, t (29) = 2.36, p = 0.03]. No significant effect of time after stroke on SNR was observed. Furthermore, there was no significant difference in the predictive value between EmNSA-UE and SNR for predicting motor function at 26 weeks after stroke. Conclusion: The SNR of the evoked cortical response does not significantly change as a function of time after stroke and differs between patients with clinically assessed impaired and unimpaired proprioception, suggesting that SNR reflects persistent damage to proprioceptive pathways. A similar predictive value with respect to EmNSA-UE suggests that SNR may be used as an objective predictor next to clinical sensory assessments for predicting motor function at 26 weeks after stroke. [ABSTRACT FROM AUTHOR]

Published
2021
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