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1. Extracellular vesicles miR-574-5p and miR-181a-5p as prognostic markers in NSCLC patients treated with nivolumab

Author

Genova, Carlo, Marconi, Silvia, Chiorino, Giovanna, Guana, Francesca, Ostano, Paola, Santamaria, Sara, Rossi, Giovanni, Vanni, Irene, Longo, Luca, Tagliamento, Marco, Zullo, Lodovica, Dal Bello, Maria Giovanna, Dellepiane, Chiara, Alama, Angela, Rijavec, Erika, Ludovini, Vienna, Barletta, Giulia, Passiglia, Francesco, Metro, Giulio, Baglivo, Sara, Chiari, Rita, Rivoltini, Licia, Biello, Federica, Baraibar, Iosune, Gil-Bazo, Ignacio, Novello, Silvia, Grossi, Francesco, and Coco, Simona

Published
2024
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4. Proximal sealing in the aortic arch for inner curve disease using the custom Relay scalloped and fenestrated stent graft

Author

Alberti, Antonino, Buia, Francesco, Di Marco, Luca, Massara, Mafalda, Bonanno, Paolo, Lepidi, Sandro, Berti, Sergio, Sica, Simona, Pratesi, Giovanni, Rossi, Giovanni, Ferraresi, Marco, Lovato, Luigi, Volpe, Pietro, Fadda, Gian Franco, Ferri, Michelangelo, Rizza, Antonio, D'Oria, Mario, Micheli, Raimondo, Tshomba, Yamume, and Tinelli, Giovanni

Published
2024
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5. Outcomes of off-the-shelf preloaded inner branch device for urgent endovascular thoraco-abdominal aortic repair in the ItaliaN Branched Registry of E-nside EnDograft

Author

Antonello, Michele, Piazza, Michele, Squizzato, Francesco, Spezia, Matteo, Grego, Franco, Pratesi, Giovanni, Spinella, Giovanni, Esposito, Davide, Bastianon, Martina, Tshomba, Yamume, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Gaggiano, Andrea, Vento, Vincenzo, Carbonari, Luciano, Gatta, Emanuele, Lenti, Massimo, Simonte, Gioele, Isernia, Giacomo, Parlani, Giambattista, Piffaretti, Gabriele, Frigatti, Paolo, Scrivere, Paola, Furlan, Federico, Veraldi, Gian Franco, Mezzetto, Luca, Gennai, Stefano, Leone, Nicola, Silingardi, Roberto, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Costantini Brancadoro, Emidio, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Compagnoni, Nicola Monzio, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Ronchey, Sonia, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Bertoglio, Luca, Volpe, Pietro, Massara, Mafalda, Milite, Domenico, and Xodo, Andrea

Published
2024
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7. Uncomplicated Type B Aortic Dissection: A European Multicentre Cross-Sectional Evaluation

Author

Bashir, Mohamad, Jubouri, Matti, Surkhi, Abdelaziz O., Williams, Ian M., Davidovic, Lazar B., Koncar, Igor, Baltrūnas, Tomas, Kunt, Aysegul, Tanyeli, Ömer, Bayram, Muhammed, Ugur, Murat, Rossi, Giovanni, Stelzmueller, Marie-Elisabeth, Hoksbergen, Arjan W.J., Jongkind, Vincent, Bertoglio, Luca, Zacà, Sergio, Mansour, Wassim, Sirignano, Pasqualino, D'Oria, Mario, Tolva, Valerio Stefano, Van Herzeele, Isabelle, Klincheva, Milka, Atanasov, Zvonka, Bartoli, Stefano, Bellosta, Raffaello, Chisci, Emiliano, Guagliano, Alberto, Teraa, Martin, Ivak, Peter, Recicarova, Sandra, Pellenc, Quentin, Heijmen, Robin, Pfister, Karin, Piffaretti, Gabriele, Hutchings, Hayley, Holland, Gail, Bailey, Damian M., Thielmann, Matthias, and Jakob, Heinz

Published
2024
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8. Front-line liquid biopsy for early molecular assessment and treatment of hospitalized lung cancer patients

Author

Parisi, Francesca, De Luca, Giuseppa, Mosconi, Manuela, Lastraioli, Sonia, Dellepiane, Chiara, Rossi, Giovanni, Puglisi, Silvia, Bennicelli, Elisa, Barletta, Giulia, Zullo, Lodovica, Santamaria, Sara, Mora, Marco, Ballestrero, Alberto, Montecucco, Fabrizio, Bellodi, Andrea, Del Mastro, Lucia, Lambertini, Matteo, Barisione, Emanuela, Cittadini, Giuseppe, Tagliabue, Elena, Spagnolo, Francesco, Tagliamento, Marco, Coco, Simona, Dono, Mariella, and Genova, Carlo

Published
2024
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10. Diagnosis of lung cancer following emergency admission: Examining care pathways, clinical outcomes, and advanced NSCLC treatment in an Italian cancer Center

Author

Vallome, Giacomo, Cafaro, Iacopo, Bottini, Annarita, Dellepiane, Chiara, Rossi, Giovanni, Bennicelli, Elisa, Parisi, Francesca, Zullo, Lodovica, Tagliamento, Marco, Ballestrero, Alberto, Barisione, Emanuela, Grazia Piroddi, Ines Maria, Montecucco, Fabrizio, Carbone, Federico, Pronzato, Paolo, Lambertini, Matteo, Spagnolo, Francesco, Barletta, Giulia, Barcellini, Lucrezia, Ferrante, Michele, Nardin, Simone, Coco, Simona, Marconi, Silvia, Zinoli, Linda, Moscatelli, Paolo, Arboscello, Eleonora, Del Mastro, Lucia, Bellodi, Andrea, and Genova, Carlo

Published
2023
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13. Editor's Choice – Early Outcomes of a Novel Off the Shelf Preloaded Inner Branch Endograft for the Treatment of Complex Aortic Pathologies in the ItaliaN Branched Registry of E-nside EnDograft (INBREED)

Author

Forcella, Edoardo, Grego, Franco, Spinella, Giovanni, Di Gregorio, Sara, Donati, Tommaso, Sica, Simona, Tinelli, Giovanni, Ferri, Michelangelo, Quaglino, Simone, Vento, Vincenzo, Carbonari, Luciano, Lenti, Massimo, Isernia, Giacomo, Parlani, Giambattista, Scrivere, Paola, Furlan, Federico, Mezzetto, Luca, Mastrorilli, Davide, Gennai, Stefano, Leone, Nicola, Iacono, Gustavo, Turricchia, Giorgio Ubaldo, Angiletta, Domenico, Maione, Massimo, Apostolou, Dimitri, Pulli, Raffaele, Fargion, Aaron, Pratesi, Carlo, Filippi, Federico, De Angelis, Filippo, Arici, Vittorio, Bozzani, Antonio, Luigi Molinari, Alessandro Carlo, Rossi, Giovanni, Brancadoro, Emidio Costantini, Ferraris, Matteo, Dorrucci, Vittorio, Derone, Graziana, Tolva, Valerio Stefano, Segramora, Vittorio Maria, Deleo, Gaetano, Bracale, Umberto, Guzzardi, Giuseppe, Ferrer, Ciro, Giudice, Rocco, Sbarigia, Enrico, Cuozzo, Simone, Gattuso, Roberto, Mansour, Wassim, Di Marzo, Luca, Grimaldi, Sabrina, Corona, Mario, Chisci, Emiliano, Mechelagnoli, Stefano, De Donato, Gianmarco, Palasciano, Giancarlo, Pasqui, Edoardo, Candeloro, Laura, Ricci, Carmelo, Neri, Eugenio, Mangialardi, Nicola, Orrico, Matteo, Fazzini, Stefano, Ippoliti, Arnaldo, Discalzi, Andrea, Rossato, Denis, Vio, Elias, Galeazzi, Edoardo, Farneti, Fabrizio, Piazza, Michele, Squizzato, Francesco, Pratesi, Giovanni, Tshomba, Yamume, Gaggiano, Andrea, Gatta, Emanuele, Simonte, Gioele, Piffaretti, Gabriele, Frigatti, Paolo, Veraldi, Gian Franco, Silingardi, Roberto, and Antonello, Michele

Published
2023
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15. An Italian prospective multicenter study on colonoscopy practice and quality: What has changed in the last 10 years

Author

Alvisi, Costanza, Amato, Loretta, Azzurro, Maurizio, Benazzato, Luca, Bianco, Maria Antonia, Biviano, Ivano, Bravi, Ivana, Brunacci, Matteo, Bucci, Cristina, Buonocore, Matteo Rossano, Cadoni, Sergio, Camellini, Lorenzo, Capone, Pietro, Cavallaro, Lucas G., Condino, Giovanna, Crosta, Cristiano, de Bellis, Mario, de Colibus, Patrizia, de Nigris, Francesca, Esposito, Dario, Fiori, Giancarla, Fornasarig, Mara, Fracchia, Mario, Gemme, Carlo, Germanà, Bastianello, Gianni, Elena, Giunta, Mariangela, Guarnieri, Giovanni, Iabichino, Giuseppe, Luigiano, Carmelo, Maiero, Stefania, Marini, Mario, Marone, Pietro, Meucci, Costantino, Morandi, Elisabetta, Mura, Donatella, Nucci, Andrea, Peccianti, Caterina, Praianò, Francesca, Prisco, Antonio, Rastelli, Carlotta, Ravizza, Davide, Rocca, Rodolfo, Rosa, Cesare, Rossi, Giovanni Battista, Sannino, Angela, Testoni, Sabrina, Urban, Flavia, Testoni, Pier Alberto, Notaristefano, Chiara, Soncini, Marco, Hassan, Cesare, Monica, Fabio, Radaelli, Franco, Triossi, Omero, Pasquale, Luigi, Neri, Matteo, Cannizzaro, Renato, and Leandro, Gioacchino

Published
2023
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19. The Role of Rituximab in Primary Focal Segmental Glomerular Sclerosis of the Adult

Author

Affatato, Stefania, Caroti, Leonardo, Mancini, Elena, Semeraro, Luca, Siligato, Rossella, Arnaldo Cassia, Matthias, Napodano, Pietro, Calatroni, Marta, Distratis, Cosimo, Campo, Andrea, Tedesco, Martina, Mescia, Federica, Pisani, Isabella, Allinovi, Marco, Casazza, Giovanni, Del Vecchio, Lucia, Santostefano, Marisa, Cirillo, Luigi, Ferrario, Francesca, Esposito, Ciro, Esposito, Pasquale, Santoro, Domenico, Lazzarin, Roberta, Rossi, Giovanni Maria, Fiaccadori, Enrico, Ferrantelli, Angelo, Sinico, Renato Alberto, Cozzolino, Mario, Gallieni, Maurizio, Cirami, Lino, Scolari, Francesco, Vaglio, Augusto, and Alberici, Federico

Published
2022
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22. Longitudinal observational (single cohort) study on the causes of trypanocide failure in cases of African animal trypanosomosis in cattle near wildlife protected areas of Northern Tanzania.

Author

Richards, Shauna, Pagnossin, Davide, Buyugu, Paul Samson, Manangwa, Oliver, Mramba, Furaha, Sindoya, Emmanuel, Paxton, Edith, Torr, Steve J., Ritchie, Ryan, Rossi, Giovanni E., Anyanwu, Lawrence Nnadozie, Barrett, Michael P., Morrison, Liam J., and Auty, Harriet

Subjects
HIGH performance liquid chromatography, ANIMAL herds, AFRICAN animals, INSECTICIDE application, CATTLE herding
Abstract

African animal trypanosomosis (AAT) in cattle is primarily managed through trypanocide administration and insecticide application. Trypanocides can be used for both treatment and prophylaxis, but failure is often reported; this may occur due to resistance, substandard drugs, or inappropriate administration. This study in Tanzania aims to quantify reasons for trypanocide failure. An observational year-long longitudinal study was conducted in high-risk AAT areas in Serengeti District between June 2021-October 2022. Purposive sampling targeted herds with high utilization of the prophylactic trypanocide isometamidium chloride (ISM). When a farmer administered a trypanocide (ISM, diminazine aceturate, homidium), the project veterinarian assessed administration and treatment outcomes were determined based on PCR results from blood samples. A multivariable mixed model was utilized to evaluate risk factors for prophylaxis failure. Quality analysis was performed on trypanocide samples using High Performance Liquid Chromatography. A total of 630 cattle from 21 farms were monitored for a year-long period. A total of 295 trypanocide administrations were reported, predominantly being ISM (56%) used for prophylaxis (87%). One-third of trypanocide administrations were not given adequately, and many trypanocides were given to animals that tested negative for trypanosome infections by PCR. Failures occurred in 7% (95% CI 3.0–14%) of curative treatments, and 44% (95% CI 35–42%) of prophylactic administrations. The brand of ISM was significantly associated with odds of prophylaxis failure (p = 0.011). On quality analysis, two ISM samples had no detectable ISM isomers, but the remainder of ISM and DA samples (n = 46) fell within the range of acceptable levels. Drug counterfeiting, inadequate use of trypanocides, and resistance are all contributing to trypanocide failure, limiting effective AAT control and with implications for human disease risk. In order to curb trypanocide failure a multi-modal approach to managing the use of trypanocides is required to address all contributing factors. Author summary: African animal trypanosomosis (AAT) in cattle is commonly controlled through the use of medications called trypanocides. However, these interventions often fail to control AAT due to reasons such as drug resistance, poor-quality medicines, or incorrect administration. This study, conducted in Tanzania between December 2019 and October 2022, aimed to understand why trypanocides fail. Researchers focused particularly on cattle herds that used a preventive drug called isometamidium chloride (ISM). During the study, a veterinarian monitored how farmers administered trypanocides like ISM, diminazine aceturate (DA), or homidium, ensuring proper dosage and storage. Blood samples from cattle were tested to check if treatments were effective. The study found that one-third of trypanocide treatments were not given correctly, and many cattle treated with trypanocides were not actually infected. It was determined that 7% of treatments and 44% of preventive doses failed. The type of ISM brand used played a significant role in failure rates, with some brands performing worse than others. Additionally, tests revealed that some ISM samples lacked the active ingredients necessary for effectiveness. The study highlights that counterfeit drugs, improper use, and drug resistance all contribute to the problem, and a more comprehensive strategy is needed to tackle these issues. [ABSTRACT FROM AUTHOR]

Published
2025
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23. New Treatment Regimens, New Drugs, and New Treatment Goals for Lupus Nephritis.

Author

Rossi, Giovanni M. and Vaglio, Augusto

Subjects
*CHRONIC kidney failure, *LUPUS nephritis, *SYSTEMIC lupus erythematosus, *MYCOPHENOLIC acid, *BELIMUMAB
Abstract

Lupus nephritis is one of the most severe manifestations of systemic lupus erythematosus, affecting roughly 40% of all lupus patients. With the introduction of cyclophosphamide and mycophenolate mofetil, outcomes have dramatically improved. However, 10% of patients still progress towards end-stage kidney disease, which carries an elevated mortality rate. In recent years, several novel agents have been approved for use or have shown preliminary evidence of efficacy in lupus nephritis. These agents include belimumab, voclosporin, and obinutuzumab, among others. Efficacy has also been demonstrated in recent trials combining older drugs. However, determining which patients would benefit the most from novel agents or combined drug regimens and whether these drugs might serve as an alternative to current remission-induction drug regimens rather than as add-on therapies remain unresolved issues. In this review, we will explore the current evidence regarding the efficacy of novel agents. [ABSTRACT FROM AUTHOR]

Published
2025
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28. Definition and management of colorectal polyposis not associated with APC/MUTYH germline pathogenic variants: AIFEG consensus statement

Author

Adami, Francesca, Alducci, Elisa, Amadori, Lucia, Arcangeli, Valentina, Balestrino, Luisa, Bao, Quoc Riccardo, Barana, Daniela, Bertario, Lucio, Bonanni, Bernardo, Boni, Stefania, Bullian, Pierluigi, Carbonardi, Fiorella, Carnevali, Ileana, Castelli, Paola, Celotto, Francesco, Cini, Giulia, Crivellari, Gino, Libera, Duilio Della, Dell'elice, Anastasia, Digennaro, Maria, D'urso, Alessandra, Fabretto, Antonella, Fanale, Daniele, Feroce, Irene, Furlan, Daniela, Ghiorzo, Paola, Giacché, Mara, Gusella, Milena, Liserre, Barbara, Lucci Cordisco, Emanuela, Mammi, Isabella, Martayan, Aline, Massuras, Stefania, Mazzà, Daniela, Mollica, Eleonora, Morabito, Alberto, Nardo, Giorgia, Oliani, Cristina, Palermo, Flavia, Panizza, Elena, Patruno, Margherita, Pedroni, Monica, Pensotti, Valeria Grazia Maria, Piozzi, Guglielmo Niccolo, Ponz de Leon, Maurizio, Pozzi, Simonetta, Presi, Silvia, Pucciarelli, Salvatore, Puzzono, Marta, Ranzani, Guglielmina Nadia, Ravegnani, Mila, Remo, Andrea, Ricci, Maria Teresa, Roncucci, Luca, Rossi, Giovanni Battsita, Sala, Elena Maria, Mete, Lupe Sanchez, Sandonà, Daniele, Sciallero, Stefania, Serrano, Davide, Signoroni, Stefano, Spina, Francesca, Stigliano, Vittoria, Taborelli, Monica, Tedaldi, Gianluca, Tibiletti, Maria Grazia, Tognazzo, Silvia, Tolva, Gianluca, Trovato, Cristina Maria Concetta, Turchetti, Daniela, Urso, Emanuele Damiano Luca, Varvara, Dora, Viel, Alessandra, Vitellaro, Marco, Vivanet, Caterina, Zovato, Stefania, Zuppardo, Raffaella Alessia, and Piozzi, Guglielmo Niccolò

Published
2021
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29. Regional Survey in Lombardy, Northern Italy, on Vascular Surgery Intervention Outcomes During The COVID-19 Pandemic

Author

Briolini, Franco, Cefali, Pietro, Caronno, Roberto, Arzini, Aldo, Diaco, Domenico, Baratta, Vittorio, Aiello, Stefano, Molinari, Alessandro C.L., Giovannini, Francesca, Socrate, Anna Maria, Ferraris, Matteo, Silvestro, Antonino, Canu, Gianluca, Costantini, Emidio, Logaldo, Davide, Romani, Federico, Lista, Alfredo, Busoni, Cristina, Setti, Marco, Mezzetti, Roberto, Sala, Piergiorgio, Bassi, Luca, Luzzani, Luca, Pegorer, Matteo A., Attisani, Luca, Carugati, Claudio, Vescovi, Monica, Trabattoni, Piero, Zoli, Stefano, Rignano, Andrea, Magri, Clara, Vandone, Pierluigi, Losa, Sergio, Civilini, Efrem, Nano, Giovanni, Mazzaccaro, Daniela, Tolva, Valerio, Lanza, Jessica, Curci, Ruggiero, Simonetti, Giovanna, Lomazzi, Chiara, Grassi, Viviana, Bissacco, Daniele, Kahlberg, Andrea, Mascia, Daniele, Dallatana, Raffaello, Carmo, Michele, Ragni, Franco, Marone, Enrico M., Bozzani, Antonio, Tozzi, Matteo, Franchin, Marco, Lussardi, Gianluca, Segramora, Vittorio, Deleo, Gaetano, Crippa, Matteo, Porretta, Tiziano, Viani, Marco, Stegher, Silvia, Foresti, Davide, Bonalumi, Giovanni, Bellosta, Raffaello, Piffaretti, Gabriele, Bonardelli, Stefano, Castelli, Patrizio, Chiesa, Roberto, Frigerio, Dalmazio, Lanza, Gaetano, Pirrelli, Stefano, Rossi, Giovanni, and Trimarchi, Santi

Published
2021
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32. Proximal sealing in the aortic arch for inner curve disease using the custom Relay scalloped and fenestrated stent graft.

Author

Sica, Simona, Pratesi, Giovanni, Rossi, Giovanni, Ferraresi, Marco, Lovato, Luigi, Volpe, Pietro, Fadda, Gian Franco, Ferri, Michelangelo, Rizza, Antonio, D'Oria, Mario, Micheli, Raimondo, Tshomba, Yamume, and Tinelli, Giovanni

Abstract

This study aimed to analyze early and midterm results of custom-made proximal scallop and fenestrated stent grafts for thoracic endovascular aortic repair (TEVAR) with a proximal landing zone (PLZ) in the aortic arch. All consecutive patients treated with the custom made proximal scalloped and fenestrated Relay stent grafts (Terumo Aortic Bolton Medical Inc.) in 10 Italian centers between January 2014 and December 2022 were included. The primary end points were technical success, incidence of intraoperative major adverse events, deployment accuracy, and rate of early neurological complications, endoleaks (ELs) and retrograde aortic dissection. During the study period, 49 patients received TEVAR with Relay custom-made endograft in Italy were enrolled. The median patient age was 70.1 years (interquartile range, 23-86 years) and 65.3% were male. The indication for treatment was atherosclerotic aneurysms in 59.2% of cases and penetrating aortic ulcer in 22.4%. The endograft configuration was proximal fenestration in 55.1% and scallop in 44.9%. The proximal landing zone was zone 0 in 25 cases (51%), zone 1 in 14 cases (28.6%), and zone 2 in 10 cases (20.4%). The supra-aortic debranching procedures were 38 (77.5%). Technical success was 97.9% (48/49) owing to one case (2.0%) of inaccurate deployment. Intraoperatively, one (2.0%) type Ia and one (2.0%) type III EL were detected. There were no cases of in-hospital mortality, major adverse events, or retrograde dissection. Three minor strokes (6.1%) (National Institutes of Health Stroke Scale score of ≤4) were observed. At a mean follow-up time of 36.3 ± 21.3 months the rate of types I to III ELs and reintervention was 4.1%, respectively. Four patients (8.2%) died during the follow-up period, one (2.1%) from abdominal aortic rupture and three (6.1%) from nonaortic causes. Our early and midterm outcomes suggest that scalloped and fenestrated TEVAR may provide an acceptable alternative treatment option for aortic arch pathologies. Large-scale studies are needed to assess the long-term durability of this technique. [ABSTRACT FROM AUTHOR]

Published
2024
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33. The Controversial Role of Glucocorticoids in Atheroembolic Renal Disease: A Narrative Review.

Author

Pacchiarini, Maria Chiara, Di Mario, Francesca, Greco, Paolo, Fiaccadori, Enrico, and Rossi, Giovanni Maria

Subjects
ACUTE kidney failure, ATHEROSCLEROTIC plaque, DELAYED diagnosis, CYTOTOXINS, ANTI-inflammatory agents
Abstract

Cholesterol crystal embolism (CCE) is an underrecognized multisystemic disease caused by the displacement of cholesterol crystals from atheromatous aortic plaques to distal vascular beds, leading to ischemic injury of target organs, particularly the kidneys, i.e., atheroembolic renal disease (ARD). According to recent research, cellular necrosis, induced by crystal-induced cytotoxicity, enhances the autoinflammatory cascade of the NLPR3 inflammasome, leading in turn to the so-called "necroinflammation". The purported involvement of the latter in CCE offers a rationale for the therapeutic approach with anti-inflammatory drugs such as glucocorticoids, the use of which has long been a matter of debate in CCE. Diagnostic delay and no consistent evidence regarding efficacious treatment, leading to inconsistency in clinical practice, may worsen the already poor prognosis of ARD. The possible role of glucocorticoids in the treatment of ARD is thereby herein explored in a narrative fashion, analyzing the limited data from case reports and clinical trials. [ABSTRACT FROM AUTHOR]

Published
2024
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41. Early-onset lupus nephritis.

Author

Peyronel, Francesco, Rossi, Giovanni M, Palazzini, Giulia, Odone, Ludovica, Errichiello, Carmela, Emmi, Giacomo, and Vaglio, Augusto

Subjects
*COMPLEMENT activation, *SYMPTOMS, *GENETIC variation, *NUCLEIC acids, *ADULTS, *LUPUS nephritis
Abstract

Early-onset systemic lupus erythematous (SLE) is a distinct clinical entity characterized by the onset of disease manifestations during childhood. Despite some similarities to patients who are diagnosed during adulthood, early-onset SLE typically displays a greater disease severity, with aggressive multiorgan involvement, lower responsiveness to classical therapies, and more frequent flares. Lupus nephritis is one of the most severe complications of SLE and represents a major risk factor for long-term morbidity and mortality, especially in children. This review focuses on the clinical and histological aspects of early-onset lupus nephritis, aiming at highlighting relevant differences with adult patients, emphasizing long-term outcomes and discussing the management of long-term complications. We also discuss monogenic lupus, a spectrum of conditions caused by single gene variants affecting the complement cascade, extracellular and intracellular nucleic acid sensing and processing, and occasionally other metabolic pathways. These monogenic forms typically develop early in life and often have clinical manifestations that resemble sporadic SLE, whereas their response to standard treatments is poor. [ABSTRACT FROM AUTHOR]

Published
2024
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42. Volumetric analysis in primary and residual type B aortic dissection treated with stented-assisted balloon-induced intimal disruption and relamination technique can predict aortic reintervention.

Author

Ferraresi, Marco, Molinari, Alessandro Carlo Luigi, Katsarou, Maria, and Rossi, Giovanni

Abstract

The aim of this study was to investigate the mid-term results of stented-assisted balloon-induced intimal disruption and relamination (STABILISE) in patients with aortic dissection with the implementation of volumetric analysis. This was a single-center retrospective analysis of prospectively collected data. From May 2017 to September 2022, 42 patients underwent STABILISE for acute complicated or subacute high-risk aortic dissection. STABILISE was completed with distal extended endovascular aortic repair in 24 patients. A computed tomography scan was performed at baseline, before hospital discharge, and at 1, 3, and 5 years. Perfused total aortic, true lumen, and false lumen volumes were assessed for thoracic, visceral, and aorto-iliac segment. The ratio between false lumen and total volume was named perfusion dissection index (PDI). Complete remodeling was defined as PDI = 0, and positive remodeling as PDI ≤0.1. Technical success was 97.6%. No 30-day deaths, spinal cord injuries, or retrograde dissections were observed. Mean follow-up was 44 ± 19.4 months. Thoracic diameter was lower at last available computed tomography scan (36.7 vs 33.0 mm; P =.01). Aortic growth >5 mm was observed in 9.5% of the patients. Thoracic and visceral aortic complete remodeling were 92.8% and 83.3%, respectively, with no difference between acute and subacute group. Distal extended endovascular aortic repair significantly increased complete remodeling in the aorto-iliac segment, compared with STABILISE alone (69.6% vs 21.4%; P <.001). Freedom from vascular reinterventions at 3 years was 83.1% (95% confidence interval, 71.5%-96.6%). Total PDI ≤0.1 at first postoperative control was a predictor of vascular reinterventions (P <.0001). STABILISE is a safe and feasible technique associated with high mid-term rates of complete remodeling in the thoracic and visceral aorta. Volumetric analysis allows the quantification of aortic remodeling and represents a predictor of aortic reinterventions. [ABSTRACT FROM AUTHOR]

Published
2024
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43. No-Restraint Committed General Hospital Psychiatric Units (SPDCs) in Italy—A Descriptive Organizational Study.

Author

Pocobello, Raffaella, Camilli, Francesca, Rossi, Giovanni, Davì, Maurizio, Corbascio, Caterina, Tancredi, Domenico, Oretti, Alessandra, Bonavigo, Tommaso, Galeazzi, Gian Maria, Wegenberger, Oliver, and el Sehity, Tarek

Subjects
PUBLIC hospitals, MEDICAL protocols, DEINSTITUTIONALIZATION, HUMAN services programs, CONTROL (Psychology), MENTAL health, HEALTH policy, RISK management in business, EMPIRICAL research, HOSPITAL care, RESTRAINT of patients, JUDGMENT sampling, DESCRIPTIVE statistics, ORGANIZATIONAL structure, HUMAN rights, RESEARCH, PSYCHIATRIC hospitals, DATA analysis software, REGRESSION analysis
Abstract

This study describes and explores the application of no-restraint policies in General Hospital Psychiatric Units (GHPUs) in Italy, a country pioneering in deinstitutionalization and psychiatric reform. The research aims to assess the organizational characteristics and effectiveness of no-restraint practices, contributing to the global discourse on humane psychiatric care. Following a purposive sampling approach, a nationwide descriptive study was conducted involving a detailed online survey distributed to 24 GHPUs actively engaged in or aspiring toward no-restraint practices. The survey, comprising 60 items across seven sections, gathered comprehensive data on the structural, organizational, and operational dimensions of the units, along with the prevalence and management of restraint episodes. Results reveal a significant commitment to no-restraint policies, with 14 GHPUs reporting zero restraint incidents in 2022. Despite variations in infrastructure and staffing, a common thread was the implementation of systematic procedures and risk management training aimed at reducing coercive practices. The study identified a correlation between the use of exclusive garden spaces and an increased incidence of restraints, suggesting nuanced factors influencing restraint practices. The findings underscore the viability and ethical alignment of no-restraint practices within psychiatric care, highlighting the crucial role of organizational protocols and training. This research adds empirical weight to the advocacy for restraint-free environments in mental health settings, signaling a paradigm shift toward more humane and rights-respecting psychiatric care. [ABSTRACT FROM AUTHOR]

Published
2024
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45. Baseline serum levels of osteopontin predict clinical response to treatment with nivolumab in patients with non-small cell lung cancer

Author

Carbone, Federico, Grossi, Francesco, Bonaventura, Aldo, Vecchié, Alessandra, Minetti, Silvia, Bardi, Nicholas, Elia, Edoardo, Ansaldo, Anna Maria, Ferrara, Daniele, Rijavec, Erika, Dal Bello, Maria Giovanna, Biello, Federica, Rossi, Giovanni, Tagliamento, Marco, Alama, Angela, Coco, Simona, Spallarossa, Paolo, Dallegri, Franco, Genova, Carlo, and Montecucco, Fabrizio

Published
2019
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46. Serum PCSK9 levels at the second nivolumab cycle predict overall survival in elderly patients with NSCLC: a pilot study

Author

Bonaventura, Aldo, Grossi, Francesco, Carbone, Federico, Vecchié, Alessandra, Minetti, Silvia, Bardi, Nicholas, Elia, Edoardo, Ansaldo, Anna Maria, Ferrara, Daniele, Rijavec, Erika, Dal Bello, Maria Giovanna, Rossi, Giovanni, Biello, Federica, Tagliamento, Marco, Alama, Angela, Coco, Simona, Spallarossa, Paolo, Dallegri, Franco, Genova, Carlo, and Montecucco, Fabrizio

Published
2019
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50. Antineutrophil cytoplasmic antibody-associated vasculitides and IgG4-related disease: A new overlap syndrome

Author

Danlos, François-Xavier, Rossi, Giovanni Maria, Blockmans, Daniel, Emmi, Giacomo, Kronbichler, Andreas, Durupt, Stéphane, Maynard, Claire, Luca, Luminita, Garrouste, Cyril, Lioger, Bertrand, Mourot-Cottet, Rachel, Dhote, Robin, Arlet, Jean-Benoit, Hanslik, Thomas, Rouvier, Philippe, Ebbo, Mikael, Puéchal, Xavier, Nochy, Dominique, Carlotti, Agnès, Mouthon, Luc, Guillevin, Loïc, Vaglio, Augusto, and Terrier, Benjamin

Published
2017
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