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Abstract The MEG experiment, designed to search for the $${\mu ^+ \rightarrow \hbox {e}^+ \gamma }$$ μ+→e+γ decay, completed data-taking in 2013 reaching a sensitivity level of $${5.3\times 10^{-13}}$$ 5.3×10-13 for the branching ratio. In order to increase the sensitivity reach of the experiment by an order of magnitude to the level of $$6\times 10^{-14}$$ 6×10-14 , a total upgrade, involving substantial changes to the experiment, has been undertaken, known as MEG II. We present both the motivation for the upgrade and a detailed overview of the design of the experiment and of the expected detector performance.

Il progetto per l’isola di Lampedusa è articolato sull’idea di un segno forte che incide la crosta terrestre, la cui espressività formale può essere ricondotta a interventi quali il Cretto di Burri e il memoriale di Eisenman a Berlino. L’intervento è concepito come un’opera di land art che dialoga con il territorio attraverso i dispositivi analitici dell’architettura e si definisce con il sistema della percorrenza. La forma architettonica-territoriale del monumento-memoriale identifica e riconosce nel carattere del progetto di architettura il valore di significato che il lemma transito è in grado di trasferire ed esprimere attraverso la forma d’arte. Il percorso, incidendo la crosta terrestre, lascia un segno indelebile al suolo che rimanda al tema del labirinto e alle incisioni rupestri.

It has long been suspected by general relativists that physicists who do not specialize in general relativity (GR) believe that special relativity (SR) is incapable of modeling dynamics within accelerated reference frames. Consequently, many physicists may conclude that certain phenomena, such as time dilation due to acceleration, can only be described with GR. The fact of the matter is, as long as spacetime is flat, SR is fully capable of describing the dynamics of accelerated reference frames. In the classic textbook "Gravitation," the authors state that "special relativity was developed precisely to predict the physics of accelerated objects." To quote Sean Carroll in his textbook "Spacetime and Geometry," "The notion of "acceleration" in special relativity has a bad reputation, for no good reason." Finally, in a quote that drives the main point of this article home, the late general relativist Alfred Schild once said, "A good many believe that [the twin] paradox can only be resolved by the general theory of relativity. They find great comfort in this because they don't know any general relativity."

Background Corallium japonicum, a prized resource in Japan, plays a vital role in traditional arts and fishing industries. Because of diminished stock due to overexploitation, ongoing efforts are focused on restoration through transplantation. This study aimed to enhance our understanding of the reproductive biology of these valuable corals and find more efficient methods for sex determination, which may significantly contribute to conservation initiatives. Methods We used 12 three-month aquarium reared C. japonicum colony fragments, conducted histological analysis for maturity and sex verification, and performed transcriptome analysis via de novo assembly and mapping using the C. rubrum transcriptome to explore gene expression differences between female and male C. japonicum. Results Our histological observations enabled sex identification in 33% of incompletely mature samples. However, the sex of the remaining 67% of samples, classified as immature, could not be identified. RNA-seq yielded approximately 21–31 million short reads from 12 samples. De novo assembly yielded 404,439 highly expressed transcripts. Among them, 855 showed significant differential expression, with 786 differentially expressed transcripts between females and males. Heatmap analysis highlighted 283 female-specific and 525 male-specific upregulated transcripts. Transcriptome assembly mapped to C. rubrum yielded 28,092 contigs, leading to the identification of 190 highly differentially expressed genes, with 113 upregulated exclusively in females and 70 upregulated exclusively in males. Blastp analysis provided putative protein annotations for 83 female and 72 male transcripts. Annotation analysis revealed that female biological processes were related to oocyte proliferation and reproduction, whereas those in males were associated with cell adhesion. Discussion Transcriptome analysis revealed sex-specific gene upregulation in incompletely mature C. japonicum and shared transcripts with C. rubrum, providing insight into its gene expression patterns. This study highlights the importance of using both de novo and reference-based assembly methods. Functional enrichment analysis showed that females exhibited enrichment in cell proliferation and reproduction pathways, while males exhibited enrichment in cell adhesion pathways. To the best of our knowledge, this is the first report on the gene expressions of each sex during the spawning season. Our findings offer valuable insights into the physiological ecology of incompletely mature red Japanese precious corals and suggest a method for identifying sex using various genes expressed in female and male individuals. In the future, techniques such as transplantation, artificial fertilization, and larval rearing may involve sex determination methods based on differences in gene expression to help conserve precious coral resources and ecosystems.

Abstract The temporal Talbot effect is a passive phenomenon that occurs when a periodic signal propagates through a dispersive medium with a quadratic phase response that modulates the output pulse repetition rate based on the input period. As previously proposed, this effect enables innovative applications such as passive amplification. However, its observation in the microwave regime has been impractical due to the requirement for controlled propagation through a highly dispersive waveguide. To overcome this challenge, we employed an ultra-wide band linearly chirped Bragg grating within a standard microwave X-Band waveguide. By utilizing backwards Talbot array illuminators aided by particle swarm optimization, we achieved passive amplification with a gain of 3.45 dB and 4.03 dB for gaussian and raised cosine pulses, respectively. Furthermore, we numerically verified that with higher quality substrates this gain can be theoretically increased to over 8 dB. Our work paves the way for numerous applications of the Talbot effect in the microwave regime, such as temporal cloaking, sub-noise microwave signal detection, microwave pulse shaping, and microwave noise reduction.

At the beginning of De vita beata, Seneca defines the vulgus in an original way: aristocrats are included in his definition of the notion. We will study this definition from three different perspectives. Firstly, this paper looks into the manuscript transmission of this passage and outlines the history of the discussions about this definition, whose cryptic nature has generated a lot of commentary since the Renaissance period. Secondly, it aims at explaining the meaning of this passage by giving new arguments to support the view that the participles chlamydati and coronati refer to the aristocrats, who are usually excluded from the vulgus. Thirdly, it situates this definition in Stoicism and Seneca’s works.

Abstract Mounting evidence shows sex-related differences in the experience of pain with women suffering more from chronic pain than men. Yet, our understanding of the biological basis underlying those differences remains incomplete. Using an adapted model of formalin-induced chemical/inflammatory pain, we report here that in contrast to male mice, females distinctly display two types of nocifensive responses to formalin, distinguishable by the duration of the interphase. Females in proestrus and in metestrus exhibited respectively a short-lasting and a long-lasting interphase, underscoring the influence of the estrus cycle on the duration of the interphase, rather than the transcriptional content of the dorsal horn of the spinal cord (DHSC). Additionally, deep RNA-sequencing of DHSC showed that formalin-evoked pain was accompanied by a male-preponderant enrichment in genes associated with the immune modulation of pain, revealing an unanticipated contribution of neutrophils. Taking advantage of the male-enriched transcript encoding the neutrophil associated protein Lipocalin 2 (Lcn2) and using flow cytometry, we confirmed that formalin triggered the recruitment of LCN2-expressing neutrophils in the pia mater of spinal meninges, preferentially in males. Our data consolidate the contribution of female estrus cycle to pain perception and provide evidence supporting a sex-specific immune regulation of formalin-evoked pain.

In recent years, the need for systems capable of achieving the dynamic learning and information storage efficiency of the biological brain has led to the emergence of neuromorphic research. In particular, neuromorphic optics was born with the idea of reproducing the functional and structural properties of the biological brain. In this context, solitonic neuromorphic research has demonstrated the ability to reproduce dynamic and plastic structures capable of learning and storing through conformational changes in the network. In this paper, we demonstrate that solitonic neural networks are capable of mimicking the functional behaviour of biological neural tissue, in terms of synaptic formation procedures and dynamic reinforcement.

CEA/Cadarache operates the MADERE facility dedicated to measuring the activity of radionuclides generated during the irradiation of specific dosimeters made of hyper-pure materials. This facility is equipped with seven spectrometers, two of which are dedicated to the detection of radionuclides that emit X-rays. The laboratory that operates the MADERE facility processes solid-state rhodium and niobium dosimeters, which emit X-rays of 20 keV and 16 keV respectively. In recent years, there have been significant improvements in nuclear decay data, leading to better measurement of these two X-ray emitters. A joint LDCI and LNHB thesis, defended in 2018, produced major advances (for example self-attenuation corrections for 93mNb and 103mRh). The most significant achievements and outlooks are presented in this paper for the both niobium and rhodium dosimeters.

Fruit-bearing food products are controlled by phytosanitary regulatory mechanisms. Among the existing pests of economic interest, Cetatitis capitata (medfly) can be highlighted, which can infest from 250 to 400 vegetable varieties. Vicilins, constitutive proteins of chitin-binding seeds, are potentially candidates to fight this pest. Vicillin-rich fractions of Erythrina veluntina (mulungu), Canavalia ensiformis (pork beans) and Phaseolus vulgaris (common beans), isolated by affinity chromatography on a chitin column, were tested on adults of C. capitata, in laboratory and semi-laboratory bioassays. field. All were able to bind chitin, have acidic characteristics and association with carbohydrates. E. velutina vicilin was the only one to present a high lethality (100 %) in a 15 % diet (w/w). In semi-field it was observed that 10 and 15 % (w/w) of vicilin added to the diet were lethal. For TL50, death of half the population in days were 3.5 (10 %) and 3 (15 %). These results showed that vicilins are potential bioinsecticides in the control of C. capitata.

IntroductionSARS-CoV-2 infection in the pediatric population can be associated with a multiorgan inflammatory syndrome called children’s multisystem inflammatory syndrome (MIS-C). The kidneys can be affected by a broad spectrum of possible injuries, whose pathogenetic mechanisms are still unclear.Case reportWe report the case of a 5-year-old boy with severe cardiac involvement in the context of MIS-C. After two weeks of hospitalization, an abdominal ultrasound showed massive bladder “debris”, followed by the onset of normoglycemic glycosuria. Over time, there was a progressive increase in glycosuria, and the presence of a mat of amorphous phosphate crystals was evidenced on urinary sediment. Together with the findings of hypo-uricemia, increased urinary uric acid, and globally increased urinary amino acids, a clinical picture of kidney proximal tubular damage with secondary Fanconi-like syndrome took shape.DiscussionThis case report describes the case of a patient with MIS-C with cardiac and kidney involvement characterized by proximal tubular damage, which slowly improved but still persisted at the 8-month follow-up. The pathogenesis of the damage is unclear and probably multifactorial.

Background: Most head and neck cancer (HNC) patients undergoing aggressive treatments with chemoradiotherapy and surgical resection of tumors suffer from symptoms long after treatment is completed that hinder adequate oral food intake, collectively known as Nutrition Impact Symptoms (NIS). Our aim was to examine the correlations between NIS and HNC survivors’ vegetable intake and use of seasoning. Methods: We conducted a 29-item telephone administrated survey to collect vegetable intake and seasoning habits among HNC survivors (n=22, age 61.4 ± 9.8 years, mean ± standard deviation) who received radiation therapy between 6 months and 10 years before recruitment identified through the cancer registry at Carle Foundation Hospital. Treatment-related side-effects (11 items) including difficulty swallowing, dry mouth, and mouth sores reflected NIS. A mean composite score was created for all the symptoms where higher scores indicated greater NIS. Spearman correlations examined the relationships between NIS, vegetable intake, and seasoning. Results: Half (50%) of the participants reported no change in their vegetable intake since diagnosis of cancer, and on average, ate 1 cup/day of total vegetables. Higher NIS scores associated with higher pumpkin and sweet potatoes intake (r (20) = .43, p

Background: Celiac disease (CD) is the most common multisystemic autoimmune disorder affecting the pediatric population. However, little data is available regarding SARS-CoV-2 vaccination coverage in pediatric patients with CD. This study aims to evaluate the adherence to national recommendations for SARS-CoV-2 vaccination in children and adolescents with CD and its variation over time. Methods: We retrospectively analyzed medical charts and electronic registry records of SARS-CoV-2 vaccination of patients aged 0–19 years diagnosed with CD in a tertiary center. The vaccination coverage was evaluated according to age groups (young children, children, and adolescents), considering the patients' eligibility for vaccination at different times. Results: Among the 172 patients enrolled, 44.8% received at least one dose of the SARS-CoV-2 vaccine, showing no significant differences compared to the Italian population of similar age. Vaccination coverage demonstrated a progressive reduction after an initial peak (up to 65.5% in December 2021) concomitant with a gradual extension of vaccinable eligibility and falling SARS-CoV-2 infections. Histological diagnosis and the presence of other associated autoimmune diseases were associated with higher levels of adherence to vaccination. Conclusions: Adherence to the SARS-CoV-2 vaccination in young Italian children with CD was very low, while it was better in adolescents and patients with other associated autoimmune diseases. Vaccine hesitancy remains a concern, particularly among those diagnosed using the biopsy-sparing approach. Hesitancy increased during the pandemic period, suggesting the need for ongoing efforts to improve adherence to SARS-CoV-2 vaccination recommendations. [ABSTRACT FROM AUTHOR]

Glucagon‐like peptide‐1 (GLP‐1)‐based therapies, effective in treating obesity and type 2 diabetes, hold potential for reducing alcohol‐seeking behaviour. However, the understanding of how alcohol consumption affects endogenous GLP‐1 responses—important for understanding GLP‐1‐based therapies' potential in addressing alcohol misuse—is limited, given the absence of placebo‐controlled studies examining these effects. This study aimed to determine the acute effects of alcohol ingestion on GLP‐1 and other peptides and evaluate whether metabolic surgery, which increases GLP‐1 responses, blood alcohol concentrations (BAC) and alcohol misuse risk, influences this effect. Additionally, we assessed the acute effects of alcohol on plasma glucose and insulin concentrations. Using a placebo‐controlled crossover study, we examined hormonal and glucose responses after oral alcohol consumption (0.5 g/kg of fat‐free mass) versus placebo drinks in 18 women who underwent metabolic surgery <5 years ago and in 14 non‐operated controls (equivalent in age, body mass index [BMI], race and alcohol consumption patterns). Women had a mean (SD) age of 41 (10) years and a BMI of 33 (5) kg/m2. Compared with the control group, the surgery group exhibited a higher peak BAC (0.99 [0.20] g/L vs. 0.75 [0.16] g/L; P < 0.005). Alcohol decreased GLP‐1 by 34% (95% CI, 16%–52%) in both groups and decreased ghrelin more in the control (27%) than in the surgery group (13%). Alcohol modestly decreased plasma glucose and transiently increased insulin secretion in both groups (P < 0.05). However, alcohol lowered blood glucose concentrations to the hypoglycaemic range in 28% of the women in the surgery group versus none in the control group. These findings provide compelling evidence that acute alcohol consumption decreases GLP‐1, a satiation signal, elucidating alcohol's 'apéritif' effect. This study also highlights the potential increase in alcohol‐related hypoglycaemic effects after metabolic surgery. [ABSTRACT FROM AUTHOR]

Cotton Boll Weevil (CBW, Anthonomus grandis) is a devastating insect-pest affecting cotton (Gossypium spp), using cotton internal floral structures for larval development, making it difficult to control. Little is known about the mechanism underlying CBW-plant interactions leading to infestation or resistance. Here, we investigated the plant molecular responses triggered by CBW extracts from eggs, larvae, and oral secretions (OS) of larvae and adult. The MAPK pathway, one of the early signaling events in plant pattern-triggered immunity (PTI), was activated by CBW extracts in Arabidopsis thaliana. In cotton, CBW OS activated GhMPK3 and GhMPK6. Importantly, CBW OS activated the PTI marker gene FRK1 and the effector-triggered immunity (ETI) marker gene WRKY46 in Arabidopsis reporter lines, suggesting that Herbivore-Associated Molecular Patterns (HAMPs) present in OS from CBW can elicit plant defense responses in cotton and Arabidopsis. Interestingly, CBW OS-induced MAPK activation shows similar patterns in wild-type and Arabidopsis mutants, which bear mutations in already known receptor and co-receptors complex components, suggesting a distinct signaling cascade likely triggered by the putative HAMPs present in CBW OS. The work points to potentials in the identification and development of CBW extract-derived elicitors for effective pest control combating CBW infestation.

Exploring the potential of 3D printing in electromagnetic wave manipulation, this paper introduces a novel, cost-effective instrument for microwave metasurface characterization. Metasurfaces, designed to alter wave propagation, are promising tools for enhancing antenna efficiency in advanced telecommunication methods, such as 5G systems. However, their complex profile characterization often poses significant challenges. Our proposed fully automated four-axis instrument, leveraging 3D printing capable of creating complex structures (such as metasurfaces), addresses these challenges by offering an efficient and precise solution. The instrument, costing approximately USD 1550, successfully characterized a metalens designed for modulating 30 GHz signals with a 20 cm focal distance, proving its utility. The 2D and 3D intensity distribution profiles and key parameters (including 8.05 dB gain, 11 cm 3 dB depth of focus, and 2.17 cm full width at half maximum) were extracted. Our measurements notably corresponded with the theoretical diffraction calculations, validating the instrument’s efficacy. This breakthrough significantly contributes to microwave metasurface characterization techniques which are vital for future millimeter-wave communication systems.

Background: Published evidence indicates that mean arterial pressure (MAP) below a goal range (hypotension) is associated with worse outcomes, though MAP management failures are common. We sought to characterize hypotension occurrences in ICUs and consider the implications for MAP management. Methods: Retrospective analysis of 3 hospitals' cohorts of adult ICU patients during continuous vasopressor infusion. Two cohorts were general, mixed ICU patients and one was exclusively acute spinal cord injury patients. "Hypotension-clusters" were defined where there were ≥10 min of cumulative hypotension over a 60-min period and "constant hypotension" was ≥10 continuous minutes. Trend analysis was performed (predicting future MAP using 14 min of preceding MAP data) to understand which hypotension-clusters could likely have been predicted by clinician awareness of MAP trends. Results: In cohorts of 155, 66, and 16 ICU stays, respectively, the majority of hypotension occurred within the hypotension-clusters. Failures to keep MAP above the hypotension threshold were notable in the bottom quartiles of each cohort, with hypotension durations of 436, 167, and 468 min, respectively, occurring within hypotension-clusters per day. Mean arterial pressure trend analysis identified most hypotension-clusters before any constant hypotension occurred (81.2%-93.6% sensitivity, range). The positive predictive value of hypotension predictions ranged from 51.4% to 72.9%. Conclusions: Across 3 cohorts, most hypotension occurred in temporal clusters of hypotension that were usually predictable from extrapolation of MAP trends. [ABSTRACT FROM AUTHOR]

Rappresentare significa dare forma, attraverso le capacità cognitive, ai frammenti di un mondo passato, presente o mai esistito. Il mondo immaginario che irrompe attraverso le capacità analitiche del nostro intelletto unisce e percorre frammenti lontani nel tempo e nello spazio tra loro, restituendo un'immagine onirica. Il disegno eretico affronta la stessa rarefatta logica costruttiva dell'idea che abbiamo appena delineato. L'eresia sta nella costruzione geometrica della messa in scena retorica e formale delle figure che abitano lo spazio della rappresentazione e che, nel momento in cui introducono l'imprevisto, dissentono dalla logica formale del tempo in cui il disegno stesso è ambientato. L'astrazione eretica e la figuratività immaginifica del mondo distopico rappresentato da Hieronymus Bosch sono un primo tentativo di introdurre l'eresia attraverso le operazioni di scalatura e di assemblaggio di parti di figure che non avrebbero mai potuto esistere in quel modo tra loro, evidenziando la complessa realtà dell'umanità e dello spazio antropico. L'architettura di Bosch è oggetto di antropomorfismo, il fascino della contaminazione e dell'ibridazione riscrive il rapporto tra le cose, trasfigurando gli oggetti naturali nel surreale. Giovanni Battista Piranesi, nel creare una realtà fatta di figure di un mondo architettonico passato, produce la stessa vertigine del mondo surreale di Bosch, poiché entrambi rendono visibile il non visibile. Questa dualità e trasfigurazione dei significati delle figure, formalmente e semanticamente ibridate, è stata esplorata in alcune opere di Maurizio Sacripanti, Franco Purini e Massimo Scolari, proiettando immagini e figure che, emergendo da un tempo passato, strappano un nuovo sguardo sulla realtà del presente. Questo testo ripercorre e indaga alcune forme di pensiero teorico che hanno originato le rappresentazioni di artisti e architetti che, attraverso il disegno, hanno stabilito un modello di comunicazione delle condizioni del tempo.

Neuromorphic models are proving capable of performing complex machine learning tasks, overcoming the structural limitations imposed by software systems and electronic neuromorphic models. Unlike computers, the brain uses a unified geometry whereby memory and computation occur in the same physical location. The neuromorphic approach tries to reproduce the functional blocks of biological neural networks. In the photonics field, one possible and efficient way is to use integrated circuits based on soliton waveguides, ie channels self-written by light. Thanks to the nonlinearity of some crystals, propagating light can write waveguides and then can modulate them according to the information it carries. Thus, the created structures are not static but they can self-modify by varying the input information pattern. These hardware systems show a neuroplasticity which is very close to the one which characterize the brain functioning. The solitonic neuromorphic paradigm this work introduces is based on X-junction solitonic neurons as the fundamental elements for complex neural networks. These solitonic units are able to learn information both in supervised and unsupervised ways by unbalancing the X-junction. The storage of information coincides with the evolution of structure that changes plastically. Thus, complex solitonic networks can store information as propagation trajectories and use them for reasoning.

This research introduces a novel highly efficient method to interconnect two metallic nanostrips that support the propagation of surface plasmon polariton (SPP) waves exploiting photorefractive soliton guide. The intricate design of the multilayer geometry enables light control diffraction at the metallic nanostrip’s end and reduces its angular dispersion. Moreover, the system’s on/off state can be switched by exploiting the epsilon near zero properties of the indium tin oxide (ITO) layer. The photorefractive crystal positioned between the two plasmonic waveguides enables the self-confinement of light, generating a waveguide that can be utilized by both the writing light and other wavelengths transmitted as signals. The resulting SPP waves can be efficiently recoupled in the second nanostrip, with an efficiency of around 40% across a broad range of wavelengths. This cutting-edge approach paves the way for significant advancements in the field of nanophotonics and provides a fundamental framework for the development of new, highly efficient optical interconnects in nanoscale systems. The findings of this study have implications for a wide range of applications, including nanoscale sensing, optical computing, and data communication.

Background. Corallium japonicum, a prized resource in Japan, plays a vital role in traditional arts and fishing industries. Because of diminished stock due to overexploitation, ongoing efforts are focused on restoration through transplantation. This study aimed to enhance our understanding of the reproductive biology of these valuable corals and find more efficient methods for sex determination, which may significantly contribute to conservation initiatives. Methods. We used 12 three-month aquarium reared C. japonicum colony fragments, conducted histological analysis for maturity and sex verification, and performed tran- scriptome analysis via de novo assembly and mapping using the C. rubrum transcrip- tome to explore gene expression differences between female and male C. japonicum. Results. Our histological observations enabled sex identification in 33% of incompletely mature samples. However, the sex of the remaining 67% of samples, classified as immature, could not be identified. RNA-seq yielded approximately 21-31 million short reads from 12 samples. De novo assembly yielded 404,439 highly expressed transcripts. Among them, 855 showed significant differential expression, with 786 differentially expressed transcripts between females and males. Heatmap analysis highlighted 283 female-specific and 525 male-specific upregulated transcripts. Transcriptome assembly mapped to C. rubrum yielded 28,092 contigs, leading to the identification of 190 highly differentially expressed genes, with 113 upregulated exclusively in females and 70 upregulated exclusively in males. Blastp analysis provided putative protein annotations for 83 female and 72 male transcripts. Annotation analysis revealed that female biological processes were related to oocyte proliferation and reproduction, whereas those in males were associated with cell adhesion. Discussion. Transcriptome analysis revealed sex-specific gene upregulation in incom- pletely mature C. japonicum and shared transcripts with C. rubrum, providing insight into its gene expression patterns. This study highlights the importance of using both de novo and reference-based assembly methods. Functional enrichment analysis showed that females exhibited enrichment in cell proliferation and reproduction pathways, while males exhibited enrichment in cell adhesion pathways. To the best of our knowledge, this is the first report on the gene expressions of each sex during the spawning season. Our findings offer valuable insights into the physiological ecology of incompletely mature red Japanese precious corals and suggest a method for identifying sex using various genes expressed in female and male individuals. In the future, techniques such as transplantation, artificial fertilization, and larval rearing may involve sex determination methods based on differences in gene expression to help conserve precious coral resources and ecosystems. [ABSTRACT FROM AUTHOR]

In recent years, the need for systems capable of achieving the dynamic learning and information storage efficiency of the biological brain has led to the emergence of neuromorphic research. In particular, neuromorphic optics was born with the idea of reproducing the functional and structural properties of the biological brain. In this context, solitonic neuromorphic research has demonstrated the ability to reproduce dynamic and plastic structures capable of learning and storing through conformational changes in the network. In this paper, we demonstrate that solitonic neural networks are capable of mimicking the functional behaviour of biological neural tissue, in terms of synaptic formation procedures and dynamic reinforcement. [ABSTRACT FROM AUTHOR]

During the COVID-19 pandemic, lung ultrasound (LUS) was widely used to assess SARS-CoV-2 infection. To date, there are patients with persistence of symptoms after acute infection. Therefore, it may be useful to have an objective tool to follow these patients. The aim of our study was to evaluate the presence of LUS artifacts after SARS-CoV-2 infection in children and to analyze the associations between time elapsed since infection and symptomatology during acute infection. We conducted an observational study, enrolling 607 children infected with SARS-CoV-2 in the previous twelve months. All patients performed a LUS and medical history of demographic and clinical data. We observed irregular pleural lines in 27.5%, B-lines in 16.9%, and subpleural consolidations in 8.6% of the cases. These artifacts were more frequently observed in the lower lobe projections. We have observed that the frequency of artifacts decreases with increasing time since infection. In symptomatic patients during COVID infection, B-lines (p = 0.02) were more frequently found. In our sample, some children, even after months of acute infection, have ultrasound artifacts and showed an improvement with the passage of time from the acute episode. Our study provides additional evidence about LUS in children with previous COVID-19 as a support to follow these patients in the months following the infection.

In recent years, technological development has focused on the construction of ever smaller devices, characterized by dimensions limited to the nanometer order and by a very low energy requirement to be able to function. This allows them to be integrated into chips, which are then able to perform many tasks from filtering to computation. Here, we present a magnetic switch capable of working with surface plasmon polaritons.