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The “Color Circle” is an important chromatic Gestalt in the visual arts. There is not really a formal equivalent in conventional colorimetry. The fact that the hues can be linearly ordered and that such an order is necessarily periodic was intuited by artists in the early 19th century, but only formally explained by Ostwald and later Schrödinger a century later. As with musical keys, various metrical orders are in common use. Is there such a thing as a “well tempered” order? We consider this an issue for experimental phenomenology. We discuss an attempt based on observations by 30 (nonartist) observers.

Introduction and Objectives: Hepatic encephalopathy (HE) is a frequent complication of cirrhosis and may cause cerebral damage. Neurodegenerative diseases can induce the release of neuroproteins like neurofilament light chain (NfL) and glial fibrillary acidic protein (GFAP) in body fluids, including blood plasma. We investigated whether NfL and GFAP could serve as potential diagnostic plasma biomarkers for overt HE (oHE). Materials and Methods: We included 85 patients from three prospective cohorts with different stages of liver disease and HE severity. The following patients were included: 1) 34 patients with primary sclerosing cholangitis (PSC) with compensated disease; 2) 17 patients with advanced liver disease without oHE before elective transjugular intrahepatic portosystemic shunt (TIPS) placement; 3) 17 intensive care unit (ICU) patients with oHE and 17 ICU patients without cirrhosis or oHE. Plasma NfL and GFAP were measured using single molecule assays. Results: ICU oHE patients had higher NfL concentrations compared to pre-TIPS patients or ICU controls (p < 0.05, each). Median GFAP concentrations were equal in the ICU oHE and pre-TIPS patients or ICU controls. Plasma NfL and GFAP concentrations correlated with Model for End-Stage Liver Disease (MELD) scores (R = 0.58 and R = 0.40, p < 0.001, each). Conclusions: Plasma NfL deserves further evaluation as potential diagnostic biomarker for oHE and correlates with the MELD score.

Climate adaptation and water management, in particular flood risk management (FRM), in the Netherlands are strongly integrated policy domains. The observed and expected effects of climate change in the Netherlands will create a variety of pressures, particularly in relation to sea-level rise, increasing river discharges and changing precipitation patterns. Whereas the focus in the Netherlands until recently was mainly and successfully on minimizing the probability of flooding (‘the fight against water’) and preparedness in case of a flood threat, in the course of time other strategies aimed at mitigating the effects of potential floods have gained a more prominent position (‘living with water’). As a result, FRM measures increasingly demand more space and more diverse actors became involved in Dutch FRM. This has increased complexity and fragmentation in the responsibilities for Dutch FRM, which resulted in an increasing need for communication, coordination and collaboration between different public and private actors in order to secure the effectiveness of FRM.

In urban environments, humans often encounter other people that may engage one in interaction. How do humans perceive such invitations to interact at a glance? We briefly presented participants with pictures of actors carrying out one of 11 behaviors (e.g., waving or looking at a phone) at four camera-actor distances. Participants were asked to describe what they might do in such a situation, how they decided, and what stood out most in the photograph. In addition, participants rated how likely they deemed interaction to take place. Participants formulated clear responses about how they might act. We show convincingly that what participants would do depended on the depicted behavior, but not the camera-actor distance. The likeliness to interact ratings depended both on the depicted behavior and the camera-actor distance. We conclude that humans perceive the “gist” of photographs and that various aspects of the actor, action, and context depicted in photographs are subjectively available at a glance. Our conclusions are discussed in the context of scene perception, social robotics, and intercultural differences.

Around the globe, coastal communities are increasingly coping with changing environmental conditions as a result of climate change and ocean acidification, including sea level rise, more severe storms, and decreasing natural resources and ecosystem services. A natural adaptation response is to engineer the coast in a perilous and often doomed attempt to preserve the status quo. In the long term, however, most coastal nations will need to transition to approaches based on ecological resilience—that is, to coastal zone management that allows coastal communities to absorb and adapt to change rather than to resist it—and the law will be critical in facilitating this transition. Researchers are increasingly illuminating law's ability to promote social-ecological resilience to a changing world, but this scholarship—mostly focused on U.S. law—has not yet embraced its potential role in helping to create new international norms for social-ecological resilience. Through its comparison of coastal zone management in Australia, Finland, and the Netherlands, this article demonstrates that a comparative law approach offers a fruitful expansion of law-and-resilience research, both by extending this research to other countries and, more importantly, by allowing scholars to identify critical variables, or variable constellations associated with countries' decisions to adopt laws designed to promote social-ecological resilience and to identify mechanisms that allow for a smoother transition to this approach. For example, our comparison demonstrates, among other things, that countries can adopt coastal zone management techniques that integrate social-ecological resilience without fully abandoning more traditional engineering approaches to adapt to environmental change and its impacts.

Patients with hepatocellular carcinoma (HCC) face a common type of cancer, which is amongst the most deadly types of cancer worldwide. The therapeutic options range from curative resection or ablation to loco regional therapies in palliative setting and last but not least, systemic treatment. The latter group underwent major changes in the last decade and a half. Since the introduction of sorafenib in 2007, many other systemic treatments have been investigated. Most without success. It took more than ten years before lenvatinib could be added as alternative first-line treatment option. Just recently a new form of systemic treatment, immunotherapy, entered the field of therapeutic options in patients with HCC. Immune checkpoint inhibitors are becoming the new standard of care in patients with HCC. Several reviews reported on the latest phase 1/2 studies and discussed the higher response rates and better tolerability when compared to current standard of care therapies. This review will focus on elaborating the working mechanism of these checkpoint inhibitors, give an elaborate update of the therapeutic agents that are currently available or under research, and will give an overview of the latest trials, as well as ongoing and upcoming trials.

We studied whether human observers can estimate the illumination direction from 3D textures of random Brownian surfaces, containing undulations over a range of scales. The locally Lambertian surfaces were illuminated with a collimated beam from random directions. The surfaces had a uniform albedo and thus texture appeared only through shading and shadowing. The data confirm earlier results with Gaussian surfaces, containing undulations of a single scale. Observers were able to accurately estimate the source azimuth. If shading dominated the images, the observers committed 180° errors. If cast shadows were present, they resolved this convex-concave-ambiguity almost completely. Thus, observers relied on second-order statistics in the shading regime and used an unidentified first-order cue in the shadow regime. The source elevations could also be estimated, which can be explained by the observers’ exploitation of the statistical homogeneity of the stimulus set. The fraction of the surface that is in shadow and the median intensity are likely cues for these elevation estimates.

Research on the influence of reference frames has generally focused on visual phenomena such as the oblique effect, the subjective visual vertical, the perceptual upright, and ambiguous figures. Another line of research concerns mental rotation studies in which participants had to discriminate between familiar or previously seen 2-D figures or pictures of 3-D objects and their rotated versions. In the present study, we disentangled the influence of the environmental and the viewer-centered reference frame, as classically done, by comparing the performances obtained in various picture and participant orientations. However, this time, the performance is the pictorial relief: the probed 3-D shape percept of the depicted object reconstructed from the local attitude settings of the participant. Comparisons between the pictorial reliefs based on different picture and participant orientations led to two major findings. First, in general, the pictorial reliefs were highly similar if the orientation of the depicted object was vertical with regard to the environmental or the viewer-centered reference frame. Second, a viewpoint-from-above interpretation could almost completely account for the shears occurring between the pictorial reliefs. More specifically, the shears could largely be considered as combinations of slants generated from the viewpoint-from-above, which was determined by the environmental as well as by the viewer-centered reference frame.

In this paper, we focus on how people perceive the aspect ratio of city squares. Earlier research has focused on distance perception but not so much on the perceived aspect ratio of the surrounding space. Furthermore, those studies have focused on “open” spaces rather than urban areas enclosed by walls, houses and filled with people, cars, etc. In two experiments, we therefore measured, using a direct and an indirect method, the perceived aspect ratio of five city squares in the historic city center of Delft, the Netherlands. We also evaluated whether the perceived aspect ratio of city squares was affected by the position of the observer on the square. In the first experiment, participants were asked to set the aspect ratio of a small rectangle such that it matched the perceived aspect ratio of the city square. In the second experiment, participants were asked to estimate the length and width of the city square separately. In the first experiment, we found that the perceived aspect ratio was in general lower than the physical aspect ratio. However, in the second experiment, we found that the calculated ratios were close to veridical except for the most elongated city square. We conclude therefore that the outcome depends on how the measurements are performed. Furthermore, although indirect measurements are nearly veridical, the perceived aspect ratio is an underestimation of the physical aspect ratio when measured in a direct way. Moreover, the perceived aspect ratio also depends on the location of the observer. These results may be beneficial to the design of large open urban environments, and in particular to rectangular city squares.

Whereas existing literature on the interactions among law, adaptive governance, and resilience in the water sector often focuses on quality or supply issues, this paper addresses adaptation in national water laws in relation to increasing flood risks. In particular, this paper analyzes the extent to which legal rules governing flood defense infrastructure in a selection of European countries (England, France, Sweden, and The Netherlands) allow for response and adaptation to change and uncertainty. Although there is evidence that the legal rules on the development of new infrastructure require that changing conditions be considered, the adaptation of existing infrastructure is a more complicated matter. Liability rules fail to adequately address damages resulting from causes external to the action or inaction of owners and managers, in particular extreme events. A trend toward clearer, and in some cases, increased public powers to ensure the safety of flood defense infrastructure is observed. The paper concludes that legal rules should ensure not only that decisions to build flood defenses are based on holistic and future-oriented assessments, but also that this is reflected in the implementation and operation of these structures.

There is a wealth of literature on the design of ex post compensation mechanisms for natural disasters. However, more research needs to be done on the manner in which these mechanisms could steer citizens toward adopting individual-level preventive and protection measures in the face of flood risks. We have provided a comparative legal analysis of the financial compensation mechanisms following floods, be it through insurance, public funds, or a combination of both, with an empirical focus on Belgium, the Netherlands, England, and France. Similarities and differences between the methods in which these compensation mechanisms for flood damages enhance resilience were analyzed. The comparative analysis especially focused on the link between the recovery strategy on the one hand and prevention and mitigation strategies on the other. There is great potential within the recovery strategy for promoting preventive action, for example in terms of discouraging citizens from living in high-risk areas, or encouraging the uptake of mitigation measures, such as adaptive building. However, this large potential has yet to be realized, in part because of insufficient consideration and promotion of these connections within existing legal frameworks. We have made recommendations about how the linkages between strategies can be further improved. These recommendations relate to, among others, the promotion of resilient reinstatement through recovery mechanisms and the removal of legal barriers preventing the establishment of link-inducing measures.

We seek to examine the manner in which either the EU member states of France, the Netherlands, Poland, and Sweden or parts of them, such as the country of England in the UK or the Flemish Region in Belgium, deal with the distributional effects of the flood risk management strategies prevention, defense, and mitigation. Measures carried out in each of these strategies can cause preflood harm, as in the devaluation of property or loss of income. However, different member states and authorities address this harm in different ways. A descriptive overview of the different compensation regimes in the field of flood risk management is followed by an analysis of these differences and an explanation of what may cause them, such as the geographical differences that lead to differences in the way that they interfere with private rights and the dominant legal principles that underlie compensation regimes. An elaborated compensation regime could lead to more equitable and legitimate flood risk management because the burdens are fairly spread and all interests - including those of injured parties - are considered in the decision-making process. Our aim is to stimulate the hardly existent discussion on the financial harm that is caused by measures to prevent floods (preflood), in addition to the already existing discussion on the ex post flood distributional effects.

Diversity in flood risk management approaches is often considered to be a strength. However, in some national settings, and especially for transboundary rivers, variability and incompatibility of approaches can reduce the effectiveness of flood risk management. Placed in the context of increasing flood risks, as well as the potential for flooding to undermine the European Union's sustainable development goals, a desire to increase societal resilience to flooding has prompted the introduction of a common European Framework. We provide a legal and policy analysis of the implementation of the Floods Directive (2007/60/EC) in six countries: Belgium (Flemish region), England, France, the Netherlands, Poland, and Sweden. Evaluation criteria from existing legal and policy literature frame the study of the Directive and its effect on enhancing or constraining societal resilience by using an adaptive governance approach. These criteria are initially used to analyze the key components of the EU approach, before providing insight of the implementation of the Directive at a national level. Similarities and differences in the legal translation of European goals into existing flood risk management are analyzed alongside their relative influence on policy and practice. The research highlights that the effect of the Floods Directive on increasing societal resilience has been nationally variable, in part because of its focus on procedural obligations, rather than on more substantive requirements. Analysis shows that despite a focus on transboundary river basin management, existing traditions of flood risk management have overridden objectives to harmonize flood risk management in some cases. The Directive could be strengthened by requiring more stringent cooperation and providing the competent authorities in international river basin districts with more power. Despite some shortcomings in directly affecting flood risk outcomes, the Directive has positively stimulated discussion and flood risk management planning in countries that were perhaps lagging behind.

We study the effect of stylistic differences on the nature of pictorial spaces as they appear to an observer when looking into a picture. Four pictures chosen from diverse styles of depiction were studied by 2 different methods. Each method addresses pictorial depth but draws on a different bouquet of depth cues. We find that the depth structures are very similar for 8 observers, apart from an idiosyncratic depth scaling (up to a factor of 3). The differences between observers generalize over (very different) pictures and (very different) methods. They are apparently characteristic of the person. The differences between depths as sampled by the 2 methods depend upon the style of the picture. This is the case for all observers except one.

Human observers group local shading patterns into global super-patterns that appear to be illuminated in some unitary fashion. Many years ago, this was noticed for the case of uniform, unidirectional illumination. Recently, we found that it also applies to convergent and divergent illumination flows, but that human observers are blind to rotational light flow patterns (in the sense of being unable to group the local shading patterns). We now report that human observers are also blind to deformation patterns. This is perhaps interesting because convergent, divergent, rotational, and deformation patterns all occur in natural light fields. This is an idiosyncrasy of the human visual system, on par with the fact that visual awareness fails to present the observer with saddle shapes.

Local space-time scrambling of optical data leads to violent jerks and dislocations. On masking these, visual awareness of the scene becomes cohesive, with dislocations discounted as amodally occluding foreground. Such cohesive space-time of awareness is technically illusory because ground truth is jumbled whereas awareness is coherent. Apparently the visual field is a construction rather than a (veridical) perception.

In the physical environment familiar size is an effective depth cue because the distance from the eye to an object equals the ratio of its physical size to its angular extent in the visual field. Such simple geometrical relations do not apply to pictorial space, since the eye itself is not in pictorial space, and consequently the notion “distance from the eye” is meaningless. Nevertheless, relative size in the picture plane is often used by visual artists to suggest depth differences. The depth domain has no natural origin, nor a natural unit; thus only ratios of depth differences could have an invariant significance. We investigate whether the pictorial relative size cue yields coherent depth structures in pictorial spaces. Specifically, we measure the depth differences for all pairs of points in a 20-point configuration in pictorial space, and we account for these observations through 19 independent parameters (the depths of the points modulo an arbitrary offset), with no meaningful residuals. We discuss a simple formal framework that allows one to handle individual differences. We also compare the depth scale obtained by way of this method with depth scales obtained in totally different ways, finding generally good agreement.

Depth is the feeling of remoteness, or separateness, that accompanies awareness in human modalities like vision and audition. In specific cases depths can be graded on an ordinal scale, or even measured quantitatively on an interval scale. In the case of pictorial vision this is complicated by the fact that human observers often appear to apply mental transformations that involve depths in distinct visual directions. This implies that a comparison of empirically determined depths between observers involves pictorial space as an integral entity, whereas comparing pictorial depths as such is meaningless. We describe the formal structure of pictorial space purely in the phenomenological domain, without taking recourse to the theories of optics which properly apply to physical space—a distinct ontological domain. We introduce a number of general ways to design and implement methods of geodesy in pictorial space, and discuss some basic problems associated with such measurements. We deal mainly with conceptual issues.

We propose a novel method to probe the depth structure of the pictorial space evoked by paintings. The method involves an exocentric pointing paradigm that allows one to find the slope of the geodesic connection between any pair of points in pictorial space. Since the locations of the points in the picture plane are known, this immediately yields the depth difference between the points. A set of depth differences between all pairs of points from an N -point ( N > 2) configuration then yields the configuration in depth up to an arbitrary depth offset. Since an N -point configuration implies N ( N -1) (ordered) pairs, the number of observations typically far exceeds the number of inferred depths. This yields a powerful check on the geometrical consistency of the results. We report that the remaining inconsistencies are fully accounted for by the spread encountered in repeated observations. This implies that the concept of ‘pictorial space’ indeed has an empirical significance. The method is analyzed and empirically verified in considerable detail. We report large quantitative interobserver differences, though the results of all observers agree modulo a certain affine transformation that describes the basic cue ambiguities. This is expected on the basis of a formal analysis of monocular optical structure. The method will prove useful in a variety of potential applications.

The shading cue is supposed to be a major factor in monocular stereopsis. However, the hypothesis is hardly corroborated by available data. For instance, the conventional stimulus used in perception research, which involves a circular disk with monotonic luminance gradient on a uniform surround, is theoretically ‘explained’ by any quadric surface, including spherical caps or cups (the conventional response categories), cylindrical ruts or ridges, and saddle surfaces. Whereas cylindrical ruts or ridges are reported when the outline is changed from circular to square, saddle surfaces are never reported. We introduce a method that allows us to differentiate between such possible responses. We report observations on a number of variations of the conventional stimulus, including variations of shape and quality of the boundary, and contexts that allow the observer to infer illumination direction. We find strong and expected influences of outline shape, but, perhaps surprisingly, we fail to find any influence of context, and only partial influence of outline quality. Moreover, we report appreciable differences within the generic population. We trace some of the idiosyncrasies (as compared to shape from shading algorithms) of the human observer to generic properties of the environment, in particular the fact that many objects are limited in size and elliptically convex over most of their boundaries.