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4. Influence of a structured, 1-year-long dietary intervention regarding body composition and cardiovascular risk (ARCTIC) in coeliac disease: a protocol of a multicentre randomised controlled trial

Author

Zsolt Szakács, Nelli Farkas, Judit Bajor, Nándor Faluhelyi, Krisztina Hagymási, Zsófia Vereczkei, Míra Zsófia Peresztegi, Klára Lemes, Sarolta Dakó, Eszter Dakó, Szilvia Lada, Gábor Szekeres, Gyula Pásztor, Gabriella Pár, and Emese Mezősi

Subjects
Medicine
Abstract

Introduction Coeliac disease (CD) affects 1% of the population worldwide. The only available evidence-based treatment is a strict gluten-free diet (GFD), which can readily lead to weight gain and unfavourable metabolic changes (eg, dyslipidaemia, fatty liver disease and insulin resistance) if followed without adequate dietary control. That can lead to increased cardiovascular risk (CV). We planned a randomised controlled trial to test the effect of a group-based, structured, 1-year, advanced dietary education, per the proposal of a Mediterranean diet vs standard of care, regarding the most relevant CV risk factors (eg, metabolic parameters and body composition) in CD patients.Methods and analysis Randomisation will occur after the baseline dietary education and interview in a 1:1 allocation ratio. Outcomes include anthropometric parameters (body composition analysis including weight, Body Mass Index, fat mass, per cent body fat, skeletal muscle mass, visceral fat area and total body water) and CV risk-related metabolic parameters (eg, lipid profile, homocysteine, fasting glucose, haemoglobin A1c, Homeostatic Model Assessment Index, metabolic hormones, waist circumference, blood pressure, liver function tests, liver steatosis rate and diet composition). In this study, we aim to draw attention to a new aspect regarding managing CD: dietary education can lead to a better quality of the GFD, thereby reducing the risk of potential metabolic and CV complications.Ethics and dissemination The study was approved by the Scientific and Research Ethics Committee of the Hungarian Medical Research Council (27521-5/2022/EÜIG). Findings will be disseminated at research conferences and in peer-reviewed journals.Trial registration number NCT05530070

Published
2024
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10. Discharge protocol in acute pancreatitis: an international survey and cohort analysis

Author

Rita Nagy, Klementina Ocskay, Zoltán Sipos, Andrea Szentesi, Áron Vincze, László Czakó, Ferenc Izbéki, Natalia V. Shirinskaya, Vladimir L. Poluektov, Alexandr N. Zolotov, Yin Zhu, Liang Xia, Wenhua He, Robert Sutton, Peter Szatmary, Rajarshi Mukherjee, Isobel Saffron Burridge, Emma Wauchope, Elsa Francisco, David Aparicio, Bruno Pinto, António Gomes, Vitor Nunes, Vasile Marcel Tantau, Emanuela Denisa Sagau, Alina Ioana Tantau, Andra Iulia Suceveanu, Cristina Tocia, Andrei Dumitru, Elizabeth Pando, Piero Alberti, Arturo Cirera, Xavier Molero, Hong Sik Lee, Min Kyu Jung, Eui Joo Kim, Sanghyub Lee, María Lourdes Ruiz Rebollo, Reyes Busta Nistal, Sandra Izquierdo Santervas, Dusan Lesko, Marek Soltes, Jozef Radonak, Hubert Zatorski, Ewa Małecka-Panas, Adam Fabisiak, M. Susak Yaroslav, V. Maksymenko Mykhailo, A. Tkachenko Olekcandr, Giedrius Barauskas, Vytautas Simanaitis, Povilas Ignatavicius, Mariana Jinga, Vasile-Daniel Balaban, Cristina Patoni, Liang Gong, Kai Song, Yunlong Li, T. Cúrdia Gonçalves, Marta Freitas, Vítor Macedo, Marlies Vornhuelz, Sarah Klauss, Georg Beyer, Aydin Seref Koksal, Mukaddes Tozlu, Ahmet Tarik Eminler, Nuria Torres Monclús, Eva Pijoan Comas, Juan Armando Rodriguez Oballe, Łukasz Nawacki, Stanisław Głuszek, Alberto Rama-Fernández, Marco Galego, Daniel de la Iglesia, Umut Emre Aykut, Deniz Güney Duman, Rahmi Aslan, Adriana Gherbon, Lihui Deng, Wei Huang, Qing Xia, Goran Poropat, Anja Radovan, Luka Vranić, Claudio Ricci, Carlo Ingaldi, Riccardo Casadei, Ionut Negoi, Cezar Ciubotaru, Florin Mihail Iordache, Gabriel Constantinescu, Vasile Sandru, Engin Altintas, Hatice Rizaoglu Balci, Júlio Constantino, Débora Aveiro, Jorge Pereira, Suleyman Gunay, Seda Misirlioglu Sucan, Oleksiy Dronov, Inna Kovalska, Nikhil Bush, Surinder Singh Rana, Serge Chooklin, Serhii Chuklin, Ionut Adrian Saizu, Cristian Gheorghe, Philipp Göltl, Michael Hirth, Radu Bogdan Mateescu, Geanina Papuc, Georgi Angelov Minkov, Emil Tihomirov Enchev, Laura Mastrangelo, Elio Jovine, Weiwei Chen, Quping Zhu, Anita Gąsiorowska, Natalia Fabisiak, Mihailo Bezmarevic, Andrey Litvin, Martina Cattani Mottes, Eun Kwang Choi, Peter Bánovčin, Lenka Nosáková, Mila Dimitrova Kovacheva-Slavova, Ali Kchaou, Ahmed Tlili, Marco V. Marino, Katarzyna Kusnierz, Artautas Mickevicius, Marcus Hollenbach, Pavol Molcan, Orestis Ioannidis, Mark Valerievich Tokarev, Ali Tüzün Ince, Ivan Albertovich Semenenko, Shamil Galeev, Elena Ramírez-Maldonado, Ville Sallinen, Petr Pencik, Judit Bajor, Patricia Sarlós, Roland Hágendorn, Szilárd Gódi, Imre Szabó, József Czimmer, Gabriella Pár, Anita Illés, Nándor Faluhelyi, Péter Kanizsai, Tamás Nagy, Alexandra Mikó, Balázs Németh, József Hamvas, Barnabás Bod, Márta Varga, Imola Török, János Novák, Árpád Patai, János Sümegi, Csaba Góg, Mária Papp, Bálint Erőss, Szilárd Váncsa, Brigitta Teutsch, Katalin Márta, Péter Jenő Hegyi, Tamás Tornai, Balázs Lázár, Tamás Hussein, Dorottya Tarján, Mónika Lipp, Beáta Kovács, Orsolya Urbán, Emese Fürst, Edina Tari, Ibolya Kocsis, Pál Maurovich-Horvát, Balázs Tihanyi, Orsolya Eperjesi, Zita Kormos, Pál Ákos Deák, Andrea Párniczky, and Péter Hegyi

Subjects
Medicine, Science
Abstract

Abstract There are several overlapping clinical practice guidelines in acute pancreatitis (AP), however, none of them contains suggestions on patient discharge. The Hungarian Pancreatic Study Group (HPSG) has recently developed a laboratory data and symptom-based discharge protocol which needs to be validated. (1) A survey was conducted involving all members of the International Association of Pancreatology (IAP) to understand the characteristics of international discharge protocols. (2) We investigated the safety and effectiveness of the HPSG-discharge protocol. According to our international survey, 87.5% (49/56) of the centres had no discharge protocol. Patients discharged based on protocols have a significantly shorter median length of hospitalization (LOH) (7 (5;10) days vs. 8 (5;12) days) p

Published
2023
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14. Results from the european survey on preoperative management and optimization protocols for PeriHilar cholangiocarcinoma

Author

Sutcliffe, Robert, Olthof, Pim, Ruzzenente, Andrea, Botea, Florin, Gringeri, Enrico, Bartsch, Fabian, Russolillo, Nadia, Sposito, Carlo, Serenari, Matteo, Ardito, Francesco, Garnier, Jonathan, Fretland, Asmund, Ivanecz, Arpad, Scatton, Olivier, Lukashenko, Andrii, Ben, Santi L., Lopez Bravo, Miguel A., Siriwardena, Ajith, Schiesser, Marc, Jovine, Elio, Koerkamp, Bas G., Soubrane, Olivier, Dejong, Cornelis H., Muscari, Fabrice, Trudnikov, Andre, Sallinen, Ville, Sandstrom, Par, Barauskas, Giedrius, Pudil, Jiri, Bjornsson, Bergthor, Schwarz, Lilian, Schadde, Erik, Gruenberger, Thomas, Rotellar, Fernando, Christos, Dervenis, Treska, Vladislav, Fuks, David, Schmidt, Jan, Can, Fatih M., Aranda, Fernando P., Solecki, Michal, Ratti, Francesca, Marino, Rebecca, Muiesan, Paolo, Zieniewicz, Krzysztof, Van Gulik, Tomas, Guglielmi, Alfredo, Marques, Hugo P., Andres, Valdivieso, Schnitzbauer, Andreas, Irinel, Popescu, Schmelzle, Moritz, Sparrelid, Ernesto, Fusai, Giuseppe K., Adam, Renè, Cillo, Umberto, Lang, Hauke, Oldhafer, Karl, Ruslan, Alikhanov, Ciria, Ruben, Ferrero, Alessandro, Mazzaferro, Vincenzo, Cescon, Matteo, Giuliante, Felice, Nadalin, Silvio, Golse, Nicolas, Sulpice, Laurent, Serrablo, Alejandro, Ramos, Emilio, Marchese, Ugo, Rosok, Bard, Lopez-Lopez, Victor, Clavien, Pierre, and Aldrighetti, Luca

Published
2023
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21. Improved body composition decreases the fat content in non-alcoholic fatty liver disease, a meta-analysis and systematic review of longitudinal studies

Author

Dóra Mátis, Péter Hegyi, Brigitta Teutsch, Tamás Tornai, Bálint Erőss, Gabriella Pár, and Szilárd Váncsa

Subjects
non-alcoholic fatty liver disease, metabolic syndrome, weight loss, muscle mass, fat mass, Medicine (General), R5-920
Abstract

BackgroundBased on cross-sectional studies, there is a link between body composition parameters and steatosis in non-alcoholic fatty liver disease (NAFLD). However, whether long-term changes in different body composition parameters will result in NAFLD resolution is unclear. Therefore, we aimed to summarize the literature on longitudinal studies evaluating the association between NAFLD resolution and body composition change.MethodsBased on the recommendations of the Cochrane Handbook, we performed a systematic search on September 26th, 2021, in three databases: Embase, MEDLINE (via PubMed), and Cochrane Central Register of Controlled Trials (CENTRAL). Eligible studies reported on patients with NAFLD (liver fat >5%) and examined the correlation between body composition improvement and decrease in steatosis. We did not have pre-defined body composition or steatosis measurement criteria. Next, we calculated pooled correlation coefficient (r) with a 95% confidence interval (CI). Furthermore, we narratively summarized articles with other statistical methods.ResultsWe included 15 studies in our narrative review and five in our quantitative synthesis. Based on two studies with 85 patients, we found a pooled correlation coefficient of r = 0.49 (CI: 0.22–0.69, Spearman's correlation) between the change of visceral adipose tissue and liver steatosis. Similarly, based on three studies with 175 patients, the correlation was r = 0.33 (CI: 0.19–0.46, Pearson's correlation). On the other hand, based on two studies with 163 patients, the correlation between subcutaneous adipose tissue change and liver steatosis change was r = 0.42 (CI: 0.29–0.54, Pearson's correlation). Furthermore, based on the studies in the narrative synthesis, body composition improvement was associated with steatosis resolution.ConclusionsBased on the included studies, body composition improvement may be associated with a decrease in liver fat content in NAFLD.Systematic review registrationIdentifier: CRD42021278584.

Published
2023
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28. EASY‐APP: An artificial intelligence model and application for early and easy prediction of severity in acute pancreatitis

Author

Balázs Kui, József Pintér, Roland Molontay, Marcell Nagy, Nelli Farkas, Noémi Gede, Áron Vincze, Judit Bajor, Szilárd Gódi, József Czimmer, Imre Szabó, Anita Illés, Patrícia Sarlós, Roland Hágendorn, Gabriella Pár, Mária Papp, Zsuzsanna Vitális, György Kovács, Eszter Fehér, Ildikó Földi, Ferenc Izbéki, László Gajdán, Roland Fejes, Balázs Csaba Németh, Imola Török, Hunor Farkas, Artautas Mickevicius, Ville Sallinen, Shamil Galeev, Elena Ramírez‐Maldonado, Andrea Párniczky, Bálint Erőss, Péter Jenő Hegyi, Katalin Márta, Szilárd Váncsa, Robert Sutton, Peter Szatmary, Diane Latawiec, Chris Halloran, Enrique de‐Madaria, Elizabeth Pando, Piero Alberti, Maria José Gómez‐Jurado, Alina Tantau, Andrea Szentesi, Péter Hegyi, and the Hungarian Pancreatic Study Group

Subjects
acute pancreatitis, artificial intelligence, severity prediction, Medicine (General), R5-920
Abstract

Abstract Background Acute pancreatitis (AP) is a potentially severe or even fatal inflammation of the pancreas. Early identification of patients at high risk for developing a severe course of the disease is crucial for preventing organ failure and death. Most of the former predictive scores require many parameters or at least 24 h to predict the severity; therefore, the early therapeutic window is often missed. Methods The early achievable severity index (EASY) is a multicentre, multinational, prospective and observational study (ISRCTN10525246). The predictions were made using machine learning models. We used the scikit‐learn, xgboost and catboost Python packages for modelling. We evaluated our models using fourfold cross‐validation, and the receiver operating characteristic (ROC) curve, the area under the ROC curve (AUC), and accuracy metrics were calculated on the union of the test sets of the cross‐validation. The most critical factors and their contribution to the prediction were identified using a modern tool of explainable artificial intelligence called SHapley Additive exPlanations (SHAP). Results The prediction model was based on an international cohort of 1184 patients and a validation cohort of 3543 patients. The best performing model was an XGBoost classifier with an average AUC score of 0.81 ± 0.033 and an accuracy of 89.1%, and the model improved with experience. The six most influential features were the respiratory rate, body temperature, abdominal muscular reflex, gender, age and glucose level. Using the XGBoost machine learning algorithm for prediction, the SHAP values for the explanation and the bootstrapping method to estimate confidence, we developed a free and easy‐to‐use web application in the Streamlit Python‐based framework (http://easy‐app.org/). Conclusions The EASY prediction score is a practical tool for identifying patients at high risk for severe AP within hours of hospital admission. The web application is available for clinicians and contributes to the improvement of the model.

Published
2022
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32. Dietary phytochemical approaches to stem cell regulation

Author

Zhang, Shuai, Lam, Kargo Kar Ho, Wan, Jack Hei, Yip, Chun Wang, Liu, Harry Kwun-Hung, Lau, Queenie Ming-Ngai, Man, Alice Hei-Yi, Cheung, Chun-Hei, Wong, Lik Hang, Chen, Hu Biao, Shi, Jun, Leung, George Par-Heng, Lee, Calvin Kai-Fai, Shi, Yi-Gang, Tang, Sydney Chi-Wai, and Zhang, Kalin Yan Bo

Published
2020
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35. Uncertainty in the impact of liver support systems in acute-on-chronic liver failure: a systematic review and network meta-analysis

Author

Klementina Ocskay, Anna Kanjo, Noémi Gede, Zsolt Szakács, Gabriella Pár, Bálint Erőss, Jan Stange, Steffen Mitzner, Péter Hegyi, and Zsolt Molnár

Subjects
Network meta-analysis, Liver support therapy, Overall survival, Transplant-free survival, SUCRA, Plasma exchange, Medical emergencies. Critical care. Intensive care. First aid, RC86-88.9
Abstract

Abstract Background The role of artificial and bioartificial liver support systems in acute-on-chronic liver failure (ACLF) is still controversial. We aimed to perform the first network meta-analysis comparing and ranking different liver support systems and standard medical therapy (SMT) in patients with ACLF. Methods The study protocol was registered with PROSPERO (CRD42020155850). A systematic search was conducted in five databases. We conducted a Bayesian network meta-analysis of randomized controlled trials assessing the effect of artificial or bioartificial liver support systems on survival in patients with ACLF. Ranking was performed by calculating the surface under cumulative ranking (SUCRA) curve values. The RoB2 tool and a modified GRADE approach were used for the assessment of the risk of bias and quality of evidence (QE). Results In the quantitative synthesis 16 trials were included, using MARS®, Prometheus®, ELAD®, plasma exchange (PE) and BioLogic-DT®. Overall (OS) and transplant-free (TFS) survival were assessed at 1 and 3 months. PE significantly improved 3-month OS compared to SMT (RR 0.74, CrI: 0.6–0.94) and ranked first on the cumulative ranking curves for both OS outcomes (SUCRA: 86% at 3 months; 77% at 1 month) and 3-month TFS (SUCRA: 87%) and second after ELAD for 1-month TFS (SUCRA: 76%). Other comparisons did not reach statistical significance. QE was moderate for PE concerning 1-month OS and both TFS outcomes. Other results were of very low certainty. Conclusion PE seems to be the best currently available liver support therapy in ACLF regarding 3-month OS. Based on the low QE, randomized trials are needed to confirm our findings for already existing options and to introduce new devices.

Published
2021
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37. Early changes in laboratory parameters are predictors of mortality and ICU admission in patients with COVID-19: a systematic review and meta-analysis

Author

Kiss, Szabolcs, Gede, Noémi, Hegyi, Péter, Németh, Dávid, Földi, Mária, Dembrovszky, Fanni, Nagy, Bettina, Juhász, Márk Félix, Ocskay, Klementina, Zádori, Noémi, Molnár, Zsolt, Párniczky, Andrea, Hegyi, Péter Jenő, Szakács, Zsolt, Pár, Gabriella, Erőss, Bálint, and Alizadeh, Hussain

Published
2021
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40. Antibiotic therapy in acute pancreatitis: From global overuse to evidence based recommendations

Author

Párniczky, Andrea, Lantos, Tamás, Tóth, Eszter Margit, Szakács, Zsolt, Gódi, Szilárd, Hágendorn, Roland, Illés, Dóra, Koncz, Balázs, Márta, Katalin, Mikó, Alexandra, Mosztbacher, Dóra, Németh, Balázs Csaba, Pécsi, Dániel, Szabó, Anikó, Szücs, Ákos, Varjú, Péter, Szentesi, Andrea, Darvasi, Erika, Erőss, Bálint, Izbéki, Ferenc, Gajdán, László, Halász, Adrienn, Vincze, Áron, Szabó, Imre, Pár, Gabriella, Bajor, Judit, Sarlós, Patrícia, Czimmer, József, Hamvas, József, Takács, Tamás, Szepes, Zoltán, Czakó, László, Varga, Márta, Novák, János, Bod, Barnabás, Szepes, Attila, Sümegi, János, Papp, Mária, Góg, Csaba, Török, Imola, Huang, Wei, Xia, Qing, Xue, Ping, Li, Weiqin, Chen, Weiwei, Shirinskaya, Natalia V., Poluektov, Vladimir L., Shirinskaya, Anna V., Hegyi, Péter Jenő, Bátovský, Marian, Rodriguez-Oballe, Juan Armando, Salas, Isabel Miguel, Lopez-Diaz, Javier, Dominguez-Munoz, J. Enrique, Molero, Xavier, Pando, Elizabeth, Ruiz-Rebollo, María Lourdes, Burgueño-Gómez, Beatriz, Chang, Yu-Ting, Chang, Ming-Chu, Sud, Ajay, Moore, Danielle, Sutton, Robert, Gougol, Amir, Papachristou, Georgios I., Susak, Yaroslav Mykhailovych, Tiuliukin, Illia Olehovych, Gomes, António Pedro, Oliveira, Maria Jesus, Aparício, David João, Tantau, Marcel, Kurti, Floreta, Kovacheva-Slavova, Mila, Stecher, Stephanie-Susanne, Mayerle, Julia, Poropat, Goran, Das, Kshaunish, Marino, Marco Vito, Capurso, Gabriele, Małecka-Panas, Ewa, Zatorski, Hubert, Gasiorowska, Anita, Fabisiak, Natalia, Ceranowicz, Piotr, Kuśnierz-Cabala, Beata, Carvalho, Joana Rita, Fernandes, Samuel Raimundo, Chang, Jae Hyuck, Choi, Eun Kwang, Han, Jimin, Bertilsson, Sara, Jumaa, Hanaz, Sandblom, Gabriel, Kacar, Sabite, Baltatzis, Minas, Varabei, Aliaksandr Vladimir, Yeshy, Vizhynis, Chooklin, Serge, Kozachenko, Andriy, Veligotsky, Nikolay, and Hegyi, Péter

Published
2019
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41. A Missense Variant in PTPN22 is a Risk Factor for Drug-induced Liver Injury

Author

Aithal, Guruprasad P., Andrade, Raul J., Bessone, Fernando, Bjornsson, Einar, Cascorbi, Ingolf, Daly, Ann K., Dillon, John F., Day, Christopher P., Hallberg, Par, Hernández, Nelia, Ibanez, Luisa, Kullak-Ublick, Gerd A., Laitinen, Tarja, Larrey, Dominique, Lucena, M. Isabel, Maitland-van der Zee, Anke, Martin, Jennifer H., Menzies, Dick, Molokhia, Mariam, Pirmohamed, Munir, Qin, Shengying, Wadelius, Mia, Cirulli, Elizabeth T., Nicoletti, Paola, Abramson, Karen, Bjornsson, Einar S., Chalasani, Naga, Fontana, Robert J., Hallberg, Pär, Li, Yi Ju, Long, Nanye, Nelson, Matthew R., Odin, Joseph A., Rafnar, Thorunn, Serrano, Jose, Stefánsson, Kári, Stolz, Andrew, and Watkins, Paul B.

Published
2019
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45. The maximal density of product-free sets in Z/nZ

Author

Kurlberg, Par, Lagarias, Jeffrey C., and Pomerance, Carl

Subjects
Mathematics - Number Theory, 11B05, 11B75
Abstract

This paper studies the maximal size of product-free sets in Z/nZ. These are sets of residues for which there is no solution to ab == c (mod n) with a,b,c in the set. In a previous paper we constructed an infinite sequence of integers (n_i)_{i > 0} and product-free sets S_i in Z/n_iZ such that the density |S_i|/n_i tends to 1 as i tends to infinity, where |S_i|$ denotes the cardinality of S_i. Here we obtain matching, up to constants, upper and lower bounds on the maximal attainable density as n tends to infinity., Comment: Minor typos corrected. To appear in IMRN

Published
2011
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46. Diabetes Mellitus Increases the Risk of Hepatocellular Carcinoma After Direct-Acting Antiviral Therapy: Systematic Review and Meta-Analysis

Author

Szilárd Váncsa, Dávid Németh, Péter Hegyi, Zsolt Szakács, Ádám Farkas, Szabolcs Kiss, Péter Jenő Hegyi, Anna Kanjo, Patrícia Sarlós, Bálint Erőss, and Gabriella Pár

Subjects
chronic hepatitis, glucose metabolism, prognosis, carcinogenesis, liver cancer, Medicine (General), R5-920
Abstract

Background: Hepatitis C virus (HCV)-infected patients treated with direct-acting antivirals (DAAs) are still at risk of developing hepatocellular carcinoma (HCC) after sustained virologic response (SVR). This study aimed to investigate the role of diabetes mellitus (DM) as a potential predictive risk factor in developing de novo HCC in HCV-infected patients after DAA treatment.Methods: This study was registered on PROSPERO under registration number CRD42021230457. We performed a systematic search in four medical databases from inception through November 3rd, 2020. Studies were eligible if they reported on HCV-infected patients treated with DAAs and compared the frequency of de novo HCC in patients with and without DM. We calculated pooled odds ratios, unadjusted (UHR), and adjusted hazard ratios (AHR) with 95% confidence intervals (CIs) in meta-analysis.Results: We included 30 articles in our systematic review and meta-analysis. DM proved to be a significant risk factor of HCC in DAA-treated HCV patients in unadjusted (UHR = 1.44, CI: 1.15–1.79) and adjusted analyses (AHR = 1.31, CI: 1.06–1.62). In the group of patients achieving SVR after DAA therapy, DM increased the risk of HCC in unadjusted (UHR = 1.3, CI: 1.09–1.51) analysis; however, in adjusted results, the risk was non-significant (AHR = 1.07, CI: 0.89–1.28). In patients with advanced liver fibrosis, DM was a risk factor for HCC in adjusted (AHR = 1.36, CI: 1.03–1.8), but not in unadjusted analysis (UHR = 1.11, CI: 0.8–1.42).Conclusions: DM is an independent risk factor of de novo HCC after DAA treatment in HCV-infected patients.Systematic Review Registration:https://www.crd.york.ac.uk/prospero/display_record.php?RecordID=230457, identifier: CRD42021230457.

Published
2021
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