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目的基于简单易得的临床资料，开发并验证２型糖尿病（T2DM）患者并发威胁视力的视网膜病变（VTDR）的风险预测模型，为基层医院提供便捷有效的预测工具，以便早期识别和转诊高危人群。方法使用2017年至2020年广州糖尿病眼病研究中T2DM患者临床数据构建列线图预测模型。使用Logistic回归分析VTDR的影响因素并建立模型，受试者工作特征曲线（ROC）、Hosmer-Lemeshow检验、校准曲线、决策曲线（DCA）用于评价模型的性能。使用k折交叉验证得到的平均ROC下面积对模型进行内部验证，使用东莞眼科研究数据对模型进行外部验证。结果建模集共纳入患者2 161例，并发VTDR者135例（6.25%）。年龄（P＜0.001，OR=0.927，95%CI：0.898~0.957）、体质量指数（P＜0.001，OR =0.845，95%CI：0.821~0.932）与VTDR负相关，糖尿病病程（P＜0.001，OR=1.064，95%CI：1.035~1.094）、是否使用胰岛素（P =0.045，OR =1.534，95%CI：1.010~2.332）、收缩压（P＜0.001，OR =1.019，95%CI：1.008~1.029）、糖化血红蛋白（P＜0.001，OR =1.484，95%CI：1.341~1.643）和血清肌酐（P＜0.001，OR =1.017，95%CI：1.010~1.023）与VTDR正相关，均被纳入模型。ROC提示建模集和验证集中该模型预测VTDR发生的曲线下面积分别为0.797和0.762；Hosmer-Lemeshow检验（P＞0.05）及校准曲线表明预测概率与观测概率具有较高一致性；DCA表明模型在建模集和验证集中均能产生净效益。结论年龄、糖尿病病程、是否使用胰岛素、体质量指数、收缩压、糖化血红蛋白和血清肌酐是VTDR的独立影响因素，基于上述变量构建的列线图模型有良好的预测效力，可以为基层医院早期识别和转诊VTDR提供科学依据，值得应用推广。

目的人工智能（AI）全涂片自动化硅藻检验技术能比人类专家更快速、高效进行法医病理学溺死硅藻检验。然而，该技术仅与硅藻提取率较低的硝酸消化法联用过，本研究拟采用更加高效的蛋白酶K组织消解法（以下简称酶消化法）作为硅藻提取方法，探究该技术在其他硅藻提取方法中的泛化能力及可行性。方法收集6例溺死尸体的肺组织进行蛋白酶K消解并制成涂片，利用数字化图像矩阵切割方法将涂片进行数字化处理并据此建立硅藻-背景数据库，将数据集按照3：1：1的比例分为训练集、验证集和测试集，在ImageNet预训练基础上对卷积神经网络（CNN）模型进行训练和内部验证及外部测试。结果结果显示最佳模型外部测试的准确率达97.65%，且模型特征提取区域即为硅藻所在区域。实际应用中最佳的CNN模型对溺水尸体的硅藻检测精准率高达80 %以上。结论研究表明，基于CNN模型的AI自动化硅藻检验技术和酶消化法联用能高效识别硅藻，可以作为溺水鉴定中硅藻检测的辅助方法。

目的探讨外周血白细胞端粒长度与慢性心力衰竭（CHF）发生风险的相关性。方法本研究招募了224例患者，根据左心室射血分数分为非CHF（Non-CHF）组（117例）和CHF组（107例），用实时荧光定量多聚核苷酸链式反应（ qPCR） 进行外周血白细胞端粒长度的测量。比较Non-CHF组和CHF组患者端粒长度，并采用二元 Logistic回归模型分析端粒长度与CHF发生风险是否相关。结果Non-CHF组和CHF组患者外周血白细胞端粒相对长度分别为0.9（0.64~1.18）、0.7（0.53~0.89），CHF组患者的端粒长度比Non-CHF组患者缩短，差异有统计学意义 （PPP

【目的】对1例斑驳病小家系中的先证者进行致病基因KIT和SLUG（SNAI2）编码序列的突变检测，寻找致病性 突变。【方法】应用PCR扩增KIT和SLUG基因编码区及外显子-内含子交界区，对PCR产物进行直接测序。在50例正常对 照中进行新突变的测序分析，以排除多态性。【结果】家系先证者SLUG基因检测未发现异常，KIT基因检测到1个国际数据 库中尚未报道的点突变c.860T>A（p.V287E），患者父母均未检测到此突变。该突变位于KIT基因编码蛋白的细胞外配体结 合区域，第287位的缬氨酸突变为谷氨酸，可能导致了与249位谷氨酸相排斥，破坏了D3结构域中βD 和βD/βE稳定性，最 终影响SCF（stem cell factor）的结合功能。【结论】KIT基因的新生突变可能是引起本重型斑驳病患者发病的原因。

将正硅酸乙酯与HCl水解,加入HF与发烟二氧化硅的混合物充分地分散,再加NH4OH溶液将溶胶的pH值调到4.5,溶胶倒入聚四氟模具凝胶,然后干燥成干胶并烧成石英玻璃。制得石英管外径为20mm、壁厚2.5mm、长250mm,从湿胶到石英管的收缩比是50%,干胶不易破裂,成品率达90%。

【目的】探讨肝癌射频术中应用氟比洛芬是否可以减少静脉麻醉导致的呼吸抑制的发生。【方法】选择射频治疗肝癌患者60例，随机分为K组和N组，每组各30例，其中K组术前15min静脉注射氟比洛芬50mg，N组术前15min静脉注射生理盐水5mL，两组均以异丙酚复合瑞芬太尼微量泵维持麻醉。使记录术前、手术开始时、手术开始后5min及患者术后苏醒时的平均动脉压、心率、脉搏氧饱和度及呼吸频率，监测动脉血二氧化碳分压；记录患者苏醒时间；记录出现术中体动、呼吸暂停的例数。【结果】瑞芬太尼用量K组[（0．22±0．03）mg]显著少于N组[（0.51±0．07）mg，P〈0．01]。术中体动K组（2例）少于N组（7例），呼吸暂停N组（12例）显著大于K组（2例）。【结论】氟比洛芬可以减少肝癌射频术中瑞芬太尼的用量，降低呼吸抑制等副作用的发生率。

[目的]了解监狱警察睡眠和应对方式的关系。[方法]用匹兹堡睡眠质量指数（PSQI）和应对方式问卷（CSQ）对广东省监狱管理局的2093名监狱警察的睡眠和应对方式进行了调查。[结果]监狱警察PSQI均分为7.10±3.68,40.71%的监狱警察有睡眠问题。最常用的应对方式是解决问题（0.65±0.16）和求助（0.53±0.23）。不同性别、年龄和工作性质者的睡眠障碍和应对方式是有差异的。多元回归分析发现,PSQI分与自责和合理化的得分成正相关,与解决问题和求助的得分成负相关。[结论]对监狱警察的应对方式的干预可能有助于改善其睡眠质量。

目的】了解手术创伤对术后全身炎症反应综合征(SIRS)的影响。【方法】搜集外科重症监护室(SICU)335 例 患者的术后资料, 分析不同手术组SIRS 发病率;手术时间、失血量与SIRS 持续时间的关系;SIRS 持续时间与术后并发症的关 系。【结果】术后SIRS 发病率为75.8 %, 大手术高达92.4 %;无并发症患者失血量与SIRS 持续时间呈正相关(r 1=0.783, P

【目的】探讨早产发生率及随年代变化的趋势。【方法】对我院从1969 ～ 1998 年的分娩资料进行回顾性分析, 并 抽取逐年8 月份的早产病例共253 例做为样本, 分为3 个年代进行产科因素的比较。【结果】①30 年早产发生率为4.72% (95 %置信区间4.16, 5.32);②早产发生率不随年代发展出现明显变化, 且无明显季节倾向性;③1989 ～ 1998 年度剖宫产率较 1969～ 1978 年及1979 ～ 1988 年两个年度明显升高(P

目的: 研究神经肽 Y 对血管平滑肌细胞增殖的影响。方法: 应用快速自动微量 MTT 比色法和荧光免疫组化定量 技术观察缩血管物质神经肽 Y 对体外培养血管平滑肌细胞的 MTT 比色吸光度和细胞核增殖抗原( PCNA)表达的平均荧光值。 结果: 神经肽 Y 作用下血管平滑肌细胞的增殖活度和 PCNA 表达比对照组明显升高。MTT 值在NPY 组和对照组中分别为 0. 2 626±0. 0 025和 0. 2 239±0. 0 010,两者差异明显(P

目的: 通过分析我院外科加强医疗病区( SICU)感染耐甲氧西林金黄色葡萄球菌( MRSA)患者的资料, 总结引起 MRSA 感染的危险因素。方法: 回顾性调查1996年 1 月～ 1998年 12月入 SICU 的 1 069例患者资料, 按感染细菌分为MRSA 组和 非MRSA 组,比较两组的发病率及病死率; 比较两组患者在 ICU 住院时间、广谱抗生素应用、血清白蛋白含量的差异,计算各因素 的优势比( OR)。结果: MRSA 20例,非MRSA 57例,MRSA 感染患者病死率为非MRSA 的 1. 9倍, P

文章介绍了新一代光缆填充阻水油膏,它的工作机制是利用油膏遇热膨胀的特性将光缆中的空隙填满,从而达到完全隔断水份的目的。文章阐述了热膨胀阻水油膏的研制过程及制作工艺,给出了该热膨胀阻水油膏的性能测试指标。与目前国内普遍使用的遇水膨胀油膏相比,热膨胀阻水油膏具有明显的优势。

摘 要 应用冠状动脉造影评价链激酶加速静脉溶栓(n =25 , 链激酶150 万U/ 30 min)治疗急性心肌梗 死的临床效果, 并与常规方法(n =25 , 链激酶150 万/ 60 min)作对照, 血管再通率分别为84 %和56 %, 两组比 较有显著性差异, P >0 .05 ;副作用和住院期间死亡率组间比较无差异, P >0 .05 。结果显示, 链激酶加速静脉 溶栓治疗急性心肌梗死有增加血管再通率而不增加副作用的优点, 值得临床推广。

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本文介绍了光缆用ＧＺＳＨ０１阻水油膏的用途、阻水原理、ＧＺＳＨ０１阻水油膏研制生产中的配方设计、配方及工艺对阻水油膏性能的影响，最后给出ＧＺＳＨ０１阻水油膏产品的测试结果。

本文详细地介绍一种用于多芯挤出法制造塑料光纤外包层的涂覆液及其性能的测试结果。

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制作光通信用光纤需要低衰耗、低色散等传输性能良好的材料,所以对光纤预制棒工艺的研究是很重要的。实现棒材中组份的最佳径向分布是这一研究中的关键课题。在生产工艺中是采用逐渐改变相关组份的载气流量的办法来实现组份的径向分布的。为了稳定载气组汾的浓度,通常只是控制组份液的温度,而对环境的温度变化往往未加重视。由于载气温度随环境温度变化,因此气—液（组份液）温度差是变化的。在此种状态下,载气中组份

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By comparing and analyzing the solidification/stabilization technology of heavy metals in fly ash, it is found that the chemical stabilization method is simple in operation, low in energy eonsumption, and easy to realize the large-scale disposal of fly ash, but there is also a problem of expensive chemicals. If the chemical additive agent is combined w让h the mechanochemical method to dispose the heavy metals in fly ash, it can react with heavy metal compounds under the action of mechanical force, and generate insoluble heavy metal compounds to achieve the effect of stabilizing heavy metals. The disposal process has low energy consumption, less add让ive amount and can stabilize multiple heavy metals at the same time, which is expected to realize the harmless and resource utilization of fly ash on a large scale. In addition, the leaching risk of heavy metals in fly ash after disposal is easily affected by environmental factors, and the control mechanism of different leaching stages is also different. The eommonly used environmental Risk assessment code(RAC) only considers the proportion of mild acido-soluble fraction state when calculating the environmental risk of fly ash after disposal, which may lead to differences in the evaluation results. In order to accurately predict the environmental risk of fly ash after disposal, a combination of multiple evaluation methods to evaluate the environmental risk of fly ash after disposal may better reflect the accuracy of the evaluation results. The development of new effective and cost chemical stabilizers combined w让h meehanochemieal methods to treat heavy metals in fly ash is an important means to control heavy metals in waste incineration fly ash, and it is necessary to further improve the environmental risk assessment system of fly ash after disposal. [ABSTRACT FROM AUTHOR]

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In order to improve the efficiency of domestic wastewater treatment process design, a wastewater treatment process database was established to save data samples abstracted from real domestic wastewater treatment processes, and the process was selected by the support vector machine classification algorithm based on boundary points(BP-SVM). Support vector machine classification algorithm based on boundary points(BP-SVM)was used to select the process. Multiple BP-SVMs were set up to solve the multi-classification problem. Parameter optimization of BP-SVM parameters was performed using genetic algorithm(GA). The results of the study show that the process design algorithm gives a suitable solution, verifies an accuracy of 94%, and consumes less compared to other algorithms. The feasibility and effectiveness of the algorithm is proved. [ABSTRACT FROM AUTHOR]

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Copyright of Journal of Jilin University (Medicine Edition) is the property of Jilin University Press and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

In order to understand the present situation of germplasm resources of different Cuora flavomarginata in Zhejiang Province, the genetic diversity and genetic structure of eight C. flavomarginata populations from wild and breeding farms in Zhejiang Province were compared based on mitochondrial DNA COI sequence. The results showed that the se⁃ quence length of COI gene of C. flavomarginata was 1，040 bp, and the average base content was A=27. 4%、T=30. 5%、C= 24. 6%、G=17. 5%, with strong AT preference. Nine haplotypes were identified in the eight populations, and the haplotype diversity (Hd) was (0. 79900±0. 21000), and the nucleotide diversity (Pi) was (0. 00209±0. 00147), showing“ high Hd and low Pi” genetic distribution. The genetic distance between different populations ranged from 0 to 0. 003. The genetic distance within populations was between 0 and 0. 004, among which the genetic distance within Pan’an Houge Village (YS) population was the largest, which was 0. 004. The haplotype phylogenetic tree did not show obvious pedigree structure. The genetic differentiation index (FST) interval was from -0. 34752 to 0. 82222, and the genetic differentiation was not significant (p>0. 05) in eight populations. Tajima’s D and Fu’s FS test values were either positive (Tajima’s D=-0. 36627, Fu’s FS=-0. 605), but statistically insignificant. The distribution of nucleotide mismatches indicated that the population of the C. flavomarginata in Zhejiang Province did not experience a population expansion event. Mantel test showed that there was no significant correlation between genetic distance and geographical distance (R=0. 2938，p>0. 05). AMOVA analysis found that the genetic variation within populations was higher than that between populations (85. 06%>14. 94%). The results showed that the populations of C. flavomarginata in Zhejiang Province are characterized by high haplotype diversity and low nucleic acid genetic diversity, and there was a certain level of genetic differentiation, and there was obvious gene exchange among the populations. The wild C. flavomarginata obtained in Pan’an County was identified as Zhejiang species according to COI gene analysis. Moreover, it was also found that there were hybrids between Zhejiang species and Anhui species. It is suggested that the C. flavomarginata populations with different degrees of differentiation should be divided into different units for protection. This study uses genetic diversity analysis to provide a basis for the development and utilization of C. flavomarginata germplasm resources in Zhejiang Province and the formulation of reasonable protection measures. [ABSTRACT FROM AUTHOR]