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目的探讨基因多态性对先天性心脏病儿童心脏介入手术中舒芬太尼（SUF）药代动力学的影响。方法选择年龄6~72月，ASA分级Ⅱ级并拟行心脏介入手术的患儿168例。使用丙泊酚2 mg·kg-1、SUF 0.3 μg·kg-1及苯磺顺阿曲库铵0.2 mg·kg-1行麻醉诱导，丙泊酚8 mg·kg-1·h-1维持麻醉。采用稀释采样法收集给予SUF后5、10、20、30、45、60、75、90 min的血液标本。使用UHPLC-MS/MS法测定血浆中SUF的药物浓度，并用Phoenix WinNonlinTM软件计算药代动力学参数。基因型检测采用基质辅助激光解析电离飞行时间质谱进行检测。应用SNPStats对基因型数据和药代动力学数据进行分析，选择赤池信息量准则数值最小的模型为最优模型。结果共纳入可能影响SUF药代动力学和药效学相关的靶点、代谢酶、转运体及通路相关的9个基因中30个单核苷酸多态性位点。发现基因ABCG2 rs2054576和OPRM1 rs4870266与SUF药物暴露量相关（P OPRM1 rs2236257与SUF表观分布容积相关（PCYP3A4 rs2246709和OPRM1 rs2236257，rs4870266与SUF药物清除率相关（PABCG2 rs2054576，CYP3A4 rs2246709和OPRM1 rs2236257，rs4870266的基因多态性可显著地影响SUF的药代动力学变化。

近年来，随着全球经济快速发展和城镇化加速，城市能耗及排放持续增长，面临严峻的资源短缺和环境污染问题。为满足城市居民多样化的能源需求，以及能源系统安全高效、清洁低碳的转型要求，城市能源系统应运而生，并迅速成为能源领域的研究热点。针对城市能源系统的规划设计及能耗分析，各国研究学者已经开发了一系列相关工具，然而各类工具的开发目的及开发者专业背景存在差异，其适用场景不尽相同，且模型的时间和空间颗粒度也存在较大差异。通过聚焦城市能源系统的规划设计及能耗分析工具，分别选取对比典型商用工具的功能和特性，并结合应用案例对工具的适用性进行分析，为相关工具的后续开发及应用提供参考。

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Craniofacial fibrous dysplasia (CFD) occurs in the craniofacial bones. CFD is characterized by painless and progressive single or multiple non-inflammatory masses on the head and face. The involvement of different craniofacial tissues and organs may result in facial deformities, impaired vision, sinus infections, hearing impairment, and displaced missing teeth, which seriously affect the patient's appearance, quality of life, and physical and mental health. Patients with specific types of CFD may also have extra-skeletal manifestations such as skin and/or endocrine system disorders. Due to the complex disease spectrum and diverse clinical phenotypes of CFD, the treatment strategy for CFD is still in the exploratory stage. We have discussed how to balance conservative and surgical treatment, develop individualized surgical plans at the appropriate time of surgery, and establish multidisciplinary teams for this disease. [ABSTRACT FROM AUTHOR]

Northwest Helan Mountain's East Foothill is considered as one of best regions for grapes growing and fermenting. Helan Mountain's East Foothill has been divided to 5 wine origin included Shizuishan, Yinchuan, Yongning, Qingtongxia and Hongsibu. These still not establishes a scientific approach to classify and manage the wine origin because of different terroir. This study analyzed correlation and origin’s variance wine color and taste indicators producing by Helan Mountain's East Foothill, and identified the color and taste indicators relating to wine origin based on the leaves node weights of random forest. Then, the Fourier transform near infrared spectra (FT-NIR) and chemometrics methods were used to construct quantitative analysis models for each indicator. Finally, using the database composed by the predictive values of the color and taste indicators as the input layer, an artificial neural networks (ANN) model with ReLU as the optimal activation function was trained to classify the specific origin of wine from Helan Mountain's East Foothill. The research results indicated that tartaric acid esters and pH values had significant difference between the wine from different origins, and many indicators had strong correlation with other indicator. Based on the analysis of removing low weights parameters one by one, 14 wine color and taste indicators (lightness L*, redness a*,yellowness b*, chroma C*ab , total anthocyanins, monomer anthocyanin, polymeric anthocyanins, ionization index, flavonol, total tannin, ethanol index, tartaric acid ester, pH value, titrable acid) were considered as relevant to the origin. The FT-NIR quantitative analysis models of all 14 wine color and taste indicators had the bigger determination coefficient (r²c) than 0.95, the bigger relative percent deviation (RPDc) than 5, smaller root mean squared error (RMSEC) than 5% of the mean of each indicator for calibration set; and had the bigger determination coefficient (r²v) than 0.9, the bigger relative percent deviation (RPDv) than 2.5, smaller root mean squared error (RMSEV) than 15.7% of the mean of each indicator for validation set. The FT-NIR models had good quantitative prediction ability for 14 wine color and taste indicators. The 3 kinds of ANN models were established with different activation function include sigmoid, tanh and ReLU. The accuracies for determining of the origin of dry red wines were 84.06%, 91.30% and 94.20% separately. The model with ReLU as the activation function was proved to be the best one. Further analysis shows that the best model has 100% sensitivity and 100% accuracy in classifying the Shizishan wine samples, 100% sensitivity and 90% accuracy in classifying the Yanchuan wine samples, 87.5% sensitivity and 93.33% accuracy in classifying the Yongning wine samples, 94.74% sensitivity and 100% accuracy in classifying the Qingtongxia wine samples, 92.31% sensitivity and 92.31% accuracy in classifying the Hongsibu wine samples. The results indicated that the model proposed in this study can accurately discriminate the specific origin of wine from the Helan Mountain's East Foothill. This study would provide technical support for the product zoning management of dry red wines in the Helan Mountain's East Foothill, and help the establishment and development of Chinese wine origin protection system. [ABSTRACT FROM AUTHOR]

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Summary Building a new development pattern is a strategic choice made in the light of China's own development stage and conditions, taking full account of economic globalization and changes in the external environment. It is an inevitable choice for China to rebuild its competitive advantage after entering a new development stage. In-depth exploration of the industrial policy system's evolution and main trends that adapt to the new development pattern is not only the need for actively responding to the actions of developed countries to suppress China with the stick of industrial policy. but also the need for promoting China's high-quality development. For more than 40 years since the reform and opening up, the main goal of industrial policy system has been to promote China's economic growth. The selective industrial policy committed to catching up with developed countries has promoted economic growth, but also caused great damage to the market environment of fair competition. Under the new development pattern, stimulating internal competition and strengthening external security have become the new main goals of industrial policy system. To build a new development pattern, industrial policy is still an indispensable tool for promoting domestic and international double circulation and promoting high-quality economic development due to great changes in internal and external environment and factors such as the development environment of the times and industrial policy objectives. However, the previous industrial policy objectives and pattern should be adjusted and upgraded. The narrow industrial policy which is represented by industrial structure policy and industrial development policy with selective characteristics, scientific and technological innovation policy and competition policy and some other polices together constitute the broad industrial policy system closely related to economic development, but the implications of above policies overlap. Based on the perspective of economic development stage, this paper clarifies the integration. coordination withdrawal and reconstruction of industrial policy, scientific and technological innovation policy and competition policy. And we clarify the evolution of the three types of policies in the four stages of economic development, and try to explore the basic role of various policies in the construction of new development pattern. The new development pattern that makes the national economy supply and demand to achieve a virtuous cycle is a dynamic process. It requires that industrial policy and competition policy, special science and technology innovation policy dedicated to overcome the"stuck neck" difficulties and conventional science and technology innovation policy are balanced and coordinated with each other. Based on the above analysis, this paper proposes that under the diversified policy goals of the new development pattern. the relationship between the three types of economic policies is not the opposite but the complementary and coordinated. And China's policy system should be structured as follows: competition policy should be the basis of all policies: industrial policy and competition policy coordinate with each other; selective industrial policy gradually gives way to functional industrial policy; science and technology policy pay more attention to the front of the innovation chain than the back and the new nationwide system keeps the selective character. Finally, this paper further puts forward some suggestions to improve the industrial policy system under the new development pattern. such as establishing anti-monopoly law enforcement agencies. establishing a multi-level policy coordination mechanism. improving the whole-process governance mechanism of industrial policy. The conclusion in this paper is of great significance for exploring what kind of industrial policy system is needed in the new development pattern and what is the evolution trend of China's industrial policy system in the future. It also provides institutional innovation impetus and important policy tools for China to build a new development pattern. [ABSTRACT FROM AUTHOR]

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To explore the current status of soil quality in Pinggu District, Beijing, this study considered microbial factors based on the traditional comprehensive evaluation system of soil quality. A total of 228 samples were collected using grid-based sampling, and 11 soil indicators were selected considering the three dimensions of soil fertility, soil environment, and soil microorganisms. The soil quality index method was used to quantitatively analyze each indicator and calculate the soil quality index to comprehensively evaluate the soil quality in Pinggu District, Beijing. The results showed that the Integrated Soil Quality Index(ISQI)of Pinggu District ranged from good to excellent (0.60-0.96), with a mean value of 0.74, and the average integrated soil quality evaluation grade was good. Overall spatial distribution showed that areas with low values were in the south and west, whereas high values were obtained in the north and east, respectively. The northern areas, such as Xiong′ erzhai, Huangsongyu, and east area Jinmeihu, were mostly in mountainous or woodland regions, rich in vegetation with few human activities, with high levels of soil fertility, rich in microorganisms, and had a relatively high overall soil quality evaluation grade, whereas the southwestern areas, such as Mafang and Machangying towns, had low levels of soil fertility and few microorganisms, and a relatively low overall quality evaluation grade. The comprehensive quality evaluation grade was relatively low. The ISQI of Xiong′ erzhai Town was the highest at 0.81 and that of Pinggu Town was the lowest at 0.64. The order of ISQI for different land use conditions in Pinggu District was orchard>forest land>wasteland>vegetable land>farmland. The results showed that the comprehensive evaluation grade of soil quality was good but different in spatial distribution in Pinggu District, Beijing. The northeastern part was mostly mountainous and forested, with a comprehensive evaluation grade of excellent; the central and southwestern parts were mostly agricultural vegetable land, with the comprehensive evaluation grade of good and medium, and should focus on scientific fertilization and soil quality management in the future. [ABSTRACT FROM AUTHOR]

Objective To investigate the predictive value of systemic inflammatory response index (SIRI) for acute ischemic stroke-associated pneumonia of the brain. Methods The baseline data of patients diagnosed with acute ischemic stroke in the First Affiliated Hospital of Kunming Medical University from January 2017 to December 2022 were gathered to calculate the SIRI index. Patients were divided into SAP group (665 cases) and Non-SAP (466 cases) group according to whether SAP occurred within 7 days of stroke onset. Logistic regression was used to analyze the relationship between SIRI index and SAP in patients with acute ischemic stroke-associated pneumonia of the brain, and ROC was used to analyze the predictive value of SIRI for SAP. Results The analysis included 665 patients with acute ischemic stroke whose median age was 67.00 (56.00～76.00) years old, and the incidence of SAP was 29.92%. The age, the incidence of atrial fibrillation, the use rate of acid suppressive drugs, the use rate of indwelling gastric tube, fasting blood glucose, the proportion of moderate and severe patients in the NHISS score, the number of white blood cells, neutrophils, monocytes, and SIRI index in the SAP group were higher than those in the non SAP group (P < 0.05). However, the hemoglobin value and lymphocyte number in SAP group were lower than those in non SAP group (P < 0.05). Logistic regression analysis showed that age, indwelling gastric tube, higher NHISS score group and SIRI index were the risk factors of SAP in patients with acute ischemic stroke. ROC analysis showed that the prediction accuracy of SIRI for patients with acute ischemic stroke-associated pneumonia of the brain was 0.707 (95%CI: 0.662～0.753, P < 0.001). Conclusion SIRI index is correlated with the occurrence of acute ischemic stroke- associated pneumonia and has the predictive value for it. [ABSTRACT FROM AUTHOR]

Soils contaminated w让h heavy metals(Cu, Zn, Cd) were remediated with un-, acid- and alkali-modified sludge biochar (SC1, SC2 and SC3)・ The influence of soil physical and chemical properties, nutrient indexes and heavy metal morphological distribution were investigated・ The results showed that soil pH and conductivity increased significantly after the application of the three SCs; nutrient indexes such as cation exchange, organic matter, effective phosphorus and quickpotassium were also positively affected, i・ e., the cation exchange was improved better under the treatment of SC3, the content of organic matter and effective phosphorus was increased more significantly under the treatment of SC2, and the content of quick・acting potassium was improved around 50%; the repair and curing effect of the three heavy metals was better under the treatment of SC3. [ABSTRACT FROM AUTHOR]

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【Objective】Epidermal patterning factor（EPF）is a unique secreted protein found in plants that plays a crucial role in plant growth and development, particularly in stomatal morphogenesis. The aims of this study was to gain insights into the characteristics and functions of the EPF gene in melon.【Method】We conducted a comprehensive analysis of the entire CmEPF family, including gene structure, phylogeny, and tissue expression, using bioinformatics tools.【Result】Our findings revealed that the melon genome contained 11 members of the CmEPF family, which can be classified into three subfamilies. The gene structure of CmEPF was found to be relatively conserved, typically consisting of 1-3 introns, with most genes located in the melon chloroplast. Phylogenetic analysis further confirmed the division of CmEPF into three subfamilies. By performing RT-qPCR analysis on various organs, we observed widespread expression of the CmEPF gene in melon, albeit with different expression patterns among family members in different organs. Notably, the CmEPF gene had high expression in the second leaf, which was correlated with the highest stomatal density, photosynthetic rate, and transpiration rate. These results suggest that the expression level of CmEPF is closely associated with photosynthetic parameters and photosynthesis.【Conclusion】Our findings provide evidence that the CmEPF gene can affect stomatal density in melon, thereby affecting photosynthesis and regulating stomatal response to the external environment in melon leaves. [ABSTRACT FROM AUTHOR]

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SIRT家族(SIRT1-7)是-组烟酰胺腺嘌呤二核苷酸(NAD+ )依赖性的组蛋白去乙酰酶, 可通过不同的途径 及机制参与炎症、代谢、氧化应激及细胞凋亡等许多生物过程, 被认为是心血管疾病的潜在治疗靶点. 铁死亡是近 年来发现的一种新的细胞死亡类型, 其与多种心血管疾病的病理生理过程密切相关. SIRT家族可以通过影响氧化 还原平衡、铁代谢及脂质代谢等途径参与铁死亡的发生, 同时在铁死亡介导的心肌损伤、心力衰竭、心房颤动、动脉 粥样硬化等心血管疾病的发生发展过程中发挥重要作用. 深入研究SIRT家族在铁死亡介导心血管疾病中的作用 机制, 可为心血管疾病靶向药物的研发提供新的思路. [ABSTRACT FROM AUTHOR]

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The basement membrane is a specialized extracellular matrix between the epithelium and the mesenchyme. In stratified epithelium, only the basal cells in contact with the basement membrane exhibit the apical-basal polarity, whereas the epithelial cells do being not in contact with the basement membrane do not exhibit the apical-basal polarity. The basement membrane plays an important role in epithelial cell polarization. It is an important extracellular matrix (ECM) structure in the multicellular organisms, is situated between the epithelium and the mesenchyme, and is produced jointly by the epithelial cells and mesenchymal cells. Its components mainly include Laminin, type Ⅳ collagen (Col-Ⅳ), nidogen(NDG), and heparan sulfate proteoglycans (HSPG), and each component plays the different role in influencing the epithelial cell polarity. The network scaffold formed by Col-Ⅳ and Laminin is the main structure of the basement membrane, and the integrity of the structure affects the epithelial cell polarization. This review summarizes the composition and structure of the basement membrane, focuses on its role in epithelial cell polarization and its mechanism, and compiles the current status of biomimetic basement membrane materials that promotes the epithelial cell polarization, and provides the theoretical foundation for further exploration of the establishment and maintenance of epithelial cell polarity. [ABSTRACT FROM AUTHOR]

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Hydrodynamical interaction in circumbinary discs (CBDs) plays a crucial role in various astrophysical systems, ranging from young stellar binaries to supermassive black hole binaries in galactic centres. Most previous simulations of binary-disc systems have adopted locally isothermal equation of state. In this study, we use the grid-based code Athena++ to conduct a suite of two-dimensional viscous hydrodynamical simulations of circumbinary accretion on a Cartesian grid, resolving the central cavity of the binary. The gas thermodynamics is treated by thermal relaxation towards an equilibrium temperature (based on the constant − β cooling ansatz, where β is the cooling time in units of the local Keplerian time). Focusing on equal mass, circular binaries in CBDs with (equilibrium) disc aspect ratio H / R  = 0.1, we find that the cooling of the disc gas significantly influences the binary orbital evolution, accretion variability, and CBD morphology, and the effect depends sensitively on the disc viscosity prescriptions. When adopting a constant kinematic viscosity, a finite cooling time (β ≳ 0.1) leads to a binary inspiral as opposed to an outspiral and the CBD cavity becomes more symmetric. When adopting a dynamically varying α-viscosity, binary inspiral only occurs within a narrow range of cooling time (corresponding to β around 0.5). [ABSTRACT FROM AUTHOR]

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