Objective: To study the clinical efficacy of endoscopic-assisted subgingival scaling combined with erythritol subgingival sand blasting technology for the treatment of peri-implantitis, and to provide the theoretical basis for the effective treatment of peri-implantitis. Methods: The patients with peri-implantitis who attended the Periodontology Department in our hospital and received treatment were selected. A total of 58 peri-implantitis patients were sequentially observed according to the time of visit and were randomly divided into control group (28 cases) and minimally invasive group (30 cases); the patients in control group underwent traditional blind subgingival curettage, while the patients in minimally invasive group were received endoscopic-assisted subgingival scaling combined with erythritol subgingival sandblasting. The probing depth (PD), modified plaque index (mPLI), modified sulcus bleeding index (mSBI), and levels of interleukin-1β(IL-1β), interleukin-6(IL-6), and tumor necrosis factor-α(TNF-α) in gingival crevicular fluid of the patients in two groups were analyzed before and after treatment. Results: Before treatment, there were no significant differences in PD, mPLI, mSBI, and levels of IL-1β, IL-6, and TNF- α in gingival crevicular fluid of the patients between two groups(P>0. 05), demonstrating there was comparability. Compared with before treatment, the PD, mPLI, mSBI, and levels of IL-1β, IL-6, and TNF-α in gingival crevicular fluid of the patients in two groups after treatment were decreased (P<0. 05). Compared with control group, the PD, mPLI, and mSBI of the patients in minimally invasive group were obviously decreased (P<0. 05), and the levels of IL-1 β, IL-6, and TNF- α were also significantly decreased (P<0. 05). Conclusion: In the short term, endoscopic-assisted subgingival scaling combined with erythritol subgingival sandblasting technology for the treatment of peri-implantitis is more beneficial in controlling inflammation around the peri-implant tissue and improving clinical symptoms. [ABSTRACT FROM AUTHOR]