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Copyright of Journal of Materials Engineering / Cailiao Gongcheng is the property of Journal of Materials Engineering Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Objective: To explore the predictive value of serum thyroglobulin autoantibody (TgAb) for recurrence / metastasisin of thyroglobulin (TG)-negative and TgAb-positive patients with differentiated thyroid carcinoma(DTC) after thyroid ablation. Methods: The clinical data of 57 patients with DTC,undergoing complete resection of thyroid tissue, TG negative and TgAb positive, who were reviewed in Liaocheng People's Hospital during April 2013 to April 2015, were selected and divided into recurrence/metastasis group (n=20) and no recurrence/metastasis group (n=37). The TG and TgAb levels in the two groups were detected and compared by the electrochemical luminescence method,the sensitivity, specificity, positive predictive value and negative predictive value of TgAb in the diagnosis of DTC recurrence / metastasis were analyzed; the independent risk factors of DTC recurrence / metastasis were analyzed by Logistic regression. Results: The TgAb levels(72～3850 IU/mL) in the recurrence/metastasis group was higher than that(18～3638 IU/mL) in the no recurrence/metastasis group, the difference was statistically significant (P＜0.05). The sensitivity, specificity positive predictive value, negative preictive value of TgAb in the diagnosis of recurrence/metastasis of DTC were 85.71％, 83.33％, 75.00％, 90.91％, respectively. Logistic Regression analysis showed that the 100≤ TgAb ＜204 IU/mL, 204≤ TgAb≤ 1000IU/mL, and ＞ 1000IU/rnL levels of TgAb were the independent risk factors of rucurrence/metastasis of DTC (OR=1.267, 2.853, 6.791, P＜0.05). Conclusion: TgAb can be used as evaluation of an important index of the recurrence/metastasis of patients with DTC when serum thyroglobulin (TG) was negative and TgAb was positive after thyroid ablation. The higher the TgAb levels, the more probability of the recurrence/metastasis. [ABSTRACT FROM AUTHOR]

Copyright of Research & Exploration in Laboratory is the property of Research & Exploration in Laboratory and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)