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Objective 　We aimed to evaluate the clinical efficacy and safety of Luofushan Rheumatic Plaster in the treatment of rheumatoid arthritis(RA) combined with wrist inflammation. Methods 　A multicenter, block-randomized, double-blind, placebo-controlled clinical trial was conducted including 180 patients with RA combined with wrist tenosynovitis and/ or synovitis from eight hospitals who were randomly divided into the Luofushan group (90 cases) and the control group (90 cases). Patients in both groups were given basic treatment such as disease-modifying antirheumatic drugs (DMARDs). Patients in the Luofushan group were given Luofushan Rheumatic Plaster, while patients in the control group were given Luofushan Rheumatic Plaster simulant. The core trial duration was 4 weeks, and the extended trial was conducted in three centers (participants could voluntarily choose to continue to receive Luofushan Rheumatic Plaster for an additional 4 weeks). Follow-up of local symptoms of the wrist joint ( VAS score, swelling degree, duration of morning stiffness ), bilateral wrist joint ultrasound (tenosynovitis, synovitis, synovial hyperplasia), overall evaluation of disease ( DAS28-CRP score, Health Assessment Questionnaire Disability Index [HAQ-DI], and Chinese Patient-Reported Activity Index with Rheumatoid Arthritis [CPRI-RA]), and erythrocyte sedimentation rate(ESR)was conducted one or two times, and skin irritation and adverse events during the experiment were recorded. Effectiveness was analyzed using the per-protocol set, and the safety indicators were analyzed using the safety set. Results　Compared to pre-treatment, adjuvant therapy with Luofushan Rheumatic Plaster for 4 weeks can improve the VAS score (P <0. 05), the degree of swelling (P <0. 05), morning stiffness duration (P<0. 05), wrist tenosynovitis (P<0. 05), synovitis (P<0. 05), DAS28-CRP (P<0. 05), HAQ-DI(P <0. 05), and CPRI-RA(P <0. 05), but there were no statistically significant difference compared to the control group. Compared to the control group, pain was alleviated in the Luofushan group after 8 weeks of treatment(P <0. 05). Compared to pre-treatment adjuvant therapy for 8 weeks can provide additional improvement in the synovial hyperplasia of the wrist joint (P <0. 05), and the ESR level (P <0. 05), but there were no statistically significant difference compared to the control group. There was no increase in the incidence of skin irritation and adverse events between the two groups (P > 0. 05). Conclusion　Luofushan Rheumatic Plaster has a definite analgesic effect in the treatment of wrist rheumatoid arthritis, and it improves ultrasound imaging result, the degree of joint swelling, and ESR. Moreover, it is safe and suitable for long-term clinical use. [ABSTRACT FROM AUTHOR]

Copyright of Application Research of Computers / Jisuanji Yingyong Yanjiu is the property of Application Research of Computers Edition and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Rheumatism is a group of immuno-inflammatory diseases that involve the musculoskeletal system, joints, and surrounding soft tissues. With its unique theoretical system and rich treatment method, traditional Chinese medicine plays an important role in the treatment of rheumatism. This paper summarizes the achievements of traditional Chinese medicine in the treatment theory of rheumatism, its clinical research and mechanism over the past 40 years; explores the characteristics and advantages of Chinese medicine treatment; and suggests development trends of the discipline. [ABSTRACT FROM AUTHOR]

We combine the theory of healthy qi and pathogenic factors in traditional Chinese medicine (TCM) with the theory of immunology in western medicine, and we realized that rheumatic immune disease is predominantly caused by excessive pathogenic factors and declined healthy qi. “Healthy qi” refers to the influencing factors that maintain the normal physiological function of the human body and the optimal state of life, and “ pathogenic factors” refers to all pathological factors that cause immune abnormalities, or pathological products that damage the body tissues and viscera due to immune abnormalities. We clarified the biological connotation of pathogenic factors such as wind, cold, and dampness, so as to objectify and modernize the etiology of TCM. In TCM treatment of rheumatic immune disease, the disease condition should first be clarified, and the focus should then be placed on the main contradictions, clearing the order of priority, making use of the respective advantages of both TCM and western medicine. Eliminating pathogenic factors and reinforcing healthy qi is considered as the basic treatment principle of rheumatic immune diseases. [ABSTRACT FROM AUTHOR]

Copyright of Journal of Beijing University of Traditional Chinese Medicine is the property of Journal of Beijing University of Traditional Chinese Medicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Sjögren syndrome, a systemic autoimmune disease that is characterized by dry mouth and eyes, on which treatment decision remain challenging, while traditional Chinese medicine ( TCM) has advantages and is widely used in China. However, the lack of consensus on standardized TCM patterns diagnosis and treatment based on evidence-based evidence, limits the further improvement of clinical efficacy and scientific research level. Rheumatology Branch, Chinese Academy of Chinese Medicine organized more than 50 experts from 48 hospitals across the country to form Expert Consensus for TCM Patterns of Sjögren Syndrome: (ⅰ) pattern of yin deficiency and depletion of fluid; (ⅱ) pattern of deficiency of both qi and yin; (ⅲ) pattern of endogenous heat due to yin deficiency ( pattern of yin deficiency and heat-poison, included); (ⅳ) pattern of intermingled dryness and blood stasis; (ⅴ) pattern of intermingled dryness and dampness. According to the patterns, principles of treatment and prescriptions are also on the same page. The formation and promotion of this consensus is of importance in the TCM course of diagnosis and treatment of Sjögren syndrome. [ABSTRACT FROM AUTHOR]

Copyright of Arid Zone Research / Ganhanqu Yanjiu is the property of Arid Zone Research Editorial Office and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Progress in Modern Biomedicine is the property of Publishing House of Progress in Modern Biomedicine and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)

Copyright of Chinese Journal of Inorganic Analytical Chemistry / Zhongguo Wuji Fenxi Huaxue is the property of Beijing Research Institute of Mining & Metallurgy Technology Group and its content may not be copied or emailed to multiple sites or posted to a listserv without the copyright holder's express written permission. However, users may print, download, or email articles for individual use. This abstract may be abridged. No warranty is given about the accuracy of the copy. Users should refer to the original published version of the material for the full abstract. (Copyright applies to all Abstracts.)