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During excavation of the cremation cemetery of urnfield culture in Legnica at Spokojna Street (Lower Silesia, Poland), dated to 1100-700 BC, the largest - so far in Poland – a collection of casting moulds from the Bronze Age was discovered: three moulds for axes casting made out of stone and five moulds for casting sickles, razors, spearhead and chisels, made out of clay. This archaeological find constituted fittings of foundrymen’s graves. In order to perform the complete analysis of moulds in respect of their application in the Bronze Age casting technology analytical methods, as well as, computer aided methods of technological processes were used. Macroscopic investigations were performed and the X-ray fluorescence spectrometry method was used to analyse the chemical composition and metal elements content in mould cavities. Moulds were subjected to three-dimensional scanning and due to the reverse engineering the geometry of castings produced in these moulds were obtained.

Presented work focused on the movement of SiC particles in the vicinity of the solidification front in AZ91/(SiC)P composite. Authors describe the mathematical model that governs this phenomenon. On the base of following numerical model own computer program was prepared. The behavior of a particle moving parallel to the solidification front was analyzed. Three variants of local velocity gradient of liquid metallic phase were analyzed for a particle of radius 10, 50 and 100 μm. At a bigger velocity gradient the SiC particle was observed to go down quicker and to move towards the solidification front. This effect was stronger for SiC particles, which had a bigger radius, i.e. 100 and 50 μm

The process of steel solidification in the CCS mould is accompanied by a number of phenomena relating to the formation of non-metallic phase, as well as the mechanism of its interaction with the existing precipitations and the advancing crystallization front. In the solidification process the non-metallic inclusions may be absorbed or repelled by the moving front. As a result a specific distribution of non-metallic inclusions is obtained in the solidified ingot, and their distribution is a consequence of these processes. The interaction of a non-metallic inclusion with the solidification front was analyzed for alumina, for different values of the particle radius. The simulation was performed with the use of own computer program. Each time a balance of forces acting on a particle in its specific position was calculated. On this basis the change of position of alumina particle in relation to the front was defined for a specific radius and original location of the particle with respect to the front.

The removal of non-metallic inclusions from liquid steel is a result of co-operation of fluctuation, adhesion and agglomeration effects, with emphasis on agglomeration which plays the most important role. It is based on a few types of collisions between non-metallic particles, where turbulent collisions are most prominent. As a result of agglomeration, nonmetallic inclusions are intensely removed through flotation and increase of different dimensions of inclusions, which manifests itself with the occurrence of clusters mainly composed of Al2O3 precipitations. Authors investigated the agglomeration effect by making computer simulations with the use of the PSG method. The calculations were performed for a definite population of spherical particles of radius r in the steel volume. The applied calculation method allows for analyzing the dynamics of the collision process. The assumed initial number of particles remains constant, only the number of particles in specific size-groups varies. It was also revealed that the process of agglomerates formation is much faster for particles having a bigger initial radius. In the case of very small precipitations (r=1 μm) their removal through agglomeration is very difficult because the probability those collisions can take place between them rapidly decreases.

The quality of rail steel is conditioned by its high mechanic qualities, which greatly depend on the presence of undesired nonmetallic inclusions. The paper is devoted to the segregation of components, mainly sulphur, and the formation of manganese sulphide in the process of steel solidification, at the casting rate of 100 and 500 K/min. Sulphur is a steel component which disadvantageously influences its numerous parameters. The oxide-sulphide and sulphide precipitations cause cracks and lower the strength of the material. This phenomenon was modeled with the use of author’s computer program based on Matsumiya interdendritic microsegregation model. The main assumptions of this model and thermodynamic conditions of inclusion formation during casting of steel are discussed in this paper. Two cases were analyzed: in the first one the MnS was assumed to form a pure and constant compound, whereas in the other one the manganese sulfide was precipitated as a component of a liquid oxide solution, and its activity was lower than unity. The final conclusion is that chemical composition of steel is the major parameter deciding about the formation of MnS inclusions.

Abstract Background Digital maturity can help primary care facilities enhance their processes, communication, and adaptability to change, thereby fostering trust and job involvement. This study aimed to examine the causal relationships between perceived environmental uncertainty, digital maturity, organizational trust, and job involvement among managers of primary care facilities in the UK. The researchers applied socio-technical theory to examine the consequences of technology implementation on work practices and utilized contingency theory to ensure long-term stability in primary care facilities. Methods The study was conducted in the second quarter of 2023, surveying 200 managers from primary care facilities in the UK. The survey was conducted using a computer-assisted web interview (CAWI) method based on a purchased panel of respondents. Data were analyzed using descriptive statistics and structural equation modeling. Results The results showed that perceived environmental uncertainty moderately impacts digital maturity. A greater level of perceived environmental uncertainty is related to greater organizational digital maturity, although perceived environmental uncertainty explains only 15.0% of the variance in digital maturity. The analysis also showed that the impact of digital maturity on organizational trust is positive, significant, and strong, while its impact on job involvement is positive and significant but rather moderate. Moreover, digital maturity mediates the relationship between environmental uncertainty and job involvement among managers of primary care facilities. The weakest link in the model is the connection between organizational trust and job involvement. Conclusions The analysis showed that digital maturity is key in shaping organizational trust in primary care facilities and job involvement among their managers. As organizations progress in their digital capabilities, they are better positioned to cultivate trust within their structures. The results of this research contribute to the literature on human resource management in the healthcare sector by deepening knowledge about the impact of environmental uncertainty and digital transformation on organizational trust and job involvement. This study provides important policy information for managers who seek tools to mitigate the adverse effects of environmental uncertainty and want to increase job involvement within primary care facilities.

The authors own computer software, based on the Ueshima mathematical model with taking into account the back diffusion, determined from the Wołczyński equation, was developed for simulation calculations. The applied calculation procedure allowed to determine the chemical composition of the non-metallic phase in steel deoxidised by means of Mn, Si and Al, at the given cooling rate. The calculation results were confirmed by the analysis of samples taken from the determined areas of the cast ingot. This indicates that the developed computer software can be applied for designing the steel casting process of the strictly determined chemical composition and for obtaining the required non-metallic precipitates.

The main aim of this work was to numerically investigate and optimize feeding and geometrical parameters to produce inlet valves of Ti6Al4V alloy that are free from defects, especially porosity. It was found that the change of geometry orientation as well as inlet feeder diameter and angle showed distinct relationships between geometric alteration and occurrence of porosity. Alteration in the pouring parameters such as temperature and time had none or only slight effect on occurrence or position of porosity in the valve. It was also found that investigating individual parameters of simple geometry and then utilizing these best fit results in complex geometry yielded beneficial results that would otherwise not be attainable.

An experimental investigation was conducted to observe and analyze the microstructural evolution of phases present in the AK64 Al-Si-Cu alloy subjected to a modified T6 heat treatment (HT). The AK64 alloy1 is the Polish alternative of the A319.0 ASM standard aluminium alloy. The modified T6 HT schedule with a higher temperature and shorter duration was applied in the solutioning process and lower quenching and higher artificial ageing temperature than the prescribed by the ASM standard were used. The cooling curves registered during the liberating of overheating and solidifying processes give important information on nucleation temperatures for the Al dendrite network, Al-Si eutectic reaction and precipitation of Cu-rich phases. Comparison of the as-cast and heat treated microstructures revealed predicted microstructural changes and also partial fragmentation of the Fe-rich phases was observed after the application of the modified HT programme.

Mental disorders are becoming an increasingly common health condition in society worldwide, significantly affecting pregnant women as well. According to the latest research, 1.5 million people in Poland and as many as 350 million people worldwide suffer from depression. It has also been established that the problem affects as much as 10.5% of women across Europe. An increased risk of developing affective disorders is noted in the age group between 18 and 44 years, which is the population of women of reproductive age. The medical community faces the dilemma of implementing treatment that ensures the safety of the child during medication intake, while also considering the consequences of discontinuing treatment related to withdrawal effects of psychotropic substances and the potential for relapse of symptoms in women. The aim of the study was to review and summarize methods of treating depressive disorders in pregnant women, as well as to assess the benefits and risks associated with undertaking various therapeutic treatments. A review of scientific publications published in English and Polish was conducted using the PubMed and Google Scholar databases. Keywords such as “depression” and “pregnancy” were used. The treatment of depressive disorders in pregnant women remains a controversial topic and requires an individualized approach to each patient. During therapy, the potential benefits of pharmacological treatment, which carries the risk of complications for the fetus, and the choice of less invasive non-pharmacological methods should be considered. The diagnostic process and choice of further management should also include the potential risks associated with not treating unipolar affective disorder in pregnant women.

Abstract A facile esterification of α,β-unsaturated aldehydes with alcohols has been developed for the synthesis of esters by using bulky N-heterocyclic (NHC) carbene as a metal-free and eco-friendly organocatalyst. This new protocol has been proved to be effective with a wide substrate scope, giving selective esters in yields greater than 84% under mild conditions. Moreover, proposed synthetic strategy enables modification of various types of silsesquioxanes (SQ) which cannot or are technically difficult to be carried out with known protocols. For the first time, a one-pot sequential esterification/hydrosilylation has been successfully carried out.

Celem artykułu jest analiza wybranych aspektów znaczenia muzeum w postrzeganiu i odczuwaniu wspólnotowości (zwłaszcza europejskiej) w obliczu współczesnych przemian instytucji muzealnych. Zasadnicza refleksja odnosi się do problemu wspólnego świata w rozumieniu Hannah Arendt i pojęcia wspólnoty m.in. w duchu Thomasa Stearnsa Eliota oraz do roli społecznej i kulturowej muzeów jako heterotopii w ujęciu Michela Foucaulta i Petera Sloterdijka. Rozważania skoncentrowane są wokół kwestii „różnorodności w jedności” i pytania o to, jak ją zachować w obliczu ogromu i wielości w perspektywie nieskończoności gromadzenia dóbr.

The Tree Packing Conjecture (TPC) by Gyárfás states that any set of trees \(T_2,\dots,T_{n-1}, T_n\) such that \(T_i\) has \(i\) vertices pack into \(K_n\). The conjecture is true for bounded degree trees, but in general, it is widely open. Bollobás proposed a weakening of TPC which states that \(k\) largest trees pack. The latter is true if none tree is a star, but in general, it is known only for \(k=5\). In this paper we prove, among other results, that seven largest trees pack.

The article is dedicated to the architectural works in Viterbo commissioned by the pope Pius II (1458–1464) to prepare the city for the solemnity of Corpus Christi (June 17th 1462). These works will be presented in the context of relations between popes and the capital of Tuscia in the 1450s and 1460s. The aim of the paper is to present their symbolic dimension which was used by the Pope to manifest his domination over Viterbo.

In the paper, the results of a numerical analysis of KCl and KF particles present in liquid aluminium assimilation to the slag are presented. The authors analysed particle movement in the slag model, which is based on buoyant, capillary, viscosity, Newton and repulsion forces, interfacial tensions at the interface of phases and surface energy during the particle movement through phases boundary. On the basis of the mathematical model, a computer programme was written to make simulations under different conditions. The results of particle position in the slag are presented for different particle radiuses: 1, 5, 10, 20 μm, and constant viscosity of the slag including velocity evolution of the velocity. Another approach was used to indicate the influence of slag viscosity on particle and slag penetration depth. During computations, selected viscosities of slag of 0.0012, 0.0015, 0.0018 [kg/m·s] were taken into account. Different comparisons were made for the chosen particle sizes. Each examination takes into account the impact of the particle type. The results clearly show that for larger particles the penetration depth is greater and viscosity of the slag has an impact on the velocity evolution during assimilation process.

Astaxanthin is an organic fat-soluble compound from the xanthophyll group derived mainly from marine organisms. It has greater antioxidant properties than vitamins e, c and beta-carotene. It may have potential applications in various areas of medicine and dietetics. The safe daily dose appears to be 6-8 mg per day. Its use may be beneficial in cardiology by lowering insulin resistance, improving lipid profile and reducing the extent of myocardial infarction. In addition, it improves cognitive function and has beneficial effects on skin properties such as texture and hydration. Its positive effects on visual acuity have also been proven. Its use can increase fat burning during aerobic exercise and increase physical performance during exercise. Considering the available research results, astaxanthin seems to be a promising supplement with strong antioxidant properties. Most of the studies, however, were conducted on animals and more human studies are needed. The purpose of this work is to summarize the available knowledge regarding this unique substance. The article reviews studies and scientific papers available in PubMed databases on Astaxanthin for the period 2010-2023.

Background: In 2020, the World Health Organization (WHO) estimated that 650 million adults worldwide are obese, and 2.8 billion individuals struggle with overweight. Obesity is associated with an increased risk of cardiovascular diseases, type 2 diabetes, heart disease, adverse effects on mental health, the development of certain cancers, and other conditions. In recent years, there has been growing interest in the role of melatonin, which has therapeutic potential in the treatment of obesity. Studies suggest that melatonin supplementation may lead to weight reduction and improvement in metabolic parameters, significantly reduce cardiovascular disease risk factors, and enhance insulin sensitivity in obese individuals. Aim of study: This review aims to present the latest scientific findings on the impact of melatonin supplementation on the development of obesity and its complications. We focus primarily on the mechanisms of melatonin's action in the context of obesity, particularly on potential pathways that have not yet been thoroughly explored. Our aim is to provide deeper insights into research on obesity and its prevention. Materials and Methods: Search was conducted using PubMed and Google Scholar databases, utilizing the keywords "obesity," "melatonin," and "weight loss" in various configurations. The review primarily considers studies published after 2016 that are available online. Summary Melatonin supplementation leads to a statistically significant reduction in blood glucose levels and an increase in cellular insulin sensitivity. Its promising properties in the treatment of obesity have been demonstrated through the reduction of oxidative stress, indicating a potential adjunct for weight loss. Based on the cited studies, the beneficial effects of melatonin supplementation on cardiovascular risk factors have been confirmed. Melatonin could be considered as an adjunctive therapy for obese individuals who do not respond to other treatment modalities.

INTRODUCTION AND PURPOSE: Long non-coding RNAs are key regulators of gene expression and tumorigenesis. Deleted in leukemia 1 (DLEU1) is significant in cancer development. This article reviews DLEU1's role across cancers, assessing its diagnostic and therapeutic potential. METHODS: A review of scientific articles from PubMed and Google Scholar was conducted. DESCRIPTION OF THE STATE OF KNOWLEDGE: DLEU1 drives tumor growth in glioblastoma, esophageal, colorectal, and oral cancers by interacting with key miRNAs and genes, promoting malignancy. In breast and ovarian cancers, DLEU1 modulates migration and invasion via specific pathways. In cervical cancer, DLEU1 is linked to immune modulation and serves as a prognostic marker. SUMMARY: DLEU1 is a vital regulator in various cancers, offering potential as a diagnostic and therapeutic target.

Introduction: Cytomegalovirus (CMV) is a double-strand DNA virus, member of the viral family known as Herpesviridae which is wide-spread. CMV infection is the most common congenital infection worldwide. Disease is mostly asymptomatic for healthy people, therefore is detected late, when the children start presenting symptoms. Unfortunately the congenital CMV infection leads to the serious health problems for infants. Detection of the virus is typically done through quantitative PCR assays. Infection especially affects nervous system and can present infant’s deafness. Earlier it was equivalent with the children being deaf till the end of life, but nowadays thanks to the development of laryngological methods (ex. cochlear implantation) patients have chance to grow up correctly. Material and methods: A literature search was conducted using Google Scholar, PubMed, and Web of Science databases. We searched articles by entering key words in the appropriate configuration: “CMV”, “Congenital CMV infection”, “valganciclovir”, “infant’s deafness”. Scientific articles published between 1991–2023 were analyzed from all over the world and guidelines of Polish Society of Epidemiology and Infectious Diseases. Conclusions: Currently we haven’t got prevention towards congenital CMV, only the treatment for infants: valganciclovir. It stops development of severe symptoms. There are available analysis, where using valganciclovir during pregnancy reduces the possibility or soften the course of the congenital CMV infection , but it’s not the obligatory guidelines. In many countries researchers want to conduct screening test for CMV IgG among the pregnant women.

The aim of the article is to assess the effects of the implementation of the sub-measure “Sup-port for young farmers to start their business”, type of measure “Bonuses for Young Farmers” under the Rural Development Program 2014-2020 on the results of farms and their competi-tiveness. In 2017, the group of farms that joined the implementation of the “Bonuses for Young Farmers” measure included 84 farms. It was a research sample and a panel at the same time. The control group consisted of farms of young farmers who did not benefit from sup-port under the Rural Development Program 2014-2020 in the research years, i.e. in 2017 and 2021 (latest FADN results). The subject of the farm panel research was: production potential, production organization, production and economic results, efficiency of use of production factors. During the analysis, it was found that the production potential of young farmers’ farms in both samples in 2017 was similar. The effect of the support was to increase the pro-duction potential in 2021 in the research sample by an average of 35%. Farm income in 2017 was similar in both farm samples. In 2021, differences in farm income levels were even greater. Income in the research sample increased by 211% and was by 149 percentage points higher than in the control sample. Land productivity in the research sample increased by 75.5% and labor productivity by 102.7% and was higher than in the control group by 44.6 and 53.4 percentage points, respectively. Labor profitability in the analyzed years increased in the research group by 220%, and in the control group by 71.7%. Evaluation of the support for young farm-ers' farms in the “Bonuses for Young Farmers” measure indicated that thanks to the support, their production potential increased and their production and economic results improved and, as a result, their competitiveness increased.

The required rail straightness is achieved by straightening with roller straighteners. The consequence of the straightening operation is the introduction of residual stresses to the straightened rail. An excessive level of residual stresses accumulated in the rail during use in the track may lead to its damage or fracture. ArcelorMittal Poland S.A., in cooperation with Łukasiewicz Research Network – Institute for Ferrous Metallurgy, carried out a research project (POI R.01.02.00-00-0167/16) the aim of which was to reduce residual stresses in railway rails by changing the technological parameters of the straightening process. The results of the presented study relate to rails 60E1 and 60E2. The study includes the measurement, testing, calculations and analyses of the obtained results. The conducted research indicates the possibility of obtaining a low level of residual stress in the rails for a system consisting of a 7-roller vertical straightener and a 9-roller horizontal straightener by changing the roller settings, the shape of the rollers, the shape of the rail foot and its curvature.

Abstract Mechanical thrombectomy (MT) is the current standard treatment for strokes in the anterior cerebral circulation (AMT) and has recently been proven to be beneficial in the posterior circulation strokes (PMT). Our study aims to evaluate parameters for favorable outcomes in PMT-patients and to compare the clinical characteristics of individuals who received AMT and PMT. For this purpose, we confronted AMT and PMT-receipients and performed a multivariate regression analysis to assess the influence of factors on favorable outcomes in the study group and in the AMT and PMT subgroups. When analysing 623 MT-patients, those who received PMT had significantly lower admission National Institutes of Health Stroke Scale (NIHSS) scores (9 vs. 13; p

Interwencje mające na celu stymulowanie pamięci osób starszych bez zaburzeń poznawczych przyjmują różne formy. Wśród nich znajdują się niefarmakologiczne podejścia ukierunkowane na pamięć oraz programy takie jak trening pamięci. Celem artykułu jest przegląd oferowanych na świecie rodzajów treningów pamięci o charakterze edukacyjnym. W niniejszej pracy zostaną przedstawione ich cechy oraz kluczowe aspekty, takie jak personalizacja programów czy integracja wielu interwencji. Istotna będzie również identyfikacja cech najefektywniejszych strategii i najlepszych praktyk w zakresie stymulowania pamięci osób starszych bez zaburzeń pamięci. Niniejsza praca może dostarczyć wskazówek dla badaczy i specjalistów w odniesieniu do projektowania i rozwoju nowych koncepcji treningowych.

Introduction and purpose Infective endocarditis (IE) is a disease resulting from infection of the endocardium. In addition to cardiac symptoms, frequent complications of IE include various damage to the nervous system. The aim of this study is to describe the current state of knowledge about the neurological complications of infective endocarditis. Methods Medical publications were reviewed using the "PubMed" and "Google Scholar" databases. The obtained results were verified in terms of the following criteria: publication in 2016, retrospective analysis, obtaining 44 papaers covering a total of 8067 patients. The information was supplemented with case reports and meta-analyses. Description of the state of knowledge Neurologic complications occur in 20 to 60% of patients with IE. The most common is ischemic stroke, the symptoms of which may precede the diagnosis of IE. Less common complications that often remain asymptomatic include mycotic aneurysms and intracranial hemorrhages. Infectious material entering the brain may also cause meningitis and brain abscess. However, these complications do not occur often. Magnetic resonance imaging of the head is an effective test for detecting neurological damage in the course of IE. The recommendation for routine use of this test is debatable. In addition to antibiotic therapy, cardiac surgery is used to treat IE to remove bacterial vegetation. Research indicates the high effectiveness of this type of surgery in the prevention and treatment of neurological complications of infective endocarditis.

Background: Kallmann syndrome is a rare congenital disorder characterized by hypogonadotropic hypogonadism and anosmia or hyposmia. KS results from abnormalities in the migration of GnRH neurons from the nasal placode to the hypothalamus. The prevalence of KS is estimated to be approximately 1:30,000 in males and 1:125,000 in females. KS manifests at various stages of life, ranging from the neonatal period through adolescence to adulthood. In the neonatal period, boys may present with cryptorchidism and micropenis, while symptoms in girls may be less apparent. During adolescence, patients often experience the absence or incomplete development of secondary sexual characteristics. In adulthood, KS often leads to infertility, cardiovascular issues, and neurological symptoms. Diagnostic methods include olfactory tests and hormonal analysis, assessing levels of gonadotropins, testosterone, LH and FSH. MRI can reveal structural abnormalities in the olfactory system. Aim of study: The goal of this article was to gather information about the Kallmann syndrome, focusing on its epidemiology, etiology, characteristic features, and treatment strategies. Materials and Methods: A review of the literature available in the “PubMed”, Google Scholar and Medline databases. The search was performed by using following keywords: “kallmann syndrome”, “anosmia”, hypogonadotropic hypogonadism”. Results and conclusions: Kallmann syndrome is a complex condition that necessitates a multifaceted approach to diagnosis and treatment. Early identification of the disorder is crucial, allowing for the timely initiation of appropriate hormonal therapy and psychological support, which significantly improves the quality of life for patients. Further research into the genetic and neurobiological mechanisms of KS is essential for the development of more effective therapeutic and diagnostic methods.

Background: This review analyzes current knowledge on the pathophysiology, prevention and art of treatment of preeclampsia. Preeclampsia (known as EPH-gestosis) is nowadays the leading cause of maternal and neonatal mortality in the world. According to statistics it affects up to 5% of pregnant women. The symptoms are high blood pressure, edema, proteinuria. The scientists all over the world are trying their best to know the pathogenesis to devise a cure for the disease. Aim of study: The goal of this article was to gather information about the pathophisiology and treatment of preeclempsia to prevent the risk of ilness’ development. Materials and methods: A review of the literature available in the “PubMed”, Google Scholar and Medline databases. The search was performed by using following keywords: “preeclampsia”, “ophthalmic artery doppler”, “PIGF”, “aspirin”, “placenta”. Results and conclusions: In spite of the progress of science the preeclampsia is still a serious threat for pregnant women all around the world. Thank to the advanced molecular and ultrasonographic techniques the doctors can estimate the risk of complications. The most important is screening, which helps the doctors to define the group of risk and then launch the treatment. That should decrease the amount of maternal and neonatal complications and deaths.

Colchicine, a lipid-soluble alkaloid derived from Colchicum autumnale, has a long history of use dating back to ancient Egypt. Traditionally used to alleviate pain and swelling, colchicine is now administered for various diseases, including gout and Familial Mediterranean Fever (FMF). Recent studies have expanded its applications to atherosclerotic cardiovascular diseases, such as acute coronary syndromes and COVID-19. This review aims to summarize the diverse clinical applications of colchicine, with a particular focus on its role in athletes and the synergistic effects of physical exercise in these conditions. Colchicine exhibits broad anti-inflammatory effects primarily by disrupting microtubule functions, which impairs neutrophil migration and reduces cytokine production. Despite its narrow therapeutic window and potential for drug interactions, colchicine is considered safe and effective for managing conditions like gout, FMF, and acute coronary syndromes. Physical exercise complements colchicine treatment by enhancing symptom control and disease management. However, the role of colchicine in COVID-19 treatment remains inconclusive, necessitating further research.

Abstract Porous dental implants are clinically used, but the mechanism of load distribution for stepped implant shaft surrounded by compliance bushings is still not known, especially for different bone conditions. The aim of the study was to assess the impact of the design of a dental implant with compliance bushings (CBs) on the occlusal load distribution during primary and secondary stability using finite element simulation (FEA), with a distinction between low and high quality cervical support under primary stability. The FEA of the oblique occlusal load transfer (250 N; 45°) was carried out for implants under variable bone conditions. The stepped shaft in the intermediate part of the dental implant was surrounded by CBs with an increasing modulus of elasticity of 2, 10 and 50 GPa. With a smaller Young's modulus of the bushings the increase of stress in the trabecular bone indicated that more bone tissue can be protected against disuse. The beneficial effect for the trabecular bone derived from the reduction of the stiffness of the bushings in relation to the loss of the implant's load bearing ability can be assessed using the FEM method.

Abstract The most common complications related to the treatment of childhood acute lymphoblastic leukemia (ALL) are infections. The aim of the study was to analyze the incidence and mortality rates among pediatric patients with ALL who were treated in 17 Polish pediatric hematology centers in 2020–2021 during the pandemic. Additionally, we compared these results with those of our previous study, which we conducted in the years 2012–2017. The retrospective analysis included 460 patients aged 1–18 years with newly diagnosed ALL. In our study, 361/460 (78.5%) children were reported to have microbiologically documented bacterial infections during chemotherapy. Ten patients (2.8%) died due to sepsis. Fungal infections were reported in 99 children (21.5%), of whom five (5.1%) died due to the infection. We especially observed an increase in bacterial infections during the pandemic period compared to the previous study. The directions of our actions should be to consider antibiotic prophylaxis, shorten the duration of hospitalization, and educate parents and medical staff about complications (mainly infections) during anticancer therapy. It is necessary to continue clinical studies evaluating infection prophylaxis to improve outcomes in childhood ALL patients.

In paternity cases, genetic tests are of great importance as they allow to exclude or confirm paternity. As a result of paternity tests we can also obtain information on the frequency of short tandem repeat mutations, which are important in the statistical analysis of test results. A total of 468 cases of full paternity trios (mother, child and alleged father) were analysed from years 2018 - 2022 from the central part of Poland. For further analysis of the occurrence of the mutation 346 cases in which paternity was confirmed were qualified. DNA analysis was performed using the PowerPlex®Fusion 6C kit (Promega, USA). 36 mutations were observed in 13 of the 23 genetic markers analysed. 94.44% were one-step mutations and 5.56% were two-step mutations. Among those mutations, there were 18 insertions and 10 deletions, while in 8 cases it was not possible to determine whether an insertion or deletion occurred. There was also a significantly higher share of the father mutation in relation to the mother mutation at a ratio of 4.17:1.

The aim of the theoretical analysis is to define the connections and dependencies between the rationality of decisions made and personality determinants, in this case the construct of being good to oneself. The achievement of the intended goals was based on a systematic review of the literature on the subject, referring to the results of foreign and domestic empirical research, mainly in the field of social sciences and philosophy. The implementation of the theoretical goal complements the research gap that comes from the fact of inflation in the field of self-compassion and praxeological leadership, and their mutual functional connections. The practical usefulness of the conducted analysis is an interesting and solid contribution to asking research questions and planning further research on the participation of personality factors in decision-making processes in leadership.As a result of the critical analysis, a concept of praxeological leadership was presented, which highlighted the role and importance of self-compassion, indicating the positive and negative aspects of the analyzed correlation in the decision-making process in management and leadership.

Abstract The low glass-forming ability of aluminium-based metallic glasses significantly limits their development and preparation. This paper updates the current state of knowledge by presenting the results of structural studies of two newly-developed Al79Ni5Fe5Y11 and Al79Ni11Fe5Y5 alloys with a reduced aluminium content (

The objective of this study is to assess the impact of low-frequency electromagnetic fields (LF EMFs) generated by power infrastructure on the nearby environment. Measurements of electric (E) and magnetic (H) field intensities were conducted around high-voltage power lines, transformer stations and facilities related to them. Numerical simulations were also performed to model the distribution of the field values around real buildings in close proximity to power delivery systems. Given the ongoing scientific debate regarding the effects of EMFs on living organisms, the current analysis was based on the existing standards—particularly ICNIRP 2010 guidelines, which set the maximum allowable E and magnetic induction (B) values at 5 kV/m and 200 μT, respectively. Stricter national regulations were also examined, such as Poland’s 1 kV/m E limit in residential areas and Belgium’s 10 μT limit for B. The results showed that while most cases complied with ICNIRP 2010 standards, certain stricter local regulations were exceeded. Specifically, 9 of 14 cases exceeded Poland’s E limits, and 8 failed to meet Belgium’s B requirements. Only in one place—a warehouse near 110 kV power lines (in a critical case)—the ICNIRP limit B was exceeded. These findings underscore the variability in regulatory standards and highlight the need for localized assessments of EMF exposure.

The chemical composition of honey, and therefore its quality and properties, is influenced by many factors, including its botanical origin and the harvesting conditions—the location of the apiary, access to melliferous plants, the proximity of industrial infrastructure and communication routes, etc. This quality may be reduced by undesirable, toxic compounds that penetrate honey from a contaminated environment, such as heavy metals and residues from other environmental pollutants. Therefore, the aim of our research was to assess the quality of honeys from urbanized areas—in particular, to assess contamination with heavy metals and persistent organic pollutants (PAHs). In total, 35 samples from six different apiaries located in urbanized areas were examined. The content of heavy metals (Cd, Pb, Zn) was determined by atomic absorption spectrophotometry (AAS), and the content of total PAHs as the sum of the concentrations of the compounds benzo(a)anthracene, chrysene, benzo(b)fluoranthene and benzo(a)pyrene was determined by high-performance liquid chromatography with fluorescence detection (HPLC-FLD). The average zinc content ranged from about 2 to 4.5 mg/kg, the average lead content ranged from 3.5 µg/kg to 388 µg/kg and the average cadmium content ranged from 0.5 to 14 µg/kg. It was found that all honeys contained certain amounts of harmful metals, and only lead exceeded the permissible limits. None of the samples tested contained sum content of PAHs exceeding 10 µg/kg of honey. Contrary to our expectations, the results obtained indicate that honeys from urbanized areas do not contain these harmful substances. In general, the presence of harmful metals does not, however, reduce honey’s quality or its health value.