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Your search keyword '"Álvarez Cermeño, J.C."' showing total 21 results
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21 results on '"Álvarez Cermeño, J.C."'

3. Consensus statement on the use of alemtuzumab in daily clinical practice in Spain

Author

Meca-Lallana, J.E., Fernández-Prada, M., García Vázquez, E., Moreno Guillén, S., Otero Romero, S., Rus Hidalgo, M., Villar Guimerans, L.M., Eichau Madueño, S., Fernández Fernández, Ó., Izquierdo Ayuso, G., Álvarez Cermeño, J.C., Arnal García, C., Arroyo González, R., Brieva Ruiz, L., Calles Hernández, C., García Merino, A., González Plata, M., Hernández Pérez, M.Á., Moral Torres, E., Olascoaga Urtaza, J., Oliva-Nacarino, P., Oreja-Guevara, C., Ortiz Castillo, R., Oterino, A., Prieto González, J.M., Ramió-Torrentá, L., Rodríguez-Antigüedad, A., Saiz, A., Tintoré, M., and Montalbán Gairin, X.

Published
2022
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4. Consenso de expertos sobre el uso de alemtuzumab en la práctica clínica diaria en España

Author

Meca-Lallana, J.E., Fernández-Prada, M., García Vázquez, E., Moreno Guillén, S., Otero Romero, S., Rus Hidalgo, M., Villar Guimerans, L.M., Eichau Madueño, S., Fernández Fernández, Ó., Izquierdo Ayuso, G., Álvarez Cermeño, J.C., Arnal García, C., Arroyo González, R., Brieva Ruiz, L., Calles Hernández, C., García Merino, A., González Platas, M., Hernández Pérez, M.Á., Moral Torres, E., Olascoaga Urtaza, J., Oliva-Nacarino, P., Oreja-Guevara, C., Ortiz Castillo, R., Oterino, A., Prieto González, J.M., Ramió-Torrentá, L., Rodríguez-Antigüedad, A., Saiz, A., Tintoré, M., and Montalbán Gairin, X.

Published
2022
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9. Assessment of the reproducibility of oligoclonal IgM band detection for its application in daily clinical practice

Author

Espiño, M., Abraira, V., Arroyo, R., Bau, L., Cámara, C., Campos-Ruiz, L., Casanova, B., Espejo, C., Fernández, O., García-Merino, A., García-Sánchez, M.I., Gómez, M., Gosis, A., Izquierdo, G., Meca, J., Montalban, X., Morandeira, F., Olascoaga, J., Prada, A., Quintana, E., Ramió-Torrentà, Ll., Rodríguez-Antigüedad, A., Salgado, G., Santiago, J.L., Sarasola, E., Simó-Castelló, M., Alvarez-Cermeño, J.C., and Villar, L.M.

Published
2015
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20. The expression of integrins on activated T-cells in multiple sclerosis. Effect of intravenous methylprednisolone treatment.

Author

Luján, S., Masjuan, J., Roldán, E., Villar, L.M., González-Porqué, P., and Álvarez-Cermeño, J.C.

Subjects
DRUGS, LYMPHOCYTES, MULTIPLE sclerosis, CELL adhesion molecules, INTEGRINS
Abstract

We studied the effect of intravenous methylprednisolone (MP) on the expression of the integrins, LFA-1 and VLA-4, on activated blood T-lymphocytes in 17 patients with relapses of clinically definite relapsing-remitting MS. MP treatment did not induce changes in the expression of CD3, CD4, DR, LFA-1 or VLA-4 markers when measured in the total population of lymphocytes in MS patients in relation to treatment. Treatment influenced neither the LFA-1 nor VLA-4 positive cells within the CD3+ population. MP treatment clearly decreased the DR+ CD3+ cells (P<0.01) and the percentage of DR+ CD3+ lymphocytes bearing VLA-4 (P<0.01). However, this was not the case when we studied the percentage of lymphocytes which expressed LFA-1. Glucocorticoids did not influence the mean intensity of the expression of the two integrins quantified in either total or DR+ CD3+ lymphocytes. Although, further research seems warranted to investigate a possible effect of MP on lymphocyte integrin function, this work corroborates the idea that MP treatment may interfere with the mechanisms of T-cell migration into CNS, thus modulating the activity of multiple sclerosis. [ABSTRACT FROM AUTHOR]

Published
1998

21. An ultrasensitive method for the detection of oligoclonal IgG bands

Author

Sádaba, M.C., González Porqué, P., Masjuan, J., Álvarez-Cermeño, J.C., Bootello, A., and Villar, L.M.

Subjects
*ISOELECTRIC focusing, *CEREBROSPINAL fluid, *IMMUNOGLOBULINS, *IMMUNODIAGNOSIS
Abstract

We have developed an ultrasensitive isoelectrofocusing (IEF) method for the detection of oligoclonal (OGC) IgG bands in cerebrospinal fluid (CSF) and sera. In this procedure, double antibody and peroxidase immunodetection have been substituted by a single antibody labelled with alkaline phosphatase. Alkaline phosphatase immunodetection not only improves tenfold the sensitivity of the assay but also gives a sharper pattern resolution making the interpretation easier and increases the specificity of this technique. This preliminary report should be validated in a larger number of patients with and without multiple sclerosis (MS). [Copyright &y& Elsevier]

Published
2004
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