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This study assesses the potential of using multispectral images collected by an unmanned aerial system (UAS) on machine learning (ML) frameworks to estimate cereal rye (Secale cereal L.) biomass. Multispectral images and ground-truth cereal rye biomass data were collected from 15 farmers' fields up to three times between March and May in northwest Ohio. Images were processed to derive 13 vegetation indices (VIs). Out of 13 VIs, six optimal sets of VIs, including excess green (ExG), normalized green red difference index (NGRDI), soil adjusted vegetation index (SAVI), blue green ratio (B_G_ratio), red-edge triangular vegetation index (RTVI), and normalized difference red-edge (NDRE) were selected using the variance inflation factor (VIF) based feature selection approach. Six regression models including a multiple linear regression (MLR), elastic net (ENET), multivariate adaptive regression splines (MARS), support vector machine (SVM), random forest (RF), and extreme gradient boosting (XGB) were investigated for estimation of cereal rye biomass based on the VIs. For most of the models, the six selected VIs performed better than or similar to the full set of 13 VIs with R2 ranging from 0.24 to 0.59 and RMSE ranging from 83.13 to 91.89 g/m2 during 10-fold cross-validation. During independent accuracy assessment with the selected set of VIs, XGB exhibited the highest R2 (0.67) and lowest RMSE (83.13 g/m2) and MAE (48.13 g/m2) followed by RF and ENET. For all the models, the agreement between observed and predicted biomass was high for biomass less than or equal to 200 g/m2 but decreased for biomass greater than 200 g/m2. When field-collected structural features were integrated with the selected VIs, the models showed improved performance, with R2 and RMSE of the models reaching up to 0.82 and 61.67 g/m2 respectively. Among the six VIs, SAVI showed the strongest impact on the model prediction for the best-performing RF and XGB regression models. The findings of this study demonstrate the potential of precisely estimating and mapping cereal rye biomass based on UAS-captured multispectral images. Timely information on cover crop growth can facilitate numerous decision-making processes, including planning the planting operations, and management of nutrients, weeds, and soil moisture to improve agronomic and environmental outcomes. [ABSTRACT FROM AUTHOR]

We must urgently synthesize highly efficient and stable oxygen-evolution reaction (OER) catalysts for acidic media. Herein, we constructed a series of Ti mesh (TM)-supported RuO2/CoMoyOx catalysts (RuO2/CoMoyOx/TM) with heterogeneous structures. By optimizing the ratio of Co to Mo, RuO2/CoMo2Ox/TM with low Ru loading (0.079 mg/cm2) achieves remarkable OER performance (η = 243 mV at 10 mA/cm2) and high stability (300 h @ 10 mA/cm2) in 0.5 mol/L H2SO4 electrolyte. The activity of RuO2/CoMoyOx/TM can be maintained for 50 h at 100 mA/cm2, and a water electrolyzer with RuO2/CoMo2Ox/TM as anode can operate for 40 h at 100 mA/cm2, suggesting the remarkable OER durability of RuO2/CoMoyOx/TM in acidic electrolyte. Owing to the heterogeneous interface between CoMo2Ox and RuO2, the electronic structure of Ru atoms was optimized and electron-rich Ru was formed. With modulated electronic properties, the dissociation energy of H2O is weakened, and the OER barrier is lowered. This study provides the design of low-cost noble metal catalysts with long-term stability in an acidic environment. [ABSTRACT FROM AUTHOR]

Mindfulness is an increasingly popular practice among elite athletes to improve performance and well-being, but its application for coaches is still very limited. Therefore, a new program (M×E; Mindfulness para Entrenadores) was designed and implemented online for 6 weeks for coaches, support staff, and technical directors. Participants were 58 (57 men), aged between 23 and 58 (M = 31.8). The between-subject analysis (RM ANOVA 2×2) included experimental (n = 26) and wait-list control group (n = 21). A total of 29 completed the within-subject analysis (RM ANOVA) completing follow-up measurements until six months. The analysis was complemented with 21 individual semi-structured interviews. The experimental group showed significant improvements in mindfulness trait (p <.001), interpersonal mindfulness (p =.010), and a significant improvement in emotional regulation (p =.010) in comparison to the wait-list control group. The experimental group's positive trend in all variables' levels was maintained until six months after the program. The qualitative analysis showed a positive impact on professional, personal, and social areas with improvements related to performance and well-being. Several participants considered the program as "fundamental" for their professional role. This study provides information on best practices in implementing mindfulness-based programs, highlighting their practical orientation, the training plan, and the safe space. These results offer initial validation of the potential of the M×E and invite sports organizations to incorporate mindfulness-based programs specially designed for coaches, support staff and technical directors. [ABSTRACT FROM AUTHOR]

The innate immune system serves as the body's first line of defense, utilizing pattern recognition receptors like Toll‐like receptors to detect pathogens and initiate rapid response mechanisms. Following this initial response, adaptive immunity provides highly specific and sustained killing of pathogens via B cells, T cells, and antibodies. Traditionally, it has been assumed that innate immunity activates adaptive immunity; however, recent studies have revealed more complex interactions. This review provides a detailed dissection of the composition and function of the innate and adaptive immune systems, emphasizing their synergistic roles in physiological and pathological contexts, providing new insights into the link between these two forms of immunity. Precise regulation of both immune systems at the same time is more beneficial in the fight against immune‐related diseases, for example, the cGAS–STING pathway has been found to play an important role in infections and cancers. In addition, this paper summarizes the challenges and future directions in the field of immunity, including the latest single‐cell sequencing technologies, CAR‐T cell therapy, and immune checkpoint inhibitors. By summarizing these developments, this review aims to enhance our understanding of the complexity interactions between innate and adaptive immunity and provides new perspectives in understanding the immune system. [ABSTRACT FROM AUTHOR]

Organizational and family support may be invested to reduce workers' family-to-work conflict and increase their and their family members' family satisfaction. However, data on the extent to which workplace and family support, family-to-work conflict, and family satisfaction were linked during the COVID-19 pandemic for workers and their families is still limited. This study explored the actor and partner effects between perceived workplace support for families and perceived family support, family-to-work conflict, and family satisfaction, in different-sex dual-earner parents with adolescents and the mediating role of parents' family-to-work conflict. In the Metropolitan Region of Chile, 430 dual-earner parents and their adolescent child (mean age of 12.8 years, 53.7% female) were recruited for the study. Mothers and fathers responded to measures of family-to-work conflict and perceived workplace support for families and the Perceived Family Support Scale. The three family members answered the Satisfaction with Family Life Scale. Analyses were conducted using the Actor-Partner Interdependence Model and structural equation modeling. Results showed that mothers' and fathers' perceived workplace support for families and perceived family support helped reduce their family-to-work conflict; no other association involving parents' perceived workplace support for families was significant. By contrast, direct actor and partner effects were found between parents' perceived family support and the three family members' family satisfaction. Family-to-work conflict showed two significant mediating roles: One intraindividual in fathers and one intraindividual from fathers to adolescents. These findings indicate that resources both parents gain from perceived family support positively affect the three family members' family satisfaction by different mechanisms and underscore the importance of family support for family satisfaction during the pandemic. [ABSTRACT FROM AUTHOR]

Previous research has established a positive correlation between meaning in life and academic achievement, yet several gaps remain unaddressed. Firstly, the directionality of their relationships is unclear, particularly the potential impact of academic engagement on life meaning. Secondly, most studies have not distinguished between the distinct dimensions of meaning in life—presence of meaning and search for meaning. Thirdly, the underlying mechanisms of these relationships are not well-understood. To address these gaps, this study conducted a six-month, two-wave longitudinal analysis involving 3,895 Chinese secondary school students. Utilizing a cross-lagged panel model, we examined the causal relationships between both dimensions of meaning in life and academic engagement, with a specific focus on the mediating role of hope. Results indicated a reciprocal relationship between presence of meaning and academic engagement, where hope acted as a positive mediator within their bidirectional causal pathways. Conversely, the relationship between the search for meaning and academic engagement was unidirectional, with academic engagement significantly and positively predicting the search for meaning via increased levels of hope, but not vice versa. The study concludes with a discussion of research implications and future research directions. [ABSTRACT FROM AUTHOR]

The main objective of this study is to examine the psychometric properties of the PERMA-Profiler in a Spanish context. The PERMA-Profiler, developed by Butler & Kern (Int J Wellbeing 6(3):1-48, 2016) to measure Seligman's (Flourish: A visionary new understanding of happiness and well-being, 2011) PERMA model of flourishing, consists of five domains that assess well-being: Positive Emotion (P), Engagement (E), Relationships (R), Meaning (M), and Accomplishment (A). We translated and adapted the PERMA-Profiler, analyzed the instrument's reliability, its validity based on an internal structure through three confirmatory factor analyses, gender and age invariance, and its convergent and discriminant validity. A total of 2525 participants completed all measures. The results of the analyses to confirm the internal consistency are very acceptable in all the domains and in Overall Well-being (PERMA), except for the Engagement domain. The results of three confirmatory factor analyses show that the model of five independent interrelated factors (domains) presents the best fit. The analysis shows the invariance across gender and age groups. The analyses of the convergent validity show that are positively and significantly related to satisfaction with life (SWLS), to the six evaluated dimensions of psychological well-being (PWB), to positive affect (PANAS) and dispositional optimism (LOT-R) and the general physical and mental health status (SF-36). The discriminant validity analyses show that are related negatively and significantly to negative affect (PANAS), the total score of depression (BDI-II) and the Cognitive-Affective and Somatic-Motivational factors. The findings of this study indicate that the PERMA-Profiler is transferable to the Spanish context, and the Spanish version is a reliable and valid measure of well-being. [ABSTRACT FROM AUTHOR]

Objective: This study investigates patients' medication‐taking routines and the feasibility of harnessing habit formation through context cues and rewards to improve medication adherence. Methods: Semistructured qualitative interviews with patients with gout from an urban health care system were conducted to explore typical medication‐taking behavior, experiences using electronic pill bottles, barriers to adherence, existing context cues, and potential cues and rewards for habit‐forming behavior. Medication‐taking patterns were recorded for six weeks using electronic pill bottles before interviews to inform discussion. Transcribed interviews were analyzed to generate themes using codes developed by the study team, with representative quotations selected as illustrations. Results: We conducted interviews with 15 individuals (mean age 60.6 [SD 20.3] years, three women [20%], and nine White patients [60%]). Pill bottle–recorded adherence to urate‐lowering therapy (ULT) was high (mean 0.91 [SD 0.10]), and one patient was experiencing an active gout flare. Five key themes emerged: (1) reasons for nonadherence, (2) internal and external motivations for adherence, (3) structured routines around taking medications, (4) rewards for good medication adherence, and (5) the role of pill cap technology in medication‐taking. Conclusion: The importance of a predictable, structured routine in which participants could incorporate their medication‐taking behavior emerged as a key factor that promoted consistent adherence. Further, identifying context cues and reminders seemed to promote incorporation of medication‐taking into routines. Therefore, habit‐based interventions that use context cues to establish routines around medication‐taking may be a feasible strategy to improve adherence in patients with chronic conditions such as gout. [ABSTRACT FROM AUTHOR]

Background: Cannabis use can generate potential avoidable harms, hence the need for effective preventive measures and treatment. Studies show the efficacy of harm reduction (HR) in minimizing undesirable consequences associated with this use. Despite its proven efficacy, HR in cannabis use remains poorly applied by many health and social services (HSS) practitioners, especially with young people. However, knowledge regarding the underlying reasons for this is limited. To fill this gap, we aimed to identify facilitators of and obstacles to HSS practitioners' adoption of HR in cannabis use across OECD countries. Methods: We conducted a scoping review, guided by Arksey and O'Malley's model. The search strategy, executed on health databases and in the grey literature, captured 1804 studies, of which 35 were retained. Data from these studies were extracted in summary sheets for qualitative and numerical analysis. Results: Facilitators and obstacles were grouped into four themes: stakeholders' characteristics (e.g., education, practice experience); clients' characteristics (e.g., personal, medical); factors related to HR (e.g., perceived efficacy, misconceptions); factors related to the workplace (e.g., type of workplace). Data were also extracted to describe the populations recruited in the selected studies: type of population, clientele, workplace. Conclusion: Several factors might facilitate or hinder HSS practitioners' adoption of HR in cannabis use. Taking these into consideration when translating knowledge about HR can improve its acceptability and applicability. Future research and action should focus on this when addressing practitioners' adoption of HR. [ABSTRACT FROM AUTHOR]

Purpose: Distinguished from cuproptosis and ferroptosis, disulfidptosis has been described as a newly discovered form of non-programmed cell death tightly associated with glucose metabolism. However, the prognostic profile of disulfidptosis-related lncRNAs (DRLRs) in ovarian cancer (OC) and their biological mechanisms need to be further elucidated. Materials and methods: First, we downloaded the profiles of RNA transcriptome, clinical information for OC patients from the TCGA database. Generated from Cox regression analysis, prognostic lncRNAs were utilized to identify the risk signature by least absolute shrinkage and selection operator analysis. Then, we explored the intimate correlations between disulfidptosis and lncRNAs. What's more, we performed a series of systemic analyses to assess the robustness of the model and unravel its relationship with the immune microenvironment comprehensively. Results: We identified two DRLR clusters, in which OC patients with low-risk scores exhibited a favorable prognosis, up-regulated immune cell infiltrations and enhanced sensitivity to immunotherapy. Furthermore, validation of the signature by clinical features and Cox analysis demonstrated remarkable consistency, suggesting the universal applicability of our model. It's worth noting that high-risk patients showed more positive responses to immune checkpoint inhibitors and potential chemotherapeutic drugs. Conclusion: Our findings provided valuable insights into DRLRs in OC for the first time, which indicated an excellent clinical value in the selection of management strategies, spreading brilliant horizons into individualized therapy. [ABSTRACT FROM AUTHOR]

Background: This study uses a randomized controlled trial (RCT) to test the health benefits of expressive writing that is culturally adapted for Chinese immigrant breast cancer survivors (BCSs) and to characterize how acculturation moderates the effects of expressive writing interventions. Methods: We will recruit Chinese immigrant BCSs (N = 240) diagnosed with stage 0-III breast cancer and within 5 years of completion of primary treatment. Recruitment will occur primarily through community-based organizations and cancer registries. Participants will be randomly assigned either to a control condition to write about neutral topics or to one of two intervention conditions, self-regulation or self-cultivation, both of which aim to promote adaptive cognitive processes but differ in how they achieve this goal. The self-regulation intervention culturally adapts a Western expressive writing paradigm and incorporates emotional disclosure, whereas the self-cultivation intervention originates from Asian cultural values without disclosing emotions. Participants in all three conditions will be asked to write in their preferred language for three 30-minute sessions. The primary outcome will be quality of life (QOL) at the 6- and 12-month follow-ups, and the secondary outcomes will be perceived stress, stress biomarkers, and medical appointments for cancer-related morbidities. Discussion: This project will be the first large RCT to test culturally based brief interventions to improve QOL and reduce stress among Chinese immigrant BCSs. This project is expected to address two important needs of Chinese immigrant BCSs: their unmet psychological needs and the lack of culturally competent mental health care for Chinese immigrant BCSs. The immediate product of this line of research will be empirically evaluated, culturally responsive interventions ready for dissemination to Chinese immigrant BCSs across the United States. ClinicalTrials.gov identifier: NCT04754412. [ABSTRACT FROM AUTHOR]

Assessing the prognosis of patients with aggressive non-Hodgkin B cell lymphoma mainly relies on a clinical risk score (IPI). Standard first-line therapies are based on a chemo-immunotherapy with rituximab, which mediates CD16-dependent antibody-dependent cellular cytotoxicity (ADCC). We phenotypically and functionally analyzed blood samples from 46 patients focusing on CD16+ NK cells, CD16+ T cells and CD16+ monocytes. Kaplan-Meier survival curves show a superior progression-free survival (PFS) for patients having more than 1.6% CD16+ T cells (p = 0.02; HR = 0.13 (0.007–0.67)) but an inferior PFS having more than 10.0% CD16+ monocytes (p = 0.0003; HR = 16.0 (3.1-291.9)) at diagnosis. Surprisingly, no correlation with NK cells was found. The increased risk of relapse in the presence of > 10.0% CD16+ monocytes is reversed by the simultaneous occurrence of > 1.6% CD16+ T cells. The unexpectedly strong protective function of CD16+ T cells could be explained by their high antibody-dependent cellular cytotoxicity as quantified by real-time killing assays and single-cell imaging. The combined analysis of CD16+ monocytes (> 10%) and CD16+ T cells (< 1.6%) provided a strong model with a Harrell's C index of 0.80 and a very strong power of 0.996 even with our sample size of 46 patients. CD16 assessment in the initial blood analysis is thus a precise marker for early relapse prediction. Highlights: High CD16+ T cell counts have a positive correlation with PFS in aggressive NHL/DLBCL patients (p = 0.02; HR = 0.13, 0.01–0.7). High CD16+ monocyte counts have a negative correlation with PFS in aggressive NHL/DLBCL patients (p = 0.0003; HR = 16.0, 3-292). The combined assessment of CD16+ T cells and CD16+ monocytes accurately predicts PFS in aggressive NHL/DLBCL patients. The strong protective function of CD16+ T cells could be explained by their high antibody-dependent cellular cytotoxicity. [ABSTRACT FROM AUTHOR]

Meaning salience, or awareness of meaning in the present moment, is an emerging concept with potential implications for health and wellness. The purpose of this study was to understand the relationships between meaning salience and eight dimensions of wellness, and to see whether meaning salience moderated the relationship between presence of meaning and wellness. Participants (N = 1711) were recruited to complete a cross-sectional survey through Amazon's Mechanical Turk. Meaning salience was related to better wellness in seven of the eight wellness domains (healthy eating and activity, financial stress, occupational wellness, sleep, perceived wellness, social wellness, and stress, excluding avoiding unhealthy foods). Meaning salience significantly moderated the relationships between presence of meaning and four of eight wellness dimensions, such that at high levels of meaning salience, both high and low presence of meaning had stronger relationships with wellness. Those with high meaning salience and high presence of meaning scored best on four wellness dimensions; however, those with high meaning salience and low presence of meaning scored the worst on four wellness dimensions. Future research should explore what factors drive the relationship between meaning salience and wellness. [ABSTRACT FROM AUTHOR]

Background: Parkinson's disease is characterized by symptoms such as bradykinesia and rigidity, which worsen as the disease progresses, significantly impacting patients' independence and quality of life. This study utilizes a network meta-analysis approach to quantify information gathered from randomized controlled trials (RCTs) regarding motor interventions that effectively improve the motor function of Parkinson's disease patients, aiming to provide evidence for selecting appropriate exercise intervention strategies for patients. Methods: A systematic search strategy for randomized controlled trials (RCTs) restricted to English was constructed based on multiple biomedical databases. Databases searched included PubMed, Embase, Cochrane, Web of Science, CINAHL, CBM, China National Knowledge Infrastructure (CNKI), Wan fang, VIP, etc., with searches conducted from inception to July 9, 2023. Two authors screened all studies, extracted data, and used frequency domain analysis methods. Network meta-analysis was performed using STATA software version 18.0 to compare and rank exercises that could effectively improve the motor function of Parkinson's disease patients (measured by indicators such as MDS-UPDRS-III, TUG, BBS, Mini-BES Test, 6MWT scores). Additionally, a series of analyses and evaluations were conducted, such as assessing the methodological quality of included studies using the Cochrane risk of bias tool. Results: The network meta-analysis included a total of 111 studies involving 5,358 participants, 133 intervention experiments, and 31 intervention measures. Although most exercise interventions showed effectiveness, cumulative ranking curves under the surface (SUCRA) values showed that archery exercise significantly improved patients' MDS-UPDRS-III scores (SUCRA = 95.6%), significantly superior to routine care [standardized mean difference (SMD = 16.92, 95%CI = -28.97, -4.87)]. High-intensity and agility exercise (High strength and agility) referred to as high-intensity exercise or agility training or a combination of both, collectively termed as high-intensity agility training, significantly improved patients' completion time for the time-up-and-go test (SUCRA = 99.7%), (SMD = -7.88, 95%CI = -9.47, -6.28). Dance and Tai Chi exercises significantly improved patients' balance abilities: Mini-Balance Evaluation Systems Test (SUCRA = 77.9%), (SMD = 5.25, 95%CI = -0.42, 10.92) for dance intervention and Berg Balance Scale (SUCRA = 94.7%), (SMD = 11.22, 95%CI = 3.26, 19.18) for Tai Chi intervention. Dance also significantly improved patients' walking ability in the 6-min walk test (SUCRA = 80.5%), (SMD = 71.31, 95%CI = 13.77, 128.84). Conclusion: Compared to other exercises, archery, dance, Tai Chi, and high-intensity agility exercises demonstrate superior efficacy in improving the motor function of Parkinson's disease patients. [ABSTRACT FROM AUTHOR]

Bipolar membranes in electrochemical CO2 conversion cells enable different reaction environments in the CO2-reduction and O2-evolution compartments. Under ideal conditions, water-splitting in the bipolar membrane allows for platinum-group-metal-free anode materials and high CO2 utilizations. In practice, however, even minor unwanted ion crossover limits stability to short time periods. Here we report the vital role of managing ionic species to improve CO2 conversion efficiency while preventing acidification of the anodic compartment. Through transport modelling, we identify that an anion-exchange ionomer in the catalyst layer improves local bicarbonate availability and increasing the proton transference number in the bipolar membranes increases CO2 regeneration and limits K+ concentration in the cathode region. Through experiments, we show that a uniform local distribution of bicarbonate ions increases the accessibility of reverted CO2 to the catalyst surface, improving Faradaic efficiency and limiting current densities by twofold. Using these insights, we demonstrate a fully platinum-group-metal-free bipolar membrane electrode assembly CO2 conversion system exhibiting <1% CO2/cation crossover rates and 80-90% CO2-to-CO utilization efficiency over 150 h operation at 100 mA cm−2 without anolyte replenishment. Here, authors report that local ionic transport across cathode catalyst layers is vital in improving CO production from CO2. This work demonstrates the potential of a CO2 electrolyzer constructed from materials free from platinum group metals. [ABSTRACT FROM AUTHOR]

Background: The loss of gait automaticity is a key cause of motor deficits in Parkinson's disease (PD) patients, even at the early stage of the disease. Action observation training (AOT) shows promise in enhancing gait automaticity. However, effective assessment methods are lacking. We aimed to propose a novel gait normalcy index based on dual task cost (NIDTC) and evaluate its validity and responsiveness for early-stage PD rehabilitation. Methods: Thirty early-stage PD patients were recruited and randomly assigned to the AOT or active control (CON) group. The proposed NIDTC during straight walking and turning tasks and clinical scale scores were measured before and after 12 weeks of rehabilitation. The correlations between the NIDTCs and clinical scores were analyzed with Pearson correlation coefficient analysis to evaluate the construct validity. The rehabilitative changes were assessed using repeated-measures ANOVA, while the responsiveness of NIDTC was further compared by t tests. Results: The turning-based NIDTC was significantly correlated with multiple clinical scales. Significant group-time interactions were observed for the turning-based NIDTC (F = 4.669, p = 0.042), BBS (F = 6.050, p = 0.022) and PDQ-39 (F = 7.772, p = 0.011) tests. The turning-based NIDTC reflected different rehabilitation effects between the AOT and CON groups, with the largest effect size (p = 0.020, Cohen's d = 0.933). Conclusion: The turning-based NIDTC exhibited the highest responsiveness for identifying gait automaticity improvement by providing a comprehensive representation of motor ability during dual tasks. It has great potential as a valid measure for early-stage PD diagnosis and rehabilitation assessment. Trial registration Chinese Clinical Trial Registry: ChiCTR2300067657 [ABSTRACT FROM AUTHOR]

Excessive sugar intake poses a significant risk factor for non-communicable diseases. A positive healthy eating (PHE) intervention was developed to promote low-sugar dietary practices in families. The PHE intervention capitalized on positive psychological constructs to overcome barriers to health behavior change by helping families associate feelings of joy, gratitude, and savoring with healthy eating. In a cluster randomized controlled trial, 1983 participants from 1467 families were recruited in Hong Kong. PHE included a core and booster session. Data were collected at pre-intervention, post-intervention, and at 1-month and 3-month follow-up. Compared to the control, PHE showed greater increase in intention to change at post-intervention, engagement in low-sugar dietary practices individually and with family members at 3-month follow-up, and greater reduction in sugar-sweetened beverage intake at 1-month and 3-month follow-up. Intentions to change mediated PHE's effects on low-sugar dietary practices. Focus group interviews revealed the behavior-change process and family quality of life. [ABSTRACT FROM AUTHOR]

Background: Primary care physicians (PCPs) are doctors in primary health care institutions, namely village clinics, township health centers and community health service centers (stations) who are themain providers of primary health care services in primary health care settings. Improving the overall health status of the population requires the support of a large number of primary care physicians; however, the job satisfaction of this group has not been sufficiently emphasized and recognized. Objective: The purpose of this study was to examine the effects of primary care physicians' work-family conflict on their job satisfaction, as well as the mediating role of burnout and the moderating role of social support. Methods: This cross-sectional study was conducted fromFebruary 2023 to March 2023. Participants were 749 primary care physicians from four cities of Xuzhou, Linyi, Huaibei, and Shangqiu in the Huaihai Economic Zone of China. SPSS statistical analysis was used to evaluate the relationship between work-family conflict, social support, burnout and job satisfaction among medical workers. Results: Work-family conflict had a significant negative effect on job satisfaction (b = -0.36, p< 0.001), after adding burnout in the model, work-family conflict also negatively predicted job satisfaction (b = -0.32, p< 0.001). Social support had a moderating effect on the direct effect of burnout on job satisfaction (b = 0.00, t = 2.66, p< 0.01, 95%CI [0.001, 0.007]), the predictive effect of burnout on job satisfaction at high level of social support (b = -0.45, p< 0.001) was higher than a low level of social support (b = -0.33, p< 0.001). Conclusions: This study demonstrated the negative impact of work-family conflict on primary care physicians' job satisfaction, as well as the mediating role of burnout and the moderating role of social support on burnout and job satisfaction, which are important for improving primary care physicians' job satisfaction and enhancing the quality of primary care in the future. [ABSTRACT FROM AUTHOR]

Gulf War Illness (GWI) is a chronic multisymptom disorder that affects approximately 25–32% of Gulf War veterans and is characterized by a number of symptoms such as cognitive impairment, psychiatric disturbances, chronic fatigue and gastrointestinal distress, among others. While the exact etiology of GWI is unknown, it is believed to have been caused by toxic exposures encountered during deployment in combination with other factors such as stress. In the present study we sought to evaluate the hypothesis that exposure to the toxin permethrin could prime neuroinflammatory stress response and elicit psychiatric symptoms associated with GWI. Specifically, we developed a mouse model of GWI, to evaluate the effects of chronic permethrin exposure followed by unpredictable stress. We found that subjecting mice to 14 days of chronic permethrin exposure followed by 7 days of unpredictable stress resulted in the development of depression-like behavior. This behavioral change coincided with distinct alterations in the microglia phenotype, indicating microglial activation in the hippocampus. We revealed that blocking microglial activation through Gi inhibitory DREADD receptors in microglia effectively prevented the behavioral change associated with permethrin and stress exposure. To elucidate the transcriptional networks impacted within distinct microglia populations linked to depression-like behavior in mice exposed to both permethrin and stress, we conducted a single-cell RNA sequencing analysis using 21,566 single nuclei collected from the hippocampus of mice. For bioinformatics, UniCell Deconvolve was a pre-trained, interpretable, deep learning model used to deconvolve cell type fractions and predict cell identity across spatial datasets. Our bioinformatics analysis identified significant alterations in permethrin exposure followed by stress-associated microglia population, notably pathways related to neuronal development, neuronal communication, and neuronal morphogenesis, all of which are associated with neural synaptic plasticity. Additionally, we observed permethrin exposure followed by stress-mediated changes in signal transduction, including modulation of chemical synaptic transmission, regulation of neurotransmitter receptors, and regulation of postsynaptic neurotransmitter receptor activity, a known contributor to the pathophysiology of depression in a subset of the hippocampal pyramidal neurons in CA3 subregions. Our findings tentatively suggest that permethrin may prime microglia towards a state of inflammatory activation that can be triggered by psychological stressors, resulting in depression-like behavior and alterations of neural plasticity. These findings underscore the significance of synergistic interactions between multi-causal factors associated with GWI. [ABSTRACT FROM AUTHOR]

This mixed-methods study investigates the complex factors affecting the psychological well-being of Chinese EFL teachers, particularly the direct effects of mindfulness and growth mindset, and the mediating role of teaching enthusiasm. A quantitative survey (n = 268) was distributed to EFL teachers across diverse provinces in China. Established scales measured psychological well-being, mindfulness, growth mindset, and teaching enthusiasm. The data was analyzed using structural equation modeling (SEM) with two phases in SPSS and AMOS software. A qualitative phase, employing semi-structured interviews with a subsample (n = 12) of participants, provided deeper insights into the lived experiences of teachers. The quantitative analysis yielded positive direct relationships between mindfulness, growth mindset, and well-being. Notably, teaching enthusiasm emerged as a significant mediating factor. These findings suggest that mindfulness and growth mindset indirectly influence well-being through their positive impact on teaching enthusiasm. The qualitative data corroborated these results, showcasing how mindfulness practices and a growth mindset contribute to a more passionate and fulfilling teaching experience. These combined findings underscore the importance of promoting mindfulness, growth mindset, and teaching enthusiasm to enhance the psychological well-being of Chinese EFL teachers. [ABSTRACT FROM AUTHOR]

Background: Perceived Stress has been shown as a key contributor to sleep quality, but the underlying mechanism between perceived stress and sleep quality remains unknown. This study aimed to investigate the impact of perceived stress on sleep quality of college students and the chain mediating roles of presence of meaning in life (PML) and depression, as well as the moderating role of search for meaning in life (SML). Methods: Participants were 8178 college students (4599 boys and 3579 girls; Mage = 19.10 years, SD = 1.08) who completed self-report questionnaire, including the Perceived Stress Scale (PSS), the Pittsburgh Sleep Quality Index (PSQI), the Meaning in Life Questionnaire (MLQ), and the Patient Health Questionnaire-9 (PHQ-9). Results: The results showed that higher perceived stress was directly related to poorer sleep quality. This negative impact on sleep quality was mediated through the chained roles of PML and depression. Additionally, the study found that SML moderates the influence of perceived stress, PML and depression on sleep quality. Specifically, for individuals actively search for meaning, the adverse effects of perceived stress and depression on sleep quality are diminished. Concurrently, the positive influence of PML on sleep quality is enhanced. Conclusion: This study revealed that the PML and depression mediate the effect of perceived stress on sleep quality, with SML playing a significant protective role. These results emphasize the necessity of integrating strategies to enhance PML and SML into interventions designed to improve emotion management and sleep quality among college students. [ABSTRACT FROM AUTHOR]

CD8+ T cells are the workhorses executing adaptive anti-tumour response, and targets of various cancer immunotherapies. Latest advances have unearthed the sheer heterogeneity of CD8+ tumour infiltrating lymphocytes, and made it increasingly clear that the bulk of the endogenous and therapeutically induced tumour-suppressive momentum hinges on a particular selection of CD8+ T cells with advantageous attributes, namely the memory and stem-like exhausted subsets. A scrutiny of the contemporary perception of CD8+ T cells in cancer and the subgroups of interest along with the factors arbitrating their infiltration contextures, presented herein, may serve as the groundwork for future endeavours to probe further into the regulatory networks underlying their differentiation and migration, and optimise T cell-based immunotherapies accordingly. [ABSTRACT FROM AUTHOR]

Facilitating the restoration of upper limb functionality is a key objective of stroke rehabilitation. This study aimed to compare the effects of boxing and scapular stabilization training on scapular mobility, balance angle, muscle strength, motor function, and satisfaction in hemiparetic patients. A total of sixty patients were randomly assigned to one of three groups: the boxing group (BG; n = 20), the scapular stabilization group (SSG; n = 20), or the control group (CG; n = 20) which received no treatment at all. Each treatment group participated in three sessions per week for a total of eight weeks. The scapular mobility, balance angle (SBA), muscle strength, upper extremity motor functions (Manual Function Test-MFT), and treatment satisfaction were evaluated. The BG group showed greater improvements in the SBA (F = 59,951; p = 0.000; η2 = 0.682), mobility-frontal plane (F = 7998; p = 0.000; η2 = 0.222), mobility-sagittal plane (F = 91,632; p = 0.000; η2 = 0.766), and mobility-transverse plane (F = 48,713; p = 0.000; η2 = 0.635) than did the CG group. BG strengthened the serratus anterior (F = 42,227; p = 0.000; η2 = 0.601), while SSG strengthened the infraspinatus (F = 31,772; p = 0.000; η2 = 0.532) more than did CG. Compared with those in the SSG, supraspinatus (F = 52,589; p = 0.000; η2 = 0.653), upper trapezius (F = 42,890; p = 0.000; η2 = 0.605), anterior deltoideus (F = 30,844; p = 0.000; η2 = 0.524), latissimus dorsi (F = 84,345; p = 0.000; η2 = 0.751), MFTs (F = 52,363; p = 0.000; η2 = 0.652) and satisfaction (p = 0.008) were greater in the BG. Both approaches had a beneficial impact on the recovery process. However, boxing training was more effective than scapular stabilization training for several parameters. Clinical Trial Number: NCT05568173 date 5/10/2022. [ABSTRACT FROM AUTHOR]

Background: Passion fruit (Passiflora edulis) is loved for its delicious flavor and nutritious juice. Although studies have delved into the cultivation and enhancement of passion fruit varieties, the underlying factors contributing to the fruit's appealing aroma remain unclear. Methods: This study analyzed the full-length transcriptomes of two passion fruit cultivars with different flavor profiles: "Tainong 1" (TN1), known for its superior fruit flavor, and "Guihan 1" (GH1), noted for its strong environmental resilience but lackluster taste. Utilizing PacBio Iso-Seq and Illumina RNA-Seq technologies, we discovered terpene synthase (TPS) genes implicated in fruit ripening that may help explain the flavor disparities. Results: We generated 15,913 isoforms, with N50 lengths of 1,500 and 1,648 bp, and mean lengths of 1,319 and 1,463 bp for TN1 and GH1, respectively. Transcript and isoform lengths ranged from a maximum of 7,779 bp to a minimum of 200 and 209 bp. We identified 14,822 putative coding DNA sequences (CDSs) averaging 1,063 bp, classified 1,007 transcription factors (TFs) into 84 families. Additionally, differential expression analysis of ripening fruit from both cultivars revealed 314 upregulated and 43 downregulated unigenes in TN1 compared to GH1. The top 10 significantly enriched Gene Ontology (GO) terms for the differentially expressed genes (DEGs) indicated that TN1's upregulated genes were primarily involved in nutrient transport, whereas GH1's up-regulated genes were associated with resistance mechanisms. Meanwhile, 17 PeTPS genes were identified in P. edulis and 13 of them were TPS-b members. A comparative analysis when compared PeTPS with AtTPS highlighted an expansion of the PeTPS-b subfamily in P. edulis, suggesting a role in its fruit flavor profile. Conclusion: Our findings explain that the formation of fruit flavor is attributed to the upregulation of essential genes in synthetic pathway, in particular the expansion of TPS-b subfamily involved in terpenoid synthesis. This finding will also provide a foundational genetic basis for understanding the nuanced flavor differences in this species. [ABSTRACT FROM AUTHOR]

Artificial intelligence-driven technology increasingly shapes work practices and, accordingly, employees' opportunities for meaningful work (MW). In our paper, we identify five dimensions of MW: pursuing a purpose, social relationships, exercising skills and self-development, autonomy, self-esteem and recognition. Because MW is an important good, lacking opportunities for MW is a serious disadvantage. Therefore, we need to know to what extent employers have a duty to provide this good to their employees. We hold that employers have a duty of beneficence to design for opportunities for MW when implementing AI-technology in the workplace. We argue that this duty of beneficence is supported by the three major ethical theories, namely, Kantian ethics, consequentialism, and virtue ethics. We defend this duty against two objections, including the view that it is incompatible with the shareholder theory of the firm. We then employ the five dimensions of MW as our analytical lens to investigate how AI-based technological innovation in logistic warehouses has an impact, both positively and negatively, on MW, and illustrate that design for MW is feasible. We further support this practical feasibility with the help of insights from organizational psychology. We end by discussing how AI-based technology has an impact both on meaningful work (often seen as an aspirational goal) and decent work (generally seen as a matter of justice). Accordingly, ethical reflection on meaningful and decent work should become more integrated to do justice to how AI-technology inevitably shapes both simultaneously. [ABSTRACT FROM AUTHOR]

Objectives: Although recent cross-sectional studies have shown a positive link between mindfulness and relationship satisfaction, diary and dyadic studies exploring this association are scarce and limited, especially in populations at risk for abating relationship satisfaction, such as new parents. It is currently unknown whether a new parent's mindfulness is associated with their partner's relationship satisfaction on a daily basis. Method: The present study explores this dyadic link using two measures of mindfulness (general and relational mindfulness) in a sample of couples transitioning into parenthood (M = 5.89 months postpartum). In total, 78 couples (n = 156 participants; 1506 observations) took part in this study. For 14 consecutive days, couples completed diaries measuring their general and relational mindfulness, as well as their relationship satisfaction. Data were analyzed using multilevel modelling for distinguishable dyads. Results: Overall, on days when new parents reported more general mindfulness and relational mindfulness than their habitual level, they reported more relationship satisfaction. We also found mirrored partner effects. On days when new parents reported more relational mindfulness than usual, their partner also reported greater relational satisfaction. Conclusions: This work extends previous research by showing that daily variations in general and relational mindfulness are linked to daily variations in relationship satisfaction. Preregistrations: This study was not preregistered. [ABSTRACT FROM AUTHOR]

Background: Diabetes mellitus is associated with higher risk of target lesion failure (TLF) after percutaneous coronary intervention. We studied the 5-year outcome in patients with diabetes mellitus treated with biodegradable polymer stents. Methods: The SORT OUT VII was a randomised trial comparing the ultrathin sirolimus-eluting Orsiro stent (O-SES) and the biolimus-eluting Nobori stent (N-BES) in an all-comer setting. Patients (n = 2525) were randomised to receive O-SES (n = 1261, diabetes: n = 236) or N-BES (n = 1264, diabetes: n = 235). Endpoints were TLF (a composite of cardiac death, target-lesion myocardial infarction (MI), target lesion revascularization (TLR)), definite stent thrombosis and a patient related outcome (all-cause mortality, MI and revascularization) within 5 years. Results: Patients with diabetes mellitus had higher TLF (20.6% vs 11.0%, (Rate ratio (RR) 1.85 95% confidence interval (CI): (1.42-2.40) and patient related outcome (42.0% vs 31.0%, RR 1.43 95% CI: (1.19-1.71)) compared to patients without diabetes. Among patients with diabetes mellitus, TLF after 5 years did not differ between O-SES and N-BES (21.2% vs 20.0%), RR 1.05 95% CI: (0.70-1.58), p = 0.81). Cardiac death, MI, TLR, and definite stent thrombosis did not differ between the groups. Conclusion: In patients with diabetes mellitus, 5-year outcomes were similar among patients treated with biodegradable polymer O-SES or N-BES. Clinical trial registration: URL: https://www.clinicaltrials.gov. Unique identifier: NCT01879358. [ABSTRACT FROM AUTHOR]

Bacterial pneumonia in dogs and cats can be caused by inhalation of pathogens, aspiration of bacteria, or (less likely) hematogenous spread or inhalation of foreign bodies. Before initiating empiric broad-spectrum antibiotics for patients requiring hospitalization or those predisposed to multidrug-resistant bacterial infections, airway sampling is recommended, if possible. After culture and sensitivity results are available and depending on patient response to treatment, antimicrobial therapy should be de-escalated. Adjunctive therapeutics include supplemental oxygen, intravenous fluids, and physiotherapy aimed at promoting clearance of mucus. The treatment, presentation, and approach to pneumonia frequently differ between species, and the disease is less common in cats than in dogs. [ABSTRACT FROM AUTHOR]

Consumer society has gradually disconnected consumers from the origin of their consumption, the real needs it truly satisfies, and its social and ecological impact. This research aims to study the phenomenon of consumer reconnection, through which consumers try to experience meaning by becoming mindful of their consumption experiences. We focus specifically on the consumption practice of mindful eating. Using an interpretative approach, we show how the reconnection process unfolds around three dimensions: self, nature, and society. We highlight the tensions related to reconnection in everyday life and examine the coping strategies that emerge to reduce these tensions. Finally, we discuss the implications in terms of education, health, and marketing practices. [ABSTRACT FROM AUTHOR]

Adolescents involved in the juvenile legal system (JLS) have higher rates of mental health treatment needs compared to their non-justice-involved peers, and they experience disproportionate rates of trauma exposure and trauma-related psychosocial concerns. Most research comparing these adolescent groups draws data from separate studies, making it more challenging to understand meaningful differences between the two groups. Research documenting making such comparisons can guide prevention and intervention strategies for communities and their juvenile detention centers. The current study involves a secondary data analysis of billing claims from an outpatient community clinic with a satellite location embedded in the local juvenile detention center. Descriptive statistics determined the top five primary diagnoses in the sample apart from post-traumatic stress disorder (PTSD): major depressive disorder, ADHD, adjustment disorder, unspecified trauma and stressor-related disorder (UTD), and generalized anxiety disorder (GAD). Hierarchical logistic regression models were used to understand if being evaluated in a detention or community setting, sex, and age predicted the likelihood of having one of these top primary diagnoses. Participants (n = 981) were adolescents ages 12–20 (Mage = 15.93 years, SDage = 1.924, 60.6% male) seen for psychiatric evaluation in a community mental health agency and a juvenile detention facility. Among detained adolescents (n = 635), 141 were diagnosed with PTSD (22.2%), compared to 36 in the community clinic (10.4%). The odds of an adolescent in detention receiving a PTSD diagnosis were 2.5 times higher compared to adolescents evaluated in the community (p < 0.001, ExpB 2.54). There was a decreased likelihood for adolescents to receive a GAD or UTD diagnosis while in detention. In this sample, adolescents evaluated in detention had significantly higher odds of being diagnosed with PTSD and a lower likelihood of receiving GAD or UTD that was not PTSD. This finding supports previous literature that adolescents in detention have higher rates of PTSD than their peers in the community. It is crucial to implement evidence-based trauma treatment in detention settings, and research should continue to examine the feasibility, acceptability, and effectiveness of these interventions. [ABSTRACT FROM AUTHOR]

Phytoestrogens -- soy-based proteins -- may become an acceptable alternative to hormone replacement therapy in the future. Our experts explain the current data so you can advise your patients appropriately. [ABSTRACT FROM AUTHOR]

Understanding children's psychological well-being (PWB) from a eudaimonic perspective is crucial given its impact on children's overall well-being and quality of life. This perspective denotes PWB as the realisation of one's true potential and attaining meaningful goals that lead to personal growth and fulfilment. Despite the recent increasing interest in children's PWB, there is limited literature in this area. This may be due to the abstract nature of eudaimonic concepts, which are challenging to operationalise and measure, leading to less empirical attention. Using a systematic review, we synthesised existing empirical studies on children's PWB from a eudaimonic perspective. We identified 32 quantitative articles, which presented in four different categories, namely validation studies, predictors and correlates of PWB, descriptive studies, and intervention studies. Most studies used Ryff's (Journal of Personality and Social Psychology, 57, 1069–1081, 1989) theoretical model of PWB and her PWB Scale, and were conducted in high-income countries. Future research should prioritise conducting studies in diverse socio-economic and cultural contexts to ensure a comprehensive understanding of children's PWB. By expanding geographic and socio-economic representation, and including longitudinal studies, we can develop more effective and inclusive interventions and policies that cater to the needs of children globally. [ABSTRACT FROM AUTHOR]

Consumer well-being involves not only the pursuit of pleasure, but also the pursuit of meaning. However, little is known about how people perceive the costs and benefits of meaning- versus pleasure-oriented experiences. We find that compared to pleasure-oriented experiences, people expect meaning-oriented experiences to be more satisfying after meeting a minimum time investment (i.e., the perceived minimum amount of time needed to derive benefits from consumption; study 1). As a consequence, people choose to prolong their exposure to meaningful (vs. pleasurable) experiences following interruptions (study 2). We discuss the implications of minimum time investments for firms' relationships with consumers and marketing communication design (web appendix). [ABSTRACT FROM AUTHOR]

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A proof-of-concept study was conducted to explore the acceptability and potential benefits of a blended positive psychotherapy intervention for clients with residual depressive symptoms. A single-arm pilot study was conducted in 2022 and 2023 with 24 Dutch adults experiencing residual depressive symptoms after treatment. Clients who had recently received an evidence-based treatment for depressive disorder were approached to participate in this study through opportunity sampling. The intervention consisted of nine sessions with a therapist and a six-week self-guided digital positive psychology intervention. Acceptability was examined using semi-structured interviews (n = 15). Participants filled out questionnaires pre- (n = 21), mid- (n = 14) and post-intervention (n = 8). Potential benefits were assessed in terms of changes in mental well-being (MHC-SF), depression (PHQ-9) and personal recovery (QPR). Quantitative data and qualitative data were analysed using linear mixed-effects models and framework analysis, respectively. The analyses were primarily based on Sekhon's theoretical framework of acceptability. Linear mixed-effects analyses showed changes over time in most mental health indicators, including mental well-being (Hedge's g = 1.58), depression (g = 1.43) and personal recovery (g = 1.96). Most of the interviewed participants considered blended positive psychotherapy a valuable adjunctive treatment; it connected well with their wish to become more positive in their daily life without ignoring difficult experiences. For some participants, shifting towards a positive treatment approach was difficult, resulting in early dropout. This study's findings suggest that blended positive psychotherapy is acceptable to most people with residual depressive symptoms after treatment. Its impact is yet to be established in larger samples of studies involving more robust designs. [ABSTRACT FROM AUTHOR]

Background: Depressive symptoms among nurses have been a significant public health concern. Although many studies have demonstrated the potential relationship between interpersonal conflict at work and depressive symptoms, the mechanisms underlying this relationship among nurses remain unclear. Based on the theoretical and empirical research, this study aimed to investigate the multiple mediating effects of negative emotion at work and meaning in life on the relationship between interpersonal conflict at work and depressive symptoms among nurses. Methods: An online multicenter cross-sectional study was conducted in 15 hospitals from different geographical areas of Hunan Province, China, from December 2021 to February 2022. A total of 1754 nurses completed validated self-reported questionnaires, including their sociodemographic information, interpersonal conflict at work, negative emotions at work, meaning in life, and depressive symptoms. Descriptive statistics analysis, Spearman's correlation analysis, multiple linear regression analysis, and chain mediation analysis were performed using IBM SPSS software (version 29) and Mplus software (version 8). Results: There were significant correlations between interpersonal conflict at work, negative emotions at work, meaning in life, and depressive symptoms (r = -0.206 ~ 0.518, all p < 0.01). Interpersonal conflict at work had a statistically significantly direct effect on depressive symptoms (β = 0.061; 95% confidence interval, CI: 0.011 ~ 0.126, p = 0.039). Analysis of mediating effects revealed that interpersonal conflict at work also influenced depressive symptoms through two statistically significantly indirect pathways: (a) the mediating effect of negative emotions at work (β = 0.167; 95% CI: 0.138 ~ 0.195, p < 0.001) and (b) the chain mediating effect between negative emotions at work and meaning in life (β = 0.008; 95% CI: 0.003 ~ 0.013, p = 0.005). Conclusion: Interpersonal conflict at work has a direct positive effect on depressive symptoms among nurses. Meanwhile, interpersonal conflict at work can influence depressive symptoms among nurses through the mediating effect of negative emotions at work and the chain mediating effect between negative emotions at work and meaning in life. [ABSTRACT FROM AUTHOR]