1. Insulin-like growth factor I, binding proteins -1 and -3, risk of type 2 diabetes and macronutrient intakes in men.
- Author
-
Similä, Minna E., Kontto, Jukka P., Virtamo, Jarmo, Hätönen, Katja A., Valsta, Liisa M., Sundvall, Jouko, and Männistö, Satu
- Subjects
TYPE 2 diabetes risk factors ,CONFIDENCE intervals ,CARBOHYDRATE content of food ,FAT content of food ,FOOD habits ,INGESTION ,INSULIN ,MEN'S health ,NUTRITIONAL requirements ,DIETARY proteins ,QUESTIONNAIRES ,REGRESSION analysis ,STATISTICAL sampling ,LOGISTIC regression analysis ,BODY mass index ,CASE-control method ,CONNECTIVE tissue growth factor ,ODDS ratio - Abstract
The insulin-like growth factor (IGF) axis may be involved in the development of type 2 diabetes. We examined the associations of IGF-I and IGF binding proteins (IGFBP)-1 and -3 with diabetes risk and evaluated macronutrient intakes related to the observed associations. In a nested case–control study of the Alpha-Tocopherol, Beta-Carotene Cancer Prevention Study of Finnish male smokers aged 50–69 years, the IGF variables were measured from baseline serum samples for a random sample of 310 men with diabetes diagnosed during a 12-year follow-up and for 310 controls matched by age, recruitment day and intervention group. Diet at baseline was assessed using a validated FFQ. The associations of IGF proteins with diabetes risk were estimated using conditional logistic regression and the associations with macronutrient intakes using linear regression. IGF-I and IGFBP-3 were not associated with the incidence of diabetes. Higher IGFBP-1 was associated with lower diabetes risk in an unadjusted crude model (OR 0·25; 95 % CI 0·15, 0·42 in the highest quartile compared with the lowest), but not after adjustment for BMI (corresponding OR 0·76; 95 % CI 0·41, 1·40). Intakes of carbohydrates, plant protein and milk protein associated positively and intake of meat protein and fat negatively with IGFBP-1 (P <0·005). IGFBP-1 was inversely associated with diabetes risk, but the association was substantially dependent on BMI. The associations between macronutrient intakes and IGFBP-1 may reflect influences of nutrients or foods on insulin concentrations. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF