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Background: Obesity and sarcopenia are both viewed as pathological body composition issues and indicators of compromised nutritional status. The aim of this study was to evaluate the effects of sarcopenic obesity on short- and long-term clinical outcomes. Methods: The clinical data of patients who underwent radical gastrectomy between 2013 and 2019 were prospectively collected. Sarcopenia is defined by European Working Group on Sarcopenia in Older People (EWGSOP2) and obesity is defined by the body mass index (BMI). To identify the independent predictors of postoperative complications and overall survival, we performed univariate and multivariate logistic and Cox regression analyses. Results: In a total of 508 cases, 372 (73.2%) cases were diagnosed with non-sarcopenia, 112 (22.0%) with non-obese sarcopenia, and 24 (4.7%) with sarcopenic obesity. In the multivariate logistic regression, both of non-obese sarcopenia (OR = 2.305, 95% CI = 1.444–3.679, P < 0.001) and sarcopenic obesity (OR = 2.589, 95% CI = 1.088–6.156, P = 0.031) were independent risk factors for postoperative complications. In the multivariate Cox analysis, only non-obese sarcopenia (HR = 2.614, 95% CI = 1.882–3.631, P < 0.001) was independent risk factor for overall survival. Conclusions: Sarcopenic obesity serves as an independent risk factor for postoperative complications, but not for overall survival. [ABSTRACT FROM AUTHOR]

This study employs a corpus-assisted critical discourse analysis to demystify the dominant patterns of representations around 5G in the Chinese and British press. Keyword analyses identify four thematic categories around the representation of 5G: the nature of 5G, social actors in 5G discourse, actions around 5G and timing in 5G discourse. Findings suggest that the Chinese press tends to use positive evaluative expressions to depict 5G as a trustworthy and beneficial issue and stress China's strong support for 5G development. In contrast, the British press prefers to frame 5G as a product of geopolitical rivalry and an issue with scientific uncertainties and controversies by repeatedly employing negative language patterns related to 5G risks and conspiracy theories. Besides, a subtle but varying "self versus other" schema is constructed by the two presses. The Chinese press is inclined to use positive predication strategies to construct a positive self-representation, whereas the British press tends to adopt negative predication strategies to portray China as an outgroup and meanwhile use scapegoating strategies to profile Britain as a positive self by using recurrent patterns denoting the pressure exerted on Britain by the United States. Such differences could result from their journalistic ideologies and values and the contrasting socio-political contexts where the two presses are situated. [ABSTRACT FROM AUTHOR]

The Legume family (Leguminosae or Fabaceae), is one of the largest and economically important flowering plants. Heartwood, the core of a tree trunk or branch, is a valuable and renewable resource employed for centuries in constructing sturdy and sustainable structures. Hongmu refers to a category of precious timber trees in China, encompassing 29 woody species, primarily from the legume genus. Due to the lack of genome data, detailed studies on their economic and ecological importance are limited. Therefore, this study generates chromosome-scale assemblies of five Hongmu species in Leguminosae: Pterocarpus santalinus, Pterocarpus macrocarpus, Dalbergia cochinchinensis, Dalbergia cultrata, and Senna siamea, using a combination of short-reads, long-read nanopore, and Hi-C data. We obtained 623.86 Mb, 634.58 Mb, 700.60 Mb, 645.98 Mb, and 437.29 Mb of pseudochromosome level assemblies with the scaffold N50 lengths of 63.1 Mb, 63.7 Mb, 70.4 Mb, 61.1 Mb and 32.2 Mb for P. santalinus, P. macrocarpus, D. cochinchinensis, D. cultrata and S. siamea, respectively. These genome data will serve as a valuable resource for studying crucial traits, like wood quality, disease resistance, and environmental adaptation in Hongmu. [ABSTRACT FROM AUTHOR]

In this paper we explore how a public national media outlet, the British BBC, represents an international legal case which has a highly political nature. The case is US versus Huawei/Meng Wanzhou, which took place between 2018 and 2021. Accusations were that the Chinese technology company committed fraud, leading the global HSBC bank to breach US sanctions against Iran. The charges were made by the US using what is called an 'extraterritorial law', which, while rejected as law by governments around the world, is policed by US economic powers and control over international finance. Using Critical Discourse Analysis we show that, while the BBC presents much detail of legal process, the actual nature of the law the US uses to bring criminal charges against international companies and banks, is neither considered nor questioned. Our interest is how such a law, which has a huge influence over global trade and politics, is presented to the public in this particular case. We contribute to the position that the nature of laws, how they are used and known, must always be understood within the prevailing discourses of the moment. [ABSTRACT FROM AUTHOR]

The South-to-North Water Diversion Project (SNWDP) is a significant and costly cross-basin mega water project in China, and one aim is to improve water use efficiency. To assess the effect of the SNWDP, this study conducts a quantitative evaluation of the middle route of the SNWDP's impact on water use efficiency through the event analysis method based on panel data from 2010 to 2019 of 14 cities along the middle route. The results show the construction of the SNWDP has had a positive impact on water use efficiency in the areas along the project, and the water use efficiency is constantly improving. Further empirical analysis shows that regional groundwater supply, industrial water consumption, and technical level have a significant positive impact on regional water use efficiency. Regional per-capita GDP has a significant negative impact on water use efficiency. The results can provide a scientific basis and decision-making reference for optimizing the SNWDP. [ABSTRACT FROM AUTHOR]

The properties of leachate from refuse transfer stations (RTSs) in rural China were indefinite. In this study, a total of 14 leachate samples from RTSs in nine provinces of China were characterized for their pH, electric conductivity, chromaticity, concentration of organic substances, nitrogen distribution, volatile organic compounds (VOCs), organic phosphorous pesticide, and heavy metals. The structural composition of fluorescent dissolved organic matter (FDOM) was also determined. To evaluate the leachate pollution potential in this study, a leachate pollution index was derived and used. Chromium (Cr) was the most polluting heavy metal present in rural leachate. Ethanol and ethyl acetate were the most frequently detected VOCs at high concentrations. Three-dimensional fluorescence excitation-emission matrix spectra were used to characterize the FDOM. Three components, tryptophan (C1), tyrosine-like (C2), and humic acid– and fulvic acid–like (C3) substances, were identified from all 14 samples. Tryptophan was the major component of FDOM and present in 45.7% of the samples by calculating the fluorescence intensity percentage, on average. Pearson correlations revealed that the fluorescence intensity of C1 and C3 was strongly related to soluble chemical oxygen demand and dissolved oxygen carbon, while C2 had significant positive correlations with ammonia nitrogen and total phosphorus of the solid waste. This study provided detailed data and findings that could serve as a preliminary basis for broadening options for the treatment and management of leachate from rural RTSs in China. [ABSTRACT FROM AUTHOR]

The strictest water resources management (SWRM) policy is a critical policy to address China's severe water shortage and pollution problems, and aims to promote sustainable water development and water governance. Based on data mining from multiple sources, including policy text from the strictest water resource management policy from 2011 to 2021, the reports of major media websites, and the Baidu Index, this study used the ROST-CM6 text-analysis tool to analyze the policy content, public opinion, and public perception of the strictest water resources management policy quantitatively and visually. The results found that the policy text and public-opinion are given high attention to the water resources assessment, water control management, and water resources protection, but the policy text focuses on the macro level, and pays more attention to national development and long-term planning. The public opinion belongs to the micro level and is more economic, and there is a certain degree of media bias. With notable regional disparities, the general public's opinion of the harshest water resource management policy has been rising every year. This research adds to the global body of knowledge on water governance, and serves as a guide for Chinese and other governments looking to improve their water resource management strategies. [ABSTRACT FROM AUTHOR]

The present study has conducted a diachronic analysis of law and order metaphors in a self-compiled corpus of China's Government Work Reports (CGWR) over a span of 22 years (2000–2021). By mapping target domains with source domains, we categorized four major types of legal metaphors, including building, physical object, journey, and living being, among which physical object was overwhelmingly predominant. Our analysis suggests metaphorical expressions that highlight physicality more than specificity will constantly remain in use because the stability and universality of such metaphors are conducive to the dissemination and reinforcement of legal thoughts. Additionally, there is a direct correlation between legal metaphors and the government's economic, political, and social concerns, as evidenced by increasing attention paid to various security issues and new challenges in China. Given that the rule of law with Chinese characteristics becomes more institutionally recognized and systematically theorized, legal metaphors are implemented in a top-down manner to justify the exercise of power in CGWRs, making Chinese people identified with the governing philosophy and further contributing to the ideological construction of discourse. This study is thus conducive to a general but insightful understanding of how political stances are embodied and reinforced persuasively in discourse. [ABSTRACT FROM AUTHOR]

Objective: Mild cognitive impairment (MCI) is a common, chronic, and complex disease in the elderly, which is often influenced by a variety of factors that include nutrition and inflammation. This study was undertaken to evaluate the mediation effects of inflammation on the association between vitamin D levels and MCI. Methods: We explored the associations of inflammation and cognitive impairment related to 25(OH)D3 deficiency among 360 older people from the communities in China. Demographic characteristics, lifestyle, and health status were investigated by questionnaire, cognitive function was detected by MoCA, and plasma 25(OH)D3, interleukin-1β (IL-1β), and interleukin-18 (IL-18) were measured by ELISA. Spearman's correlation analysis and logistic regression analysis were used to analyze the relationship among 25(OH)D3, IL-1β, and IL-18 in the MCI group and the control group and further to analyze the relationship between 25(OH)D3 and inflammatory factors in the MCI group. Finally, mediation analysis was performed to evaluate whether inflammation mediated the effect of 25(OH)D3 deficiency on cognitive impairment. Results: There were lower plasma 25(OH)D3 concentration and higher IL-1β and IL-18 levels in the MCI group compared with the controls. The levels of 25(OH)D3 were positively correlated with the MoCA scores and scores of different domains; the levels of IL-1β and IL-18 were negatively correlated with them (p < 0.05). In multivariate logistic analysis, there were significant associations among 25(OH)D3, IL-1β, IL-18, and MCI after adjusted. Further analysis revealed the significant association between the subjects with VD deficiency and the highest quartile of IL-18 in MCI (OR = 4.066), not with IL-1β after adjusting the confounding variables in MCI group. Ultimately, mediation analysis suggested that IL-1β and IL-18 could explain 25.4 and 17.5% of effect of the risk of cognitive impairment related to 25(OH)D3 deficiency. Conclusion: Our findings suggested that 25(OH)D3 deficiency could increase the risk of cognitive impairment by a mechanism partly involving inflammation. Therefore, vitamin D supplementation may improve or delay the decline in cognitive function caused by inflammation in the elderly. [ABSTRACT FROM AUTHOR]

While collaborative curriculum design (CCD) has gained increasing attention in the field of education, there is scant research as to how EFL teachers implement it in authentic design contexts. The present case study places particular emphasis on teacher activities during collaborative EFL curriculum development in China. The researchers adopt Activity Theory as an analytical tool to understand the relationships between EFL teachers, reform goals, and various aspects of the sociocultural context in which CCD is advocated, highlighting the pivotal role that mediation of knowledge/experience plays in the teacher learning community. Research findings indicate that the TDTs' collaborative process is a socially constructed and culturally mediated activity that promotes EFL teacher development. Moreover, in-service teachers are prone to take challenges through educational reforms out of teacher motives and external stimuli. Limitations of the CCD model are also discussed to shed light on future research. [ABSTRACT FROM AUTHOR]

As an innovative model for infrastructure and public service delivery, public–private partnership (PPP) has become increasingly more popular around the world. PPP is facing the dilemma of development direction and value orientation since current studies and practices are mostly performed from an economic perspective. PPP leads according to sustainable development goals. This study briefly reviews the development of China's PPP and summarizes the characteristics of PPP in China through the theory of evolutionary economic geography. Secondly, a conceptual framework of sustainability-oriented PPP is proposed with three phases named PPP1.0, PPP2.0, and PPP3.0. Thirdly, a case study named the Taizhou commuter-rail Line S1 PPP project has been adopted to verify the theoretical framework of the sustainability-oriented PPP. Lastly, the theoretical framework is analyzed and discussed based on the four dimensions: driving force, subject, process, and object. The results show that the sustainability-oriented PPP framework explains the development process and trend of PPP, not only meeting the PPP development needs in China, but also providing a reference value for other developing countries. This study has implications for decision making in China's PPP policy and makes an innovative contribution to the global PPP knowledge body. [ABSTRACT FROM AUTHOR]

Background: Handgrip strength (HGS) is associated with poor clinical outcomes, including all‐cause, non‐cardiovascular, and cardiovascular mortalities. The published cut‐off points for HGS are mostly based on community populations from Western countries, lacking information on cancer patients from China. The objective of this study was to establish sex‐specific cut‐off points for Chinese cancer patients and investigate the effect of low HGS on cancer mortality. Methods: We did a retrospective cohort study of patients who were diagnosed with malignant cancer from June 2012 to December 2018. HGS was measured using a hand dynamometer in 8257 cancer patients. Optimal stratification was used to solve threshold points. The hazard ratio (HR) of all cancer mortality and cancer‐specific mortality was calculated using Cox proportional hazard regression models. Results: Among all participants, there were 3902 (47.3%) women and 4355 (52.7%) men. The median age was 58 years old. The cut‐off points of HGS to best classify patients with respect to time to mortality were <16.1 kg for women and <22 kg for men. Low HGS was associated with overall cancer mortality in both women and men [HR = 1.339, 95% confidence interval (CI) = 1.170–1.531, P < 0.001; HR = 1.346, 95% CI = 1.176–1.540, P < 0.001, respectively]. For specific cancer types, low HGS was associated with breast cancer (HR = 1.593, 95% CI = 1.230–2.063, P < 0.001) in women, and lung cancer (HR = 1.369, 95% CI = 1.005–1.866, P = 0.047) and colorectal cancer (HR = 1.399, 95% CI = 1.007–1.944, P = 0.045) in men. Conclusions: On the basis of our sex‐specific cut‐off points, low HGS was strongly associated with cancer mortalities. These results indicate the usefulness of HGS measurement in routine clinical practice for improving patient assessments, cancer prognosis, and intervention. [ABSTRACT FROM AUTHOR]

Human cognition affects the result of symbolic activity. Evidentiality is a linguistic concept which encodes the source of information and expresses the attitude and confidence of speaker. This paper collects 31 judgments from the Supreme People's Court (SPC) and local people's courts in the People's Republic of China (P.R.C) as the research corpus, and analyzes the evidentiality in four aspects: information source, lingual form, evidential function and speaker's attitude of the information. It is found in this study that: 1) The information sources are divided into four types as cultural belief, sensory experience, verbal rumor and inferential hypothesis; 2) Lingual form consists of three categories: vocabulary, phrase and compound sentence; 3) Evidentiality in court judgments performs four functions: support with citation, induction with description, paraphrase with less responsibility and summarization with reasoning; 4) The reliability of evidentiality presents a two-tier structure based on different information sources. From the perspective of Peirce's semiotics, the paper analyzes the judicial practice of court judgments with actual data and proposes some suggestions. [ABSTRACT FROM AUTHOR]

Issues concerning cyber asset in cyberspace have intrigued the legislators, the judicial practitioners, the netizens, and even the onlookers in real world; simultaneously, academia is discussing the disputes aroused by this intangible object. However, various studies in the past refined the discussions in domains of law but the refinement fails to clarify the cyber-asset issues and to resolve the disputes. Therefore, a better understanding of what "cyber asset" is can be achieved by exploring cyber asset in the judicial discourses from a socio-semiotic perspective. In this study, judicial discourses are tantamount to the semiotic resource. Then, incorporating in a generic model of judicial discourses, we examine (1) how cyber asset as a sign has been framed by agents of the judicial institution of the People's Republic of China; (2) how the judicial institution justified their framing; and (3) whether any temporal change in the semiotic system of cyber asset took place. Furthermore, by applying the five questions introduced by Van Leeuwen, we examine why the quandaries of cyber asset are aroused. In conclusion, we propose that the cyber-asset disputes can hardly be resolved unless joint efforts are made by the legislature and the judiciary of the People's Republic of China. [ABSTRACT FROM AUTHOR]

As a new kind of contactless crime, the telecom and internet fraud has become a public hazard, with criminals targeting massive numbers of innocent victims. It is a prominent criminal problem that currently affects social stability and the sense of security of the public. Since the six Ministries and Commissions jointly cracked down the crime in 2016, the number of cases and the number of people deceived have decreased, but the occurrence and frequency has still been at a high rate, and the situation is deteriorating. Regardless of the scientific and technological means used by fraudsters, the main medium is language. From a sociosemiotic perspective, this study identifies that the criminal suspects use the discourse resources to fabricate false information and construct false identities through discursive practice, with the aim of achieving the communicative purpose of obtaining victims' trust, tricking, deceiving and manipulating their victims into giving out confidential information and funds. This study, taking telecom fraud discourse as one type of genre, examines the dynamic process of selecting and constructing identities by manipulating related discourse resources and strategies in the social-cultural context. This study further provides a sociosemiotic solution to telecom fraud prevention. [ABSTRACT FROM AUTHOR]

Battles against domestic violence in the People’s Republic of China (hereafter P. R. C.) have been carried out since 1995. In this study, legislative progression of laws related to domestic violence is first examined and clarified; second, findings from the legislative review are investigated on the basis of civil and criminal cases; third, the interaction among social and traditional norms, legislation, and judicial outcomes is explored and interpreted from a sociosemiotic perspective. It is found in this study that: 1) legislation and judicial practices of domestic violence in the P. R. C. are closely intertwined with social and traditional norms; 2) there is a gap between judicial practices dealing with domestic violence and the legislation; 3) the Anti-Domestic Violence Law offers a notch for state powers to embrace the familial relationship and to safeguard a victim. [ABSTRACT FROM AUTHOR]

The legal term "fundamental rights " has been well recognized in international treaties and legislations. The present study investigates the stipulations on fundamental rights in the four versions (1954, 1975, 1978, and 1982) of and four Amendments (1988, 1993, 1999, and 2004) to the Constitution of the People's Republic of China (PRC) from a sociosemiotic perspective. The findings in this study indicate that the provisions in the Constitution are crafted in such a manner that the dominant social and political participants employ them to maintain their ruling position and promote social and economic developments. In the successive versions and Amendments to the PRC Constitution, the evolution of the provisions on fundamental rights not only demonstrates the development of fundamental rights in China, but also illuminates the underlying mediation mainly among the Chinese government, the Communist Party of China (CPC), and Chinese people. The connotation and validity therein is constructed through communication and competition among various participants. It is therefore argued that the status quo of fundamental rights in China is the result of mediation among the relevant participants under the impact of the social and economic development. The State and the CPC are thus suggested to loosen their grips to promote Chinese people's participation in the mediation process with more attention to the social and economic reality. This study also implies that the definition of a legal term is constrained by other sign systems and hence the importance of an understanding of terminological dynamicity. [ABSTRACT FROM AUTHOR]

Genre has been a critical issue in discourse analysis as well as in other disciplines. Based on a literature review of the concept of genre and taking judgments as one type of genre in legal settings, the present study provides a corpus-based insight into the nature of genre. The literature review per se reveals that genre has one typical feature of a sign, that is, being subject to multiple and alternative interpretations; in other words, genre as a sign may have various interpretants. The present study unravels the actual generic structures, distinguishes different types of generic structures within the given genre, and then defines the dominant generic structure of judgments in Hong Kong, Taiwan, and Mainland China. This study also examines and contrasts the generic structure potential of judgments in each jurisdiction. In addition, the variation of Mainland China's judgments over time is briefly discussed. Comparing the generic structures of judgments among the three jurisdictions, as well as the structures of judgments in Mainland China over time, the paper argues that genre also has the essential features of a sign, that is, the characteristics of temporality and spatiality. [ABSTRACT FROM AUTHOR]

Background Genome sequencing has been widely used in plant research to construct reference genomes and provide evolutionary insights. However, few plant species have had their whole genome sequenced, thus restraining the utility of these data. We collected 1,093 samples of vascular plant species growing in the Ruili Botanical Garden, located in southwest China. Of these, we sequenced 761 samples and collected voucher specimens stored in the Herbarium of China National GeneBank. Results The 761 sequenced samples represented 689 vascular plant species from 137 families belonging to 49 orders. Of these, 257 samples were identified to the species level and 504 to the family level, using specimen and chloroplast sequences. In total, we generated 54 Tb of sequencing data, with an average sequencing depth of 60X per species, as estimated from genome sizes. A reference phylogeny was reconstructed with 78 chloroplast genes for molecular identification and other possible applications. Conclusions The large dataset of vascular plant genomes generated in this study, which includes both high-depth whole-genome sequencing data and associated voucher specimens, is valuable for plant genome research and other applications. This project also provides insight into the feasibility and technical requirements for "planetary-scale" projects such as the 10,000 Plant Genomes Project and the Earth BioGenome Project. [ABSTRACT FROM AUTHOR]

Graphical abstract Abstract A traditional Chinese medicine (TCM) formula (SL) comprising Sophorae Flos and Lonicerae Japonicae Flos was used for treating melanoma in ancient China. We have previously shown that an ethanolic extract of SL (SLE) possesses anti-melanoma effects and suppresses STAT3 signaling in vitro and in vivo. STAT3 has been linked to the development of melanoma immunosuppressive microenvironment. In this work, we investigated whether SLE inhibits melanoma growth by reprogramming the tumor microenvironment in mouse and co-culture cell models. In B16F10 melanoma-bearing mice, we found that intragastric administration of SLE (1.2 g/kg) dramatically inhibited tumor growth. This observation was associated with the downregulation of protein levels of phospho-STAT3 (Tyr 705) and STAT3-regulated immunosuppressive cytokines, and mRNA levels of STAT3-targeted genes involved in tumor growth and immune evasion. We also observed increased Th, Tc and dendritic cells in the melanomas and spleens in SLE-treated mice compared to that in control mice. In a co-culture system composed of B16F10 cells and mouse primary splenic lymphocytes, it was found that SLE not only inhibited STAT3 activation in B16F10 cells, but also downregulated mRNA levels of STAT3-targeted genes in the splenic lymphocytes. In this co-culture setting, SLE decreased the levels of STAT3-regulated immunosuppressive cytokines, increased the percentages of Th, Tc and dendritic cells as well. Furthermore, effects of SLE on STAT3 phosphorylation, cytokine levels and immune cell subtype percentages were significantly weaker in the B16STAT3C cells (stable cells harboring a constitutively active STAT3 variant STAT3C)/splenic lymphocytes co-culture system than in the B16V cells (cells stably transfected with the empty vector)/splenic lymphocytes co-culture system, indicating that STAT3 over-activation diminishes SLE's effects. In summary, our findings indicate that reprograming the immune microenvironment, partially mediated by inhibiting STAT3 signaling, contributes to the anti-melanoma mechanisms of SLE. This study provides further pharmacological groundwork for developing SLE as a modern agent for melanoma prevention/treatment, and supports the notion that reprograming immunosuppressive microenvironment is a viable anti-melanoma strategy. [ABSTRACT FROM AUTHOR]

Esophageal squamous cell carcinoma (ESCC) is one of the most common cancers worldwide and the fourth most lethal cancer in China. However, although genomic studies have identified some mutations associated with ESCC, we know little of the mutational processes responsible. To identify genome-wide mutational signatures, we performed either whole-genome sequencing (WGS) or whole-exome sequencing (WES) on 104 ESCC individuals and combined our data with those of 88 previously reported samples. An APOBEC -mediated mutational signature in 47% of 192 tumors suggests that APOBEC-catalyzed deamination provides a source of DNA damage in ESCC. Moreover, PIK3CA hotspot mutations (c.1624G>A [p.Glu542Lys] and c.1633G>A [p.Glu545Lys]) were enriched in APOBEC -signature tumors, and no smoking-associated signature was observed in ESCC. In the samples analyzed by WGS, we identified focal (<100 kb) amplifications of CBX4 and CBX8 . In our combined cohort, we identified frequent inactivating mutations in AJUBA , ZNF750 , and PTCH1 and the chromatin-remodeling genes CREBBP and BAP1 , in addition to known mutations. Functional analyses suggest roles for several genes ( CBX4 , CBX8 , AJUBA , and ZNF750 ) in ESCC. Notably, high activity of hedgehog signaling and the PI3K pathway in approximately 60% of 104 ESCC tumors indicates that therapies targeting these pathways might be particularly promising strategies for ESCC. Collectively, our data provide comprehensive insights into the mutational signatures of ESCC and identify markers for early diagnosis and potential therapeutic targets. [ABSTRACT FROM AUTHOR]