8 results on '"Wu, Jer-Yuarn"'
Search Results
2. Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan
- Author
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Huang, Chung-Ming, Hang, Liang-Wen, Chen, Chi-Lan, Wu, Jer-Yuarn, and Tsai, Fuu-Jen
- Published
- 2004
- Full Text
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3. Genome-Wide and Candidate Gene Association Analyses Identify a 14-SNP Combination for Hypertension in Patients With Type 2 Diabetes.
- Author
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Cheng, Chi-Fung, Hsieh, Ai-Ru, Liang, Wen-Miin, Chen, Ching-Chu, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Lin, Ting-Hsu, Liao, Chiu-Chu, Huang, Shao-Mei, Huang, Yu-Chuen, Ban, Bo, Lin, Ying-Ju, and Tsai, Fuu-Jen
- Subjects
TYPE 2 diabetes ,SYSTOLIC blood pressure ,HYPERTENSION ,CARDIOVASCULAR disease related mortality ,SINGLE nucleotide polymorphisms ,BODY mass index - Abstract
Background High blood pressure is common and comorbid with type 2 diabetes (T2D). Almost 50% of patients with T2D have high blood pressure. Patients with both conditions of hypertension (HTN) and T2D are at risk for cardiovascular diseases and mortality. The study aim was to investigate genetic risk factors for HTN in T2D patients. Methods This study included 999 T2D (cohort 1) patients for the first genome scan stage and 922 T2D (cohort 2) patients for the replication stage. Here, we investigated the genetic susceptibility and cumulative weighted genetic risk score for HTN in T2D patients of Han Chinese descent in Taiwan. Results Thirty novel genetic single nucleotide polymorphisms (SNPs) were associated with HTN in T2D after adjusting for age and body mass index (P value <1 × 10
−4 ). Eight blood pressure-related and/or HTN-related genetic SNPs were associated with HTN in T2D after adjusting for age and body mass index (P value <0.05). Linkage disequilibrium and cumulative weighted genetic risk score analyses showed that 14 of the 38 SNPs were associated with risk of HTN in a dose-dependent manner in T2D (Cochran–Armitage trend test: P value <0.0001). The 14-SNP cumulative weighted genetic risk score was also associated with increased regression tendency of systolic blood pressure in T2D (SBP = 122.05 + 0.8 × weighted genetic risk score; P value = 0.0001). Conclusions A cumulative weighted genetic risk score composed of 14 SNPs is important for HTN, increased tendency of systolic blood pressure, and may contribute to HTN risk in T2D in Taiwan. [ABSTRACT FROM AUTHOR]- Published
- 2021
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4. Genome-Wide Association Study for Autism Spectrum Disorder in Taiwanese Han Population.
- Author
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Kuo, Po-Hsiu, Chuang, Li-Chung, Su, Mei-Hsin, Chen, Chia-Hsiang, Chen, Chien-Hsiun, Wu, Jer-Yuarn, Yen, Chung-Jen, Wu, Yu-Yu, Liu, Shih-Kai, Chou, Miao-Chun, Chou, Wen-Jiun, Chiu, Yen-Nan, Tsai, Wen-Che, and Gau, Susan Shur-Fen
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AUTISM spectrum disorders ,TAIWANESE people ,PUBLIC health ,NERVOUS system development ,NEUROLOGICAL disorders ,SINGLE nucleotide polymorphisms ,PATIENTS ,DISEASES - Abstract
Background: Autism spectrum disorder (ASD) is a neurodevelopmental disorder with strong genetic components. Several recent genome-wide association (GWA) studies in Caucasian samples have reported a number of gene regions and loci correlated with the risk of ASD—albeit with very little consensus across studies. Methods: A two-stage GWA study was employed to identify common genetic variants for ASD in the Taiwanese Han population. The discovery stage included 315 patients with ASD and 1,115 healthy controls, using the Affymetrix SNP array 6.0 platform for genotyping. Several gene regions were then selected for fine-mapping and top markers were examined in extended samples. Single marker, haplotype, gene-based, and pathway analyses were conducted for associations. Results: Seven SNPs had p-values ranging from 3.4~9.9*10
−6 , but none reached the genome-wide significant level. Five of them were mapped to three known genes (OR2M4, STYK1, and MNT) with significant empirical gene-based p-values in OR2M4 (p = 3.4*10−5 ) and MNT (p = 0.0008). Results of the fine-mapping study showed single-marker associations in the GLIS1 (rs12082358 and rs12080993) and NAALADL2 (rs3914502 and rs2222447) genes, and gene-based associations for the OR2M3-OR2T5 (olfactory receptor genes, p = 0.02), and GLIPR1/KRR1 gene regions (p = 0.015). Pathway analyses revealed important pathways for ASD, such as olfactory and G protein–coupled receptors signaling pathways. Conclusions: We reported Taiwanese Han specific susceptibility genes and variants for ASD. However, further replication in other Asian populations is warranted to validate our findings. Investigation in the biological functions of our reported genetic variants might also allow for better understanding on the underlying pathogenesis of autism. [ABSTRACT FROM AUTHOR]- Published
- 2015
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5. Investigation of Associations between NR1D1, RORA and RORB Genes and Bipolar Disorder.
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Lai, Yin-Chieh, Kao, Chung-Feng, Lu, Mong-Liang, Chen, Hsi-Chung, Chen, Po-Yu, Chen, Chien-Hsiun, Shen, Winston W., Wu, Jer-Yuarn, Lu, Ru-Band, and Kuo, Po-Hsiu
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BIPOLAR disorder ,NUCLEAR receptors (Biochemistry) ,DISEASE susceptibility ,HUMAN genetic variation ,SINGLE nucleotide polymorphisms ,CIRCADIAN rhythms ,CHINESE people ,DISEASES - Abstract
Several genes that are involved in the regulation of circadian rhythms are implicated in the susceptibility to bipolar disorder (BD). The current study aimed to investigate the relationships between genetic variants in NR1D1 RORA, and RORB genes and BD in the Han Chinese population. We conducted a case-control genetic association study with two samples of BD patients and healthy controls. Sample I consisted of 280 BD patients and 200 controls. Sample II consisted of 448 BD patients and 1770 healthy controls. 27 single nucleotide polymorphisms in the NR1D1, RORA, and RORB genes were genotyped using GoldenGate VeraCode assays in sample I, and 492 markers in the three genes were genotyped using Affymetrix Genome-Wide CHB Array in sample II. Single marker and gene-based association analyses were performed using PLINK. A combined p-value for the joining effects of all markers within a gene was calculated using the rank truncated product method. Multifactor dimensionality reduction (MDR) method was also applied to test gene-gene interactions in sample I. All markers were in Hardy-Weinberg equilibrium (P>0.001). In sample I, the associations with BD were observed for rs4774388 in RORA (OR = 1.53, empirical p-value, P = 0.024), and rs1327836 in RORB (OR = 1.75, P = 0.003). In Sample II, there were 45 SNPs showed associations with BD, and the most significant marker in RORA was rs11639084 (OR = 0.69, P = 0.002), and in RORB was rs17611535 (OR = 3.15, P = 0.027). A combined p-value of 1.6×10−6, 0.7, and 1.0 was obtained for RORA, RORB and NR1D1, respectively, indicting a strong association for RORA with the risk of developing BD. A four way interaction was found among markers in NR1D1, RORA, and RORB with the testing accuracy 53.25% and a cross-validation consistency of 8 out of 10. In sample II, 45 markers had empirical p-values less than 0.05. The most significant markers in RORA and RORB genes were rs11639084 (OR = 0.69, P = 0.002), and rs17611535 (OR = 3.15, P = 0.027), respectively. Gene-based association was significant for RORA gene (P = 0.0007). Our results support for the involvement of RORs genes in the risk of developing BD. Investigation of the functional properties of genes in the circadian pathway may further enhance our understanding about the pathogenesis of bipolar illness. [ABSTRACT FROM AUTHOR]
- Published
- 2015
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6. Novel susceptibility genes associated with diabetic cataract in a Taiwanese population.
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Lin, Hui-Ju, Huang, Yu-Chuen, Lin, Jane-Ming, Liao, Wen-Ling, Wu, Jer-Yuarn, Chen, Chien-Hsiun, Chou, Yi-Chun, Chen, Liuh-An, Lin, Chao-Jen, and Tsai, Fuu-Jen
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CATARACT ,DISEASE susceptibility ,TYPE 2 diabetes ,PEOPLE with diabetes ,HUMAN genetic variation ,SINGLE nucleotide polymorphisms ,TAIWANESE people ,DISEASES - Abstract
Purpose: To identify genetic variants that predispose to type 2 diabetes (T2D) with cataract. Patients and methods: Genome-wide association study (GWAS) of T2D patients with cataract, as graded by Lens Opacities Classification System (LOCS). A total of 109 T2D patients with cataract score equal to or above 10 designated as the study group, 649 T2D patients with cataract score equal to or below 3 as the control group. Single nucleotide polymorphisms (SNPs) with p-values < 10
-5 were considered to be putatively associated with the diabetic cataract. Results: Fifteen SNPs were found to be putatively associated with diabetic cataract. These variants were located near the following genes: PPARD, CCDC102A, GBA3, NEDD9, GABRR1/2, RPS6KA2, tcag7.1163, TAC1, GALNTL1 and KIAA1671. We defined haplotype 1 to haplotype 4 from the alternative alleles of related polymorphisms. Distribution of haplotype 2 on chromosome 4 and haplotype 4 on chromosome 7 revealed significant differences (OR = 1.86 and 1.69, respectively; 95% confidence interval were 1.26-2.76 and 1.23-2.31, respectively). Conclusions: The 15 loci coded on chromosomes 4, 6, 7, 14, 16 and 22 were associated with diabetic cataract. Gene functions are either with mechanisms of regulating blood sugar or formation of cataract. High linkage disequilibrium appeared on chromosome 4p15.31 and chromosome 7q21.3. [ABSTRACT FROM AUTHOR]- Published
- 2013
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7. Association of Genes on Chromosome 6, GRIK2, TMEM217 and TMEM63B (Linked to MRPL14) with Diabetic Retinopathy.
- Author
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Lin, Hui-Ju, Huang, Yu-Chuen, Lin, Jane-Ming, Wu, Jer-Yuarn, Chen, Liuh-an, and Tsai, Fuu-Jen
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DIABETES ,DIABETIC retinopathy ,GENETICS ,RETINAL diseases ,LINKAGE disequilibrium ,SINGLE nucleotide polymorphisms ,HAPLOTYPES - Abstract
Purpose: Diabetic retinopathy (DR) is one of the most common complications of diabetes mellitus (DM). The susceptibility genes responsible for increasing the risk for DR in type 2 diabetes (T2D) were sought in this study. Methods: A case-control study was carried out, comprising 749 unrelated T2D individuals with (n = 174) and without (n = 575) DR. Genotypic distributions of single nucleotide polymorphisms (SNPs) were determined for subjects with and without DR. Results: Eight chromosome 6 SNPs, having the most significant differences, were delineated: rs10499298, rs10499299, rs17827966, rs1224329, rs1150790, rs713050, rs2518344 and rs487083; all were associated with genes TMEM217, MRPL14 and GRIK2. After adjusting for the duration of DM and levels of hemoglobin A
1c , the TT genotype of rs713050, and the AG + AA genotypes of rs2518344 and rs10499298, differed significantly between those with and without DR. Haplotype analysis revealed haplotype C-A-C, residing in rs10499299, rs10499298 and rs17827966, to have significant linkage disequilibrium. Conclusions: We identified new loci on chromosome 6 associated to DR; all loci showed high levels of linkage disequilibrium. Copyright © 2012 S. Karger AG, Basel [ABSTRACT FROM AUTHOR]- Published
- 2012
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8. Polymorphisms of TAP1 transporter genes in Chinese patients with systemic lupus erythematosus in Taiwan.
- Author
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Chung-Ming Huang, Liang-Wen Hang, Chi-Lan Chen, Wu, Jer-Yuarn, and Tsai, Fuu-Jen
- Subjects
GENETIC polymorphisms ,TRANSPORT theory ,GENES ,ANTIGENS ,SYSTEMIC lupus erythematosus ,AUTOIMMUNE diseases ,POLYMERASE chain reaction - Abstract
The aim of this study was to determine how polymorphisms of transporters associated with transporter and antigen processing 1 (TAP1) alleles contributed to the pathogenesis of systemic lupus erythematosus (SLE) in Taiwan. We collected 88 patients with SLE and 104 healthy people for the control group. The polymorphisms were detected as a result of polymerase chain reaction (PCR)-based restriction analysis. Associations between SLE and TAP1 polymorphisms were evaluated. The results revealed no significant differences between the healthy individuals and SLE patients with TAP1-1 (Dpn II) and TAP1-2 (Acc I) polymorphisms (P=0.10 and 0.36, respectively). However, the G alleles of TAP1-1 and TAP1-2 were significantly more common than the A alleles in serositis of SLE patients (χ
2 =11.16 and P=0.004, χ2 =8.10 and P=0.02, respectively). [ABSTRACT FROM AUTHOR]- Published
- 2004
- Full Text
- View/download PDF
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