1. Trajectories of function and biomarkers with age: the CHS All Stars Study.
- Author
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Newman, Anne B., Sanders, Jason L., Kizer, Jorge R., Boudreau, Robert M., Odden, Michelle C., Hazzouri, Adina Zeki Al, Arnold, Alice M., and Zeki Al Hazzouri, Adina
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COMORBIDITY , *BIOMARKERS , *PHYSICAL activity , *MILD cognitive impairment , *SEX hormones , *AGING , *COGNITION , *GAIT in humans , *GRIP strength , *HEALTH status indicators , *INTERLEUKINS , *LONGITUDINAL method , *NEUROPSYCHOLOGICAL tests , *PROTEINS , *PSYCHOLOGICAL tests , *RESEARCH funding , *SOMATOMEDIN , *ACTIVITIES of daily living , *ADIPONECTIN - Abstract
Background: Multimorbidity is a major driver of physical and cognitive impairment, but rates of decline are also related to ageing. We sought to determine trajectories of decline in a large cohort by disease status, and examined their correspondence with biomarkers of ageing processes including growth hormone, sex steroid, inflammation, visceral adiposity and kidney function pathways.Methods: We have followed the 5888 participants in the Cardiovascular Health Study (CHS) for healthy ageing and longevity since 1989-90. Gait speed, grip strength, modified mini-mental status examination (3MSE) and the digit symbol substitution test (DSST) were assessed annually to 1998-99 and again in 2005-06. Insulin-like growth hormone (IGF-1), dehydroepiandrosterone sulphate (DHEAS), interleukin-6 (IL-6), adiponectin and cystatin-C were assessed 3-5 times from stored samples. Health status was updated annually and dichotomized as healthy vs not healthy. Trajectories for each function measure and biomarker were estimated using generalized estimating equations as a function of age and health status using standardized values.Results: Trajectories of functional decline showed strong age acceleration late in life in healthy older men and women as well as in chronically ill older adults. Adiponectin, IL-6 and cystatin-C tracked with functional decline in all domains; cystatin-C was consistently associated with functional declines independent of other biomarkers. DHEAS was independently associated with grip strength and IL-6 with grip strength and gait speed trajectories.Conclusions: Functional decline in late life appears to mark a fundamental ageing process in that it occurred and was accelerated in late life regardless of health status. Cystatin C was most consistently associated with these functional declines. [ABSTRACT FROM AUTHOR]- Published
- 2016
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