6 results on '"Castrop, Hayo"'
Search Results
2. Angiotensin receptor-associated proteins: local modulators of the renin-angiotensin system.
- Author
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Castrop, Hayo
- Subjects
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KIDNEY secretions , *ANGIOTENSIN receptors , *IMMUNOMODULATORS , *RENIN-angiotensin system , *PROTEIN receptors , *GENE expression - Abstract
The activity of the renin-angiotensin system crucially depends on the rate of renal renin secretion. Changes in renin secretion result in fluctuations of angiotensin II concentrations in the circulation and subsequently in the activation of angiotensin receptors in all accessible target organs. Consequently, various mechanisms have evolved to regulate the local sensitivity to angiotensin II. In this review, an overview of angiotensin II receptor-associated proteins is addressed. These proteins regulate the local sensitivity of receptor-expressing cells by modulating the receptor surface expression and the receptor sensitivity. A hypothesis will be discussed that integrates the existence of various angiotensin receptor-associated proteins into an overall functional model. [ABSTRACT FROM AUTHOR]
- Published
- 2013
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3. Physiology of Kidney Renin.
- Author
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Castrop, Hayo, Höcherl, Klaus, Kurtz, Armin, Schweda, Frank, Todorov, Vladimir, and Wagner, Charlotte
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RENIN-angiotensin system , *KIDNEY physiology , *CYTOGENETICS , *GENES , *HOMOLOGY (Biology) , *CYTOLOGY , *SEQUENTIAL analysis - Abstract
The article presents a study which focuses on the physiology of kidney renin and the transcriptional control of the renin gene. The study identifies the organization of the renin gene in various species including mice, sheep and humans and sequential analysis has been performed to examine the interspecies homology in the renin gene structure. The results indicate that the discovery of the gap functions relevance in JG cells has shown novel insights in the cell biology of renin-producing cells.
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- 2010
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4. Permissive role of nitric oxide in macula densa control of renin secretion.
- Author
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Castrop, Hayo, Schwenda, Frank, Mizel, Diane, Huang, Yuning, Briggs, Josie, Kurtz, Armin, and Schnermann, Jurgen
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NITRIC oxide , *RENIN-angiotensin system , *RENIN , *BUMETANIDE , *DIURETICS , *LABORATORY mice - Abstract
Experiments were performed in neuronal (nNOS)- and endothelial nitric oxide synthase (eNOS)-deficient mice to study the role of nitric oxide (NO) in macula densa control of renin secretion in vivo and in the isolated, perfused mouse kidney. Acute and chronic administration of loop diuretics was used as a method to stimulate macula densa-mediated renin secretion. Increases in plasma renin concentration (PRC) in response to a 3-day infusion of bumetanide (50 mg·kg-1·day-1) or an acute injection of furosemide (50 mg/kg ip) were not markedly altered in nNOS-/mice. Responses to furosemide were also maintained in eNOS-/mice, but the administration of Nω-nitro-L-arginine methyl ester (LNAME) markedly attenuated the PRC response to furosemide in these mice. In the isolated kidney preparation, bumetanide caused similar relative increases in renin secretion in kidneys of wild-type, nNOS-/-, and eNOS-/- mice. Bumetanide only marginally increased renin secretion in L-NAME-treated kidneys, but the bumetanide effect was normalized by S-nitroso-N-acetyl-penicillamine. Basal PRC was significantly reduced in male nNOS-/- mice compared with nNOS+/+ (189 ± 28 vs. 355 ± 57 ng ANG I ·ml-1·h-1; P = 0.017). There was no significant difference in PRC between eNOS+/+ and eNOS-/- mice. Basal renin secretion rates in perfused kidneys isolated from nNOS-/- or eNOS-/- mice were markedly reduced compared with wild-type controls. Our data suggest that NO generated by macula densa nNOS does not play a specific mediator role in macula densa-dependent renin secretion. However, NO independent of its exact source permits the macula densa pathway of renin secretion to function normally. [ABSTRACT FROM AUTHOR]
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- 2004
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5. General inhibition of renocortical cyclooxygenase-2 expression by the renin-angiotensin system.
- Author
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Castrop, Hayo, Klar, Jürgen, Wagner, Charlotte, Höcherl, Klaus, and Kurtz, Armin
- Subjects
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RENIN-angiotensin system , *CYCLOOXYGENASES , *KIDNEY cortex , *ANGIOTENSIN converting enzyme - Abstract
Because across-the-board data indicate that renin and cyclooxygenase-2 (COX-2) expression in the kidney cortex are regulated in parallel and because ANG II can inhibit COX-2 expression, the purpose of our study was to characterize a potential general inhibitory feedback of the renin-angiotensin system on renocortical COX-2 expression in vivo. Rats were fed a high-, normal-, or low-salt diet or were chronically infused with furosemide (60 mg·kg[sup -1]· day[sup -1]) or the left renal artery was clipped, and the animals were treated in addition to or without the angiotensin-convetting enzyme inhibitor ramipril (10 mg·kg[sup -1]·day[sup -1]). A high-salt diet reduced expression of COX-2, whereas a lowsalt diet, furosemide infusion, and renal artery stenosis stimulated COX-2 expression. Additional angiotensin-converting enzyme inhibition led to further increases in renocortical COX-2 expression by 62, 136, 300, 50, and 70% for a high-, normal-, and low-salt diet, furosemide infusion, and renal artery stenosis, respectively. Thus our data suggest a general inhibitory effect of the renin-angiotensin system on renocortical COX-2 expression. [ABSTRACT FROM AUTHOR]
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- 2003
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6. Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE.
- Author
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Martins, Joana Raquel, Reichhart, Nadine, Kociok, Nobert, Stindl, Julia, Foeckler, Renate, Lachmann, Peter, Todorov, Vladimir, Castrop, Hayo, and Strauß, Olaf
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NEURAL stimulation , *RHODOPSIN , *RENIN-angiotensin system , *TYROSINE hydroxylase , *NERVE endings , *CHOROID - Abstract
Several lines of evidence support the existence of a renin-angiotensin system (RAS) in the retina that is separated from the blood stream by the retinal pigment epithelium (RPE). Under physiological conditions, increased activity of intraretinal RAS regulates neuronal activity of the retina but patho-physiologically participates in retinal degeneration such as hypertensive or diabetic retinopathy. Interestingly, the RPE appears to be a modulator of intraretinal RAS in response to changes in systemic RAS. As increased systemic RAS activity is associated with increased sympathetic tonus, we investigated whether systemic β-adrenergic stimulation of the RPE also modulates renin expression in the RPE. In vivo , the mouse RPE expresses the β-adrenergic receptor subtypes 1 and 2. Staining of retina sagittal sections showed tyrosine hydroxylase positive nerve endings in the choroid indicating adrenaline/noradrenaline production sites in close proximity to the RPE. Systemic infusion of isoproterenol increased renin expression in the RPE but not in the retina. This increase was sensitive to concomitant systemic application of the angiotensin-2 receptor-type-1 blocker losartan. In vitro analysis of renin gene expression using polarized porcine RPE showed that the activity of the renin promoter can be increased by cAMP stimulation (IBMX/forskolin) but was not influenced by angiotensin-2. Thus, with the identification of the β-adrenergic system we added a new regulator of the retinal RAS with relevance for retinal function and pathology. Furthermore, it appears that the RPE is not only a close interaction partner of the photoreceptors but also a regulator or retinal activity in general. • The retinal pigment epithelium (RPE) forms an interface between the body system and retina. • Basolateral plasma membrane receptors make the RPE being an active interface between the body system and the retina. • We show that β-adrenergic stimulation increases the renin production by the RPE and thus retinal renin-angiotensin system. • Close sympathetic nerves in the choroid suggest that sympathetic activity influences retinal function and retinal pathology. [ABSTRACT FROM AUTHOR]
- Published
- 2019
- Full Text
- View/download PDF
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