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Oral tolerance induction through early introduction of allergenic food has proven effective in randomized controlled trials. This new approach to weaning has been incorporated into many national and international infants' feeding guidelines. However, there are questions that require further discussion, such as, which foods should be introduced early, should the intervention be targeted to infants at high‐risk or to the general population, and what is the ideal timing for early food introduction. This review examines the extent to which recent trials address these critical questions and highlights areas where further research is required. [ABSTRACT FROM AUTHOR]

Keywords: allergy diagnosis; atopic dermatitis; challenge tests; complementary feeding; food allergy; pediatrics; prevention; weaning EN allergy diagnosis atopic dermatitis challenge tests complementary feeding food allergy pediatrics prevention weaning 1592 1594 3 05/17/21 20210501 NES 210501 Oral tolerance induction (OTI) is the only RCT-proven effective intervention for preventing childhood food allergy.1,2 OTI to peanut is highly effective in a high-risk population with an 81% relative risk ration (RRR) to peanut allergy.3 OTI also reduced egg allergy in the general population in a per-protocol analysis.1 These published RCT findings have changed practice and many governmental and allergy societies now recommend introducing peanut in infancy; some suggest that other foods, such as well-cooked egg, are also introduced. Commencing multiple food OTI at 4 months of age has no detrimental effect on established breastfeeding.6,7 All children may adopt a diverse weaning diet,8 including allergenic foods such as well-cooked egg and peanut, as soon as weaning commences. Allergy diagnosis, atopic dermatitis, challenge tests, complementary feeding, food allergy, pediatrics, prevention, weaning. [Extracted from the article]