6 results on '"Peat, Nicola"'
Search Results
2. Effect of a brief physical activity-based presentation by a former patient for men treated with radical prostatectomy for prostate cancer: a mixed methods pilot study
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Fox, Louis, Wiseman, Theresa, Cahill, Declan, Fleure, Louisa, Kinsella, Janette, Curtis, Emily, Peat, Nicola, and Van Hemelrijck, Mieke
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- 2021
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3. Is There a Role for Exercise When Treating Patients with Cancer with Immune Checkpoint Inhibitors? A Scoping Review.
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Handford, Jasmine, Chen, Miaoqi, Rai, Ridesh, Moss, Charlotte L., Enting, Deborah, Peat, Nicola, Karagiannis, Sophia N., Van Hemelrijck, Mieke, and Russell, Beth
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CANCER patient psychology ,PSYCHOLOGY information storage & retrieval systems ,IMMUNE checkpoint inhibitors ,MEDICAL information storage & retrieval systems ,SYSTEMATIC reviews ,TREATMENT effectiveness ,QUALITY of life ,TUMORS ,LITERATURE reviews ,MEDLINE ,EXERCISE therapy - Abstract
Simple Summary: Immune checkpoint inhibitors (ICIs) are drugs which treat cancer by manipulating the immune system. Exercise also influences the immune system and helps to reduce symptoms in people with cancer, particularly fatigue. However, the effect of combining exercise with ICIs has not been well established. We hypothesise that the combined approach will produce beneficial outcomes for people with cancer (such as fewer side effects from ICIs and better killing of cancer cells). To determine the need for, and design of, future studies which address this hypothesis, we first need to understand what previous research has already shown. We aim to identify previous studies which have investigated this topic. Subsequently, by summarising their findings, we aim to communicate the key gaps in current understanding and provide informed recommendations about the direction, and design, of future research addressing the role of exercise during ICI treatment for people with cancer. The impact of using exercise as a non-pharmacological intervention in patients with cancer receiving immune checkpoint inhibitors (ICIs) is not well known. Our objective was to determine the extent of, and identify gaps within, available literature addressing the effect of exercise on (a) oncological outcomes and (b) quality of life (QoL) in patients with cancer receiving ICIs, and (c) the underlying biological mechanisms for such effects. We conducted searches across EMBASE, APA PsycInfo and Ovid MEDLINE(R). Studies were eligible if they addressed at least one aspect of the objective and were available in the English language. Results were synthesised using a narrative approach and subsequently discussed with multidisciplinary stakeholders. As of the final search on 5 April 2022, 11 eligible studies were identified, of which 8 were preclinical and 3 were clinical. Clinical studies only focused on QoL-related outcomes. When studies were grouped by whether they addressed oncological outcomes (n = 7), QoL (n = 5) or biological mechanisms (n = 7), they were found to be heterogeneous in methodology and findings. Additional evidence, particularly in the clinical setting, is required before robust recommendations about whether, and how, to include exercise alongside ICI treatment can be made. [ABSTRACT FROM AUTHOR]
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- 2022
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4. Short-term integrated rehabilitation for people with newly diagnosed thoracic cancer: a multi-centre randomized controlled feasibility trial.
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Bayly, Joanne, Fettes, Lucy, Douglas, Eleanor, Teixiera, Maria J, Peat, Nicola, Tunnard, India, Patel, Vishit, Gao, Wei, Wilcock, Andrew, Higginson, Irene J, and Maddocks, Matthew
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CANCER patients ,CANCER patient rehabilitation ,LUNG tumors ,MEDICAL cooperation ,MESOTHELIOMA ,PATIENT satisfaction ,QUALITY of life ,QUESTIONNAIRES ,RESEARCH ,RESEARCH funding ,STATISTICAL sampling ,SELF-efficacy ,SELF-evaluation ,PATIENT participation ,PILOT projects ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,HUMAN research subjects ,PATIENT selection ,PHYSICAL activity ,DATA analysis software ,DESCRIPTIVE statistics - Abstract
Objectives: The main objective of this study is to determine the feasibility of recruiting and retaining patients recently diagnosed with thoracic cancer to a trial of short-term integrated rehabilitation; evaluate uptake of theoretically informed components targeting physical function, symptom self-management and participation; estimate sample size requirements for an efficacy trial. Design: Parallel group randomized controlled feasibility trial. Setting: Three U.K. hospitals. Participants: Patients ⩽eight weeks of thoracic cancer diagnosis, Eastern Cooperative Oncology Group Performance Status 0–3, any cancer stage and treatment plan. Interventions: Participants randomly allocated (1:1) to short-term integrated rehabilitation and standard care or standard care alone over 30 days. Main measures: Primary: participant recruitment and retention, targeting ⩾30% of eligible patients enrolling and ⩾50% of participants reporting outcomes at 30 days. Secondary: intervention fidelity; missing data and performance of outcome measures for self-efficacy, symptoms, physical activity and health-related quality of life. Results: Of 159 eligible patients approached, 54 (34%) were recruited. A total of 44 (82%) and 39 (72%) participants reported outcomes at 30 and 60 days, respectively. Intervention fidelity was high. Rehabilitation was delivered across 3 (1–3) sessions over 32 (22–45) days (median (range)). Changes in clinical outcomes were modest but most apparent at 60 days for health-related quality of life: Functional Assessment of Cancer Therapy Lung Cancer score median (interquartile range) change 9.7 (−12.0 to 16.0) rehabilitation versus 2.3 (−15.0 to 14.5) standard care. Conclusion: A trial to examine efficacy of short-term integrated rehabilitation for people newly diagnosed with thoracic cancer is feasible. A sample of 336 participants could detect a meaningful effect on health-related quality of life as the primary outcome. [ABSTRACT FROM AUTHOR]
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- 2020
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5. Barriers and facilitators to physical activity in men with prostate cancer: A qualitative and quantitative systematic review.
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Fox, Louis, Wiseman, Theresa, Cahill, Declan, Beyer, Katharina, Peat, Nicola, Rammant, Elke, and Van Hemelrijck, Mieke
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META-analysis ,PHYSICAL activity ,PROSTATE cancer ,CANCER in men ,TUMOR classification - Abstract
Objective: Existing research indicates that moderate-to-vigorous physical activity (PA) alleviates treatment side effects and is associated with survival in men with prostate cancer. We aimed to ascertain the state of research investigating barriers and facilitators to PA in men with prostate cancer and synthesise existing qualitative research on this topic.Methods: A systematic review of qualitative and quantitative studies was conducted. MEDLINE, Embase, PsycINFO, Web of Knowledge, CINAHL, PEDro, OATD, and WorldCat were searched to June 2019 for quantitative studies investigating causes or predictors of PA or qualitative studies describing patient-reported barriers/facilitators to PA, amongst men with prostate cancer of any stage. Thirty-two studies (n = 17 quantitative; n = 15 qualitative) were included from 3698 screened articles.Results: Heterogeneity and unsystematic reporting of quantitative study methods prohibited a quantitative data synthesis. Thematic synthesis of qualitative studies produced five analytical themes: individual needs by treatment pathway, self-determination and its relationship with prostate cancer-related events, co-ordination and support of the clinical care team, individual preferences in discrete aspects of PA engagement style, and the potential for a bidirectional facilitative relationship between structured group PA and spontaneous peer support. Both qualitative and quantitative studies indicated incontinence as a barrier.Conclusions: Unsystematic reporting of interventions hinders a robust quantitative understanding of behavioural intervention research in this subject area. Good co-ordination of multidisciplinary care personnel could facilitate PA, by enabling a more comprehensive approach to targeting social cognitive processes. Well-timed intervention and access to highly individualised PA support, including optional group PA classes, seem to also be important facilitators. [ABSTRACT FROM AUTHOR]- Published
- 2019
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6. The ExPeCT (Examining Exercise, Prostate Cancer and Circulating Tumour Cells) trial: study protocol for a randomised controlled trial.
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Sheill, Gráinne, Brady, Lauren, Guinan, Emer, Hayes, Brian, Casey, Orla, Greene, John, Vlajnic, Tatjana, Cahill, Fidelma, Van Hemelrijck, Mieke, Peat, Nicola, Rudman, Sarah, Hussey, Juliette, Cunningham, Moya, Grogan, Liam, Lynch, Thomas, Manecksha, Rustom P., McCaffrey, John, Mucci, Lorelei, Sheils, Orla, and O'Leary, John
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PROSTATE cancer ,PHYSICAL activity ,HEALTH of cancer patients ,EXERCISE physiology ,EXERCISE therapy ,PHYSICAL fitness for men ,PHYSIOLOGICAL therapeutics ,CANCER treatment ,OBESITY treatment ,PROSTATE tumors treatment ,ADENOCARCINOMA ,COMPARATIVE studies ,EXPERIMENTAL design ,HEALTH status indicators ,IMMUNITY ,INFLAMMATORY mediators ,LONGITUDINAL method ,RESEARCH methodology ,MEDICAL cooperation ,RESEARCH protocols ,METASTASIS ,OBESITY ,PROSTATE tumors ,QUALITY of life ,RESEARCH ,TIME ,EVALUATION research ,RANDOMIZED controlled trials ,TREATMENT effectiveness ,DIAGNOSIS - Abstract
Background: Prostate cancer (PrCa) is the second most common cancer in Ireland. Many men present with locally advanced or metastatic cancer for whom curative surgery is inappropriate. Advanced cancer patients are encouraged to remain physically active and therefore there is a need to investigate how patients with metastatic disease tolerate physical activity programmes. Physical activity reduces levels of systemic inflammatory mediators and so an aerobic exercise intervention may represent an accessible and cost-effective means of ameliorating the pro-inflammatory effects of obesity and subsequently decrease poor cancer-specific outcomes in this patient population. This study will assess the feasibility and safety of introducing a structured aerobic exercise intervention to an advanced cancer population. This study will also examine if the evasion of immune editing by circulating tumour cells (CTCs) is an exercise-modifiable mechanism in obese men with prostate cancer.Methods: This international multicentre prospective study will recruit men with metastatic prostate cancer. Participants will be recruited from centres in Dublin (Ireland) and London (UK). Participants will be divided into exposed and non-exposed groups based on body mass index (BMI) ≥ 25 kg/m2 and randomised to intervention and control groups. The exercise group will undertake a regular supervised aerobic exercise programme, whereas the control group will not. Exercise intensity will be prescribed based on a target heart rate monitored by a polar heart rate monitor. Blood samples will be taken at recruitment and at 3 and 6 months to examine the primary endpoint of platelet cloaking of CTCs. Participants will complete a detailed questionnaire to assess quality of life (QoL) and other parameters at each visit.Discussion: The overall aim of the ExPeCT trial is to examine the relationship between PrCa, exercise, obesity, and systemic inflammation, and to improve the overall QoL in men with advanced disease. Results will inform future work in this area examining biological markers of prognosis in advanced prostate cancer.Trial Registration: Clinicaltrials.gov NLM identifier: NCT02453139 . Registered on 12 May 2015. This document contains excerpts from the ExPeCT trial protocol Version 1.5, 28 July 2016. [ABSTRACT FROM AUTHOR]- Published
- 2017
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