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In this communication, we report the first demonstration of an efficient photoelectrochemical aptasensor based on sputtering Au nanoparticle-modified nanoporous BiVO4 for the excellent sensitive and selective detection of thrombin with a low detection limit of 0.5 pM and a large linear range. [ABSTRACT FROM AUTHOR]

For implementing sensitive and selective detection of biological molecules, the biosensors are been designed more and more complicated. The exploration of detection platform in a simple way without loss their sensitivity and selectivity is always a big challenge. Herein, a prototype of recognition biomolecule unit-free photoelectrochemical (PEC) sensing platform with self-cleaning activity is proposed with TiO 2 nanotube photonic crystal (TiO 2 NTPCs) materials as photoelectrode, and dopamine (DA) molecule as both sensitizer and target analyte. The unique adsorption between DA and TiO 2 NTPCs induces the formation of charge transfer complex, which not only expends the optical absorption of TiO 2 into visible light region, thus significantly boosts the PEC performance under illumination of visible light, but also implements the selective detection of DA on TiO 2 photoelectrode. This simple but efficient PEC analysis platform presents a low detection limit of 0.15 nm for detection of DA, which allows to realize the sensitive and selective determination of DA release from the mouse brain for its practical application after coupled with a microdialysis probe. The DA functionalized TiO 2 NTPCs PEC sensing platform opens up a new PEC detection model, without using extra-biomolecule auxiliary, just with target molecule naturally adsorbed on the electrode for sensitive and selective detection, and paves a new avenue for biosensors design with minimalism idea. [ABSTRACT FROM AUTHOR]

In this communication, a new photoelectrochemical aptasensor with Au nanoparticle functionalized self-doped TiO2 nanotube arrays (Au/SD-TiO2 NTs) as the core sensing unit and aptamers as the recognition unit was set up to accomplish the sensitive and selective detection of kanamycin with the lowest detection limit of 0.1 nM. [ABSTRACT FROM AUTHOR]