9 results on '"Cordon-Rosales, Celia"'
Search Results
2. Colonization With Antibiotic-Resistant Bacteria in a Hospital and Associated Communities in Guatemala: An Antibiotic Resistance in Communities and Hospitals (ARCH) Study.
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Ramay, Brooke M, Castillo, Carmen, Grajeda, Laura, Santos, Lucas F, Romero, Juan Carlos, Lopez, Maria Renee, Gomez, Andrea, Caudell, Mark, Smith, Rachel M, Styczynski, Ashley, Herzig, Carolyn T A, Bollinger, Susan, Ning, Mariangeli Freitas, Horton, Jennifer, Omulo, Sylvia, Palmer, Guy H, Cordon-Rosales, Celia, and Call, Douglas R
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AGE distribution ,COMMUNITY health services ,ANTI-infective agents ,PUBLIC health ,CEPHALOSPORINS ,DESCRIPTIVE statistics ,DRUG resistance in microorganisms ,STATISTICAL sampling ,CARBAPENEMS ,ANTIBIOTICS ,COVID-19 pandemic - Abstract
Background We estimated the prevalence of colonization with extended-spectrum cephalosporin-resistant Enterobacterales (ESCrE) and carbapenem-resistant Enterobacterales (CRE) from a hospital and associated communities in western Guatemala. Methods Randomly selected infants, children, and adults (<1, 1–17, and ≥18 years, respectively) were enrolled from the hospital (n = 641) during the coronavirus disease 2019 (COVID-19) pandemic, March to September 2021. Community participants were enrolled using a 3-stage cluster design between November 2019 and March 2020 (phase 1, n = 381) and between July 2020 and May 2021 (phase 2, with COVID-19 pandemic restrictions, n = 538). Stool samples were streaked onto selective chromogenic agar, and a Vitek 2 instrument was used to verify ESCrE or CRE classification. Prevalence estimates were weighted to account for sampling design. Results The prevalence of colonization with ESCrE and CRE was higher among hospital patients compared to community participants (ESCrE: 67% vs 46%, P <.01; CRE: 37% vs 1%, P <.01). Hospital ESCrE colonization was higher for adults (72%) compared with children (65%) and infants (60%) (P <.05). Colonization was higher for adults (50%) than children (40%) in the community (P <.05). There was no difference in ESCrE colonization between phase 1 and 2 (45% and 47%, respectively, P >.05), although reported use of antibiotics among households declined (23% and 7%, respectively, P <.001). Conclusions While hospitals remain foci for ESCrE and CRE colonization, consistent with the need for infection control programs, community prevalence of ESCrE in this study was high, potentially adding to colonization pressure and transmission in healthcare settings. Better understanding of transmission dynamics and age-related factors is needed. [ABSTRACT FROM AUTHOR]
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- 2023
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3. COVID-19 Attitudes and Vaccine Hesitancy among an Agricultural Community in Southwest Guatemala: A Cross-Sectional Survey.
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Rojop, Neudy, Calvimontes, Diva M., Barrios, Edgar, Lamb, Molly M., Paniagua-Avila, Alejandra, Monzon, Jose, Duca, Lindsey M., Iwamoto, Chelsea, Chard, Anna N., Gomez, Melissa, Arias, Kareen, Roell, Yannik, Bolanos, Guillermo Antonio, Zielinski-Gutierrez, Emily, Azziz-Baumgartner, Eduardo, Lopez, Maria Renee, Cordon-Rosales, Celia, Asturias, Edwin J., and Olson, Daniel
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VACCINE hesitancy ,HEALTH attitudes ,VACCINATION ,COVID-19 vaccines ,HEALTH facilities - Abstract
Despite offering free-of-charge COVID-19 vaccines starting July 2021, Guatemala has one of the lowest vaccination rates in Latin America. From 28 September 2021 to 11 April 2022, we conducted a cross-sectional survey of community members, adapting a CDC questionnaire to evaluate COVID-19 vaccine access and hesitancy. Of 233 participants ≥ 12 years, 127 (55%) received ≥1 dose of COVID-19 and 4 (2%) reported prior COVID-19 illness. Persons ≥ 12 years old who were unvaccinated (n = 106) were more likely to be female (73% vs. 41%, p < 0.001) and homemakers (69% vs. 24%, p < 0.01) compared with vaccinated participants (n = 127). Among those ≥18 years, the main reported motivation for vaccination among vaccinated participants was to protect the health of family/friends (101/117, 86%); on the other hand, 40 (55%) unvaccinated persons reported little/no confidence in public health institutions recommending COVID-19 vaccination. Community- and/or home-based vaccination programs, including vaccination of families through the workplace, may better reach female homemakers and reduce inequities and hesitancy. [ABSTRACT FROM AUTHOR]
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- 2023
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4. Blue-Winged Teals in Guatemala and Their Potential Role in the Ecology of H14 Subtype Influenza a Viruses.
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Ortiz, Lucia, Geiger, Ginger, Ferreri, Lucas, Moran, David, Mendez, Dione, Gonzalez-Reiche, Ana Silvia, Alvarez, Danilo, Motta, Mayra, Escobar, Francisco, Rajao, Daniela, Cordon-Rosales, Celia, Nelson, Martha I., and Perez, Daniel R.
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INFLUENZA A virus ,INFLUENZA viruses ,WATER birds ,MIXED infections ,VIRAL mutation - Abstract
Wild aquatic birds are considered the natural hosts of 16 HA (H1–H16) and 9 NA (N1–N9) subtypes of influenza A viruses (FLUAV) found in different combinations. H14 FLUAVs are rarely detected in nature. Since 2011, H14 FLUAVs have been consistently detected in Guatemala, leading to the largest collection of this subtype from a single country. All H14 FLUAVs in Guatemala were detected from blue-winged teal samples. In this report, 17 new full-length H14 FLUAV genome sequences detected from 2014 until 2019 were analyzed and compared to all published H14 sequences, including Guatemala, North America, and Eurasia. The H14 FLUAVs identified in Guatemala were mostly associated with the N3 subtype (n = 25), whereas the rest were paired with either N4 (n = 7), N5 (n = 4), N6 (n = 1), and two mixed infections (N3/N5 n = 2, and N2/N3 n = 1). H14 FLUAVs in Guatemala belong to a distinct H14 lineage in the Americas that is evolving independently from the Eurasian H14 lineage. Of note, the ORF of the H14 HA segments showed three distinct motifs at the cleavage site, two of these containing arginine instead of lysine in the first and fourth positions, not previously described in other countries. The effects of these mutations on virus replication, virulence, and/or transmission remain unknown and warrant further studies. [ABSTRACT FROM AUTHOR]
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- 2023
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5. Improved detection of influenza A virus from blue‐winged teals by sequencing directly from swab material.
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Ferreri, Lucas M., Ortiz, Lucia, Geiger, Ginger, Barriga, Gonzalo P., Poulson, Rebecca, Gonzalez‐Reiche, Ana Silvia, Crum, Jo Anne, Stallknecht, David, Moran, David, Cordon‐Rosales, Celia, Rajao, Daniela, and Perez, Daniel R.
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INFLUENZA A virus ,VIRUS isolation ,WATER birds ,MIXED infections ,H1N1 influenza ,EGGS - Abstract
The greatest diversity of influenza A virus (IAV) is found in wild aquatic birds of the orders Anseriformes and Charadriiformes. In these birds, IAV replication occurs mostly in the intestinal tract. Fecal, cloacal, and/or tracheal swabs are typically collected and tested by real‐time RT‐PCR (rRT‐PCR) and/or by virus isolation in embryonated chicken eggs in order to determine the presence of IAV. Virus isolation may impose bottlenecks that select variant populations that are different from those circulating in nature, and such bottlenecks may result in artifactual representation of subtype diversity and/or underrepresented mixed infections. The advent of next‐generation sequencing (NGS) technologies provides an opportunity to explore to what extent IAV subtype diversity is affected by virus isolation in eggs. In the present work, we evaluated the advantage of sequencing by NGS directly from swab material of IAV rRT‐PCR‐positive swabs collected during the 2013–14 surveillance season in Guatemala and compared to results from NGS after virus isolation. The results highlight the benefit of sequencing IAV genomes directly from swabs to better understand subtype diversity and detection of alternative amino acid motifs that could otherwise escape detection using traditional methods of virus isolation. In addition, NGS sequencing data from swabs revealed reduced presence of defective interfering particles compared to virus isolates. We propose an alternative workflow in which original swab samples positive for IAV by rRT‐PCR are first subjected to NGS before attempting viral isolation. This approach should speed the processing of samples and better capture natural IAV diversity. OPEN RESEARCH BADGES: This article has earned an Open Data Badge for making publicly available the digitally‐shareable data necessary to reproduce the reported results. The data is available at https://doi.org/10.5061/dryad.3h2n106. [ABSTRACT FROM AUTHOR]
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- 2019
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6. A decade of vector control activities: Progress and limitations of Chagas disease prevention in a region of Guatemala with persistent Triatoma dimidiata infestation.
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Juarez, Jose G., Pennington, Pamela M., Bryan, Joe P., Klein, Robert E., Beard, Charles B., Berganza, Elsa, Rizzo, Nidia, and Cordon-Rosales, Celia
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CHAGAS' disease ,VECTOR control ,TRIATOMA ,TRANSMISSION of protozoan diseases ,DISEASE vectors - Abstract
Introduction: Chagas disease, a neglected tropical disease that affects millions of Latin Americans, has been effectively controlled in Guatemala after multiple rounds of indoor residual insecticide spraying (IRS). However, a few foci remain with persistent Triatoma dimidiata infestation. One such area is the municipality of Comapa, Department of Jutiapa, in the southeastern region of Guatemala, where control interventions appear less effective. We carried out three cross sectional entomological and serological surveys in Comapa to evaluate a decade of vector control activities. Baseline serological (1999) and entomological (2001–2) surveys were followed by three rounds of insecticide applications (2003–2005) and intermittent focal spraying of infested houses, until approximately 2012. Household inspections to determine entomological indices and construction materials were conducted in 2001, 2007 and 2011. Seroprevalence surveys were conducted in school-age children in 1999, 2007 and 2015, and in women of child bearing age (15–44 years) only in 2015. After multiple rounds of indoor residual sprayings (IRS), the infestation index decreased significantly from 39% (2001–2) to 27% (2011). Household construction materials alone predicted <10% of infested houses. Chagas seroprevalence in Comapa declined in school-aged children by 10–fold, from 10% (1999) to 1% (2015). However, seroprevalence in women of child bearing age remains >10%. Conclusion: After a decade of vector control activities in Comapa, there is evidence of significantly reduced transmission. However, the continued risk for vector-borne and congenital transmission pose a threat to the 2022 Chagas disease elimination goal. Systematic integrated vector control and improved Chagas disease screening and treatment programs for congenital and vector-borne disease are needed to reach the elimination goal in regions with persistent vector infestation. [ABSTRACT FROM AUTHOR]
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- 2018
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7. A Rapid Epidemiological Tool to Measure the Burden of Norovirus Infection and Disease in Resource-Limited Settings.
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Olson, Daniel, Lamb, Molly M., Lopez, Maria Renee, Paniagua-Avila, M. Alejandra, Zacarias, Alma, Samayoa-Reyes, Gabriela, Cordon-Rosales, Celia, and Asturias, Edwin J.
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NOROVIRUS diseases ,GASTROENTERITIS ,NOROVIRUSES - Abstract
Background. Rapid, cost-effective tools are needed to estimate the disease burden of acute gastroenteritis (AGE) and norovirus (NoV) in resource-limited settings. Methods. Households with children (6 weeks-17 years) in rural Guatemala were randomly enrolled into 2 parallel AGE surveillance systems: (1) a prospective cohort, which included an enrollment visit followed by 1 year of prospective observation using a smartphone-based weekly symptom diary; and (2) 2 sequential cross-sectional rapid active sampling (RAS) surveys. Norovirus testing was performed during enrollment (all subjects) and for prospective AGE episodes (prospective cohort only). Results. The prospective cohort enrolled 207 households (469 children) from April to September 2015 followed by 471 person-years of observation; RAS survey 1 enrolled 210 households (402 children) during October to November 2015, and RAS survey 2 enrolled 210 separate households (368 children) during January to February 2016. The prospective cohort detected a NoV+ AGE prevalence of 11% and a population-attributable fraction (PAF) of -1.6% at enrollment, followed by an incidence of 1.4 episodes/100 person-years. Rapid active sampling surveys 1 and 2 identified a NoV+ AGE prevalence of 14%-21% and a PAF of 3.2%-12.4%. Conclusions. Rapid active sampling surveys were practical and identified more cases of NoV infection and disease compared with a parallel prospective cohort in rural Guatemala. [ABSTRACT FROM AUTHOR]
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- 2017
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8. Performance of a Mobile Phone App-Based Participatory Syndromic Surveillance System for Acute Febrile Illness and Acute Gastroenteritis in Rural Guatemala.
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Olson, Daniel, Lamb, Molly, Lopez, Maria Renee, Colborn, Kathryn, Paniagua-Avila, Alejandra, Zacarias, Alma, Zambrano-Perilla, Ricardo, Rodríguez-Castro, Sergio Ricardo, Cordon-Rosales, Celia, and Asturias, Edwin Jose
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MOBILE health ,PUBLIC health surveillance ,MOBILE apps ,CELL phones ,ACQUISITION of data ,DENGUE viruses ,NOROVIRUSES - Abstract
Background: With their increasing availability in resource-limited settings, mobile phones may provide an important tool for participatory syndromic surveillance, in which users provide symptom data directly into a centralized database.Objective: We studied the performance of a mobile phone app-based participatory syndromic surveillance system for collecting syndromic data (acute febrile illness and acute gastroenteritis) to detect dengue virus and norovirus on a cohort of children living in a low-resource and rural area of Guatemala.Methods: Randomized households were provided with a mobile phone and asked to submit weekly reports using a symptom diary app (Vigilant-e). Participants reporting acute febrile illness or acute gastroenteritis answered additional questions using a decision-tree algorithm and were subsequently visited at home by a study nurse who performed a second interview and collected samples for dengue virus if confirmed acute febrile illness and norovirus if acute gastroenteritis. We analyzed risk factors associated with decreased self-reporting of syndromic data using the Vigilant-e app and evaluated strategies to improve self-reporting. We also assessed agreement between self-report and nurse-collected data obtained during home visits.Results: From April 2015 to June 2016, 469 children in 207 households provided 471 person-years of observation. Mean weekly symptom reporting rate was 78% (range 58%-89%). Households with a poor (<70%) weekly reporting rate using the Vigilant-e app during the first 25 weeks of observation (n=57) had a greater number of children (mean 2.8, SD 1.5 vs mean 2.5, SD 1.3; risk ratio [RR] 1.2, 95% CI 1.1-1.4), were less likely to have used mobile phones for text messaging at study enrollment (61%, 35/57 vs 76.7%, 115/150; RR 0.6, 95% CI 0.4-0.9), and were less likely to access care at the local public clinic (35%, 20/57 vs 67.3%, 101/150; RR 0.4, 95% CI 0.2-0.6). Parents of female enrolled participants were more likely to have low response rate (57.1%, 84/147 vs 43.8%, 141/322; RR 1.4, 95% CI 1.1-1.9). Several external factors (cellular tower collapse, contentious elections) were associated with periods of decreased reporting. Poor response rate (<70%) was associated with lower case reporting of acute gastroenteritis, norovirus-associated acute gastroenteritis, acute febrile illness, and dengue virus-associated acute febrile illness (P<.001). Parent-reported syndromic data on the Vigilant-e app demonstrated agreement with nurse-collected data for fever (kappa=.57, P<.001), vomiting (kappa=.63, P<.001), and diarrhea (kappa=.61, P<.001), with decreased agreement as the time interval between parental report and nurse home visit increased (<1 day: kappa=.65-.70; ≥2 days: kappa=.08-.29).Conclusions: In a resource-limited area of rural Guatemala, a mobile phone app-based participatory syndromic surveillance system demonstrated a high reporting rate and good agreement between parental reported data and nurse-reported data during home visits. Several household-level and external factors were associated with decreased syndromic reporting. Poor reporting rate was associated with decreased syndromic and pathogen-specific case ascertainment. [ABSTRACT FROM AUTHOR]- Published
- 2017
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9. Independent selection of multiple mechanisms for pyrethroid resistance in Guatemalan Anopheles albimanus (Diptera: Culicidae)
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Brogdon, William G., Cordon-Rosales, Celia, McAllister, Janet C., and Corwin, Alana M.
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PEST control ,INSECTICIDE resistance ,MOSQUITOES - Abstract
Isofemale lines were established containing either, both, or neitherof the elevated esterase and oxidase resistance mechanisms conferring pyrethroid resistance in a Guatemalan strain of Anopheles albimanus(Wiedemann). Plots of esterase and oxidase levels for individual mosquitoes from these single families correlated with data obtained using oxidase and esterase synergists in bioassays run in the bottle format. Mixed populations of pyrethroid-resistant A. albimanus adult females were selected using DDT, permethrin, or malathion; and the esterase and oxidase levels of the individual progeny were plotted. These data showed that the 3 classes of insecticide selected the 2 mechanisms differently. These results are discussed in terms of the problem ofmultiresistance surveillance in the field, especially concerning pyrethroid insecticides and the interaction of agricultural and public health insecticide application. [ABSTRACT FROM AUTHOR]
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- 1999
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