1. APRO 家族基因在胃癌中的表达及预后意义.
- Author
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白玉茹, 乔璐, 谢宁, 刘娜, and 王进海
- Abstract
Objective: To analyze the expression and prognostic value of BTG/Tob antiproliferative (APRO) protein family in gastric cancer based on big data mining. Methods: The mRNA expression levels of six members of this family in gastric cancer tissues were analyzed via the Oncomine database. Moreover, the Kaplan-Meier database was used to evaluate the effect on overall survival (OS) of patients with gastric cancer. Results: Compared with the normal gastric tissue, BTG2 expression was lower in gastric cancer tissue, BTG3 expression was upregulated in intestinal gastric cancer tissue, but downregulated in total gastric cancer tissue. Patients with lower BTG3 expression had a shorter overall survival; gastric cancer patients with 5-fluorouracil based adjuvant chemotherapy had a worse prognosis in low BTG2 expression group. Conclusions: mRNA expression of BTG2 and BTG3 in gastric cancer and normal gastric tissues were significantly different. Patients with lower BTG3 expression had a poor prognosis. In addition, BTG2 may be involved in the sensitivity of 5-fluorouracil based adjuvant chemotherapy in gastric cancer patients. [ABSTRACT FROM AUTHOR]
- Published
- 2018
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