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Purpose: To describe the postoperative evolution of visual acuity, flap morphology, and stromal optical density femtosecond laser-assisted laser in situ keratomileusis (FS-LASIK). Setting: Clinica Rementeria, Madrid, Spain. Design: Prospective case series. Methods: The study comprised 44 consecutive eyes that had FS-LASIK performed with the WaveLight FS200 and the Allegretto excimer laser to correct myopia. Visual outcomes, flap thickness, and stromal optical density were assessed 1 day, 1 week, 1 month, and 3 months postoperatively. Results: A statistically significant improvement in the mean uncorrected distance visual acuity at 1 day (0.94 +/- 0.2) and 1 week (0.93 +/- 0.2) to 1 month (1.04 +/- 0.2) and 3 months (1.11 +/- 0.1) postoperatively (P <.05). At 3 months postoperatively, the femtosecond laser had good outcomes in efficacy (0.98 +/- 0.1), safety (0.98 +/- 0.1), and predictability (100% of eyes were within +/- 0.5 D of emmetropia). The femtosecond-created flaps were slightly thicker than intended, the mean SD intraflap was 7.1 [mu]m, the range between the thickest and thinnest points in each flap was 25.4 [mu]m, and the mean flap thickness homogeneity was 7.6 [mu]m at 3 months postoperatively. A progressive decrease in the optical density of the flap stroma and the residual stromal bed was detected during follow-up. Conclusions: The femtosecond laser study appears to be a safe, effective, and predictable platform to obtain LASIK flaps. The flaps were planar and homogeneous but slightly thicker than intended. The optical density of the flap stroma was slightly higher at early follow-up and decreased over time. [ABSTRACT FROM AUTHOR]