16 results on '"Morace, A."'
Search Results
2. Efficient automated localization of ECoG electrodes in CT images via shape analysis
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Roberta Morace, Giancarlo Di Gennaro, Antonio Sarno, Jessica Centracchio, Marcello Bartolo, Sara Casciato, Emilio Andreozzi, Luigi Pavone, Paolo Bifulco, Vincenzo Esposito, Daniele Esposito, Centracchio, J., Sarno, A., Esposito, D., Andreozzi, E., Pavone, L., Di Gennaro, G., Bartolo, M., Esposito, V., Morace, R., Casciato, S., and Bifulco, P.
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0301 basic medicine ,Male ,Drug Resistant Epilepsy ,Support Vector Machine ,Computer science ,Electrode ,Normal Distribution ,computer.software_genre ,Pattern Recognition, Automated ,0302 clinical medicine ,Retrospective Studie ,Voxel ,Image Processing, Computer-Assisted ,Epilepsy surgery ,Electrocorticography ,medicine.diagnostic_test ,Electroencephalography ,General Medicine ,Middle Aged ,Computer Graphics and Computer-Aided Design ,Thresholding ,Shape analysis ,Computer Science Applications ,Electrodes, Implanted ,Gaussian Support Vector Machine ,CT image processing ,Original Article ,Female ,Computer Vision and Pattern Recognition ,Human ,Shape analysis (digital geometry) ,Adult ,Similarity (geometry) ,Biomedical Engineering ,Health Informatics ,03 medical and health sciences ,Young Adult ,medicine ,Humans ,Radiology, Nuclear Medicine and imaging ,Electrodes ,Retrospective Studies ,Shape analysi ,business.industry ,Pattern recognition ,Electrodes recognition ,Support vector machine ,030104 developmental biology ,ElectroCorticoGraphy ,Surgery ,Artificial intelligence ,business ,Tomography, X-Ray Computed ,computer ,030217 neurology & neurosurgery ,Software - Abstract
Purpose People with drug-refractory epilepsy are potential candidates for surgery. In many cases, epileptogenic zone localization requires intracranial investigations, e.g., via ElectroCorticoGraphy (ECoG), which uses subdural electrodes to map eloquent areas of large cortical regions. Precise electrodes localization on cortical surface is mandatory to delineate the seizure onset zone. Simple thresholding operations performed on patients’ computed tomography (CT) volumes recognize electrodes but also other metal objects (e.g., wires, stitches), which need to be manually removed. A new automated method based on shape analysis is proposed, which provides substantially improved performances in ECoG electrodes recognition. Methods The proposed method was retrospectively tested on 24 CT volumes of subjects with drug-refractory focal epilepsy, presenting a large number (> 1700) of round platinum electrodes. After CT volume thresholding, six geometric features of voxel clusters (volume, symmetry axes lengths, circularity and cylinder similarity) were used to recognize the actual electrodes among all metal objects via a Gaussian support vector machine (G-SVM). The proposed method was further tested on seven CT volumes from a public repository. Simultaneous recognition of depth and ECoG electrodes was also investigated on three additional CT volumes, containing penetrating depth electrodes. Results The G-SVM provided a 99.74% mean classification accuracy across all 24 single-patient datasets, as well as on the combined dataset. High accuracies were obtained also on the CT volumes from public repository (98.27% across all patients, 99.68% on combined dataset). An overall accuracy of 99.34% was achieved for the recognition of depth and ECoG electrodes. Conclusions The proposed method accomplishes automated ECoG electrodes localization with unprecedented accuracy and can be easily implemented into existing software for preoperative analysis process. The preliminary yet surprisingly good results achieved for the simultaneous depth and ECoG electrodes recognition are encouraging. Ethical approval n°NCT04479410 by “IRCCS Neuromed” (Pozzilli, Italy), 30th July 2020.
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- 2021
3. Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: outcome and complications
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Morace, Roberta, Di Gennaro, Giancarlo, Picardi, Angelo, Quarato, Pier Paolo, Sparano, Antonio, Mascia, Addolorata, Meldolesi, Giulio Nicolò, Grammaldo, Liliana Graciela, De Risi, Marco, and Esposito, Vincenzo
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- 2012
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4. Bilateral epileptogenesis in temporal lobe epilepsy due to unilateral hippocampal sclerosis: A case series
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Alfredo D'Aniello, Roberta Morace, Giancarlo Di Gennaro, Luigi Pavone, Vincenzo Esposito, Pier Paolo Quarato, Angelo Picardi, Marco De Risi, Liliana G. Grammaldo, Addolorata Mascia, and Sara Casciato
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Adult ,Male ,medicine.medical_treatment ,Population ,Hippocampus ,Epileptogenesis ,Temporal lobe ,Young Adult ,Epilepsy ,Humans ,Medicine ,Ictal ,Epilepsy surgery ,education ,Anterior temporal lobectomy ,Retrospective Studies ,education.field_of_study ,Hippocampal sclerosis ,Sclerosis ,business.industry ,Electroencephalography ,General Medicine ,Middle Aged ,medicine.disease ,Epilepsy, Temporal Lobe ,Anesthesia ,Female ,Surgery ,Neurology (clinical) ,business - Abstract
Bitemporal epilepsy (biTLE), a potential cause of failure in TLE surgery, is rarely associated with unilateral HS and could be suggested by not lateralizing ictal scalp EEG/interictal PET-FDG findings. We evaluated the proportion of biTLE in a population of drug-resistant TLE-HS subjects who underwent intracranial investigation for lateralizing purpose.We retrospectively included all consecutive refractory TLE-HS patients and not lateralizing ictal scalp EEG/interictal PET-FDG findings, investigated by intracranial bilateral longitudinal hippocampal electrodes. Demographic characteristics, electroclinical findings and seizure outcome were evaluated.We identified 14 subjects (7 males; mean age 39.5 years; mean age at disease onset 14.4 years), 7 of them had biTLE diagnosed after intracranial investigations. In the remaining 7 with unilateral epileptogenesis (uniTLE) anterior temporal lobectomy was performed (6/7 were in Engel class I). Preoperative neuropsychological assessment differentiated biTLE from uniTLE, as it was normal in six uniTLE patients but only in one with biTLE (p 0.05).Not lateralizing ictal scalp EEG and functional imaging findings in TLEHS should alert about the possibility of a true biTLE also in presence of unilateral findings at MRI. Intracranial investigations with bilateral longitudinal hippocampal electrodes can localize the EZ with a good risk-benefit profile. Consistently with the warning on memory functions in TLE patients explored by using longitudinal hippocampal electrodes, further studies are needed to better define the optimal investigation strategy.
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- 2021
5. Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery
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Addolorata Mascia, Giovanni Grillea, Alfredo D'Aniello, Sara Casciato, Angelo Picardi, Pier Paolo Quarato, Roberta Morace, Liliana G. Grammaldo, Giancarlo Di Gennaro, Vincenzo Esposito, Marco De Risi, and G. N. Meldolesi
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Adult ,Male ,0301 basic medicine ,medicine.medical_specialty ,Adolescent ,Neuroimaging ,Hippocampus ,Temporal lobe ,Young Adult ,03 medical and health sciences ,Epilepsy ,0302 clinical medicine ,Atrophy ,Humans ,Medicine ,Epilepsy surgery ,Clinical significance ,Retrospective Studies ,Hippocampal sclerosis ,Sclerosis ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Surgery ,Treatment Outcome ,030104 developmental biology ,Epilepsy, Temporal Lobe ,Neurology ,Female ,Neurology (clinical) ,Neurosurgery ,business ,030217 neurology & neurosurgery - Abstract
To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.We studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according to the presence of TB or TA. Subgroups were compared on demographic, clinical, neuropsychological data and seizure outcome.TB was found in 39 (50%) patients, while TA was found in 32 (41%) patients, always ipsilateral to HS, with a considerable degree of overlap (69%) between TB and TA (p=0.01). Patients with temporopolar abnormalities did not significantly differ from those without TB or TA with regard to sex, age, age of epilepsy onset, duration of epilepsy, history of febrile convulsions or birth complications, side of surgery, seizure frequency at surgery, presence of GTCSs, and, in particular, seizure outcome. On the other hand, TB patients show a less frequent family history of epilepsy (p.05) while age at epilepsy onset showed a trend to be lower in the TB group (p=.09). Patients with temporopolar atrophy did not significantly differ from those without TA on any variable, except for age at epilepsy onset, which was significantly lower for the TA group (p.05). History of birth complications and longer duration of epilepsy also showed a trend to be associated with TA (p=.08). Multivariate analysis corroborated the association between temporopolar abnormalities and absence of family history of epilepsy and history of birth complications.High-field 3 T MRI in the preoperative workup for epilepsy surgery confirms that temporopolar abnormalities are frequent findings in TLE-HS patients and may be helpful to lateralize the epileptogenic zone. Their presence did not influence seizure outcome.
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- 2017
6. Long-term seizure outcome in frontal lobe epilepsy surgery
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Alfredo D'Aniello, Pier Paolo Quarato, Giancarlo Di Gennaro, Roberta Morace, Vincenzo Esposito, Liliana G. Grammaldo, Marco De Risi, Sara Casciato, and Addolorata Mascia
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Epilepsy, Frontal Lobe ,Electroencephalography ,03 medical and health sciences ,Behavioral Neuroscience ,Epilepsy ,Young Adult ,0302 clinical medicine ,Seizures ,medicine ,Humans ,Epilepsy surgery ,Ictal ,030212 general & internal medicine ,Child ,Retrospective Studies ,Cerebral Cortex ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,Cortical dysplasia ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Psychosurgery ,medicine.anatomical_structure ,Treatment Outcome ,Neurology ,Frontal lobe ,Scalp ,Female ,Neurology (clinical) ,Radiology ,business ,030217 neurology & neurosurgery ,Follow-Up Studies - Abstract
Purpose The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery. Method This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001–2014), followed up for at least 2 years (mean: 8.7 years). All patients underwent noninvasive presurgical evaluation and/or invasive electroencephalography (EEG) monitoring when nonconcordant data were obtained or epileptogenic zone was hypothesized to be close to the eloquent cortex. Electroclinical, neuroimaging, surgical data, and histology were compared to seizure outcome. Results Mean epilepsy duration was 19 years; mean age at surgery was 31.6 years. Preoperative magnetic resonance imaging (MRI) showed a frontal lesion in 86.4 % of cases. Scalp video-electroencephalography (VEEG) monitoring detected a focal ictal onset in 90% of cases. Twenty-seven patients (61.4%) underwent invasive recordings. Resections involved dorsolateral (47.7%), medial (9%), orbital (13.6%), and rolandic (13.6%) region. Lobectomy within functional boundaries was performed in the remaining 7 cases (16%). Transient and permanent neurological deficits were observed in 2 and 3 cases, respectively. Histology revealed focal cortical dysplasia (45.5%), World Health Organization (WHO) I–II grade tumors (15.9%), gliosis (22.7%), vascular malformations (4.5%), Rasmussen encephalitis (6.8%), and normal tissue (4.5%). At last observation 68.1% of patients were in Engel's class I, 11.4% in class II, 9% in class III, and 11.4% in class IV. A favorable outcome was associated with focal ictal scalp EEG onset (p = 0.0357). Conclusion Surgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates.
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- 2018
7. Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: Clinical significance and seizure outcome after surgery
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Sara Casciato, Roberta Morace, Giovanni Grillea, Vincenzo Esposito, Pier Paolo Quarato, Marco De Risi, Angelo Picardi, Liliana G. Grammaldo, Addolorata Mascia, Alfredo D'Aniello, and Giancarlo Di Gennaro
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Adult ,Male ,Drug Resistant Epilepsy ,medicine.medical_specialty ,Blurring ,Adolescent ,medicine.medical_treatment ,Clinical Neurology ,Neuropsychological Tests ,Temporal lobe ,Young Adult ,Epilepsy ,Atrophy ,Epilepsy surgery ,Seizures ,Humans ,Medicine ,Clinical significance ,Temporal lobe epilepsy ,Anterior temporal lobectomy ,Retrospective Studies ,Outcome ,Hippocampal sclerosis ,Sclerosis ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,Anterior Temporal Lobectomy ,Prognosis ,medicine.disease ,Magnetic Resonance Imaging ,Temporal Lobe ,Surgery ,Treatment Outcome ,Epilepsy, Temporal Lobe ,Neurology ,Preoperative Period ,Female ,Neurology (clinical) ,business ,Temporopolar abnormalities ,Follow-Up Studies - Abstract
PurposeTo assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) with a long post-surgical follow-up.MethodsWe studied 60 consecutive patients with TLE–HS and 1.5 preoperative MRI scans who underwent surgery and were followed up for at least 5 years (mean follow-up 7.3 years). Based on findings of pre-surgical MRI, patients were classified according to the presence of TB or TA. Groups were compared on demographic, clinical, neuropsychological data, and seizure outcome.ResultsTB was found in 37 (62%) patients, while TA was found in 35 (58%) patients, always ipsilateral to HS, with a high degree of overlap (83%) between TB and TA (p
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- 2015
8. Long-term seizure outcome in frontal lobe epilepsy surgery.
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Morace, Roberta, Casciato, Sara, Quarato, Pier Paolo, Mascia, Addolorata, D'Aniello, Alfredo, Grammaldo, Liliana G., De Risi, Marco, Di Gennaro, Giancarlo, and Esposito, Vincenzo
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TEMPORAL lobectomy , *EPILEPSY , *TUMOR grading , *FRONTAL lobe , *ENCEPHALITIS , *SCALP , *MAGNETIC resonance imaging - Abstract
Abstract Purpose The purpose of this study was to report long-term seizure outcome in patients who underwent frontal lobe epilepsy (FLE) surgery. Method This retrospective study included 44 consecutive subjects who underwent resective surgery for intractable FLE at IRCCS NEUROMED (period 2001–2014), followed up for at least 2 years (mean: 8.7 years). All patients underwent noninvasive presurgical evaluation and/or invasive electroencephalography (EEG) monitoring when nonconcordant data were obtained or epileptogenic zone was hypothesized to be close to the eloquent cortex. Electroclinical, neuroimaging, surgical data, and histology were compared to seizure outcome. Results Mean epilepsy duration was 19 years; mean age at surgery was 31.6 years. Preoperative magnetic resonance imaging (MRI) showed a frontal lesion in 86.4 % of cases. Scalp video-electroencephalography (VEEG) monitoring detected a focal ictal onset in 90% of cases. Twenty-seven patients (61.4%) underwent invasive recordings. Resections involved dorsolateral (47.7%), medial (9%), orbital (13.6%), and rolandic (13.6%) region. Lobectomy within functional boundaries was performed in the remaining 7 cases (16%). Transient and permanent neurological deficits were observed in 2 and 3 cases, respectively. Histology revealed focal cortical dysplasia (45.5%), World Health Organization (WHO) I–II grade tumors (15.9%), gliosis (22.7%), vascular malformations (4.5%), Rasmussen encephalitis (6.8%), and normal tissue (4.5%). At last observation 68.1% of patients were in Engel's class I, 11.4% in class II, 9% in class III, and 11.4% in class IV. A favorable outcome was associated with focal ictal scalp EEG onset (p = 0.0357). Conclusion Surgery is a safe treatment option in drug-resistant FLE with a satisfying long-term outcome. These data highlight the importance of an appropriate selection of potential surgical candidates. Highlights • Surgery is a safe option in drug-resistant FLE with a satisfying long-term outcome. • The presence of focal lesions predicts favorable outcome. • Focal ictal scalp EEG onset is associated with a favorable long-term outcome. [ABSTRACT FROM AUTHOR]
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- 2019
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9. Surgery after intracranial investigation with subdural electrodes in patients with drug-resistant focal epilepsy: outcome and complications
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Morace, Roberta, Giancarlo, Gennaro, Di Gennaro, G., Angelo, Picardi, Pier Paolo Quarato, Antonio, Sparano, Addolorata, Mascia, Giulio Nicolò Meldolesi, Liliana Graciela Grammaldo, Marco, Risi, De Risi, M., and Esposito, Vincenzo
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Adult ,Male ,medicine.medical_specialty ,Adolescent ,Drug Resistance ,Subdural Space ,Electroencephalography ,Neurosurgical Procedures ,Temporal lobe ,Lesion ,Epilepsy ,Young Adult ,Postoperative Complications ,Seizures ,Monitoring, Intraoperative ,epilepsy surgery ,extratemporal epilepsy ,subdural electrodes ,outcome ,medicine ,Image Processing, Computer-Assisted ,Humans ,Epilepsy surgery ,Subdural space ,Child ,medicine.diagnostic_test ,business.industry ,Magnetic resonance imaging ,General Medicine ,Middle Aged ,medicine.disease ,Magnetic Resonance Imaging ,Surgery ,Electrodes, Implanted ,medicine.anatomical_structure ,Treatment Outcome ,Surgery, Computer-Assisted ,Female ,Neurology (clinical) ,Neurosurgery ,Epilepsies, Partial ,medicine.symptom ,business - Abstract
Video–EEG monitoring with intracranial subdural electrodes is a useful assessment tool for the localization of the epileptogenic zone in patients with drug-resistant focal epilepsy. We aimed at assessing the morbidity related to electrode implantation and the surgical outcome in patients who underwent epilepsy surgery after intracranial EEG monitoring. All patients (N = 58) admitted to our Epilepsy Surgery Centre for drug-resistant focal epilepsy who underwent resective surgery after intracranial monitoring with subdural electrodes and were followed up for at least 2 years were included in the study. Their mean age was 30.4 years (range 8–60 years), 25 (43 %) were female, and 44 (76 %) had a preoperatively detected structural lesion. The mean duration of invasive recording was 2.3 days (range 1–14 days). Extraoperative ECoG allowed the identification of the epileptogenic focus in all cases. The temporal lobe was involved in 21 (36 %) patients, whereas extratemporal foci were identified in 24 (41 %) patients. Thirteen patients (23 %) had multilobar involvement. Functional brain mapping was performed in 15 (26 %) patients. Transient complications related to electrode implantation occurred in three patients. Among patients with evidence of lesion on preoperative MRI, lesionectomy alone was performed in 12 cases (27 %), while it was combined with tailored cortical resection in the remaining cases. Tailored cortical resection was also performed in patients without evidence of lesion on MRI. After resective surgery, transient neurological deficits occurred in five cases, while another patient experienced permanent lateral homonymous hemianopia. At the last follow-up observation, 34 (57 %) patients were seizure-free (Engel class I). This study suggests that invasive EEG recording with subdural electrodes may be useful and fairly safe for many candidates for epilepsy surgery.
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- 2011
10. Temporal pole abnormalities detected by 3 T MRI in temporal lobe epilepsy due to hippocampal sclerosis: No influence on seizure outcome after surgery.
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Casciato, Sara, Picardi, Angelo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Meldolesi, Giulio Nicolo’, Morace, Roberta, Esposito, Vincenzo, Di Gennaro, Giancarlo, D'Aniello, Alfredo, and Meldolesi, Giulio Nicolo'
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) detected by using 3 Tesla MRI in the preoperative workup in patients with temporal lobe epilepsy due to hippocampal sclerosis (TLE-HS) who underwent surgery.Methods: We studied 78 consecutive patients with TLE-HS who underwent surgery and were followed up for at least 2 years. Based on findings of pre-surgical 3 Tesla MRI, patients were subdivided in subgroups according to the presence of TB or TA. Subgroups were compared on demographic, clinical, neuropsychological data and seizure outcome.Results: TB was found in 39 (50%) patients, while TA was found in 32 (41%) patients, always ipsilateral to HS, with a considerable degree of overlap (69%) between TB and TA (p=0.01). Patients with temporopolar abnormalities did not significantly differ from those without TB or TA with regard to sex, age, age of epilepsy onset, duration of epilepsy, history of febrile convulsions or birth complications, side of surgery, seizure frequency at surgery, presence of GTCSs, and, in particular, seizure outcome. On the other hand, TB patients show a less frequent family history of epilepsy (p<.05) while age at epilepsy onset showed a trend to be lower in the TB group (p=.09). Patients with temporopolar atrophy did not significantly differ from those without TA on any variable, except for age at epilepsy onset, which was significantly lower for the TA group (p<.05). History of birth complications and longer duration of epilepsy also showed a trend to be associated with TA (p=.08). Multivariate analysis corroborated the association between temporopolar abnormalities and absence of family history of epilepsy and history of birth complications.Conclusions: High-field 3 T MRI in the preoperative workup for epilepsy surgery confirms that temporopolar abnormalities are frequent findings in TLE-HS patients and may be helpful to lateralize the epileptogenic zone. Their presence did not influence seizure outcome. [ABSTRACT FROM AUTHOR]- Published
- 2017
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11. Ictal dancing-like semiology in frontal lobe epilepsy.
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Casciato, Sara, Pruneddu, Gianluca, Morace, Roberta, Esposito, Vincenzo, and Di Gennaro, Giancarlo
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FRONTAL lobe ,SYMPTOMS ,EPILEPSY ,VISUAL memory ,TEMPORAL lobe epilepsy ,EPILEPSY surgery ,ELECTROENCEPHALOGRAPHY ,MOVEMENT disorders ,DISEASE complications - Published
- 2019
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12. Temporal pole abnormalities in temporal lobe epilepsy with hippocampal sclerosis: Clinical significance and seizure outcome after surgery.
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Di Gennaro, Giancarlo, D’Aniello, Alfredo, De Risi, Marco, Grillea, Giovanni, Quarato, Pier Paolo, Mascia, Addolorata, Grammaldo, Liliana G., Casciato, Sara, Morace, Roberta, Esposito, Vincenzo, Picardi, Angelo, and D'Aniello, Alfredo
- Abstract
Purpose: To assess the clinical significance of temporal pole abnormalities (temporopolar blurring, TB, and temporopolar atrophy, TA) in patients with temporal lobe epilepsy (TLE) and hippocampal sclerosis (HS) with a long post-surgical follow-up.Methods: We studied 60 consecutive patients with TLE-HS and 1.5 preoperative MRI scans who underwent surgery and were followed up for at least 5 years (mean follow-up 7.3 years). Based on findings of pre-surgical MRI, patients were classified according to the presence of TB or TA. Groups were compared on demographic, clinical, neuropsychological data, and seizure outcome.Results: TB was found in 37 (62%) patients, while TA was found in 35 (58%) patients, always ipsilateral to HS, with a high degree of overlap (83%) between TB and TA (p<0.001). Patients with TB did not differ from those without TB with regard to history of febrile convulsions, GTCSs, age of epilepsy onset, side of surgery, seizure frequency, seizure outcome, and neuropsychological outcome. On the other hand, they were significantly older, had a longer duration of epilepsy, and displayed lower preoperative scores on several neuropsychological tests. Similar findings were observed for TA. Multivariate analysis corroborated the association between temporopolar abnormalities and age at onset, age at surgery (for TB only), and lower preoperative scores on some neuropsychological tests.Conclusions: Temporopolar abnormalities are frequent in patients with TLE-HS. Our data support the hypothesis that TB and TA are caused by seizure-related damages. These abnormalities did not influence seizure outcome, even after a long-term post-surgical follow-up. [ABSTRACT FROM AUTHOR]- Published
- 2015
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13. Very long-term seizure outcome in frontal lobe epilepsy surgery.
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Casciato, Sara, Morace, Roberta, Quarato, Pier Paolo, Mascia, Addolorata, D'Aniello, Alfredo, Grammaldo, Liliana G., Esposito, Vincenzo, and Di Gennaro, Giancarlo
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EPILEPSY surgery , *FRONTAL lobe , *TEMPORAL lobectomy , *SEIZURES (Medicine) - Published
- 2021
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14. Temporal lobe epilepsy surgery in children and adults: A multicenter study
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Barba, Carmen, Cossu, Massimo, Guerrini, Renzo, Di Gennaro, Giancarlo, Villani, Flavio, De Palma, Luca, Grisotto, Laura, Consales, Alessandro, Battaglia, Domenica, Zamponi, Nelia, d’Orio, Piergiorgio, Revay, Martina, Rizzi, Michele, Casciato, Sara, Esposito, Vincenzo, Quarato, Pier Paolo, Di Giacomo, Roberta, Didato, Giuseppe, Pastori, Chiara, Pavia, Giusy Carfi, Pellacani, Simona, Matta, Giulia, Pacetti, Mattia, Tamburrini, Gianpiero, Cesaroni, Elisabetta, Colicchio, Gabriella, Vatti, Giampaolo, Asioli, Sofia, Caulo, Massimo, Marras, Carlo Efisio, Tassi, Laura, D’Aniello, Alfredo, Morace, Roberta, De Curtis, Marco, Deleo, Francesca, Giordano, Flavio, De Benedictis, Alessandro, Prato, Giulia, Perulli, Marco, Barba C., Cossu M., Guerrini R., Di Gennaro G., Villani F., De Palma L., Grisotto L., Consales A., Battaglia D., Zamponi N., d'Orio P., Revay M., Rizzi M., Casciato S., Esposito V., Quarato P.P., Di Giacomo R., Didato G., Pastori C., Carfi Pavia G., Pellacani S., Matta G., Pacetti M., Tamburrini G., Cesaroni E., Colicchio G., Vatti G., Asioli S., Caulo M., Marras C.E., and Tassi L.
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0301 basic medicine ,Male ,Electroencephalography ,Neuropsychological Tests ,Hippocampus ,Neurosurgical Procedures ,Epilepsy ,0302 clinical medicine ,Postoperative Complications ,Cognition ,Epilepsy surgery ,Child ,seizure outcome ,medicine.diagnostic_test ,Age Factors ,Prognosis ,Temporal Lobe ,Malformations of Cortical Development ,Neurology ,Child, Preschool ,epilepsy surgery ,Anticonvulsants ,Female ,Adult ,medicine.medical_specialty ,Referral ,Adolescent ,Temporal lobe ,03 medical and health sciences ,Young Adult ,Settore MED/39 - NEUROPSICHIATRIA INFANTILE ,children ,Internal medicine ,Early Medical Intervention ,medicine ,Humans ,Preschool ,Retrospective Studies ,Hippocampal sclerosis ,Sclerosis ,business.industry ,Magnetic resonance imaging ,Odds ratio ,cognitive outcome ,medicine.disease ,030104 developmental biology ,Epilepsy, Temporal Lobe ,Neurology (clinical) ,business ,030217 neurology & neurosurgery - Abstract
Objective: To assess seizure and cognitive outcomes and their predictors in children (
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15. Drug-resistant temporal lobe epilepsy due to cavernous malformations
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G. N. Meldolesi, Pier Paolo Quarato, Roberta Morace, Antonino Raco, Vincenzo Esposito, Liliana G. Grammaldo, Angelo Picardi, Sergio Paolini, and Giancarlo Di Gennaro
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Adult ,Male ,Hemangioma, Cavernous, Central Nervous System ,medicine.medical_specialty ,drug-resistant ,temporal lobe ,epilepsy ,Drug Resistance ,Neurosurgical Procedures ,Temporal lobe ,Hemangioma ,Epilepsy ,medicine ,Humans ,Epilepsy surgery ,Adverse effect ,Patient Care Team ,Brain Neoplasms ,business.industry ,Neuropsychology ,General Medicine ,Middle Aged ,medicine.disease ,Cavernous malformations ,Surgery ,Treatment Outcome ,Epilepsy, Temporal Lobe ,Anticonvulsants ,Female ,Neurology (clinical) ,business ,Vascular Surgical Procedures ,Psychosocial ,Follow-Up Studies - Abstract
Object Supratentorial cavernous angiomas may be associated with drug-resistant focal epilepsy. Surgical removal of the malformation may result in seizure control in a number of patients, although in most studies a long history and high frequency of attacks have been recognized as indicators of unfavorable seizure outcome. In the literature, there are no clear indications regarding the optimal diagnostic presurgical workup and the surgical strategy for this particular subgroup of patients with symptomatic epilepsy. In this paper the authors focus on the preoperative workup and the surgical management of the disease in eight consecutive patients undergoing surgery for drug-resistant temporal lobe epilepsy (TLE) due to cavernous malformations (CMs), and the relevant literature on this issue is also reviewed. Methods Preoperatively, all patients were assessed using a noninvasive protocol aimed at localizing the epileptogenic zone on the basis of anatomical, electrical, and clinical criteria. The presurgical assessment yielded an indication for lesionectomy in two cases, lesionectomy plus anteromesial temporal lobectomy in four cases, and lesionectomy plus extended temporal lobectomy in two cases. At follow-up examinations, seizure, neuropsychological, and psychiatric outcomes were all evaluated. Seven patients were categorized in Engel Class IA (seizure free), and one was categorized in Engel Class IB (occasional auras only). No adverse effects on neuropsychological or psychosocial functioning were observed. Conclusions Epilepsy surgery can be performed with excellent results in patients with intractable TLE caused by CMs. Noninvasive presurgical evaluation of these patients may enable a tailored approach, providing complete seizure relief in most cases.
16. A rapid and reliable procedure to localize subdural electrodes in presurgical evaluation of patients with drug-resistant focal epilepsy
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Sebastiano, F., Di Gennaro, G., Esposito, V., Picardi, A., Morace, R., Sparano, A., Mascia, A., Colonnese, C., Cantore, G., and Quarato, P.P.
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FRONTAL lobe epilepsy , *EPILEPSY , *BRAIN diseases , *MEDICAL imaging systems , *DIAGNOSTIC imaging - Abstract
Abstract: Objectives: To evaluate a novel method for localization of subdural electrodes in presurgical assessment of patients with drug-resistant focal epilepsy. Methods: We studied eight consecutive patients with posterior epilepsy in whom subdural electrodes were implanted for presurgical evaluation. Electrodes were detected on post-implantation brain CT scans through a semiautomated procedure based on a MATLAB routine. Then, post-implantation CT scans were fused with pre-implantation MRI to localize the electrodes in relation to the underlying cortical structures. The reliability of this procedure was tested by comparing 3D-rendered MR images of the electrodes with electrode position as determined by intraoperative digital photography. Results: In each patient, all electrodes could be correctly localized and visualized in a stereotactic space, thus allowing optimal surgery planning. The agreement between the procedure-generated images and the digital photographs was good according to two independent raters. The mean mismatch between the 3D images and the photographs was 2mm. Conclusions: While our findings need confirmation on larger samples including patients with anterior epilepsy, this procedure allowed to localize subdural electrodes and to establish the spatial relationship of each electrode to the underlying brain structure, either normal or damaged, on brain convessity, basal and medial cortex. Significance: Being simple, rapid, unexpensive, and reliable, this procedure holds promise to be useful to optimize epilepsy surgery planning. [Copyright &y& Elsevier]
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- 2006
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