1. Risk of cerebral palsy associated with neonatal encephalopathy in macrosomic neonates.
- Author
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Yamada, Takahiro, Akaishi, Rina, Yamada, Takashi, Morikawa, Mamoru, Kaneuchi, Masanori, and Minakami, Hisanori
- Subjects
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COMPLICATIONS of brain injuries , *CEREBRAL palsy , *CONFIDENCE intervals , *FISHER exact test , *GESTATIONAL age , *STATISTICS , *T-test (Statistics) , *U-statistics , *RETROSPECTIVE studies , *FETAL macrosomia , *DATA analysis software , *DESCRIPTIVE statistics , *DISEASE risk factors - Abstract
Aim To determine whether macrosomic infants with a birthweight of 4.0 kg or more have increased risk of cerebral palsy associated with neonatal encephalopathy ( Enc- CP). Methods A retrospective review of 132 singleton infants with Enc- CP fulfilling all of the following criteria: born at gestational week ( GW) 37 or more ( n = 126) or weighing 2.5 kg or more at birth ( n = 116) in or after January 2009 in Japan; no identifiable causes of cerebral palsy other than antenatal or intrapartum hypoxia; and exhibition of neonatal encephalopathy. National statistics of Japan were used to determine the numbers of infants according to birthweight categories. Results Of the 116 infants with a birthweight of 2.5 kg or more, 46 (39.7%), 49 (42.2%), 17 (14.7%) and four (3.4%) infants had birthweights of 2.5-2.99, 3.0-3.49, 3.5-3.99 and 4.0 kg or more, respectively. Corresponding figures among Japanese infants born in 2009-2011 were 42.8%, 45.4%, 10.9% and 0.90%, respectively. Infants with a birthweight of 4.0 kg or more had a relative risk (95% confidence interval) of Enc- CP of 3.89 (1.52-9.95) compared to those with a birthweight of 2.5-2.99 kg. Conclusion Japanese infants with a birthweight of 4.0 kg or more have increased risk of Enc- CP. [ABSTRACT FROM AUTHOR]
- Published
- 2014
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