1. Histologic work-up of non-palpable breast lesions classified as probably benign at initial mammography and/or ultrasound (BI-RADS category 3)
- Author
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Gruber, R., Jaromi, S., Rudas, M., Pfarl, G., Riedl, C.C., Flöry, D., Graf, O., Sickles, E.A., and Helbich, T.H.
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MAMMOGRAMS , *HISTOLOGY , *DIAGNOSTIC ultrasonic imaging , *MEDICAL needs assessment , *NEEDLE biopsy of the breast , *FOLLOW-up studies (Medicine) , *DUCTAL carcinoma - Abstract
Abstract: Purpose: To determine the accuracy of a probably benign assessment of non-palpable breast lesions (BI-RADS category 3) at mammography and/or ultrasound with immediate histological work-up. Materials and methods: Stereotactic or ultrasound guided core needle breast biopsy (NBB) was performed to evaluate 288 lesions, which were prospectively assessed as BI-RADS category 3. Imaging findings included 195 masses, 73 calcification cases, 16 focal asymmetries, and four architectural distortion cases. After NBB, patients underwent either open surgical biopsy (OSB) (n =204) or mammographic follow-up (n =84) for at least 24 months. Histological results of NBB were compared with those of OSB. Results: Three of the 288 lesions (1.0%) proved to be malignant at histological work-up, two of them were ductal carcinoma in situ (DCIS) and one of them was an invasive carcinoma. NBB revealed invasive carcinoma in 1/288 (0.35%) and atypical ductal hyperplasia (ADH) in 13/288 (4.5%) lesions. OSB revealed DCIS in 2/204 (1%) and invasive carcinoma in 1/204 (0.5%) lesions. The two DCIS were underestimated as ADH by NBB. The remaining 285 (99%) lesions proved to be benign at OSB or remained stable during follow-up. Conclusion: Confirmed by tissue diagnosis, the low likelihood of malignancy of prospectively assessed probably benign lesions is below the 2% threshold established for BI-RADS category 3. Imaging follow-up is a safe and effective alternative to immediate histological work-up for such lesions. [Copyright &y& Elsevier]
- Published
- 2013
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