1. Informing the management of the post-COVID condition: insights from the Western Australian experience comparing those who tested positive and negative to early COVID-19 strains.
- Author
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Grove, Kristen, Cavalheri, Vinicius, Chih, HuiJun, Natarajan, Varsha, Harrold, Meg, Mohd, Sheeraz, Hurn, Elizabeth, Van der Lee, Lisa, Maiorana, Andrew, Tearne, Jessica, Watson, Carol, Pearce, Jane, Jacques, Angela, White, Ann, Vicary, Caitlin, Roffman, Caroline, Synnott, Emma-Leigh, Suttie, Ian, Lin, Ivan, and Larsson, Jade
- Subjects
T-test (Statistics) ,DATA analysis ,COVID-19 testing ,POST-acute COVID-19 syndrome ,POLYMERASE chain reaction ,SEX distribution ,FATIGUE (Physiology) ,FISHER exact test ,MULTIPLE regression analysis ,LOGISTIC regression analysis ,FUNCTIONAL status ,AGE distribution ,ANXIETY ,MANN Whitney U Test ,CHI-squared test ,LONGITUDINAL method ,ODDS ratio ,CONVALESCENCE ,OBSTRUCTIVE lung diseases ,STATISTICS ,HEALTH outcome assessment ,DYSPNEA ,CONFIDENCE intervals ,COMPARATIVE studies ,DATA analysis software ,COVID-19 ,ASTHMA ,GRIP strength ,MENTAL depression - Abstract
Objective: This study aimed to compare the relative physical recovery and symptoms after SARS-CoV-2 infection between groups confirmed positive or negative to early strains of COVID-19. Methods: A prospective, longitudinal cohort study compared outcomes of metropolitan adults polymerase chain reaction-tested for COVID-19 between March and November 2020 in Western Australia. Control matching was attempted: inpatients (gender, age) and ambulatory clinic (gender, age, asthma, chronic pulmonary disease). One-year follow-up involved three repeated measures: physical function (grip strength and 1-min sit-to-stand) and patient-reported outcomes (Fatigue Severity Scale, modified Medical Research Council dyspnoea scale and Euroqol-5D-5L). Results: Three hundred and forty-four participants were recruited (154 COVID+, age 54 ± 18 years, 75 females [49%]); 190 COVID−, age 52 ± 16 years, 67 females [35%]) prior to national vaccination roll-out. No between-group differences in physical function measures were evident at any time point. Fatigue (OR 6.62, 95% CI 2.74–15.97) and dyspnoea (OR 2.21, 95% CI 1.14–4.30) were higher in the COVID+ group at second assessment (T2). On Euroqol-5D-5L, no between-group differences were evident in the physical function domains of self-care, mobility or usual activities at any time point. However, COVID+ participants were less likely to report an absence of anxiety or depression symptoms at T2 (OR 0.41, 95% CI 0.19–0.89). Conclusions: Neither statistical nor clinically meaningful differences in physical function were evident between COVID+ and COVID− participants to 12-months after acute illness. Symptoms of fatigue, dyspnoea, anxiety or depression were more prevalent in the COVID+ group til ~8 months after illness with between-group differences no longer evident at 1 year. What is known about the topic? COVID-19 evokes multi-system sequelae including persistent physical and mental health symptoms, functional impairments and poorer quality of life. What does this paper add? A COVID+ group had equivalent physical recovery over 12 months; but higher prevalence of fatigue, dyspnoea and anxiety/depression symptoms at ~8 months compared to a COVID− group. What are the implications for practitioners? Health authorities and employers should know that while adequate physical function may return within months, post-acute sequelae of COVID-19 impair sufferers for over 6 months, likely necessitating healthcare support and workplace adjustments to optimise timely return to participation. [ABSTRACT FROM AUTHOR]
- Published
- 2024
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